The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Ricardo Garcia - One of the best experts on this subject based on the ideXlab platform.

  • determination of the elastic moduli of a single cell cultured on a rigid support by force microscopy
    Biophysical Journal, 2018
    Co-Authors: Pablo D Garcia, Ricardo Garcia
    Abstract:

    Abstract The elastic response of a living cell is affected by its physiological state. This property provides mechanical fingerprints of a cell’s Dysfunctionality. The softness (kilopascal range) and thickness (2–15 μm) of mammalian cells imply that the force exerted by the probe might be affected by the stiffness of the solid support. This observation makes infinite sample thickness models unsuitable to describe quantitatively the forces and deformations on a cell. Here, we report a general theory to determine the true Young’s moduli of a single cell from a force-indentation curve. Analytical expressions are deduced for common geometries such as flat punches, paraboloids, cones, needles, and nanowires. For a given cell and indentation, the influence of the solid support on the measurements is reduced by using sharp and high aspect ratio tips. The theory is validated by finite element simulations.

Christina Darviri - One of the best experts on this subject based on the ideXlab platform.

  • the association between stress and sexual Dysfunctionality in men and women a systematic review
    Psychology, 2015
    Co-Authors: Michael Galanakis, Mariadespoina Kallianta, Chrysoula Katsira, Dimitra Liakopoulou, George P Chrousos, Christina Darviri
    Abstract:

    Purpose: Sexuality and sexual functionality are considered as an important factor of physical and psychological health. Over the years, problems with sexual functionality have been related to stress. A systematic review of the articles concerning sexual Dysfunctionality is presented in this article, with emphasis in the past five years in order to highlight new aspects and implications. Method: The study was based on relevant articles from the PubMed and Wiley online library, using the combination of keywords stress and sexual Dysfunctionality, while excluding articles prior to 2010. Results: The analysis shows that the phenomenon is complex and multifactorial. Variables such as depression, PTSD, lifestyle, gender, personality and positive coping play a crucial role. Research findings also indicate that sexual Dysfunctionality is often misdiagnosed and not immediately taken care of. Conclusion: The severity of the pathology regarding sexual Dysfunctionality calls for immediate planning and coping. Finally future research directions are discussed.

Proinnsias Breathnach - One of the best experts on this subject based on the ideXlab platform.

  • from spatial keynesianism to post fordist neoliberalism emerging contradictions in the spatiality of the irish state
    Antipode, 2010
    Co-Authors: Proinnsias Breathnach
    Abstract:

    The transition from Fordism to post-Fordism has been accompanied by profound changes in the spatiality of west European states. The hierarchical, top-down and redistributive structures that typified the Fordist welfare state have been replaced by more complex spatial configurations as elements of economic and political power have shifted both downwards to subnational territorial levels and upwards to the supranational level. A major debate has developed around the nature of these emerging forms of state spatiality and of the processes underpinning their formation. This paper examines how these processes have operated in the particular case of the Republic of Ireland. Here, the spatiality of the state was founded on a peculiar post-colonial combination of a localised populist politics and a centralised state bureaucracy. While this arrangement was quite suited to the spatial dispersal of industrial branch plants which underpinned regional policy in the 1960s and 1970s, it has become increasingly problematic with the more recent emergence of new trends in the nature and locational preferences of inward investment. This is reflected in the profound conflicts that have attended the formulation and implementation of the National Spatial Strategy, introduced in 2002. The result is a national space economy whose increasing Dysfunctionality may now be compromising the very development model upon which Ireland’s recent spectacular economic growth has been built.

Alena Viktorinova - One of the best experts on this subject based on the ideXlab platform.

  • abnormalities in the relationship of paraoxonase 1 with hdl and apolipoprotein a1 and their possible connection to hdl Dysfunctionality in type 2 diabetes
    Diabetes Research and Clinical Practice, 2018
    Co-Authors: Alena Viktorinova, S Kinova, Ingrid Jurkovicova, Lubomira Fabryova, Michal Koren, Anna Stecova, Klara Svitekova
    Abstract:

    Abstract Aims Lipid parameters, lipid risk indexes and lipid-related oxidative stress markers (paraoxonase 1 [PON1] and lipid peroxides [LPO]) reflect the actual status of lipid metabolism in type 2 diabetes (T2DM). We hypothesized that relationships of high-density lipoprotein cholesterol (HDL-c) with PON1 and apolipoprotein A1 (ApoA1) and/or PON1 with ApoA1 under conditions of hyperglycaemia and oxidative stress might reveal HDL functionality. We investigated relationships between PON1, LPO, and lipid risk markers in T2DM subjects and compared them with those in healthy subjects. Methods A total of 107 Caucasian subjects, 67 T2DM outpatients (mean age 52.2 ± 6.9 years) and 40 healthy subjects (mean age 48.1 ± 7.5 years) were included in the study. Serum levels of total cholesterol (CHOL-T), HDL-c, low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apolipoprotein B (ApoB), ApoA1, LPO, and PON1 activity were measured. Non-HDL-c, ApoB/ApoA1 and non-HDL/HDL (lipid risk indexes) were calculated. Results Higher levels of TG, LPO (P  Conclusions Impaired anti-oxidant and anti-atherogenic HDL properties associated with weakened PON1 function and lipid peroxidation may contribute to the development of atherosclerosis-related diseases in T2DM.

  • comment on gaillard et al hdl Dysfunctionality paraoxonase is worse in nondiabetic postmenopausal african american than in white women diabetes care 2011 34 e19
    Diabetes Care, 2011
    Co-Authors: Alena Viktorinova, S Kinova
    Abstract:

    We read with interest the recent study by Gaillard et al. (1) focused on relationships between paraoxonase (PON1) activity and oxidized LDL and cardiovascular disease (CVD) risk factors in nondiabetic, postmenopausal women. Higher CVD mortality and morbidity in the presence of higher HDL cholesterol is a frequent occurrence in African American women compared with white women. The authors reported the ethnic HDL–related dysfunction (as measured by PON1) in nondiabetic women. They concluded that this paradox may be caused by enhanced LDL oxidation associated with HDL Dysfunctionality (lower activity of PON1) in a group …

S Kinova - One of the best experts on this subject based on the ideXlab platform.

  • abnormalities in the relationship of paraoxonase 1 with hdl and apolipoprotein a1 and their possible connection to hdl Dysfunctionality in type 2 diabetes
    Diabetes Research and Clinical Practice, 2018
    Co-Authors: Alena Viktorinova, S Kinova, Ingrid Jurkovicova, Lubomira Fabryova, Michal Koren, Anna Stecova, Klara Svitekova
    Abstract:

    Abstract Aims Lipid parameters, lipid risk indexes and lipid-related oxidative stress markers (paraoxonase 1 [PON1] and lipid peroxides [LPO]) reflect the actual status of lipid metabolism in type 2 diabetes (T2DM). We hypothesized that relationships of high-density lipoprotein cholesterol (HDL-c) with PON1 and apolipoprotein A1 (ApoA1) and/or PON1 with ApoA1 under conditions of hyperglycaemia and oxidative stress might reveal HDL functionality. We investigated relationships between PON1, LPO, and lipid risk markers in T2DM subjects and compared them with those in healthy subjects. Methods A total of 107 Caucasian subjects, 67 T2DM outpatients (mean age 52.2 ± 6.9 years) and 40 healthy subjects (mean age 48.1 ± 7.5 years) were included in the study. Serum levels of total cholesterol (CHOL-T), HDL-c, low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apolipoprotein B (ApoB), ApoA1, LPO, and PON1 activity were measured. Non-HDL-c, ApoB/ApoA1 and non-HDL/HDL (lipid risk indexes) were calculated. Results Higher levels of TG, LPO (P  Conclusions Impaired anti-oxidant and anti-atherogenic HDL properties associated with weakened PON1 function and lipid peroxidation may contribute to the development of atherosclerosis-related diseases in T2DM.

  • comment on gaillard et al hdl Dysfunctionality paraoxonase is worse in nondiabetic postmenopausal african american than in white women diabetes care 2011 34 e19
    Diabetes Care, 2011
    Co-Authors: Alena Viktorinova, S Kinova
    Abstract:

    We read with interest the recent study by Gaillard et al. (1) focused on relationships between paraoxonase (PON1) activity and oxidized LDL and cardiovascular disease (CVD) risk factors in nondiabetic, postmenopausal women. Higher CVD mortality and morbidity in the presence of higher HDL cholesterol is a frequent occurrence in African American women compared with white women. The authors reported the ethnic HDL–related dysfunction (as measured by PON1) in nondiabetic women. They concluded that this paradox may be caused by enhanced LDL oxidation associated with HDL Dysfunctionality (lower activity of PON1) in a group …