Dysgeusia

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Michael T Brennan - One of the best experts on this subject based on the ideXlab platform.

Wei Ting Xiong - One of the best experts on this subject based on the ideXlab platform.

  • anosmia and Dysgeusia associated with sars cov 2 infection an age matched case control study
    Canadian Medical Association Journal, 2020
    Co-Authors: Alex Carignan, Louis Valiquette, Cynthia Grenier, Jean Berchmans Musonera, Delphin Nkengurutse, Anais Marcilheguy, Kim Vettese, Dominique Marcoux, Corinne Valiquette, Wei Ting Xiong
    Abstract:

    Background: Anosmia and Dysgeusia have been reported as potential symptoms of coronavirus disease 2019. This study aimed to confirm whether anosmia and Dysgeusia are specific symptoms among those who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: We conducted an age-matched case−control study in the Eastern Townships region of Quebec between Mar. 10 and Mar. 23, 2020. We included adults (age ≥ 18 yr) who tested positive for SARS-CoV-2 by reverse transcription polymerase chain reaction. Cases were matched (1:1) according to 5-year age groups with control patents selected randomly from among all patients who tested negative for SARS-CoV-2 during the same period. Demographic and laboratory information was collected from medical records. Clinical symptoms and comorbidities associated with anosmia and Dysgeusia were obtained by telephone interview with a standardized questionnaire. Results: Among 2883 people tested for SARS-CoV-2, we identified 134 positive cases (70 women [52.2%] and 64 men [47.8%]; median age 57.1 [interquartile range 41.2–64.5] yr). The symptoms independently associated with SARS-CoV-2 positivity in conditional logistic regression were anosmia or Dysgeusia or both (adjusted odds ratio [OR] 62.9, 95% confidence interval [CI] 11.0–359.7), presence of myalgia (adjusted OR 7.6, 95% CI 1.9–29.9), blurred vision (adjusted OR 0.1, 95% CI 0.0–0.8) and chest pain (adjusted OR 0.1, 95% CI 0.0–0.6). Interpretation: We found a strong association between olfactory and gustatory symptoms and SARS-CoV-2 positivity. These symptoms should be considered as common and distinctive features of SARS-CoV-2 infection and should serve as an indication for testing and possible retesting of people whose first test result is negative.

Allan Hovan - One of the best experts on this subject based on the ideXlab platform.

  • response to letter to the editor titled a matter of taste making the distinction between taste and flavor is essential for improving management of Dysgeusia
    Supportive Care in Cancer, 2011
    Co-Authors: Allan Hovan
    Abstract:

    Dear Editor, I appreciate the letter written by Boltong et al. titled A Matter of Taste: Making the Distinction Between Taste and Flavor is Essential for Improving Management of Dysgeusia. The authors accurately describe the important difference between taste and flavor and the fact that many of the papers that have been written on Dysgeusia as a side effect of cancer therapy are, in fact, assessing taste sensitivity. These two processes are often confused with each other in the literature. Taste changes are complex and, as mentioned by the authors, linked to a number of other factors including olfaction, emotional state, and medical comorbidities. In order to advance our understanding of Dysgeusia, definitions and validated assessment scales need to be agreed upon and so that more meaningful science can be conducted. In doing the systematic review, it was disappointing to discover the paucity of good research on this important side effect of cancer therapy.

  • a systematic review of Dysgeusia induced by cancer therapies
    Supportive Care in Cancer, 2010
    Co-Authors: Allan Hovan, Michele P Williams, Peter Stevensonmoore, Ylva Britt Wahlin, Kirsten Eo Ohrn, Fred K L Spijkervet, Linda S. Elting, Michael T Brennan
    Abstract:

    Purpose The purpose was to review relevant scientific papers written since 1989 which focused on the prevalence and management of Dysgeusia as an oral side effect of cancer treatment.

  • a systematic review of Dysgeusia induced by cancer therapies
    Supportive Care in Cancer, 2010
    Co-Authors: Allan Hovan, Michele P Williams, Peter Stevensonmoore, Ylva Britt Wahlin, Kirsten Eo Ohrn, Fred K L Spijkervet, Linda S. Elting, Michael T Brennan
    Abstract:

    Dysgeusia is a common oral side effect of cancer therapy (radiotherapy, chemotherapy, or combined modality therapy) and often impacts negatively on quality of life. From the current literature, the ...

Fred K L Spijkervet - One of the best experts on this subject based on the ideXlab platform.

Alex Carignan - One of the best experts on this subject based on the ideXlab platform.

  • anosmia and Dysgeusia associated with sars cov 2 infection an age matched case control study
    Canadian Medical Association Journal, 2020
    Co-Authors: Alex Carignan, Louis Valiquette, Cynthia Grenier, Jean Berchmans Musonera, Delphin Nkengurutse, Anais Marcilheguy, Kim Vettese, Dominique Marcoux, Corinne Valiquette, Wei Ting Xiong
    Abstract:

    Background: Anosmia and Dysgeusia have been reported as potential symptoms of coronavirus disease 2019. This study aimed to confirm whether anosmia and Dysgeusia are specific symptoms among those who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: We conducted an age-matched case−control study in the Eastern Townships region of Quebec between Mar. 10 and Mar. 23, 2020. We included adults (age ≥ 18 yr) who tested positive for SARS-CoV-2 by reverse transcription polymerase chain reaction. Cases were matched (1:1) according to 5-year age groups with control patents selected randomly from among all patients who tested negative for SARS-CoV-2 during the same period. Demographic and laboratory information was collected from medical records. Clinical symptoms and comorbidities associated with anosmia and Dysgeusia were obtained by telephone interview with a standardized questionnaire. Results: Among 2883 people tested for SARS-CoV-2, we identified 134 positive cases (70 women [52.2%] and 64 men [47.8%]; median age 57.1 [interquartile range 41.2–64.5] yr). The symptoms independently associated with SARS-CoV-2 positivity in conditional logistic regression were anosmia or Dysgeusia or both (adjusted odds ratio [OR] 62.9, 95% confidence interval [CI] 11.0–359.7), presence of myalgia (adjusted OR 7.6, 95% CI 1.9–29.9), blurred vision (adjusted OR 0.1, 95% CI 0.0–0.8) and chest pain (adjusted OR 0.1, 95% CI 0.0–0.6). Interpretation: We found a strong association between olfactory and gustatory symptoms and SARS-CoV-2 positivity. These symptoms should be considered as common and distinctive features of SARS-CoV-2 infection and should serve as an indication for testing and possible retesting of people whose first test result is negative.