The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Hou-wen Lin - One of the best experts on this subject based on the ideXlab platform.
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spiroetherones a and b sesquiterpene naphthoquinones as angiogenesis inhibitors from the marine sponge Dysidea etheria
Organic chemistry frontiers, 2020Co-Authors: Wei-hua Jiao, Jie Cui, Yun Zhang, Kechun Liu, Ruyi Shang, Jiabao Sun, Qi Yang, Hou-wen LinAbstract:Spiroetherones A (1) and B (2), a pair of sesquiterpene naphthoquinones with an unprecedented “spiroetherane” carbon skeleton, were isolated from the marine sponge Dysidea etheria collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses coupled with quantum chemistry DFT GIAO 13C NMR and ECD calculations. Spiroetherone A (1) showed anti-angiogenic activity in a zebrafish model with an IC50 value of 2.4 μM. In addition, the plausible biogenetic pathway of the two metabolites is proposed.
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discovery of nitrogenous sesquiterpene quinone derivatives from sponge Dysidea septosa with anti inflammatory activity in vivo zebrafish model
Bioorganic Chemistry, 2020Co-Authors: Yuhan Gui, Wei-hua Jiao, Yun Zhang, Kechun Liu, Li Liu, Zhili Jia, Yongping Shi, Haotian Kong, Hou-wen LinAbstract:Abstract Two unique nitrogenous sesquiterpene quinone meroterpenoids, dysidinoid B (1) and dysicigyhone A (2), together with eight known analogues (3–10) were isolated and characterized from the marine sponge Dysidea septosa. Their structures with absolute configurations were established by a combination of extensive spectroscopic, electron circular dichroism (ECD) and single-crystal X-ray diffraction data analysis. Structurally, dysicigyhone A (2) possessed a unique benzo[d]oxazolidine-2-one unit. Additionally, dysidinoid B (1) exhibited significant anti-inflammatory effect by inhibiting TNF-α and IL-6 generation with IC50 values of 9.15 μM and 17.62 μM, respectively. Further in vivo anti-inflammatory assay verified that the dysidinoid B (1) alleviated the CuSO4-induced robust acute inflammatory response in zebrafish model.
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frondoplysins a and b unprecedented terpene alkaloid bioconjugates from Dysidea frondosa
Organic Letters, 2019Co-Authors: Wei-hua Jiao, Mengmeng Zhang, Jie Cui, Yuhan Gui, Yun Zhang, Kechun Liu, Hou-wen LinAbstract:The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 μM.
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septosones a c in vivo anti inflammatory meroterpenoids with rearranged carbon skeletons from the marine sponge Dysidea septosa
Organic Letters, 2019Co-Authors: Yuhan Gui, Wei-hua Jiao, Yun Zhang, Kechun Liu, Mi Zhou, Dequan Zeng, Hongrui Zhu, Fan Sun, Haifeng Chen, Hou-wen LinAbstract:Three unusual meroterpenoids, septosones A-C (1-3), were isolated from the marine sponge Dysidea septosa. The structures were determined by analysis of spectroscopic data combined with single-crystal X-ray diffraction and ECD calculations. Septosone A (1) features an unprecedented "septosane" carbon skeleton, whereas septosones B (2) and C (3) share a rare spiro[4.5]decane motif. Septosone A showed in vivo anti-inflammatory activity in CuSO4-induced transgenic fluorescent zebrafish likely through inactivation of the NF-κB signaling pathway.
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dysiarenone a dimeric c21 meroterpenoid with inhibition of cox 2 expression from the marine sponge Dysidea arenaria
Organic Letters, 2018Co-Authors: Wei-hua Jiao, Guo-hua Shi, Baohui Cheng, Guodong Chen, Hou-wen LinAbstract:Dysiarenone (1), a dimeric C21 meroterpenoid featuring an unprecedented 2-oxaspiro[bicyclo[3.3.1]nonane-9,1′-cyclopentane] carbon skeleton, was isolated from the marine sponge Dysidea arenaria. The structure of 1 was determined by HRMS and NMR spectroscopic analyses coupled with ECD calculations. Dysiarenone showed inhibitory activities against COX-2 expression and the production of prostaglandin E2 with an IC50 value of 6.4 μM in LPS-stimulated RAW264.7 macrophages.
Wei-hua Jiao - One of the best experts on this subject based on the ideXlab platform.
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spiroetherones a and b sesquiterpene naphthoquinones as angiogenesis inhibitors from the marine sponge Dysidea etheria
Organic chemistry frontiers, 2020Co-Authors: Wei-hua Jiao, Jie Cui, Yun Zhang, Kechun Liu, Ruyi Shang, Jiabao Sun, Qi Yang, Hou-wen LinAbstract:Spiroetherones A (1) and B (2), a pair of sesquiterpene naphthoquinones with an unprecedented “spiroetherane” carbon skeleton, were isolated from the marine sponge Dysidea etheria collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses coupled with quantum chemistry DFT GIAO 13C NMR and ECD calculations. Spiroetherone A (1) showed anti-angiogenic activity in a zebrafish model with an IC50 value of 2.4 μM. In addition, the plausible biogenetic pathway of the two metabolites is proposed.
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discovery of nitrogenous sesquiterpene quinone derivatives from sponge Dysidea septosa with anti inflammatory activity in vivo zebrafish model
Bioorganic Chemistry, 2020Co-Authors: Yuhan Gui, Wei-hua Jiao, Yun Zhang, Kechun Liu, Li Liu, Zhili Jia, Yongping Shi, Haotian Kong, Hou-wen LinAbstract:Abstract Two unique nitrogenous sesquiterpene quinone meroterpenoids, dysidinoid B (1) and dysicigyhone A (2), together with eight known analogues (3–10) were isolated and characterized from the marine sponge Dysidea septosa. Their structures with absolute configurations were established by a combination of extensive spectroscopic, electron circular dichroism (ECD) and single-crystal X-ray diffraction data analysis. Structurally, dysicigyhone A (2) possessed a unique benzo[d]oxazolidine-2-one unit. Additionally, dysidinoid B (1) exhibited significant anti-inflammatory effect by inhibiting TNF-α and IL-6 generation with IC50 values of 9.15 μM and 17.62 μM, respectively. Further in vivo anti-inflammatory assay verified that the dysidinoid B (1) alleviated the CuSO4-induced robust acute inflammatory response in zebrafish model.
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frondoplysins a and b unprecedented terpene alkaloid bioconjugates from Dysidea frondosa
Organic Letters, 2019Co-Authors: Wei-hua Jiao, Mengmeng Zhang, Jie Cui, Yuhan Gui, Yun Zhang, Kechun Liu, Hou-wen LinAbstract:The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 μM.
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septosones a c in vivo anti inflammatory meroterpenoids with rearranged carbon skeletons from the marine sponge Dysidea septosa
Organic Letters, 2019Co-Authors: Yuhan Gui, Wei-hua Jiao, Yun Zhang, Kechun Liu, Mi Zhou, Dequan Zeng, Hongrui Zhu, Fan Sun, Haifeng Chen, Hou-wen LinAbstract:Three unusual meroterpenoids, septosones A-C (1-3), were isolated from the marine sponge Dysidea septosa. The structures were determined by analysis of spectroscopic data combined with single-crystal X-ray diffraction and ECD calculations. Septosone A (1) features an unprecedented "septosane" carbon skeleton, whereas septosones B (2) and C (3) share a rare spiro[4.5]decane motif. Septosone A showed in vivo anti-inflammatory activity in CuSO4-induced transgenic fluorescent zebrafish likely through inactivation of the NF-κB signaling pathway.
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dysiarenone a dimeric c21 meroterpenoid with inhibition of cox 2 expression from the marine sponge Dysidea arenaria
Organic Letters, 2018Co-Authors: Wei-hua Jiao, Guo-hua Shi, Baohui Cheng, Guodong Chen, Hou-wen LinAbstract:Dysiarenone (1), a dimeric C21 meroterpenoid featuring an unprecedented 2-oxaspiro[bicyclo[3.3.1]nonane-9,1′-cyclopentane] carbon skeleton, was isolated from the marine sponge Dysidea arenaria. The structure of 1 was determined by HRMS and NMR spectroscopic analyses coupled with ECD calculations. Dysiarenone showed inhibitory activities against COX-2 expression and the production of prostaglandin E2 with an IC50 value of 6.4 μM in LPS-stimulated RAW264.7 macrophages.
Yuhan Gui - One of the best experts on this subject based on the ideXlab platform.
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discovery of nitrogenous sesquiterpene quinone derivatives from sponge Dysidea septosa with anti inflammatory activity in vivo zebrafish model
Bioorganic Chemistry, 2020Co-Authors: Yuhan Gui, Wei-hua Jiao, Yun Zhang, Kechun Liu, Li Liu, Zhili Jia, Yongping Shi, Haotian Kong, Hou-wen LinAbstract:Abstract Two unique nitrogenous sesquiterpene quinone meroterpenoids, dysidinoid B (1) and dysicigyhone A (2), together with eight known analogues (3–10) were isolated and characterized from the marine sponge Dysidea septosa. Their structures with absolute configurations were established by a combination of extensive spectroscopic, electron circular dichroism (ECD) and single-crystal X-ray diffraction data analysis. Structurally, dysicigyhone A (2) possessed a unique benzo[d]oxazolidine-2-one unit. Additionally, dysidinoid B (1) exhibited significant anti-inflammatory effect by inhibiting TNF-α and IL-6 generation with IC50 values of 9.15 μM and 17.62 μM, respectively. Further in vivo anti-inflammatory assay verified that the dysidinoid B (1) alleviated the CuSO4-induced robust acute inflammatory response in zebrafish model.
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frondoplysins a and b unprecedented terpene alkaloid bioconjugates from Dysidea frondosa
Organic Letters, 2019Co-Authors: Wei-hua Jiao, Mengmeng Zhang, Jie Cui, Yuhan Gui, Yun Zhang, Kechun Liu, Hou-wen LinAbstract:The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 μM.
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septosones a c in vivo anti inflammatory meroterpenoids with rearranged carbon skeletons from the marine sponge Dysidea septosa
Organic Letters, 2019Co-Authors: Yuhan Gui, Wei-hua Jiao, Yun Zhang, Kechun Liu, Mi Zhou, Dequan Zeng, Hongrui Zhu, Fan Sun, Haifeng Chen, Hou-wen LinAbstract:Three unusual meroterpenoids, septosones A-C (1-3), were isolated from the marine sponge Dysidea septosa. The structures were determined by analysis of spectroscopic data combined with single-crystal X-ray diffraction and ECD calculations. Septosone A (1) features an unprecedented "septosane" carbon skeleton, whereas septosones B (2) and C (3) share a rare spiro[4.5]decane motif. Septosone A showed in vivo anti-inflammatory activity in CuSO4-induced transgenic fluorescent zebrafish likely through inactivation of the NF-κB signaling pathway.
Kechun Liu - One of the best experts on this subject based on the ideXlab platform.
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spiroetherones a and b sesquiterpene naphthoquinones as angiogenesis inhibitors from the marine sponge Dysidea etheria
Organic chemistry frontiers, 2020Co-Authors: Wei-hua Jiao, Jie Cui, Yun Zhang, Kechun Liu, Ruyi Shang, Jiabao Sun, Qi Yang, Hou-wen LinAbstract:Spiroetherones A (1) and B (2), a pair of sesquiterpene naphthoquinones with an unprecedented “spiroetherane” carbon skeleton, were isolated from the marine sponge Dysidea etheria collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses coupled with quantum chemistry DFT GIAO 13C NMR and ECD calculations. Spiroetherone A (1) showed anti-angiogenic activity in a zebrafish model with an IC50 value of 2.4 μM. In addition, the plausible biogenetic pathway of the two metabolites is proposed.
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discovery of nitrogenous sesquiterpene quinone derivatives from sponge Dysidea septosa with anti inflammatory activity in vivo zebrafish model
Bioorganic Chemistry, 2020Co-Authors: Yuhan Gui, Wei-hua Jiao, Yun Zhang, Kechun Liu, Li Liu, Zhili Jia, Yongping Shi, Haotian Kong, Hou-wen LinAbstract:Abstract Two unique nitrogenous sesquiterpene quinone meroterpenoids, dysidinoid B (1) and dysicigyhone A (2), together with eight known analogues (3–10) were isolated and characterized from the marine sponge Dysidea septosa. Their structures with absolute configurations were established by a combination of extensive spectroscopic, electron circular dichroism (ECD) and single-crystal X-ray diffraction data analysis. Structurally, dysicigyhone A (2) possessed a unique benzo[d]oxazolidine-2-one unit. Additionally, dysidinoid B (1) exhibited significant anti-inflammatory effect by inhibiting TNF-α and IL-6 generation with IC50 values of 9.15 μM and 17.62 μM, respectively. Further in vivo anti-inflammatory assay verified that the dysidinoid B (1) alleviated the CuSO4-induced robust acute inflammatory response in zebrafish model.
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frondoplysins a and b unprecedented terpene alkaloid bioconjugates from Dysidea frondosa
Organic Letters, 2019Co-Authors: Wei-hua Jiao, Mengmeng Zhang, Jie Cui, Yuhan Gui, Yun Zhang, Kechun Liu, Hou-wen LinAbstract:The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 μM.
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septosones a c in vivo anti inflammatory meroterpenoids with rearranged carbon skeletons from the marine sponge Dysidea septosa
Organic Letters, 2019Co-Authors: Yuhan Gui, Wei-hua Jiao, Yun Zhang, Kechun Liu, Mi Zhou, Dequan Zeng, Hongrui Zhu, Fan Sun, Haifeng Chen, Hou-wen LinAbstract:Three unusual meroterpenoids, septosones A-C (1-3), were isolated from the marine sponge Dysidea septosa. The structures were determined by analysis of spectroscopic data combined with single-crystal X-ray diffraction and ECD calculations. Septosone A (1) features an unprecedented "septosane" carbon skeleton, whereas septosones B (2) and C (3) share a rare spiro[4.5]decane motif. Septosone A showed in vivo anti-inflammatory activity in CuSO4-induced transgenic fluorescent zebrafish likely through inactivation of the NF-κB signaling pathway.
Yun Zhang - One of the best experts on this subject based on the ideXlab platform.
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spiroetherones a and b sesquiterpene naphthoquinones as angiogenesis inhibitors from the marine sponge Dysidea etheria
Organic chemistry frontiers, 2020Co-Authors: Wei-hua Jiao, Jie Cui, Yun Zhang, Kechun Liu, Ruyi Shang, Jiabao Sun, Qi Yang, Hou-wen LinAbstract:Spiroetherones A (1) and B (2), a pair of sesquiterpene naphthoquinones with an unprecedented “spiroetherane” carbon skeleton, were isolated from the marine sponge Dysidea etheria collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses coupled with quantum chemistry DFT GIAO 13C NMR and ECD calculations. Spiroetherone A (1) showed anti-angiogenic activity in a zebrafish model with an IC50 value of 2.4 μM. In addition, the plausible biogenetic pathway of the two metabolites is proposed.
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discovery of nitrogenous sesquiterpene quinone derivatives from sponge Dysidea septosa with anti inflammatory activity in vivo zebrafish model
Bioorganic Chemistry, 2020Co-Authors: Yuhan Gui, Wei-hua Jiao, Yun Zhang, Kechun Liu, Li Liu, Zhili Jia, Yongping Shi, Haotian Kong, Hou-wen LinAbstract:Abstract Two unique nitrogenous sesquiterpene quinone meroterpenoids, dysidinoid B (1) and dysicigyhone A (2), together with eight known analogues (3–10) were isolated and characterized from the marine sponge Dysidea septosa. Their structures with absolute configurations were established by a combination of extensive spectroscopic, electron circular dichroism (ECD) and single-crystal X-ray diffraction data analysis. Structurally, dysicigyhone A (2) possessed a unique benzo[d]oxazolidine-2-one unit. Additionally, dysidinoid B (1) exhibited significant anti-inflammatory effect by inhibiting TNF-α and IL-6 generation with IC50 values of 9.15 μM and 17.62 μM, respectively. Further in vivo anti-inflammatory assay verified that the dysidinoid B (1) alleviated the CuSO4-induced robust acute inflammatory response in zebrafish model.
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frondoplysins a and b unprecedented terpene alkaloid bioconjugates from Dysidea frondosa
Organic Letters, 2019Co-Authors: Wei-hua Jiao, Mengmeng Zhang, Jie Cui, Yuhan Gui, Yun Zhang, Kechun Liu, Hou-wen LinAbstract:The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 μM.
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septosones a c in vivo anti inflammatory meroterpenoids with rearranged carbon skeletons from the marine sponge Dysidea septosa
Organic Letters, 2019Co-Authors: Yuhan Gui, Wei-hua Jiao, Yun Zhang, Kechun Liu, Mi Zhou, Dequan Zeng, Hongrui Zhu, Fan Sun, Haifeng Chen, Hou-wen LinAbstract:Three unusual meroterpenoids, septosones A-C (1-3), were isolated from the marine sponge Dysidea septosa. The structures were determined by analysis of spectroscopic data combined with single-crystal X-ray diffraction and ECD calculations. Septosone A (1) features an unprecedented "septosane" carbon skeleton, whereas septosones B (2) and C (3) share a rare spiro[4.5]decane motif. Septosone A showed in vivo anti-inflammatory activity in CuSO4-induced transgenic fluorescent zebrafish likely through inactivation of the NF-κB signaling pathway.