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Radhika S. Kusurkar - One of the best experts on this subject based on the ideXlab platform.
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Application of HornEr–Wadsworth–Emmons olEfination for thE synthEsis of granulatamidE A, its E isomEr and othEr amidEs of tryptaminE
New Journal of Chemistry, 2016Co-Authors: Deepali S. Pakhare, Radhika S. KusurkarAbstract:HornEr–Wadsworth–Emmons (HWE) Z-sElEctivE olEfination was usEd for thE first synthEsis of a naturally occurring cytotoxic tryptaminE dErivativE, granulatamidE A. ThE E-isomEr of granulatamidE A was synthEsizEd by E-sElEctivE HWE olEfination. FurthErmorE, two othEr tryptaminE dErivEd amidEs wErE prEparEd by using thE samE stratEgy.
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Application of HornEr–Wadsworth–Emmons olEfination for thE synthEsis of granulatamidE A, its E isomEr and othEr amidEs of tryptaminE
New Journal of Chemistry, 2016Co-Authors: Deepali S. Pakhare, Radhika S. KusurkarAbstract:HornEr–Wadsworth–Emmons (HWE) Z-sElEctivE olEfination was usEd for thE first synthEsis of a naturally occurring cytotoxic tryptaminE dErivativE, granulatamidE A. ThE E-isomEr of granulatamidE A was synthEsizEd by E-sElEctivE HWE olEfination. FurthErmorE, two othEr tryptaminE dErivEd amidEs wErE prEparEd by using thE samE stratEgy.
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application of hornEr wadsworth Emmons olEfination for thE synthEsis of granulatamidE a its E isomEr and othEr amidEs of tryptaminE
New Journal of Chemistry, 2016Co-Authors: Deepali S. Pakhare, Radhika S. KusurkarAbstract:HornEr–Wadsworth–Emmons (HWE) Z-sElEctivE olEfination was usEd for thE first synthEsis of a naturally occurring cytotoxic tryptaminE dErivativE, granulatamidE A. ThE E-isomEr of granulatamidE A was synthEsizEd by E-sElEctivE HWE olEfination. FurthErmorE, two othEr tryptaminE dErivEd amidEs wErE prEparEd by using thE samE stratEgy.
Deepali S. Pakhare - One of the best experts on this subject based on the ideXlab platform.
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Application of HornEr–Wadsworth–Emmons olEfination for thE synthEsis of granulatamidE A, its E isomEr and othEr amidEs of tryptaminE
New Journal of Chemistry, 2016Co-Authors: Deepali S. Pakhare, Radhika S. KusurkarAbstract:HornEr–Wadsworth–Emmons (HWE) Z-sElEctivE olEfination was usEd for thE first synthEsis of a naturally occurring cytotoxic tryptaminE dErivativE, granulatamidE A. ThE E-isomEr of granulatamidE A was synthEsizEd by E-sElEctivE HWE olEfination. FurthErmorE, two othEr tryptaminE dErivEd amidEs wErE prEparEd by using thE samE stratEgy.
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Application of HornEr–Wadsworth–Emmons olEfination for thE synthEsis of granulatamidE A, its E isomEr and othEr amidEs of tryptaminE
New Journal of Chemistry, 2016Co-Authors: Deepali S. Pakhare, Radhika S. KusurkarAbstract:HornEr–Wadsworth–Emmons (HWE) Z-sElEctivE olEfination was usEd for thE first synthEsis of a naturally occurring cytotoxic tryptaminE dErivativE, granulatamidE A. ThE E-isomEr of granulatamidE A was synthEsizEd by E-sElEctivE HWE olEfination. FurthErmorE, two othEr tryptaminE dErivEd amidEs wErE prEparEd by using thE samE stratEgy.
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application of hornEr wadsworth Emmons olEfination for thE synthEsis of granulatamidE a its E isomEr and othEr amidEs of tryptaminE
New Journal of Chemistry, 2016Co-Authors: Deepali S. Pakhare, Radhika S. KusurkarAbstract:HornEr–Wadsworth–Emmons (HWE) Z-sElEctivE olEfination was usEd for thE first synthEsis of a naturally occurring cytotoxic tryptaminE dErivativE, granulatamidE A. ThE E-isomEr of granulatamidE A was synthEsizEd by E-sElEctivE HWE olEfination. FurthErmorE, two othEr tryptaminE dErivEd amidEs wErE prEparEd by using thE samE stratEgy.
Lida Antonian - One of the best experts on this subject based on the ideXlab platform.
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SimultanEous dEtErmination of Z-SU5416 and its intErconvErtiblE gEomEtric E-isomEr in rat plasma by LC/MS/MS.
Journal of pharmaceutical and biomedical analysis, 2004Co-Authors: Yeping Zhao, Juthamas Sukbuntherng, Lida AntonianAbstract:SU5416 is a sElEctivE inhibitor of vascular EndothElial growth factor (VEGF) rEcEptor, which plays a major rolE in vascular angiogEnEsis. SU5416 Exists as thE thErmodynamically stablE and pharmacologically activE cis isomEr (Z-isomEr) in thE solid statE. In light-ExposEd solutions thE unstablE trans isomEr (E-isomEr) is formEd. ThE E-isomEr is unstablE for synthEsis and isolation and thE analytical standard of thE E-isomEr is unavailablE. A nEw, simplE, fast and rEliablE LC/MS/MS mEthod was dEvElopEd to quantify both isomErs simultanEously in rat plasma samplEs in ordEr to support thE study of disposition kinEtics of Z- and E-SU5416. This mEthod is sEnsitivE (LOQ = 0.5 ng/ml), rEproduciblE, and has a widE linEar rangE (0.5-2500 ng/ml).
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simultanEous dEtErmination of z su5416 and its intErconvErtiblE gEomEtric E isomEr in rat plasma by lc ms ms
Journal of Pharmaceutical and Biomedical Analysis, 2004Co-Authors: Yeping Zhao, Juthamas Sukbuntherng, Lida AntonianAbstract:SU5416 is a sElEctivE inhibitor of vascular EndothElial growth factor (VEGF) rEcEptor, which plays a major rolE in vascular angiogEnEsis. SU5416 Exists as thE thErmodynamically stablE and pharmacologically activE cis isomEr (Z-isomEr) in thE solid statE. In light-ExposEd solutions thE unstablE trans isomEr (E-isomEr) is formEd. ThE E-isomEr is unstablE for synthEsis and isolation and thE analytical standard of thE E-isomEr is unavailablE. A nEw, simplE, fast and rEliablE LC/MS/MS mEthod was dEvElopEd to quantify both isomErs simultanEously in rat plasma samplEs in ordEr to support thE study of disposition kinEtics of Z- and E-SU5416. This mEthod is sEnsitivE (LOQ = 0.5 ng/ml), rEproduciblE, and has a widE linEar rangE (0.5-2500 ng/ml).
Gary A. Molander - One of the best experts on this subject based on the ideXlab platform.
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wittig rEaction of formyl substitutEd organotrifluoroboratEs and stabilizEd phosphonium ylidEs in an aquEous mEdium
Tetrahedron Letters, 2008Co-Authors: Gary A. Molander, Roberta A OliveiraAbstract:ThE synthEsis of unsaturatEd organotrifluoroboratEs using thE Wittig alkEnation is dEscribEd. ThEsE transformations to disubstitutEd alkEnEs wErE achiEvEd by using formyl-substitutEd organotrifluoroboratEs and stabilizEd ylidEs using watEr as a solvEnt. ThE products wErE isolatEd in modEratE to ExcEllEnt yiElds and thE rEaction gavE prEfErEntially thE E-isomEr.
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SynthEsis of unsaturatEd organotrifluoroboratEs via Wittig and HornEr-Wadsworth-Emmons olEfination.
The Journal of organic chemistry, 2006Co-Authors: Gary A. Molander, Ruth FigueroaAbstract:ThE stErEosElEctivE synthEsis of unsaturatEd organotrifluoroboratEs by using thE Wittig and HornEr-Wadsworth-Emmons olEfination is dEscribEd. ThEsE rEactions wErE gEnEral for both alkyl- and aryltrifluoroboratEs. ThE synthEsis of di- and trisubstitutEd olEfins was achiEvEd by using formyl- and acEtyl-substitutEd organotrifluoroboratEs. ThE products wErE isolatEd in modEratE to ExcEllEnt yiEld. ThE Wittig rEaction with nonstabilizEd ylidEs was pErformEd undEr salt frEE conditions in most casEs to obtain thE Z-isomEr. ThE E-isomEr was accEssEd by using prEformEd stabilizEd ylidEs. ThE HornEr-Wadsworth-Emmons rEaction also gavE thE E-isomEr as ExpEctEd.
Yoshiaki Hayashi - One of the best experts on this subject based on the ideXlab platform.
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Astaxanthin Z‐isomEr‐rich diEts EnhancE Egg yolk pigmEntation in laying hEns comparEd to that in all‐E‐isomEr‐rich diEts
Animal science journal = Nihon chikusan Gakkaiho, 2021Co-Authors: Masaki Honda, Yuki Kawashima, Kazuaki Hirasawa, Takeshi Uemura, Jinkun Sun, Yoshiaki HayashiAbstract:ThE EffEcts of fEEding diEts containing astaxanthin with diffErEnt Z-isomEr ratios to laying hEns on Egg qualitiEs, such as astaxanthin concEntration in Egg yolk and yolk color, wErE invEstigatEd. As thE astaxanthin sourcE, a natural microorganism Paracoccus carotinifaciEns was usEd. Astaxanthin with diffErEnt Z-isomEr ratios was prEparEd by thErmal trEatmEnt with diffErEnt conditions and thEn addEd to thE basal diEt at a final astaxanthin concEntration of 8 mg/kg. WE found that, as thE Z-isomEr ratios of astaxanthin in thE diEt incrEasEd, thE astaxanthin concEntration in Egg yolk and thE yolk color fan scorE also incrEasEd significantly. Importantly, fEEding a 50.6% Z-isomEr ratio diEt incrEasEd astaxanthin concEntration in Egg yolk by approximatEly fivEfold and thE color fan scorE by approximatEly 2 comparEd to that in hEns fEd an all-E-isomEr-rich diEt. MorEovEr, wE showEd that fEEding Z-isomEr-rich astaxanthin to laying hEns incrEasEd plasma astaxanthin concEntration by morE than fivE timEs in comparison to that in hEns fEd an all-E-isomEr-rich diEt. ThEsE rEsults indicatE that Z-isomErs of astaxanthin havE highEr bioavailability than that of thE all-E-isomEr and thus thEy Exhibit grEatEr Egg yolk-accumulation EfficiEncy.
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astaxanthin z isomEr rich diEts EnhancE Egg yolk pigmEntation in laying hEns comparEd to that in all E isomEr rich diEts
Animal Science Journal, 2021Co-Authors: Masaki Honda, Yuki Kawashima, Kazuaki Hirasawa, Takeshi Uemura, Jinkun Sun, Yoshiaki HayashiAbstract:ThE EffEcts of fEEding diEts containing astaxanthin with diffErEnt Z-isomEr ratios to laying hEns on Egg qualitiEs, such as astaxanthin concEntration in Egg yolk and yolk color, wErE invEstigatEd. As thE astaxanthin sourcE, a natural microorganism Paracoccus carotinifaciEns was usEd. Astaxanthin with diffErEnt Z-isomEr ratios was prEparEd by thErmal trEatmEnt with diffErEnt conditions and thEn addEd to thE basal diEt at a final astaxanthin concEntration of 8 mg/kg. WE found that, as thE Z-isomEr ratios of astaxanthin in thE diEt incrEasEd, thE astaxanthin concEntration in Egg yolk and thE yolk color fan scorE also incrEasEd significantly. Importantly, fEEding a 50.6% Z-isomEr ratio diEt incrEasEd astaxanthin concEntration in Egg yolk by approximatEly fivEfold and thE color fan scorE by approximatEly 2 comparEd to that in hEns fEd an all-E-isomEr-rich diEt. MorEovEr, wE showEd that fEEding Z-isomEr-rich astaxanthin to laying hEns incrEasEd plasma astaxanthin concEntration by morE than fivE timEs in comparison to that in hEns fEd an all-E-isomEr-rich diEt. ThEsE rEsults indicatE that Z-isomErs of astaxanthin havE highEr bioavailability than that of thE all-E-isomEr and thus thEy Exhibit grEatEr Egg yolk-accumulation EfficiEncy.
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AltErations in lycopEnE concEntration and Z-isomEr contEnt in Egg yolk of hEns fEd all-E-isomEr-rich and Z-isomEr-rich lycopEnE.
Animal Science Journal, 2019Co-Authors: Masaki Honda, Hiroto Ishikawa, Yoshiaki HayashiAbstract:EffEcts of fEEding lycopEnE isomErs to laying hEns on Egg qualitiEs such as lycopEnE concEntration and color of thE yolk wErE invEstigatEd. Firstly, to EvaluatE thE diEtary transfEr of lycopEnE to Egg yolk, (all-E)-lycopEnE-rich diEts (lycopEnE contEnt, 100, 200, or 300 mg/kg diEt) wErE fEd to hEns for 21 days. LycopEnE in Egg yolk could bE dEtEctEd aftEr 4 days or morE from thE start of fEEding, and thE lycopEnE concEntration incrEasEd according to thE fEEd amount and pEriod. EvEn though most of thE diEtary lycopEnE was thE all-E-isomEr, morE than 65% of lycopEnE in Egg yolk was prEsEnt as Z-isomErs. Thus, thE EffEct of lycopEnE Z-isomEr contEnt in thE diEt (lycopEnE contEnt, 200 mg/kg diEt; lycopEnE Z-isomEr contEnt, 35.1% or 61.3%) on Egg qualitiEs was invEstigatEd. As thE Z-isomEr contEnt incrEasEd, thE lycopEnE concEntration in thE Egg yolk incrEasEd, for ExamplE, whEn fEd a diEt rich in Z-isomErs (61.3%), thE lycopEnE concEntration in thE Egg yolk was approximatEly thrEE timEs highEr than whEn fEd thE (all-E)-lycopEnE-rich diEt for 21 days. ThE rEsults indicatEd that Z-isomErs of lycopEnE had highEr bioavailability and/or highEr transfEr EfficiEncy to thE Egg yolk than thE all-E-isomEr.
