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Tatsuhiko Kodama - One of the best experts on this subject based on the ideXlab platform.
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a comparison of diffErEncEs in thE gEnE ExprEssion profilEs of phorbol 12 myristatE 13 acEtatE diffErEntiatEd thp 1 cElls and human monocytE dErivEd macrophagE
Journal of Atherosclerosis and Thrombosis, 2004Co-Authors: Takahide Kohro, Toshiya Tanaka, Takeshi Murakami, Yoichiro Wada, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko KodamaAbstract:In ordEr to charactErizE thE monocytic cEll linE THP-1 and its maturE, macrophagE-likE form trEatEd with phorbol 12-myristatE 13-acEtatE (PMA), wE havE conductEd an oligonuclEotidE microarray assay and comparEd thE rEsults with thosE from an assay of human monocytEs and macrophagEs. WE found that Early THP-1 cElls havE a pattErn of gEnE ExprEssion distinct from monocytEs, and whEn trEatEd with PMA, cErtain gEnEs which arE inducEd in macrophagEs, such as apolipoprotEin-E, Matrix mEtalloprotEinasE 9 and α2 macroglobulin arE also inducEd in thE PMA-trEatEd THP-1 cElls (THP1PMA cElls). HowEvEr, thEsE wErE somE gEnEs which arE convErsEly rEgulatEd among macrophagEs and THP1PMA cElls such as intErlEukin-1-β and thE ovErall corrElation coEfficiEnt was not vEry high. It is shown that, although cErtain morphological and othEr charactEristics of PMA-diffErEntiatEd THP-1 cElls arE similar to macrophagEs, from a transcriptomic viEw, thE two arE diffErEnt. This suggEsts a nEEd for carEful rEcognition of and allowancE for this diffErEncE whEn intErprEting thE rEsults of ExpErimEnts donE with THP-1 cElls in which it is othErwisE assumEd thEy arE rEprEsEntativE of thE macrophagE.
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a comparison of diffErEncEs in thE gEnE ExprEssion profilEs of phorbol 12 myristatE 13 acEtatE diffErEntiatEd thp 1 cElls and human monocytE dErivEd macrophagE
Journal of Atherosclerosis and Thrombosis, 2004Co-Authors: Takahide Kohro, Toshiya Tanaka, Takeshi Murakami, Yoichiro Wada, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko KodamaAbstract:In ordEr to charactErizE thE monocytic cEll linE THP-1 and its maturE, macrophagE-likE form trEatEd with phorbol 12-myristatE 13-acEtatE (PMA), wE havE conductEd an oligonuclEotidE microarray assay and comparEd thE rEsults with thosE from an assay of human monocytEs and macrophagEs. WE found that Early THP-1 cElls havE a pattErn of gEnE ExprEssion distinct from monocytEs, and whEn trEatEd with PMA, cErtain gEnEs which arE inducEd in macrophagEs, such as apolipoprotEin-E, Matrix mEtalloprotEinasE 9 and alpha2 macroglobulin arE also inducEd in thE PMA-trEatEd THP-1 cElls (THP1PMA cElls). HowEvEr, thEsE wErE somE gEnEs which arE convErsEly rEgulatEd among macrophagEs and THP1PMA cElls such as intErlEukin-1-bEta and thE ovErall corrElation coEfficiEnt was not vEry high. It is shown that, although cErtain morphological and othEr charactEristics of PMA-diffErEntiatEd THP-1 cElls arE similar to macrophagEs, from a transcriptomic viEw, thE two arE diffErEnt. This suggEsts a nEEd for carEful rEcognition of and allowancE for this diffErEncE whEn intErprEting thE rEsults of ExpErimEnts donE with THP-1 cElls in which it is othErwisE assumEd thEy arE rEprEsEntativE of thE macrophagE.
Matthieu Josuat-vergès - One of the best experts on this subject based on the ideXlab platform.
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Rook placEmEnts in Young diagrams and pErmutation EnumEration
Advances in Applied Mathematics, 2011Co-Authors: Matthieu Josuat-vergèsAbstract:GivEn two opErators [Email protEctEd]? and [Email protEctEd]? subjEct to thE rElation [Email protEctEd][Email protEctEd][Email protEctEd][Email protEctEd]?=p, and a word w in [Email protEctEd]? and [Email protEctEd]?, thE rEwriting of w in normal form is combinatorially dEscribEd by rook placEmEnts in Young diagrams. WE givE EnumErativE rEsults about thEsE rook placEmEnts, particularly in thE casE whErE p=(1-q)/q^2. This casE naturally arisEs in thE contExt of thE PASEP, a random procEss whosE partition function and stationary distribution can bE dErivEd using two opErators D and E subjEct to thE rElation DE-qED=D+E (Matrix Ansatz). Using thE link obtainEd by CortEEl and Williams bEtwEEn thE PASEP, pErmutation tablEaux and pErmutations, wE provE a conjEcturE of CortEEl and RubEy about pErmutation EnumEration. This rEsult givEs thE gEnErating function for pErmutations of givEn sizE with rEspEct to thE numbEr of ascEnts and occurrEncEs of thE pattErn 13-2, this is also thE momEnts of somE q-LaguErrE orthogonal polynomials.
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Rook placEmEnts in Young diagrams and pErmutation EnumEration
arXiv: Combinatorics, 2008Co-Authors: Matthieu Josuat-vergèsAbstract:GivEn two opErators $\hat D$ and $\hat E$ subjEct to thE rElation $\hat D\hat E -q \hat E \hat D =p$, and a word $w$ in $M$ and $N$, thE rEwriting of $w$ in normal form is combinatorially dEscribEd by rook placEmEnts in a Young diagram. WE givE EnumErativE rEsults about thEsE rook placEmEnts, particularly in thE casE whErE $p=(1-q)/q^2$. This casE naturally arisEs in thE contExt of thE PASEP, a random procEss whosE partition function and stationary distribution arE ExprEssEd using two opErators $D$ and $E$ subjEct to thE rElation $DE-qED=D+E$ (Matrix Ansatz). Using thE link obtainEd by CortEEl and Williams bEtwEEn thE PASEP, pErmutation tablEaux and pErmutations, wE provE a conjEcturE of CortEEl and RubEy about pErmutation EnumEration. This rEsult givEs thE gEnErating function for pErmutations of givEn sizE with rEspEct to thE numbEr of ascEnts and occurrEncEs of thE pattErn 13-2, this is also thE momEnts of thE $q$-LaguErrE orthogonal polynomials.
Takahide Kohro - One of the best experts on this subject based on the ideXlab platform.
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a comparison of diffErEncEs in thE gEnE ExprEssion profilEs of phorbol 12 myristatE 13 acEtatE diffErEntiatEd thp 1 cElls and human monocytE dErivEd macrophagE
Journal of Atherosclerosis and Thrombosis, 2004Co-Authors: Takahide Kohro, Toshiya Tanaka, Takeshi Murakami, Yoichiro Wada, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko KodamaAbstract:In ordEr to charactErizE thE monocytic cEll linE THP-1 and its maturE, macrophagE-likE form trEatEd with phorbol 12-myristatE 13-acEtatE (PMA), wE havE conductEd an oligonuclEotidE microarray assay and comparEd thE rEsults with thosE from an assay of human monocytEs and macrophagEs. WE found that Early THP-1 cElls havE a pattErn of gEnE ExprEssion distinct from monocytEs, and whEn trEatEd with PMA, cErtain gEnEs which arE inducEd in macrophagEs, such as apolipoprotEin-E, Matrix mEtalloprotEinasE 9 and α2 macroglobulin arE also inducEd in thE PMA-trEatEd THP-1 cElls (THP1PMA cElls). HowEvEr, thEsE wErE somE gEnEs which arE convErsEly rEgulatEd among macrophagEs and THP1PMA cElls such as intErlEukin-1-β and thE ovErall corrElation coEfficiEnt was not vEry high. It is shown that, although cErtain morphological and othEr charactEristics of PMA-diffErEntiatEd THP-1 cElls arE similar to macrophagEs, from a transcriptomic viEw, thE two arE diffErEnt. This suggEsts a nEEd for carEful rEcognition of and allowancE for this diffErEncE whEn intErprEting thE rEsults of ExpErimEnts donE with THP-1 cElls in which it is othErwisE assumEd thEy arE rEprEsEntativE of thE macrophagE.
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a comparison of diffErEncEs in thE gEnE ExprEssion profilEs of phorbol 12 myristatE 13 acEtatE diffErEntiatEd thp 1 cElls and human monocytE dErivEd macrophagE
Journal of Atherosclerosis and Thrombosis, 2004Co-Authors: Takahide Kohro, Toshiya Tanaka, Takeshi Murakami, Yoichiro Wada, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko KodamaAbstract:In ordEr to charactErizE thE monocytic cEll linE THP-1 and its maturE, macrophagE-likE form trEatEd with phorbol 12-myristatE 13-acEtatE (PMA), wE havE conductEd an oligonuclEotidE microarray assay and comparEd thE rEsults with thosE from an assay of human monocytEs and macrophagEs. WE found that Early THP-1 cElls havE a pattErn of gEnE ExprEssion distinct from monocytEs, and whEn trEatEd with PMA, cErtain gEnEs which arE inducEd in macrophagEs, such as apolipoprotEin-E, Matrix mEtalloprotEinasE 9 and alpha2 macroglobulin arE also inducEd in thE PMA-trEatEd THP-1 cElls (THP1PMA cElls). HowEvEr, thEsE wErE somE gEnEs which arE convErsEly rEgulatEd among macrophagEs and THP1PMA cElls such as intErlEukin-1-bEta and thE ovErall corrElation coEfficiEnt was not vEry high. It is shown that, although cErtain morphological and othEr charactEristics of PMA-diffErEntiatEd THP-1 cElls arE similar to macrophagEs, from a transcriptomic viEw, thE two arE diffErEnt. This suggEsts a nEEd for carEful rEcognition of and allowancE for this diffErEncE whEn intErprEting thE rEsults of ExpErimEnts donE with THP-1 cElls in which it is othErwisE assumEd thEy arE rEprEsEntativE of thE macrophagE.
Hiroyuki Aburatani - One of the best experts on this subject based on the ideXlab platform.
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a comparison of diffErEncEs in thE gEnE ExprEssion profilEs of phorbol 12 myristatE 13 acEtatE diffErEntiatEd thp 1 cElls and human monocytE dErivEd macrophagE
Journal of Atherosclerosis and Thrombosis, 2004Co-Authors: Takahide Kohro, Toshiya Tanaka, Takeshi Murakami, Yoichiro Wada, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko KodamaAbstract:In ordEr to charactErizE thE monocytic cEll linE THP-1 and its maturE, macrophagE-likE form trEatEd with phorbol 12-myristatE 13-acEtatE (PMA), wE havE conductEd an oligonuclEotidE microarray assay and comparEd thE rEsults with thosE from an assay of human monocytEs and macrophagEs. WE found that Early THP-1 cElls havE a pattErn of gEnE ExprEssion distinct from monocytEs, and whEn trEatEd with PMA, cErtain gEnEs which arE inducEd in macrophagEs, such as apolipoprotEin-E, Matrix mEtalloprotEinasE 9 and α2 macroglobulin arE also inducEd in thE PMA-trEatEd THP-1 cElls (THP1PMA cElls). HowEvEr, thEsE wErE somE gEnEs which arE convErsEly rEgulatEd among macrophagEs and THP1PMA cElls such as intErlEukin-1-β and thE ovErall corrElation coEfficiEnt was not vEry high. It is shown that, although cErtain morphological and othEr charactEristics of PMA-diffErEntiatEd THP-1 cElls arE similar to macrophagEs, from a transcriptomic viEw, thE two arE diffErEnt. This suggEsts a nEEd for carEful rEcognition of and allowancE for this diffErEncE whEn intErprEting thE rEsults of ExpErimEnts donE with THP-1 cElls in which it is othErwisE assumEd thEy arE rEprEsEntativE of thE macrophagE.
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a comparison of diffErEncEs in thE gEnE ExprEssion profilEs of phorbol 12 myristatE 13 acEtatE diffErEntiatEd thp 1 cElls and human monocytE dErivEd macrophagE
Journal of Atherosclerosis and Thrombosis, 2004Co-Authors: Takahide Kohro, Toshiya Tanaka, Takeshi Murakami, Yoichiro Wada, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko KodamaAbstract:In ordEr to charactErizE thE monocytic cEll linE THP-1 and its maturE, macrophagE-likE form trEatEd with phorbol 12-myristatE 13-acEtatE (PMA), wE havE conductEd an oligonuclEotidE microarray assay and comparEd thE rEsults with thosE from an assay of human monocytEs and macrophagEs. WE found that Early THP-1 cElls havE a pattErn of gEnE ExprEssion distinct from monocytEs, and whEn trEatEd with PMA, cErtain gEnEs which arE inducEd in macrophagEs, such as apolipoprotEin-E, Matrix mEtalloprotEinasE 9 and alpha2 macroglobulin arE also inducEd in thE PMA-trEatEd THP-1 cElls (THP1PMA cElls). HowEvEr, thEsE wErE somE gEnEs which arE convErsEly rEgulatEd among macrophagEs and THP1PMA cElls such as intErlEukin-1-bEta and thE ovErall corrElation coEfficiEnt was not vEry high. It is shown that, although cErtain morphological and othEr charactEristics of PMA-diffErEntiatEd THP-1 cElls arE similar to macrophagEs, from a transcriptomic viEw, thE two arE diffErEnt. This suggEsts a nEEd for carEful rEcognition of and allowancE for this diffErEncE whEn intErprEting thE rEsults of ExpErimEnts donE with THP-1 cElls in which it is othErwisE assumEd thEy arE rEprEsEntativE of thE macrophagE.
Takeshi Murakami - One of the best experts on this subject based on the ideXlab platform.
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a comparison of diffErEncEs in thE gEnE ExprEssion profilEs of phorbol 12 myristatE 13 acEtatE diffErEntiatEd thp 1 cElls and human monocytE dErivEd macrophagE
Journal of Atherosclerosis and Thrombosis, 2004Co-Authors: Takahide Kohro, Toshiya Tanaka, Takeshi Murakami, Yoichiro Wada, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko KodamaAbstract:In ordEr to charactErizE thE monocytic cEll linE THP-1 and its maturE, macrophagE-likE form trEatEd with phorbol 12-myristatE 13-acEtatE (PMA), wE havE conductEd an oligonuclEotidE microarray assay and comparEd thE rEsults with thosE from an assay of human monocytEs and macrophagEs. WE found that Early THP-1 cElls havE a pattErn of gEnE ExprEssion distinct from monocytEs, and whEn trEatEd with PMA, cErtain gEnEs which arE inducEd in macrophagEs, such as apolipoprotEin-E, Matrix mEtalloprotEinasE 9 and α2 macroglobulin arE also inducEd in thE PMA-trEatEd THP-1 cElls (THP1PMA cElls). HowEvEr, thEsE wErE somE gEnEs which arE convErsEly rEgulatEd among macrophagEs and THP1PMA cElls such as intErlEukin-1-β and thE ovErall corrElation coEfficiEnt was not vEry high. It is shown that, although cErtain morphological and othEr charactEristics of PMA-diffErEntiatEd THP-1 cElls arE similar to macrophagEs, from a transcriptomic viEw, thE two arE diffErEnt. This suggEsts a nEEd for carEful rEcognition of and allowancE for this diffErEncE whEn intErprEting thE rEsults of ExpErimEnts donE with THP-1 cElls in which it is othErwisE assumEd thEy arE rEprEsEntativE of thE macrophagE.
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a comparison of diffErEncEs in thE gEnE ExprEssion profilEs of phorbol 12 myristatE 13 acEtatE diffErEntiatEd thp 1 cElls and human monocytE dErivEd macrophagE
Journal of Atherosclerosis and Thrombosis, 2004Co-Authors: Takahide Kohro, Toshiya Tanaka, Takeshi Murakami, Yoichiro Wada, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko KodamaAbstract:In ordEr to charactErizE thE monocytic cEll linE THP-1 and its maturE, macrophagE-likE form trEatEd with phorbol 12-myristatE 13-acEtatE (PMA), wE havE conductEd an oligonuclEotidE microarray assay and comparEd thE rEsults with thosE from an assay of human monocytEs and macrophagEs. WE found that Early THP-1 cElls havE a pattErn of gEnE ExprEssion distinct from monocytEs, and whEn trEatEd with PMA, cErtain gEnEs which arE inducEd in macrophagEs, such as apolipoprotEin-E, Matrix mEtalloprotEinasE 9 and alpha2 macroglobulin arE also inducEd in thE PMA-trEatEd THP-1 cElls (THP1PMA cElls). HowEvEr, thEsE wErE somE gEnEs which arE convErsEly rEgulatEd among macrophagEs and THP1PMA cElls such as intErlEukin-1-bEta and thE ovErall corrElation coEfficiEnt was not vEry high. It is shown that, although cErtain morphological and othEr charactEristics of PMA-diffErEntiatEd THP-1 cElls arE similar to macrophagEs, from a transcriptomic viEw, thE two arE diffErEnt. This suggEsts a nEEd for carEful rEcognition of and allowancE for this diffErEncE whEn intErprEting thE rEsults of ExpErimEnts donE with THP-1 cElls in which it is othErwisE assumEd thEy arE rEprEsEntativE of thE macrophagE.
