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Wren V Mccallister - One of the best experts on this subject based on the ideXlab platform.

  • Thumb Trapeziometacarpal Joint Arthritis: Partial Trapeziectomy With Ligament Reconstruction and
    2015
    Co-Authors: Interposition Costochondral, Wren V Mccallister, Md Seattle
    Abstract:

    Qualitative and quantitative outcomes were assessed clinically and radiographically in 41 patients (46 thumbs) with thumb basal joint arthritis limited to the trapeziometacarpal joint treated with hemiresection arthroplasty of the trapezium, flexor carpi radialis ligament recon-struction, and allograft costochondral interposition graft. Results of the validated Disability of Arm, Shoulder, and Hand questionnaire at a mean follow-up time of 42 months (range, 24–48 months) revealed that 90 % of the patients had a high level of function with minimal symptoms. Important improvements in web space with increased palmar and radial abduction and grip and pinch strength measurements were observed. The trapeziometacarpal space had decreased 21 % after surgery while trapeziometacarpal subluxation was 16 % compared with 21 % before surgery. There was an inverse correlation between the loss of trapezial height and subluxation and clinical outcome. The results of this study demonstrate that although the preoperative trapezial height was not maintained, the reconstructed thumbs remained stable, with little subluxation and improved clinical outcomes. (J Hand Surg 2000;25A:61–76. Copyright © 2000 by the American Society for Surgery of the Hand.) Key words: Trapeziometacarpal joint, arthritis, reconstruction, allograft, cartilage

  • thumb trapeziometacarpal joint arthritis partial trapeziectomy with ligament reconstruction and interposition costochondral allograft
    Journal of Hand Surgery (European Volume), 2000
    Co-Authors: Thomas E Trumble, Gregory Rafijah, Mary Gilbert, Christopher H Allan, Edward R North, Wren V Mccallister
    Abstract:

    Abstract Qualitative and quantitative outcomes were assessed clinically and radiographically in 41 patients (46 thumbs) with thumb basal joint arthritis limited to the trapeziometacarpal joint treated with hemiresection arthroplasty of the trapezium, flexor carpi radialis ligament reconstruction, and allograft costochondral interposition graft. Results of the validated Disability of Arm, Shoulder, and Hand questionnaire at a mean follow-up time of 42 months (range, 24–48 months) revealed that 90% of the patients had a high level of function with minimal symptoms. Important improvements in web space with increased palmar and radial abduction and grip and pinch strength measurements were observed. The trapeziometacarpal space had decreased 21% after surgery while trapeziometacarpal subluxation was 16% compared with 21% before surgery. There was an inverse correlation between the loss of trapezial height and subluxation and clinical outcome. The results of this study demonstrate that although the preoperative trapezial height was not maintained, the reconstructed thumbs remained stable, with little subluxation and improved clinical outcomes. (J Hand Surg 2000;25A:61–76. Copyright © 2000 by the American Society for Surgery of the Hand.)

Thomas E Trumble - One of the best experts on this subject based on the ideXlab platform.

  • thumb trapeziometacarpal joint arthritis partial trapeziectomy with ligament reconstruction and interposition costochondral allograft
    Journal of Hand Surgery (European Volume), 2000
    Co-Authors: Thomas E Trumble, Gregory Rafijah, Mary Gilbert, Christopher H Allan, Edward R North, Wren V Mccallister
    Abstract:

    Abstract Qualitative and quantitative outcomes were assessed clinically and radiographically in 41 patients (46 thumbs) with thumb basal joint arthritis limited to the trapeziometacarpal joint treated with hemiresection arthroplasty of the trapezium, flexor carpi radialis ligament reconstruction, and allograft costochondral interposition graft. Results of the validated Disability of Arm, Shoulder, and Hand questionnaire at a mean follow-up time of 42 months (range, 24–48 months) revealed that 90% of the patients had a high level of function with minimal symptoms. Important improvements in web space with increased palmar and radial abduction and grip and pinch strength measurements were observed. The trapeziometacarpal space had decreased 21% after surgery while trapeziometacarpal subluxation was 16% compared with 21% before surgery. There was an inverse correlation between the loss of trapezial height and subluxation and clinical outcome. The results of this study demonstrate that although the preoperative trapezial height was not maintained, the reconstructed thumbs remained stable, with little subluxation and improved clinical outcomes. (J Hand Surg 2000;25A:61–76. Copyright © 2000 by the American Society for Surgery of the Hand.)

Dennis K. Roop - One of the best experts on this subject based on the ideXlab platform.

  • Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development.
    The Journal of investigative dermatology, 1995
    Co-Authors: Jackie R Bickenbach, Donnie S Bundman, Jeanette M. Greer, Dennis K. Roop
    Abstract:

    In mouse, epidermal development proceeds from a single basal cell layer covered by a specialized single cell layer called the periderm at E14 to a fully differentiated stratified squamous epithelium at E18. To determine when loricrin, a major cell envelope component, is expressed during development, we examined fetal skin from mice of gestational ages E13 through E19 and compared the temporal pattern of loricrin expression with that of other differentiation markers. We found that loricrin mRNA and protein were expressed by E16, following the expression of keratins K1 and K10 and preceding the expression of profilaggrin. Interestingly, both loricrin and profilaggrin were initially expressed focally in areas corresponding to more advanced morphologic stages of maturation. Because the cornified envelope is a composite structure consisting of both protein and lipid components, we also monitored the appearance of lipid lamellar granules during epidermal development. These granules were first evident at E16 and the extrusion of lipids from the granules into the intercellular space occurred at E17 prior to the cross linking of loricrin into the cell envelopes. Our results document that loricrin is expressed and accumulates at the cell periphery subsequent to the extrusion of lipids, but prior to processing of profilaggrin. We suggest that the sequential regulation of these events is critical for formation of epidermal barrier function during development.

Edward R North - One of the best experts on this subject based on the ideXlab platform.

  • thumb trapeziometacarpal joint arthritis partial trapeziectomy with ligament reconstruction and interposition costochondral allograft
    Journal of Hand Surgery (European Volume), 2000
    Co-Authors: Thomas E Trumble, Gregory Rafijah, Mary Gilbert, Christopher H Allan, Edward R North, Wren V Mccallister
    Abstract:

    Abstract Qualitative and quantitative outcomes were assessed clinically and radiographically in 41 patients (46 thumbs) with thumb basal joint arthritis limited to the trapeziometacarpal joint treated with hemiresection arthroplasty of the trapezium, flexor carpi radialis ligament reconstruction, and allograft costochondral interposition graft. Results of the validated Disability of Arm, Shoulder, and Hand questionnaire at a mean follow-up time of 42 months (range, 24–48 months) revealed that 90% of the patients had a high level of function with minimal symptoms. Important improvements in web space with increased palmar and radial abduction and grip and pinch strength measurements were observed. The trapeziometacarpal space had decreased 21% after surgery while trapeziometacarpal subluxation was 16% compared with 21% before surgery. There was an inverse correlation between the loss of trapezial height and subluxation and clinical outcome. The results of this study demonstrate that although the preoperative trapezial height was not maintained, the reconstructed thumbs remained stable, with little subluxation and improved clinical outcomes. (J Hand Surg 2000;25A:61–76. Copyright © 2000 by the American Society for Surgery of the Hand.)

Christopher H Allan - One of the best experts on this subject based on the ideXlab platform.

  • thumb trapeziometacarpal joint arthritis partial trapeziectomy with ligament reconstruction and interposition costochondral allograft
    Journal of Hand Surgery (European Volume), 2000
    Co-Authors: Thomas E Trumble, Gregory Rafijah, Mary Gilbert, Christopher H Allan, Edward R North, Wren V Mccallister
    Abstract:

    Abstract Qualitative and quantitative outcomes were assessed clinically and radiographically in 41 patients (46 thumbs) with thumb basal joint arthritis limited to the trapeziometacarpal joint treated with hemiresection arthroplasty of the trapezium, flexor carpi radialis ligament reconstruction, and allograft costochondral interposition graft. Results of the validated Disability of Arm, Shoulder, and Hand questionnaire at a mean follow-up time of 42 months (range, 24–48 months) revealed that 90% of the patients had a high level of function with minimal symptoms. Important improvements in web space with increased palmar and radial abduction and grip and pinch strength measurements were observed. The trapeziometacarpal space had decreased 21% after surgery while trapeziometacarpal subluxation was 16% compared with 21% before surgery. There was an inverse correlation between the loss of trapezial height and subluxation and clinical outcome. The results of this study demonstrate that although the preoperative trapezial height was not maintained, the reconstructed thumbs remained stable, with little subluxation and improved clinical outcomes. (J Hand Surg 2000;25A:61–76. Copyright © 2000 by the American Society for Surgery of the Hand.)