The Experts below are selected from a list of 34785 Experts worldwide ranked by ideXlab platform

Irina Nazarenko - One of the best experts on this subject based on the ideXlab platform.

  • cell surface tetraspanin tspan8 contributes to molECular pathways of exosome induced endothelial cell activation
    Cancer Research, 2010
    Co-Authors: Irina Nazarenko, Sanyukta Rana, Alexandra Baumann, Jessica Mcalear, Andrea Hellwig, Michael Trendelenburg, Gunter Lochnit, Klaus T Preissner, Margot Zoller
    Abstract:

    Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. In this study, we used a rat adenocarcinoma model (AS-Tspan8) to explore the effECts of exosomal Tspan8 on angiogenesis. Tspan8 contributed to a selECtive rECruitment of proteins and mRNA into exosomes, including CD106 and CD49d, which were implicated in exosome-EC binding and EC internalization. We found that EC internalized Tspan8-CD49d complex-containing exosomes. Exosome uptake induced vascular endothelial growth factor (VEGF)-independent Regulation of several angiogenesis-related genes, including von Willebrand factor, Tspan8, chemokines CXCL5 and MIF, chemokine rECeptor CCR1, and, together with VEGF, VEGF rECeptor 2. EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors. Unraveling these new pathways of exosome-initiated EC Regulation could provide new options for therapeutic interference with tumor-induced angiogenesis.

  • cell surface tetraspanin tspan8 contributes to molECular pathways of exosome induced endothelial cell activation
    Cancer Research, 2010
    Co-Authors: Irina Nazarenko, Sanyukta Rana, Andrea Hellwig, Michael Trendelenburg, Alexandra Auma, Jessica Mcalea, Gunte Lochni, Klaus T Preissne, Margo Zolle
    Abstract:

    Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. In this study, we used a rat adenocarcinoma model (AS-Tspan8) to explore the effECts of exosomal Tspan8 on angiogenesis. Tspan8 contributed to a selECtive rECruitment of proteins and mRNA into exosomes, including CD106 and CD49d, which were implicated in exosome-EC binding and EC internalization. We found that EC internalized Tspan8-CD49d complex-containing exosomes. Exosome uptake induced vascular endothelial growth factor (VEGF)-independent Regulation of several angiogenesis-related genes, including von Willebrand factor, Tspan8, chemokines CXCL5 and MIF, chemokine rECeptor CCR1, and, together with VEGF, VEGF rECeptor 2. EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors. Unraveling these new pathways of exosome-initiated EC Regulation could provide new options for therapeutic interference with tumor-induced angiogenesis.

Margot Zoller - One of the best experts on this subject based on the ideXlab platform.

  • cell surface tetraspanin tspan8 contributes to molECular pathways of exosome induced endothelial cell activation
    Cancer Research, 2010
    Co-Authors: Irina Nazarenko, Sanyukta Rana, Alexandra Baumann, Jessica Mcalear, Andrea Hellwig, Michael Trendelenburg, Gunter Lochnit, Klaus T Preissner, Margot Zoller
    Abstract:

    Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. In this study, we used a rat adenocarcinoma model (AS-Tspan8) to explore the effECts of exosomal Tspan8 on angiogenesis. Tspan8 contributed to a selECtive rECruitment of proteins and mRNA into exosomes, including CD106 and CD49d, which were implicated in exosome-EC binding and EC internalization. We found that EC internalized Tspan8-CD49d complex-containing exosomes. Exosome uptake induced vascular endothelial growth factor (VEGF)-independent Regulation of several angiogenesis-related genes, including von Willebrand factor, Tspan8, chemokines CXCL5 and MIF, chemokine rECeptor CCR1, and, together with VEGF, VEGF rECeptor 2. EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors. Unraveling these new pathways of exosome-initiated EC Regulation could provide new options for therapeutic interference with tumor-induced angiogenesis.

Margo Zolle - One of the best experts on this subject based on the ideXlab platform.

  • cell surface tetraspanin tspan8 contributes to molECular pathways of exosome induced endothelial cell activation
    Cancer Research, 2010
    Co-Authors: Irina Nazarenko, Sanyukta Rana, Andrea Hellwig, Michael Trendelenburg, Alexandra Auma, Jessica Mcalea, Gunte Lochni, Klaus T Preissne, Margo Zolle
    Abstract:

    Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. In this study, we used a rat adenocarcinoma model (AS-Tspan8) to explore the effECts of exosomal Tspan8 on angiogenesis. Tspan8 contributed to a selECtive rECruitment of proteins and mRNA into exosomes, including CD106 and CD49d, which were implicated in exosome-EC binding and EC internalization. We found that EC internalized Tspan8-CD49d complex-containing exosomes. Exosome uptake induced vascular endothelial growth factor (VEGF)-independent Regulation of several angiogenesis-related genes, including von Willebrand factor, Tspan8, chemokines CXCL5 and MIF, chemokine rECeptor CCR1, and, together with VEGF, VEGF rECeptor 2. EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors. Unraveling these new pathways of exosome-initiated EC Regulation could provide new options for therapeutic interference with tumor-induced angiogenesis.

Michael Trendelenburg - One of the best experts on this subject based on the ideXlab platform.

  • cell surface tetraspanin tspan8 contributes to molECular pathways of exosome induced endothelial cell activation
    Cancer Research, 2010
    Co-Authors: Irina Nazarenko, Sanyukta Rana, Alexandra Baumann, Jessica Mcalear, Andrea Hellwig, Michael Trendelenburg, Gunter Lochnit, Klaus T Preissner, Margot Zoller
    Abstract:

    Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. In this study, we used a rat adenocarcinoma model (AS-Tspan8) to explore the effECts of exosomal Tspan8 on angiogenesis. Tspan8 contributed to a selECtive rECruitment of proteins and mRNA into exosomes, including CD106 and CD49d, which were implicated in exosome-EC binding and EC internalization. We found that EC internalized Tspan8-CD49d complex-containing exosomes. Exosome uptake induced vascular endothelial growth factor (VEGF)-independent Regulation of several angiogenesis-related genes, including von Willebrand factor, Tspan8, chemokines CXCL5 and MIF, chemokine rECeptor CCR1, and, together with VEGF, VEGF rECeptor 2. EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors. Unraveling these new pathways of exosome-initiated EC Regulation could provide new options for therapeutic interference with tumor-induced angiogenesis.

  • cell surface tetraspanin tspan8 contributes to molECular pathways of exosome induced endothelial cell activation
    Cancer Research, 2010
    Co-Authors: Irina Nazarenko, Sanyukta Rana, Andrea Hellwig, Michael Trendelenburg, Alexandra Auma, Jessica Mcalea, Gunte Lochni, Klaus T Preissne, Margo Zolle
    Abstract:

    Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. In this study, we used a rat adenocarcinoma model (AS-Tspan8) to explore the effECts of exosomal Tspan8 on angiogenesis. Tspan8 contributed to a selECtive rECruitment of proteins and mRNA into exosomes, including CD106 and CD49d, which were implicated in exosome-EC binding and EC internalization. We found that EC internalized Tspan8-CD49d complex-containing exosomes. Exosome uptake induced vascular endothelial growth factor (VEGF)-independent Regulation of several angiogenesis-related genes, including von Willebrand factor, Tspan8, chemokines CXCL5 and MIF, chemokine rECeptor CCR1, and, together with VEGF, VEGF rECeptor 2. EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors. Unraveling these new pathways of exosome-initiated EC Regulation could provide new options for therapeutic interference with tumor-induced angiogenesis.

Sanyukta Rana - One of the best experts on this subject based on the ideXlab platform.

  • cell surface tetraspanin tspan8 contributes to molECular pathways of exosome induced endothelial cell activation
    Cancer Research, 2010
    Co-Authors: Irina Nazarenko, Sanyukta Rana, Alexandra Baumann, Jessica Mcalear, Andrea Hellwig, Michael Trendelenburg, Gunter Lochnit, Klaus T Preissner, Margot Zoller
    Abstract:

    Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. In this study, we used a rat adenocarcinoma model (AS-Tspan8) to explore the effECts of exosomal Tspan8 on angiogenesis. Tspan8 contributed to a selECtive rECruitment of proteins and mRNA into exosomes, including CD106 and CD49d, which were implicated in exosome-EC binding and EC internalization. We found that EC internalized Tspan8-CD49d complex-containing exosomes. Exosome uptake induced vascular endothelial growth factor (VEGF)-independent Regulation of several angiogenesis-related genes, including von Willebrand factor, Tspan8, chemokines CXCL5 and MIF, chemokine rECeptor CCR1, and, together with VEGF, VEGF rECeptor 2. EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors. Unraveling these new pathways of exosome-initiated EC Regulation could provide new options for therapeutic interference with tumor-induced angiogenesis.

  • cell surface tetraspanin tspan8 contributes to molECular pathways of exosome induced endothelial cell activation
    Cancer Research, 2010
    Co-Authors: Irina Nazarenko, Sanyukta Rana, Andrea Hellwig, Michael Trendelenburg, Alexandra Auma, Jessica Mcalea, Gunte Lochni, Klaus T Preissne, Margo Zolle
    Abstract:

    Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. In this study, we used a rat adenocarcinoma model (AS-Tspan8) to explore the effECts of exosomal Tspan8 on angiogenesis. Tspan8 contributed to a selECtive rECruitment of proteins and mRNA into exosomes, including CD106 and CD49d, which were implicated in exosome-EC binding and EC internalization. We found that EC internalized Tspan8-CD49d complex-containing exosomes. Exosome uptake induced vascular endothelial growth factor (VEGF)-independent Regulation of several angiogenesis-related genes, including von Willebrand factor, Tspan8, chemokines CXCL5 and MIF, chemokine rECeptor CCR1, and, together with VEGF, VEGF rECeptor 2. EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors. Unraveling these new pathways of exosome-initiated EC Regulation could provide new options for therapeutic interference with tumor-induced angiogenesis.