The Experts below are selected from a list of 165 Experts worldwide ranked by ideXlab platform
Bruce E. Johnson - One of the best experts on this subject based on the ideXlab platform.
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Paraneoplastic syndromes associated with small cell lung cancer.
Journal of the National Comprehensive Cancer Network : JNCCN, 2006Co-Authors: Leena Gandhi, Bruce E. JohnsonAbstract:Small cell lung cancer (SCLC) is the most frequent cancer histology associated with paraneoplastic syndromes. These syndromes are typically caused by Ectopic Hormone Production or immune-mediated tissue destruction caused by neural antigen expression from cancer cells. This antigen expression induces the Production of antibodies that cross-react with neural tissue. This article discusses the most common Ectopic Hormone and neurologic paraneoplastic syndromes and emphasizes the relationships among antigens, clinical syndromes, and outcomes. Although Ectopic Hormone Production has been associated with extensive-stage disease and a poorer outcome, the antibody-mediated paraneoplastic syndromes are prognostic factors associated with more favorable outcomes. Both have the potential for improvement with cancer treatment.
Donald G. Skinner - One of the best experts on this subject based on the ideXlab platform.
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Norepinephrine producing renal cell carcinoma
The Journal of urology, 2001Co-Authors: Chester J. Koh, Bernard H. Bochner, John P. Stein, Alexander Fedenko, Vincent Dequattro, Donald G. SkinnerAbstract:Renal cell carcinoma has been associated with a variety of paraneoplastic symptoms and signs, and hence has been described as the internist’s tumor. Hypertension is one of the most common of these paraneoplastic signs. Renal cell carcinoma has also been associated with Ectopic Hormone Production, which has included renin, erythropoietin, insulin, glucagon and parathyroid Hormone. 1 We report a case of hypertension due to the Ectopic Production of norepinephrine from renal cell carcinoma.
Alessandra Rinaldo - One of the best experts on this subject based on the ideXlab platform.
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primary and secondary small cell neuroendocrine carcinoma of the larynx a review
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2008Co-Authors: Alfio Ferlito, Alessandra RinaldoAbstract:Primary laryngeal small cell neuroendocrine carci- noma (SCNC) is an unusual malignancy accounting for <0.5% of laryngeal carcinomas. To date, approximately 200 cases of primary and 5 of secondary SCNC of the larynx have been reported. This tumor most often presents in the sixth and seventh decades in men who are heavy cigarette smokers. The lesion may be associated with different paraneoplastic syndromes (Ectopic adrenocorticotropic Hormone syndrome, Schwartz-Bartter syndrome or syndrome of inappropriate secre- tion of antidiuretic Hormone, and Eaton-Lambert myasthenic syndrome) or with Ectopic Hormone Production. The diagnosis is based essentially on the histologic appearance of the tumor, confirmed by immunocytochemical investigations. Concurrent chemoradiotherapy regimens offer potential for long-term sur- vival. This tumor is biologically aggressive, and the extent of the disease is the most significant independent prognostic factor of survival. The survival rate is similar to that with pulmonary SCNC. V C 2008 Wiley Periodicals, Inc. Head Neck 30: 518- 524, 2008
Richard K. Sterling - One of the best experts on this subject based on the ideXlab platform.
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Ectopic ACTH syndrome associated with anorectal carcinoma
Digestive Diseases and Sciences, 1993Co-Authors: Richard K. SterlingAbstract:A 25-year-old black homosexual was noted to be hypertensive, hypokalemic, and to have a rectal mass. Histopathology of the biopsied lesion revealed a mixture of poorly differentiated squamous cell and undifferentiated small cell carcinoma. Abdominopelvic CT showed multiple liver metastases, minimal local tumor extension, and normal adrenal glands. Despite aggressive treatment, he remained hypertensive and hypokalemic. Endocrine work-up revealed: normal 24-hr VMA and catecholamines, normal serum aldosterone and renin levels, elevated urinary free cortisol (3360 μg/24 hr), elevated serum cortisol (60 μg/dl), and elevated serum ACTH (1697 pg/dl). Liver biopsy confirmed metastatic anorectal carcinoma, and immunohistochemical stains of the rectal biopsy were positive for ACTH and neuron-specific enolase. Although many types of neoplasms have been associated with Ectopic ACTH Production, small cell carcinoma of the lung is the most common. While there are many reports of colorectal and anorectal neuroendocrine small cell carcinomas, few of these tumors have been associated with clinical Ectopic Hormone Production. This case represents the first report of the Ectopic ACTH syndrome associated with anorectal carcinoma.
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Ectopic ACTH syndrome associated with anorectal carcinoma. Report of a case and review of the literature.
Digestive diseases and sciences, 1993Co-Authors: Richard K. SterlingAbstract:A 25-year-old black homosexual was noted to be hypertensive, hypokalemic, and to have a rectal mass. Histopathology of the biopsied lesion revealed a mixture of poorly differentiated squamous cell and undifferentiated small cell carcinoma. Abdominopelvic CT showed multiple liver metastases, minimal local tumor extension, and normal adrenal glands. Despite aggressive treatment, he remained hypertensive and hypokalemic. Endocrine work-up revealed: normal 24-hr VMA and catecholamines, normal serum aldosterone and renin levels, elevated urinary free cortisol (3360 micrograms/24 hr), elevated serum cortisol (60 micrograms/dl), and elevated serum ACTH (1697 pg/dl). Liver biopsy confirmed metastatic anorectal carcinoma, and immunohistochemical stains of the rectal biopsy were positive for ACTH and neuron-specific enolase. Although many types of neoplasms have been associated with Ectopic ACTH Production, small cell carcinoma of the lung is the most common. While there are many reports of colorectal and anorectal neuroendocrine small cell carcinomas, few of these tumors have been associated with clinical Ectopic Hormone Production. This case represents the first report of the Ectopic ACTH syndrome associated with anorectal carcinoma.
J V Hennessey - One of the best experts on this subject based on the ideXlab platform.
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Diagnosis and management of thyrotoxicosis
American family physician, 1996Co-Authors: J V HennesseyAbstract:Outcome-oriented clinical studies and comprehensive management guidelines for thyroid disease have recently been published. Thyrotoxicosis is a differential diagnostic challenge, and determining the etiology is the most critical step in management. Thyrotoxicosis is referred to as hyperthyroidism when sustained thyroid hyperfunction results in increased thyroid Hormone biosynthesis and release from the gland. The most common cause is Graves' disease, but toxic nodular goiters frequently occur in elderly patients. Less common forms include iodine-induced hyperthyroidism, human chorionic gonadotropin-associated thyrotoxicosis and pituitary resistance to thyroid Hormone regulation, in which free thyroxine is elevated in clinically euthyroid or hypothyroid patients but thyroid-stimulating Hormone is normal to increased. Nonhyperthyroid thyrotoxic states are associated with low radioactive iodine uptake ratios, as seen in the three types of subacute thyroiditis, Ectopic Hormone Production or exogenous ingestion of thyroid Hormone. Management of thyrotoxicosis requires lowering of thyroid levels to maintain a euthyroid state. The patient should actively participate in therapeutic decisions. Antithyroid drugs, radioactive iodine and surgery are the principal forms of treatment. Adjunctive therapy may be indicated in some cases. Prolonged follow-up is necessary in all cases.
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Hypoglycemia in pregnancy secondary to a non-islet cell tumor of the pleura and Ectopic insulin-like growth factor II Hormone Production.
Obstetrics and gynecology, 1995Co-Authors: M Schweichler, J V Hennessey, P Cole, J F Perdue, D Le RoithAbstract:In nondiabetic women, pregnancy alone rarely causes clinical hypoglycemia. Non-islet cell tumors have recently been shown to be associated with the Production of insulin-like growth factor II (IGF-II) and a paraneoplastic syndrome resulting in hypoglycemia. A case report and review of pathophysiologic mechanisms involved is presented. A 38-year-old multigravida presented suffering from clinical and biochemical hypoglycemia, which was found to be secondary to a mesothelioma of the pleura and Ectopic IGF-II Production. Tumor resection was performed during the 13th gestational week. The mother became euglycemic immediately after the surgery and remained asymptomatic. Clinical indicators of pregnancy and an ultrasound scan after the surgery were consistent with a normal viable fetus. Symptomatic hypoglycemia and other medical conditions occurring during pregnancy require immediate diagnosis and treatment. In addition to the more common causes, documented cases of medical conditions due to paraneoplastic syndromes of Ectopic Hormone Production during pregnancy have been described. This case establishes the non-islet cell tumor with IGF-II-induced hypoglycemia as another such syndrome to be considered when evaluating hypoglycemia in pregnancy.
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Hypoglycemia in pregnancy secondary to a non-islet cell tumor of the pleura and Ectopic insulin-like growth factor II Hormone Production.
Obstetrics & Gynecology, 1995Co-Authors: Schweichler M, J V Hennessey, Cole P, Le Roith DAbstract:Background : In nondiabetic women, pregnancy alone rarely causes clinical hypoglycemia. Non-islet cell tumors have recently been shown to be associated with the Production of insulin-like growth factor II (IGF-II) and a paraneoplastic syndrome resulting in hypoglycemia. A case report and review of pathophysiologic mechanisms involved is presented. Case : A 38-year-old multigravida presented suffering from clinical and biochemical hypoglycemia, which was found to be secondary to a mesothelioma of the pleura and Ectopic IGF-II Production. Tumor resection was performed during the 13th gestational week. The mother became euglycemic immediately after the surgery and remained asymptomatic. Clinical indicators of pregnancy and an ultrasound scan after the surgery were consistent with a normal viable fetus. Conclusion : Symptomatic hypoglycemia and other medical conditions occurring during pregnancy require immediate diagnosis and treatment In addition to the more common causes, documented cases of medical conditions due to paraneoplastic syndromes of Ectopic Hormone Production during pregnancy have been described. This case establishes the non-islet cell tumor with IGF-II-induced hypoglycemia as another such syndrome to be considered when evaluating hypoglycemia in pregnancy.
