The Experts below are selected from a list of 135 Experts worldwide ranked by ideXlab platform
Ulla Sillén - One of the best experts on this subject based on the ideXlab platform.
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Predictive Factors for Resolution of Congenital High Grade Vesicoureteral Reflux in Infants: Results of Univariate and Multivariate Analyses
The Journal of urology, 2010Co-Authors: Sofia Sjöström, Ulf Jodal, Rune Sixt, Ulla Sillén, Louise Sameby, Eira StoklandAbstract:Purpose: We studied variables with impact on cessation of congenital high grade vesicoureteral reflux in univariate analyses and provide a multivariate model for prediction of reflux resolution.Materials and Methods: A total of 80 male and 35 female infants (median age 2.7 months) were included in this prospective observational study. Of the cases 71% were diagnosed after urinary tract infection and 26% after prenatal ultrasound. Reflux was bilateral in 70% of the patients and maximum grade was III in 16%, IV in 45% and V in 39%. The study protocol included repeat videocystometries, renal scintigrams, chromium Edetic Acid clearances and free voiding observations. Median followup was 36 months.Results: Overall spontaneous reflux resolution, including cases downgraded to grade I to II, was 38%. Variables significantly negatively correlated to resolution were breakthrough febrile urinary tract infection, bladder dysfunction, higher grade of reflux at inclusion, renal abnormality, subnormal renal function, in...
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Reference interval for serum creatinine in children and adolescents with myelomeningocele
Scandinavian journal of urology and nephrology, 2009Co-Authors: Kate Abrahamsson, Ulf Jodal, Ulla SillénAbstract:Objective. In children and adolescents with myelomeningocele (MMC), the relation between muscle mass and body composition varies considerably, making it difficult to evaluate the relevance of renal function assessments done with serum (s)-creatinine. Therefore, a reference interval for enzymic s-creatinine in individuals with MMC was constructed. Material and methods. Patients with MMC aged 1.5–18 years who consistently had chromium-51-labelled Edetic Acid clearance within normal limits (88–132 ml/min/1.73 m2) were selected for the study. Included were 52 girls and 71 boys with a total of 471 s-creatinine determinations. Children with normal body composition were used as controls. Results. The mean s-creatinine concentration at the age of 1.5 years was 22 µmol/l in girls and 21 µmol/l in boys and increased to 38 µmol/l in girls and 58 µmol/l in boys at the age of 18 years. There was no difference between the genders until the age of 12. From the age of 3 years, there was a significantly lower median s-cre...
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Longitudinal Development of Renal Damage and Renal Function in Infants With High Grade Vesicoureteral Reflux
The Journal of urology, 2009Co-Authors: Sofia Sjöström, Ulf Jodal, Rune Sixt, Marc Bachelard, Ulla SillénAbstract:Purpose: We sought to study renal abnormality and renal function through time in infants with high grade vesicoureteral reflux.Materials and Methods: This prospective observational study included 115 infants (80 boys and 35 girls) younger than 1 year with grade III to V vesicoureteral reflux. The diagnosis was made after prenatal ultrasound in 26% of the patients and after urinary tract infection in 71%. Patients were followed by renal scintigraphy, 51chromium Edetic Acid clearance and video cystometry. Median followup was 62 months.Results: Renal abnormality, which was found in 90% of the children at followup, was generalized in 71% and focal in 29%. The abnormality was bilateral in 28% of the affected patients. Total glomerular filtration rate was less than 80% of expected in 30% of the patients. Single kidney function was less than 40% of expected total glomerular filtration rate in 71% of the patients. Renal status (parenchymal abnormality and function) remained unchanged through time in 84 of 108 ava...
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Estimation of Renal Function in Children and Adolescents With Spinal Dysraphism
The Journal of urology, 2008Co-Authors: Kate Abrahamsson, Ulf Jodal, Rune Sixt, Ingrid Olsson, Ulla SillénAbstract:Purpose: In children with spinal dysraphism such as myelomeningocele the relation between muscle mass and body composition varies considerably. Therefore, it is difficult to evaluate the relevance of renal function assessments done with serum creatinine. Since serum cystatin C has been suggested to be independent of body size and composition, this evaluation was compared to chromium51 Edetic Acid clearance.Materials and Methods: Simultaneous measurements of cystatin C and chromium51 Edetic Acid clearance were performed prospectively in 65 patients 2 to 19 years old with spinal dysraphism.Results: Cystatin C values were within the normal range in all patients, while chromium51 Edetic Acid clearance was reduced in 10. A significant relation was seen.Conclusions: Using chromium51 Edetic Acid clearance as a gold standard, children with spinal dysraphism and slightly to moderately reduced renal function may remain undiagnosed if cystatin C is used for evaluation.
Ulf Jodal - One of the best experts on this subject based on the ideXlab platform.
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Predictive Factors for Resolution of Congenital High Grade Vesicoureteral Reflux in Infants: Results of Univariate and Multivariate Analyses
The Journal of urology, 2010Co-Authors: Sofia Sjöström, Ulf Jodal, Rune Sixt, Ulla Sillén, Louise Sameby, Eira StoklandAbstract:Purpose: We studied variables with impact on cessation of congenital high grade vesicoureteral reflux in univariate analyses and provide a multivariate model for prediction of reflux resolution.Materials and Methods: A total of 80 male and 35 female infants (median age 2.7 months) were included in this prospective observational study. Of the cases 71% were diagnosed after urinary tract infection and 26% after prenatal ultrasound. Reflux was bilateral in 70% of the patients and maximum grade was III in 16%, IV in 45% and V in 39%. The study protocol included repeat videocystometries, renal scintigrams, chromium Edetic Acid clearances and free voiding observations. Median followup was 36 months.Results: Overall spontaneous reflux resolution, including cases downgraded to grade I to II, was 38%. Variables significantly negatively correlated to resolution were breakthrough febrile urinary tract infection, bladder dysfunction, higher grade of reflux at inclusion, renal abnormality, subnormal renal function, in...
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Reference interval for serum creatinine in children and adolescents with myelomeningocele
Scandinavian journal of urology and nephrology, 2009Co-Authors: Kate Abrahamsson, Ulf Jodal, Ulla SillénAbstract:Objective. In children and adolescents with myelomeningocele (MMC), the relation between muscle mass and body composition varies considerably, making it difficult to evaluate the relevance of renal function assessments done with serum (s)-creatinine. Therefore, a reference interval for enzymic s-creatinine in individuals with MMC was constructed. Material and methods. Patients with MMC aged 1.5–18 years who consistently had chromium-51-labelled Edetic Acid clearance within normal limits (88–132 ml/min/1.73 m2) were selected for the study. Included were 52 girls and 71 boys with a total of 471 s-creatinine determinations. Children with normal body composition were used as controls. Results. The mean s-creatinine concentration at the age of 1.5 years was 22 µmol/l in girls and 21 µmol/l in boys and increased to 38 µmol/l in girls and 58 µmol/l in boys at the age of 18 years. There was no difference between the genders until the age of 12. From the age of 3 years, there was a significantly lower median s-cre...
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Longitudinal Development of Renal Damage and Renal Function in Infants With High Grade Vesicoureteral Reflux
The Journal of urology, 2009Co-Authors: Sofia Sjöström, Ulf Jodal, Rune Sixt, Marc Bachelard, Ulla SillénAbstract:Purpose: We sought to study renal abnormality and renal function through time in infants with high grade vesicoureteral reflux.Materials and Methods: This prospective observational study included 115 infants (80 boys and 35 girls) younger than 1 year with grade III to V vesicoureteral reflux. The diagnosis was made after prenatal ultrasound in 26% of the patients and after urinary tract infection in 71%. Patients were followed by renal scintigraphy, 51chromium Edetic Acid clearance and video cystometry. Median followup was 62 months.Results: Renal abnormality, which was found in 90% of the children at followup, was generalized in 71% and focal in 29%. The abnormality was bilateral in 28% of the affected patients. Total glomerular filtration rate was less than 80% of expected in 30% of the patients. Single kidney function was less than 40% of expected total glomerular filtration rate in 71% of the patients. Renal status (parenchymal abnormality and function) remained unchanged through time in 84 of 108 ava...
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Estimation of Renal Function in Children and Adolescents With Spinal Dysraphism
The Journal of urology, 2008Co-Authors: Kate Abrahamsson, Ulf Jodal, Rune Sixt, Ingrid Olsson, Ulla SillénAbstract:Purpose: In children with spinal dysraphism such as myelomeningocele the relation between muscle mass and body composition varies considerably. Therefore, it is difficult to evaluate the relevance of renal function assessments done with serum creatinine. Since serum cystatin C has been suggested to be independent of body size and composition, this evaluation was compared to chromium51 Edetic Acid clearance.Materials and Methods: Simultaneous measurements of cystatin C and chromium51 Edetic Acid clearance were performed prospectively in 65 patients 2 to 19 years old with spinal dysraphism.Results: Cystatin C values were within the normal range in all patients, while chromium51 Edetic Acid clearance was reduced in 10. A significant relation was seen.Conclusions: Using chromium51 Edetic Acid clearance as a gold standard, children with spinal dysraphism and slightly to moderately reduced renal function may remain undiagnosed if cystatin C is used for evaluation.
Sofia Sjöström - One of the best experts on this subject based on the ideXlab platform.
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Predictive Factors for Resolution of Congenital High Grade Vesicoureteral Reflux in Infants: Results of Univariate and Multivariate Analyses
The Journal of urology, 2010Co-Authors: Sofia Sjöström, Ulf Jodal, Rune Sixt, Ulla Sillén, Louise Sameby, Eira StoklandAbstract:Purpose: We studied variables with impact on cessation of congenital high grade vesicoureteral reflux in univariate analyses and provide a multivariate model for prediction of reflux resolution.Materials and Methods: A total of 80 male and 35 female infants (median age 2.7 months) were included in this prospective observational study. Of the cases 71% were diagnosed after urinary tract infection and 26% after prenatal ultrasound. Reflux was bilateral in 70% of the patients and maximum grade was III in 16%, IV in 45% and V in 39%. The study protocol included repeat videocystometries, renal scintigrams, chromium Edetic Acid clearances and free voiding observations. Median followup was 36 months.Results: Overall spontaneous reflux resolution, including cases downgraded to grade I to II, was 38%. Variables significantly negatively correlated to resolution were breakthrough febrile urinary tract infection, bladder dysfunction, higher grade of reflux at inclusion, renal abnormality, subnormal renal function, in...
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Longitudinal Development of Renal Damage and Renal Function in Infants With High Grade Vesicoureteral Reflux
The Journal of urology, 2009Co-Authors: Sofia Sjöström, Ulf Jodal, Rune Sixt, Marc Bachelard, Ulla SillénAbstract:Purpose: We sought to study renal abnormality and renal function through time in infants with high grade vesicoureteral reflux.Materials and Methods: This prospective observational study included 115 infants (80 boys and 35 girls) younger than 1 year with grade III to V vesicoureteral reflux. The diagnosis was made after prenatal ultrasound in 26% of the patients and after urinary tract infection in 71%. Patients were followed by renal scintigraphy, 51chromium Edetic Acid clearance and video cystometry. Median followup was 62 months.Results: Renal abnormality, which was found in 90% of the children at followup, was generalized in 71% and focal in 29%. The abnormality was bilateral in 28% of the affected patients. Total glomerular filtration rate was less than 80% of expected in 30% of the patients. Single kidney function was less than 40% of expected total glomerular filtration rate in 71% of the patients. Renal status (parenchymal abnormality and function) remained unchanged through time in 84 of 108 ava...
Rune Sixt - One of the best experts on this subject based on the ideXlab platform.
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Predictive Factors for Resolution of Congenital High Grade Vesicoureteral Reflux in Infants: Results of Univariate and Multivariate Analyses
The Journal of urology, 2010Co-Authors: Sofia Sjöström, Ulf Jodal, Rune Sixt, Ulla Sillén, Louise Sameby, Eira StoklandAbstract:Purpose: We studied variables with impact on cessation of congenital high grade vesicoureteral reflux in univariate analyses and provide a multivariate model for prediction of reflux resolution.Materials and Methods: A total of 80 male and 35 female infants (median age 2.7 months) were included in this prospective observational study. Of the cases 71% were diagnosed after urinary tract infection and 26% after prenatal ultrasound. Reflux was bilateral in 70% of the patients and maximum grade was III in 16%, IV in 45% and V in 39%. The study protocol included repeat videocystometries, renal scintigrams, chromium Edetic Acid clearances and free voiding observations. Median followup was 36 months.Results: Overall spontaneous reflux resolution, including cases downgraded to grade I to II, was 38%. Variables significantly negatively correlated to resolution were breakthrough febrile urinary tract infection, bladder dysfunction, higher grade of reflux at inclusion, renal abnormality, subnormal renal function, in...
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Longitudinal Development of Renal Damage and Renal Function in Infants With High Grade Vesicoureteral Reflux
The Journal of urology, 2009Co-Authors: Sofia Sjöström, Ulf Jodal, Rune Sixt, Marc Bachelard, Ulla SillénAbstract:Purpose: We sought to study renal abnormality and renal function through time in infants with high grade vesicoureteral reflux.Materials and Methods: This prospective observational study included 115 infants (80 boys and 35 girls) younger than 1 year with grade III to V vesicoureteral reflux. The diagnosis was made after prenatal ultrasound in 26% of the patients and after urinary tract infection in 71%. Patients were followed by renal scintigraphy, 51chromium Edetic Acid clearance and video cystometry. Median followup was 62 months.Results: Renal abnormality, which was found in 90% of the children at followup, was generalized in 71% and focal in 29%. The abnormality was bilateral in 28% of the affected patients. Total glomerular filtration rate was less than 80% of expected in 30% of the patients. Single kidney function was less than 40% of expected total glomerular filtration rate in 71% of the patients. Renal status (parenchymal abnormality and function) remained unchanged through time in 84 of 108 ava...
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Estimation of Renal Function in Children and Adolescents With Spinal Dysraphism
The Journal of urology, 2008Co-Authors: Kate Abrahamsson, Ulf Jodal, Rune Sixt, Ingrid Olsson, Ulla SillénAbstract:Purpose: In children with spinal dysraphism such as myelomeningocele the relation between muscle mass and body composition varies considerably. Therefore, it is difficult to evaluate the relevance of renal function assessments done with serum creatinine. Since serum cystatin C has been suggested to be independent of body size and composition, this evaluation was compared to chromium51 Edetic Acid clearance.Materials and Methods: Simultaneous measurements of cystatin C and chromium51 Edetic Acid clearance were performed prospectively in 65 patients 2 to 19 years old with spinal dysraphism.Results: Cystatin C values were within the normal range in all patients, while chromium51 Edetic Acid clearance was reduced in 10. A significant relation was seen.Conclusions: Using chromium51 Edetic Acid clearance as a gold standard, children with spinal dysraphism and slightly to moderately reduced renal function may remain undiagnosed if cystatin C is used for evaluation.
Terrence Forrester - One of the best experts on this subject based on the ideXlab platform.
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Microalbuminuria, renal function and waist:hip ratio in black hypertensive Jamaicans
Journal of human hypertension, 1998Co-Authors: Marvin Reid, Franklyn I. Bennett, Rainford Wilks, Terrence ForresterAbstract:Objective: To investigate the relationship between blood pressure (BP), renal haemodynamics, anthropometric measures of obesity and urinary albumin excretion in hypertension and in a control group. Methods: Urinary albumin, BP and anthropometric measurements were carried out in patients attending the hypertension clinic of the University Hospital of the West Indies. A randomised stratified sample was then selected for renal haemodynamic assessment. A normoalbuminuric control group without hypertension or diabetes was also selected. Renal haemodynamics was assessed by measuring glomerular filtration rate using 51-chromium Edetic Acid (51Cr-EDTA) and renal blood flow using 125-iodohippurate (125-PAH). Results: Urinary albumin excretion was positively and significantly correlated with systolic pressure (b 5 0.011, P , 0.003, R 5 0.22), current body weight (b 5 0.014, P , 0.04, R 5 0.15) and the presence of diabetes (b 5 0.9, P , 0.001, R 5 0.3). In the sample selected for
