The Experts below are selected from a list of 159 Experts worldwide ranked by ideXlab platform
Junzo Otera - One of the best experts on this subject based on the ideXlab platform.
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one pot transformation of ph2p o protected ethynes deprotection followed by transition metal catalyzed Coupling
Journal of Organic Chemistry, 2013Co-Authors: Lifen Peng, Feng Xu, Yoshinori Suzuma, Akihiro Orita, Junzo OteraAbstract:Ph2P(O)-protected ethynes were successfully transformed to arylethynes in one-pot manner through t-BuOK-catalyzed deprotection followed by Sonogashira Coupling with aryl halide. The arylethynes were obtained similarly by Ph2P(O)-deprotection, stannylation of the resulting terminal ethynes, and Migita-Kosugi-Stille Coupling. Deprotection followed by intramolecular Eglinton Coupling could be carried out in one-pot to provide cyclic butadiynes.
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One-Pot Transformation of Ph2P(O)-Protected Ethynes: Deprotection Followed by Transition Metal-Catalyzed Coupling
2013Co-Authors: Lifen Peng, Yoshinori Suzuma, Akihiro Orita, Junzo OteraAbstract:Ph2P(O)-protected ethynes were successfully transformed to arylethynes in one-pot manner through t-BuOK-catalyzed deprotection followed by Sonogashira Coupling with aryl halide. The arylethynes were obtained similarly by Ph2P(O)-deprotection, stannylation of the resulting terminal ethynes, and Migita-Kosugi-Stille Coupling. Deprotection followed by intramolecular Eglinton Coupling could be carried out in one-pot to provide cyclic butadiynes
Michael M. Haley - One of the best experts on this subject based on the ideXlab platform.
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one pot desilylation dimerization of ethynyl and butadiynyltrimethylsilanes synthesis of tetrayne linked dehydrobenzoannulenes
Tetrahedron Letters, 1997Co-Authors: Michael M. Haley, Michael L. Bell, Stephen C. Brand, David B. Kimball, Joshua J. Pak, Brad W WanAbstract:Abstract Addition of K2CO3 to standard Eglinton Coupling conditions effects a one-pot desilylation/dimerization reaction of alkynyltrimethylsilanes. Use of this procedure on substituted phenylbutadiynylsilanes ultimately leads to the formation of dehydrobenzoannulenes possessing an unprecedented number of acetylene linkers. © 1997 Elsevier Science Ltd.
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One-Pot Desilylation/Dimerization of Ethynyl- and Butadiynyltrimethylsilanes. Synthesis of Tetrayne-Linked Dehydrobenzoannulenes.
Tetrahedron Letters, 1997Co-Authors: Michael M. Haley, Michael L. Bell, Stephen C. Brand, David B. Kimball, Joshua J. Pak, W. Brad WanAbstract:Abstract Addition of K2CO3 to standard Eglinton Coupling conditions effects a one-pot desilylation/dimerization reaction of alkynyltrimethylsilanes. Use of this procedure on substituted phenylbutadiynylsilanes ultimately leads to the formation of dehydrobenzoannulenes possessing an unprecedented number of acetylene linkers. © 1997 Elsevier Science Ltd.
Jean-françois Lutz - One of the best experts on this subject based on the ideXlab platform.
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Compartmentalization of Single Polymer Chains by Stepwise Intramolecular Cross-Linking of Sequence-Controlled Macromolecules
Journal of the American Chemical Society, 2014Co-Authors: Raj Kumar Roy, Jean-françois LutzAbstract:We report the intramolecular double compaction of sequence-controlled linear macromolecules into “structured” random coils. These compartmentalized single-chain objects were prepared by performing successive cross-linking reactions in an orthogonal fashion. The foldable precursors were synthesized by sequence-controlled copolymerization of styrene with N-substituted maleimides (MIs), namely pentafluorophenyl 4-maleimidobenzoate (1) and TIPS-protected N-propargyl maleimide (2). These two functional MIs allow intramolecular cross-linking. The activated ester pentafluorophenyl moieties of 1 were reacted with ethylenediamine, whereas the deprotected alkyne functions of 2 were self-reacted by Eglinton Coupling. The compaction of model copolymers containing only one cross-linkable zone (i.e., either 1 or 2) was first studied. 1H NMR and SEC analysis indicated that these structures could be efficiently compacted into single-chain objects. Thus, more complex copolymers containing two individually addressable cros...
Lifen Peng - One of the best experts on this subject based on the ideXlab platform.
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one pot transformation of ph2p o protected ethynes deprotection followed by transition metal catalyzed Coupling
Journal of Organic Chemistry, 2013Co-Authors: Lifen Peng, Feng Xu, Yoshinori Suzuma, Akihiro Orita, Junzo OteraAbstract:Ph2P(O)-protected ethynes were successfully transformed to arylethynes in one-pot manner through t-BuOK-catalyzed deprotection followed by Sonogashira Coupling with aryl halide. The arylethynes were obtained similarly by Ph2P(O)-deprotection, stannylation of the resulting terminal ethynes, and Migita-Kosugi-Stille Coupling. Deprotection followed by intramolecular Eglinton Coupling could be carried out in one-pot to provide cyclic butadiynes.
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One-Pot Transformation of Ph2P(O)-Protected Ethynes: Deprotection Followed by Transition Metal-Catalyzed Coupling
2013Co-Authors: Lifen Peng, Yoshinori Suzuma, Akihiro Orita, Junzo OteraAbstract:Ph2P(O)-protected ethynes were successfully transformed to arylethynes in one-pot manner through t-BuOK-catalyzed deprotection followed by Sonogashira Coupling with aryl halide. The arylethynes were obtained similarly by Ph2P(O)-deprotection, stannylation of the resulting terminal ethynes, and Migita-Kosugi-Stille Coupling. Deprotection followed by intramolecular Eglinton Coupling could be carried out in one-pot to provide cyclic butadiynes
Raj Kumar Roy - One of the best experts on this subject based on the ideXlab platform.
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Compartmentalization of Single Polymer Chains by Stepwise Intramolecular Cross-Linking of Sequence-Controlled Macromolecules
Journal of the American Chemical Society, 2014Co-Authors: Raj Kumar Roy, Jean-françois LutzAbstract:We report the intramolecular double compaction of sequence-controlled linear macromolecules into “structured” random coils. These compartmentalized single-chain objects were prepared by performing successive cross-linking reactions in an orthogonal fashion. The foldable precursors were synthesized by sequence-controlled copolymerization of styrene with N-substituted maleimides (MIs), namely pentafluorophenyl 4-maleimidobenzoate (1) and TIPS-protected N-propargyl maleimide (2). These two functional MIs allow intramolecular cross-linking. The activated ester pentafluorophenyl moieties of 1 were reacted with ethylenediamine, whereas the deprotected alkyne functions of 2 were self-reacted by Eglinton Coupling. The compaction of model copolymers containing only one cross-linkable zone (i.e., either 1 or 2) was first studied. 1H NMR and SEC analysis indicated that these structures could be efficiently compacted into single-chain objects. Thus, more complex copolymers containing two individually addressable cros...
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Compartmentalization of Single Polymer Chains by Stepwise Intramolecular Cross-Linking of Sequence-Controlled Macromolecules
2014Co-Authors: Raj Kumar Roy, Jean-françois LutzAbstract:We report the intramolecular double compaction of sequence-controlled linear macromolecules into “structured” random coils. These compartmentalized single-chain objects were prepared by performing successive cross-linking reactions in an orthogonal fashion. The foldable precursors were synthesized by sequence-controlled copolymerization of styrene with N-substituted maleimides (MIs), namely pentafluorophenyl 4-maleimidobenzoate (1) and TIPS-protected N-propargyl maleimide (2). These two functional MIs allow intramolecular cross-linking. The activated ester pentafluorophenyl moieties of 1 were reacted with ethylenediamine, whereas the deprotected alkyne functions of 2 were self-reacted by Eglinton Coupling. The compaction of model copolymers containing only one cross-linkable zone (i.e., either 1 or 2) was first studied. 1H NMR and SEC analysis indicated that these structures could be efficiently compacted into single-chain objects. Thus, more complex copolymers containing two individually addressable cross-linking zones were prepared and sequentially compacted. Detailed characterization of the folding process indicated that double-compaction occurred and that the formed single-chain particles contain distinct cross-linked subdomains