The Experts below are selected from a list of 159 Experts worldwide ranked by ideXlab platform
Torsten Hain - One of the best experts on this subject based on the ideXlab platform.
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inhibitory activity of a standardized elderberry liquid extract against clinically relevant human respiratory bacterial pathogens and influenza a and b viruses
BMC Complementary and Alternative Medicine, 2011Co-Authors: Christian Krawitz, Mobarak Abu Mraheil, M Stein, Can Imirzalioglu, Eugen Domann, Stephan Pleschka, Torsten HainAbstract:Black Elderberries (Sambucus nigra L.) are well known as supportive agents against common cold and influenza. It is further known that bacterial super-infection during an influenza virus (IV) infection can lead to severe pneumonia. We have analyzed a standardized elderberry extract (Rubini, BerryPharma AG) for its antimicrobial and antiviral activity using the microtitre broth micro-dilution assay against three Gram-positive bacteria and one Gram-negative bacteria responsible for infections of the upper respiratory tract, as well as cell culture experiments for two different strains of influenza virus. The antimicrobial activity of the elderberry extract was determined by bacterial growth experiments in liquid cultures using the extract at concentrations of 5%, 10%, 15% and 20%. The inhibitory effects were determined by plating the bacteria on agar plates. In addition, the inhibitory potential of the extract on the propagation of human pathogenic H5N1-type influenza A virus isolated from a patient and an influenza B virus strain was investigated using MTT and focus assays. For the first time, it was shown that a standardized elderberry liquid extract possesses antimicrobial activity against both Gram-positive bacteria of Streptococcus pyogenes and group C and G Streptococci, and the Gram-negative bacterium Branhamella catarrhalis in liquid cultures. The liquid extract also displays an inhibitory effect on the propagation of human pathogenic influenza viruses. Rubini elderberry liquid extract is active against human pathogenic bacteria as well as influenza viruses. The activities shown suggest that additional and alternative approaches to combat infections might be provided by this natural product.
Christian Krawitz - One of the best experts on this subject based on the ideXlab platform.
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inhibitory activity of a standardized elderberry liquid extract against clinically relevant human respiratory bacterial pathogens and influenza a and b viruses
BMC Complementary and Alternative Medicine, 2011Co-Authors: Christian Krawitz, Mobarak Abu Mraheil, M Stein, Can Imirzalioglu, Eugen Domann, Stephan Pleschka, Torsten HainAbstract:Black Elderberries (Sambucus nigra L.) are well known as supportive agents against common cold and influenza. It is further known that bacterial super-infection during an influenza virus (IV) infection can lead to severe pneumonia. We have analyzed a standardized elderberry extract (Rubini, BerryPharma AG) for its antimicrobial and antiviral activity using the microtitre broth micro-dilution assay against three Gram-positive bacteria and one Gram-negative bacteria responsible for infections of the upper respiratory tract, as well as cell culture experiments for two different strains of influenza virus. The antimicrobial activity of the elderberry extract was determined by bacterial growth experiments in liquid cultures using the extract at concentrations of 5%, 10%, 15% and 20%. The inhibitory effects were determined by plating the bacteria on agar plates. In addition, the inhibitory potential of the extract on the propagation of human pathogenic H5N1-type influenza A virus isolated from a patient and an influenza B virus strain was investigated using MTT and focus assays. For the first time, it was shown that a standardized elderberry liquid extract possesses antimicrobial activity against both Gram-positive bacteria of Streptococcus pyogenes and group C and G Streptococci, and the Gram-negative bacterium Branhamella catarrhalis in liquid cultures. The liquid extract also displays an inhibitory effect on the propagation of human pathogenic influenza viruses. Rubini elderberry liquid extract is active against human pathogenic bacteria as well as influenza viruses. The activities shown suggest that additional and alternative approaches to combat infections might be provided by this natural product.
ângelo C Salvador - One of the best experts on this subject based on the ideXlab platform.
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effect of elderberry sambucus nigra l extract supplementation in stz induced diabetic rats fed with a high fat diet
International Journal of Molecular Sciences, 2016Co-Authors: ângelo C Salvador, Ewelina Krol, Virginia C Lemos, Sonia A O Santos, Fernanda P M S Bento, Carina Pedrosa Costa, Adelaide Almeida, Dawid Szczepankiewicz, Bartosz Kulczynski, Zbigniew KrejpcioAbstract:Elderberry (Sambucus nigra L.) lipophilic and polar extract dietary supplementation effects were evaluated according to diabetes management indices, using an in vivo model. A research pipeline was constructed, that ranged from extract preparation, partial chemical characterization and toxicity evaluation, to examining the elderberry extract dietary supplementation effects on biofluid and tissues. Extracts toxicity was screened using an Aliivibrio fischeri bioluminescence model. A concentration of up to 60 mg/L was selected, and rat doses for oral supplementation were computed applying the interspecies correlation between A. fischeri and rats. Wistar type 2 diabetic rats, induced by streptozotocin (STZ), were fed a high-fat diet and supplemented for 4 weeks at doses of 190 and 350 mg/kg body weight/day of lipophilic and polar extract, respectively. As far as we know, lipophilic elderberry extract supplementation was assessed for the first time, while polar extract was administrated at higher doses and for a shorter period compared to previous studies, aiming to evaluate subacute supplementation effects. The polar extract modulated glucose metabolism by correcting hyperglycemia, while the lipophilic extract lowered insulin secretion. Both extracts lowered insulin resistance, without remarkable alterations to hematological indices, sera lipids and sera and tissular trace element homeostasis. In conclusion, Elderberries are a potential source of bioactive compounds for formulations to be used as co-adjuvants in diabetes management.
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lipophilic phytochemicals from Elderberries sambucus nigra l influence of ripening cultivar and season
Industrial Crops and Products, 2015Co-Authors: ângelo C Salvador, Sílvia M. Rocha, Armando J D SilvestreAbstract:Abstract The chemical composition of the lipophilic extracts of three Portuguese Elderberries cultivars belonging to the Sambucus nigra L. species (‘Bastardeira’, ‘Sabugueira’ and ‘Sabugueiro’), was studied by gas chromatography–mass spectrometry. The influence of the harvesting season (2012 and 2013), cultivar and the ripening stage was evaluated. Regarding the amount of lipophilic extractives, they ranged from 0.56% to 1.84% of the dry weight. The major chemical families present in these fractions were triterpenoids and fatty acids accounting with 84.9–93.8% and 4.3–11.4% of the total amount of lipophilic components, respectively. The most abundant compounds, identified as Elderberries components were ursolic and oleanolic acids, followed by smaller amounts of long chain aliphatic alcohols and sterols. During ripening, a similar profile of the studied chemical families was found for the two sampling seasons and the three cultivars, with an initial growth of their content followed by a systematic decrease until maturity, yet, a higher lipophilic content (p
Eugen Domann - One of the best experts on this subject based on the ideXlab platform.
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inhibitory activity of a standardized elderberry liquid extract against clinically relevant human respiratory bacterial pathogens and influenza a and b viruses
BMC Complementary and Alternative Medicine, 2011Co-Authors: Christian Krawitz, Mobarak Abu Mraheil, M Stein, Can Imirzalioglu, Eugen Domann, Stephan Pleschka, Torsten HainAbstract:Black Elderberries (Sambucus nigra L.) are well known as supportive agents against common cold and influenza. It is further known that bacterial super-infection during an influenza virus (IV) infection can lead to severe pneumonia. We have analyzed a standardized elderberry extract (Rubini, BerryPharma AG) for its antimicrobial and antiviral activity using the microtitre broth micro-dilution assay against three Gram-positive bacteria and one Gram-negative bacteria responsible for infections of the upper respiratory tract, as well as cell culture experiments for two different strains of influenza virus. The antimicrobial activity of the elderberry extract was determined by bacterial growth experiments in liquid cultures using the extract at concentrations of 5%, 10%, 15% and 20%. The inhibitory effects were determined by plating the bacteria on agar plates. In addition, the inhibitory potential of the extract on the propagation of human pathogenic H5N1-type influenza A virus isolated from a patient and an influenza B virus strain was investigated using MTT and focus assays. For the first time, it was shown that a standardized elderberry liquid extract possesses antimicrobial activity against both Gram-positive bacteria of Streptococcus pyogenes and group C and G Streptococci, and the Gram-negative bacterium Branhamella catarrhalis in liquid cultures. The liquid extract also displays an inhibitory effect on the propagation of human pathogenic influenza viruses. Rubini elderberry liquid extract is active against human pathogenic bacteria as well as influenza viruses. The activities shown suggest that additional and alternative approaches to combat infections might be provided by this natural product.
Stephan Pleschka - One of the best experts on this subject based on the ideXlab platform.
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inhibitory activity of a standardized elderberry liquid extract against clinically relevant human respiratory bacterial pathogens and influenza a and b viruses
BMC Complementary and Alternative Medicine, 2011Co-Authors: Christian Krawitz, Mobarak Abu Mraheil, M Stein, Can Imirzalioglu, Eugen Domann, Stephan Pleschka, Torsten HainAbstract:Black Elderberries (Sambucus nigra L.) are well known as supportive agents against common cold and influenza. It is further known that bacterial super-infection during an influenza virus (IV) infection can lead to severe pneumonia. We have analyzed a standardized elderberry extract (Rubini, BerryPharma AG) for its antimicrobial and antiviral activity using the microtitre broth micro-dilution assay against three Gram-positive bacteria and one Gram-negative bacteria responsible for infections of the upper respiratory tract, as well as cell culture experiments for two different strains of influenza virus. The antimicrobial activity of the elderberry extract was determined by bacterial growth experiments in liquid cultures using the extract at concentrations of 5%, 10%, 15% and 20%. The inhibitory effects were determined by plating the bacteria on agar plates. In addition, the inhibitory potential of the extract on the propagation of human pathogenic H5N1-type influenza A virus isolated from a patient and an influenza B virus strain was investigated using MTT and focus assays. For the first time, it was shown that a standardized elderberry liquid extract possesses antimicrobial activity against both Gram-positive bacteria of Streptococcus pyogenes and group C and G Streptococci, and the Gram-negative bacterium Branhamella catarrhalis in liquid cultures. The liquid extract also displays an inhibitory effect on the propagation of human pathogenic influenza viruses. Rubini elderberry liquid extract is active against human pathogenic bacteria as well as influenza viruses. The activities shown suggest that additional and alternative approaches to combat infections might be provided by this natural product.