The Experts below are selected from a list of 26640 Experts worldwide ranked by ideXlab platform
Colin Campbell - One of the best experts on this subject based on the ideXlab platform.
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cellular redox potential and the biomolecular Electrochemical Series a systems hypothesis
Free Radical Biology and Medicine, 2012Co-Authors: Venkatesh Mallikarjun, David J Clarke, Colin CampbellAbstract:The role of cellular redox potential in the regulation of protein activity is becoming increasingly appreciated and characterized. In this paper we put forward a new hypothesis relating to redox regulation of cellular physiology. We have exemplified our hypothesis using apoptosis since its redox phenomenology is well established, but believe that it is equally applicable to several other pathways. Our hypothesis is that since multiple proteins in the apoptosis pathway are thought to be regulated via oxidation/reduction reactions and since cellular redox potentials have been shown to become progressively more oxidative during apoptosis, that the proteins could be arranged in an Electrochemical Series where the protein's standard potential correlates with its position in the pathway. Since the most stable oxidation state of the protein is determined by its standard potential and the redox potential of its environment (in a way predictable by the Nernst equation), a quantitative model of the redox regulation of the pathway could be developed. We have outlined our hypothesis, illustrating it using a pathway map which assembles a selection of the literature on apoptosis into a readable graphical format. We have also outlined experimental approaches suitable for testing our hypothesis.
C. Rüssel - One of the best experts on this subject based on the ideXlab platform.
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The Electrochemical Series of elements in the Na2O . 2SiO2 glass melt
Journal of Non-crystalline Solids, 1999Co-Authors: C. Rüssel, Gordon Von Der GönnaAbstract:Abstract The thermodynamics of redox equilibria were studied by square-wave voltammetry in a glass melt with the basic composition of Na2O · 2SiO2 in the temperature range of 850–1600°C. The melts were doped with oxides of As, Sb, Sn, Cu, V, Fe, Cr and Ti. While iron and titanium-doped glass melts exhibit only one reduction step, all other polyvalent compounds studied are reduced in two electron steps. In the case of As-, Sb-, Sn- and Cu-doped melts, the metallic state is formed during the second reduction step. Standard potentials measured depend linearly upon the temperature. In all cases studied, the reduced states are favored at higher temperatures. The Electrochemical Series of elements is nearly the same as those previously reported for soda–lime–silicate and borosilicate glass melts. However, in comparison to these glass melt compositions, the standard potentials in the Na2O · 2SiO2 melt are shifted to lower potentials. This cathodic shift can be explained as an effect of the higher basicity of the Na2O · 2SiO2 melt.
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Thermodynamics of various polyvalent main group elements in a borosilicate glass melt
Journal of Non-Crystalline Solids, 1997Co-Authors: Olaf Claußen, C. RüsselAbstract:Abstract The thermodynamics of redox equilibria were studied by square-wave-voltammetry in a borosilicate glass melt at temperatures in the range of 700 to 1100°C. The glass melts were doped with oxides of As, Sb, Bi, Te, Sn and Pb. While lead and bismuth are reduced in one redox step to the metallic state, glass melts doped with the other elements have two well separated redox steps. Standard potentials linearly depend on temperature and hence both the standard enthalpy and the standard entropy are constant. The Electrochemical Series of elements is nearly the same as that reported in soda–lime–silica glass melts. With the exception of the Pb2+/Pb0-redox step, all standard potentials in the borosilicate glass melt are notably shifted to more negative potentials by comparison with those reported from soda–lima–silica glass melts.
Venkatesh Mallikarjun - One of the best experts on this subject based on the ideXlab platform.
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cellular redox potential and the biomolecular Electrochemical Series a systems hypothesis
Free Radical Biology and Medicine, 2012Co-Authors: Venkatesh Mallikarjun, David J Clarke, Colin CampbellAbstract:The role of cellular redox potential in the regulation of protein activity is becoming increasingly appreciated and characterized. In this paper we put forward a new hypothesis relating to redox regulation of cellular physiology. We have exemplified our hypothesis using apoptosis since its redox phenomenology is well established, but believe that it is equally applicable to several other pathways. Our hypothesis is that since multiple proteins in the apoptosis pathway are thought to be regulated via oxidation/reduction reactions and since cellular redox potentials have been shown to become progressively more oxidative during apoptosis, that the proteins could be arranged in an Electrochemical Series where the protein's standard potential correlates with its position in the pathway. Since the most stable oxidation state of the protein is determined by its standard potential and the redox potential of its environment (in a way predictable by the Nernst equation), a quantitative model of the redox regulation of the pathway could be developed. We have outlined our hypothesis, illustrating it using a pathway map which assembles a selection of the literature on apoptosis into a readable graphical format. We have also outlined experimental approaches suitable for testing our hypothesis.
Abby Kavner - One of the best experts on this subject based on the ideXlab platform.
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w wo joins the deep earth Electrochemical Series
American Mineralogist, 2016Co-Authors: Abby KavnerAbstract:The short-lived 182W-182Hf isotope system is useful for constraining early mantle and core differentiation processes (e.g., Klein et al. 2002), if its siderophile behavior is understood. With the publication of the bulk thermoelastic properties of the high-pressure polymorphs of WO2 in the January issue of American Mineralogist , Shofner et al. (2016) determine the relative energetics of the W-WO system as a function of pressure and temperature, thus defining the W-WO redox equilibrium relative to Fe-FeO, Ni-NiO, and Co-Co, at deep Earth conditions.
David J Clarke - One of the best experts on this subject based on the ideXlab platform.
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cellular redox potential and the biomolecular Electrochemical Series a systems hypothesis
Free Radical Biology and Medicine, 2012Co-Authors: Venkatesh Mallikarjun, David J Clarke, Colin CampbellAbstract:The role of cellular redox potential in the regulation of protein activity is becoming increasingly appreciated and characterized. In this paper we put forward a new hypothesis relating to redox regulation of cellular physiology. We have exemplified our hypothesis using apoptosis since its redox phenomenology is well established, but believe that it is equally applicable to several other pathways. Our hypothesis is that since multiple proteins in the apoptosis pathway are thought to be regulated via oxidation/reduction reactions and since cellular redox potentials have been shown to become progressively more oxidative during apoptosis, that the proteins could be arranged in an Electrochemical Series where the protein's standard potential correlates with its position in the pathway. Since the most stable oxidation state of the protein is determined by its standard potential and the redox potential of its environment (in a way predictable by the Nernst equation), a quantitative model of the redox regulation of the pathway could be developed. We have outlined our hypothesis, illustrating it using a pathway map which assembles a selection of the literature on apoptosis into a readable graphical format. We have also outlined experimental approaches suitable for testing our hypothesis.