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S Attapattu - One of the best experts on this subject based on the ideXlab platform.

  • acute yellow oleander thevetia peruviana poisoning cardiac arrhythmias Electrolyte Disturbances and serum cardiac glycoside concentrations on presentation to hospital
    Heart, 2000
    Co-Authors: Michael Eddleston, C A Ariaratnam, L Sjostrom, S Jayalath, K Rajakanthan, Senaka Rajapakse, D Colbert, W P Meyer, G Perera, S Attapattu
    Abstract:

    OBJECTIVE—To describe the cardiac arrhythmias, Electrolyte Disturbances, and serum cardiac glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN—Case series. SETTING—Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS—351 patients with a history of oleander ingestion. MEASUREMENTS—ECG and blood sample analysis on admission. RESULTS—Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum cardiac glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum cardiac glycoside levels. CONCLUSIONS—Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum cardiac glycoside concentrations and hyperkalaemia but not with Disturbances of magnesium. Keywords: oleander poisoning; arrhythmias; cardiac glycosides

Michael Eddleston - One of the best experts on this subject based on the ideXlab platform.

  • acute yellow oleander thevetia peruviana poisoning cardiac arrhythmias Electrolyte Disturbances and serum cardiac glycoside concentrations on presentation to hospital
    Heart, 2000
    Co-Authors: Michael Eddleston, C A Ariaratnam, L Sjostrom, S Jayalath, K Rajakanthan, Senaka Rajapakse, D Colbert, W P Meyer, G Perera, S Attapattu
    Abstract:

    OBJECTIVE—To describe the cardiac arrhythmias, Electrolyte Disturbances, and serum cardiac glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN—Case series. SETTING—Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS—351 patients with a history of oleander ingestion. MEASUREMENTS—ECG and blood sample analysis on admission. RESULTS—Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum cardiac glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum cardiac glycoside levels. CONCLUSIONS—Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum cardiac glycoside concentrations and hyperkalaemia but not with Disturbances of magnesium. Keywords: oleander poisoning; arrhythmias; cardiac glycosides

C A Ariaratnam - One of the best experts on this subject based on the ideXlab platform.

  • acute yellow oleander thevetia peruviana poisoning cardiac arrhythmias Electrolyte Disturbances and serum cardiac glycoside concentrations on presentation to hospital
    Heart, 2000
    Co-Authors: Michael Eddleston, C A Ariaratnam, L Sjostrom, S Jayalath, K Rajakanthan, Senaka Rajapakse, D Colbert, W P Meyer, G Perera, S Attapattu
    Abstract:

    OBJECTIVE—To describe the cardiac arrhythmias, Electrolyte Disturbances, and serum cardiac glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN—Case series. SETTING—Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS—351 patients with a history of oleander ingestion. MEASUREMENTS—ECG and blood sample analysis on admission. RESULTS—Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum cardiac glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum cardiac glycoside levels. CONCLUSIONS—Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum cardiac glycoside concentrations and hyperkalaemia but not with Disturbances of magnesium. Keywords: oleander poisoning; arrhythmias; cardiac glycosides

  • Acute yellow oleander (Thevetia peruviana) poisoning: cardiac arrhythmias, Electrolyte Disturbances, and serum cardiac glycoside concentrations on presentation to hospital.
    'BMJ', 2000
    Co-Authors: Eddleston M, C A Ariaratnam, W P Meyer, Sjöström L, Jayalath S, Rajakanthan K, Rajapakse S, Colbert D, Perera G, Attapattu S
    Abstract:

    OBJECTIVE: To describe the cardiac arrhythmias, Electrolyte Disturbances, and serum cardiac glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN: Case series. SETTING: Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS: 351 patients with a history of oleander ingestion. MEASUREMENTS: ECG and blood sample analysis on admission. RESULTS: Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum cardiac glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum cardiac glycoside levels. CONCLUSIONS: Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum cardiac glycoside concentrations and hyperkalaemia but not with Disturbances of magnesium

W P Meyer - One of the best experts on this subject based on the ideXlab platform.

  • acute yellow oleander thevetia peruviana poisoning cardiac arrhythmias Electrolyte Disturbances and serum cardiac glycoside concentrations on presentation to hospital
    Heart, 2000
    Co-Authors: Michael Eddleston, C A Ariaratnam, L Sjostrom, S Jayalath, K Rajakanthan, Senaka Rajapakse, D Colbert, W P Meyer, G Perera, S Attapattu
    Abstract:

    OBJECTIVE—To describe the cardiac arrhythmias, Electrolyte Disturbances, and serum cardiac glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN—Case series. SETTING—Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS—351 patients with a history of oleander ingestion. MEASUREMENTS—ECG and blood sample analysis on admission. RESULTS—Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum cardiac glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum cardiac glycoside levels. CONCLUSIONS—Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum cardiac glycoside concentrations and hyperkalaemia but not with Disturbances of magnesium. Keywords: oleander poisoning; arrhythmias; cardiac glycosides

  • Acute yellow oleander (Thevetia peruviana) poisoning: cardiac arrhythmias, Electrolyte Disturbances, and serum cardiac glycoside concentrations on presentation to hospital.
    'BMJ', 2000
    Co-Authors: Eddleston M, C A Ariaratnam, W P Meyer, Sjöström L, Jayalath S, Rajakanthan K, Rajapakse S, Colbert D, Perera G, Attapattu S
    Abstract:

    OBJECTIVE: To describe the cardiac arrhythmias, Electrolyte Disturbances, and serum cardiac glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN: Case series. SETTING: Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS: 351 patients with a history of oleander ingestion. MEASUREMENTS: ECG and blood sample analysis on admission. RESULTS: Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum cardiac glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum cardiac glycoside levels. CONCLUSIONS: Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum cardiac glycoside concentrations and hyperkalaemia but not with Disturbances of magnesium

Javier P. Gisbert - One of the best experts on this subject based on the ideXlab platform.

  • systematic review the adverse effects of sodium phosphate enema
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J L Mendoza, Jesus Legido, Saioa Rubio, Javier P. Gisbert
    Abstract:

    Summary Background Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side effects. Aim A systematic review of the literature was conducted to identify the most common adverse effects of sodium-phosphate enemas and associated risk factors. Methods A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007. Results A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty-eight per cent of the patients having adverse effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side effects were due to water and Electrolyte Disturbances. Most patients were under 18 years of age (66%) or older than 65 years (25%). A total of 12 deaths were found. Conclusion The main side effects caused by sodium phosphate enemas are water and Electrolyte Disturbances. The main risk factors are extreme age and associated comorbidity.

  • systematic review the adverse effects of sodium phosphate enema
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J L Mendoza, Jesus Legido, Saioa Rubio, Javier P. Gisbert
    Abstract:

    Summary Background Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side effects. Aim A systematic review of the literature was conducted to identify the most common adverse effects of sodium-phosphate enemas and associated risk factors. Methods A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007. Results A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty-eight per cent of the patients having adverse effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side effects were due to water and Electrolyte Disturbances. Most patients were under 18 years of age (66%) or older than 65 years (25%). A total of 12 deaths were found. Conclusion The main side effects caused by sodium phosphate enemas are water and Electrolyte Disturbances. The main risk factors are extreme age and associated comorbidity.