The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform

Adam Dickler - One of the best experts on this subject based on the ideXlab platform.

  • twelve month follow up results of a trial utilizing axxent Electronic brachytherapy to deliver intraoperative radiation therapy for early stage breast cancer
    Annals of Surgical Oncology, 2011
    Co-Authors: Olga Ivanov, Adam Dickler, Bennett Y F Lum, James V Pellicane, Darius Francescatti
    Abstract:

    Accelerated partial breast irradiation (APBI) is emerging as a valid alternative to whole-breast radiation therapy (WBRT) in breast-conserving therapy (BCT) for early-stage breast cancer. Axxent Electronic brachytherapy (EBX) is a form of portable, balloon-based APBI that utilizes an Electronic Source of kilovoltage irradiation delivery with minimal shielding requirements. As such, EBX becomes a logical and convenient modality for delivery of intraoperative radiation therapy (IORT). We report 1-year results and clinical outcomes of a trial that utilizes EBX to deliver IORT for patients with early-stage breast cancer. Eleven patients were enrolled on an institutional review board (IRB)-approved protocol. Inclusion criteria were patient age >45 years, unifocal tumors with infiltrating ductal or ductal carcinoma in situ (DCIS) histology, tumors ≤3 cm, and uninvolved lymph nodes. Preloaded radiation plans were used to deliver radiation prescription dose of 20 Gy to the balloon surface. The mean time for radiation delivery was 22 min; the total mean procedure time was 1 h 39 min. All margins of excision were negative on final pathology. At mean follow-up of 12 months, overall cosmesis was excellent in 10 of 11 patients. No infection, fat necrosis, desquamation, rib fracture or cancer recurrence has been observed. There was no evidence of fibrosis at last follow-up. IORT utilizing EBX is emerging as a feasible, well-tolerated alternative to postsurgical APBI. Further research and longer follow-up data on EBX and other IORT methods are needed to establish the clinical efficacy and safety of this treatment.

  • intraoperative radiation therapy in the treatment of early stage breast cancer utilizing xoft axxent Electronic brachytherapy
    World Journal of Surgical Oncology, 2009
    Co-Authors: Adam Dickler, Olga Ivanov, Darius Francescatti
    Abstract:

    In an effort to overcome the barriers to BCT, alternative methods of delivering radiation therapy have been explored. APBI allows the radiation treatment to be accomplished in one week or less. XB is a form of balloon-based APBI that uses an Electronic Source generated by a mobile controller unit. Investigators have also explored IORT treatment that delivers a single fraction of radiation in the operating suite at the time of surgery. We report on the first patient treated with XB to deliver IORT. IORT treatment utilizing XB is feasible and can be accomplished with a total procedure time of approximately 2 hours. Further research on XB and other methods of IORT is needed to establish clinical efficacy and safety for patients with early-stage breast cancer.

  • xoft axxent Electronic brachytherapy a new device for delivering brachytherapy to the breast
    Nature Reviews Clinical Oncology, 2009
    Co-Authors: Adam Dickler
    Abstract:

    Balloon-based brachytherapy was developed to simplify the bracytherapy technique to make it more accessible to breast cancer patients. Balloon-based brachytherapy is associated with a more-convenient delivery of radiotherapy, improved quality of life and patient compliance. This Review discusses a new device called Xoft Axxent®Electronic brachytherapy, which uses a disposable Electronic radiation Source and avoids the need of a high-dose-rate afterloader unit, thereby enhancing the convenience for patients. Balloon-based brachytherapy was developed to simplify the brachytherapy technique and make accelerated partial breast irradiation more accessible to patients with breast cancer who are suitable candidates for this technique. Xoft Axxent® (Xoft, Inc., Sunnyvale, CA) Electronic brachytherapy is a novel method of accelerated partial breast irradiation that uses an Electronic Source to produce X-rays. Xoft Axxent® treatment does not require a high-dose-rate afterloader unit or a shielded vault, unlike other brachytherapy techniques that use iridium-192, such as MammoSite® brachytherapy. Xoft Axxent® is associated with the delivery of less radiation to normal tissues, and increased high radiation dose regions or 'hot spots' to the target volume compared with treatment with the MammoSite® device. Further research will be needed to determine subgroups of patients who might benefit from treatment with Xoft Axxent® Electronic brachytherapy.

Darius Francescatti - One of the best experts on this subject based on the ideXlab platform.

  • twelve month follow up results of a trial utilizing axxent Electronic brachytherapy to deliver intraoperative radiation therapy for early stage breast cancer
    Annals of Surgical Oncology, 2011
    Co-Authors: Olga Ivanov, Adam Dickler, Bennett Y F Lum, James V Pellicane, Darius Francescatti
    Abstract:

    Accelerated partial breast irradiation (APBI) is emerging as a valid alternative to whole-breast radiation therapy (WBRT) in breast-conserving therapy (BCT) for early-stage breast cancer. Axxent Electronic brachytherapy (EBX) is a form of portable, balloon-based APBI that utilizes an Electronic Source of kilovoltage irradiation delivery with minimal shielding requirements. As such, EBX becomes a logical and convenient modality for delivery of intraoperative radiation therapy (IORT). We report 1-year results and clinical outcomes of a trial that utilizes EBX to deliver IORT for patients with early-stage breast cancer. Eleven patients were enrolled on an institutional review board (IRB)-approved protocol. Inclusion criteria were patient age >45 years, unifocal tumors with infiltrating ductal or ductal carcinoma in situ (DCIS) histology, tumors ≤3 cm, and uninvolved lymph nodes. Preloaded radiation plans were used to deliver radiation prescription dose of 20 Gy to the balloon surface. The mean time for radiation delivery was 22 min; the total mean procedure time was 1 h 39 min. All margins of excision were negative on final pathology. At mean follow-up of 12 months, overall cosmesis was excellent in 10 of 11 patients. No infection, fat necrosis, desquamation, rib fracture or cancer recurrence has been observed. There was no evidence of fibrosis at last follow-up. IORT utilizing EBX is emerging as a feasible, well-tolerated alternative to postsurgical APBI. Further research and longer follow-up data on EBX and other IORT methods are needed to establish the clinical efficacy and safety of this treatment.

  • intraoperative radiation therapy in the treatment of early stage breast cancer utilizing xoft axxent Electronic brachytherapy
    World Journal of Surgical Oncology, 2009
    Co-Authors: Adam Dickler, Olga Ivanov, Darius Francescatti
    Abstract:

    In an effort to overcome the barriers to BCT, alternative methods of delivering radiation therapy have been explored. APBI allows the radiation treatment to be accomplished in one week or less. XB is a form of balloon-based APBI that uses an Electronic Source generated by a mobile controller unit. Investigators have also explored IORT treatment that delivers a single fraction of radiation in the operating suite at the time of surgery. We report on the first patient treated with XB to deliver IORT. IORT treatment utilizing XB is feasible and can be accomplished with a total procedure time of approximately 2 hours. Further research on XB and other methods of IORT is needed to establish clinical efficacy and safety for patients with early-stage breast cancer.

Olga Ivanov - One of the best experts on this subject based on the ideXlab platform.

  • twelve month follow up results of a trial utilizing axxent Electronic brachytherapy to deliver intraoperative radiation therapy for early stage breast cancer
    Annals of Surgical Oncology, 2011
    Co-Authors: Olga Ivanov, Adam Dickler, Bennett Y F Lum, James V Pellicane, Darius Francescatti
    Abstract:

    Accelerated partial breast irradiation (APBI) is emerging as a valid alternative to whole-breast radiation therapy (WBRT) in breast-conserving therapy (BCT) for early-stage breast cancer. Axxent Electronic brachytherapy (EBX) is a form of portable, balloon-based APBI that utilizes an Electronic Source of kilovoltage irradiation delivery with minimal shielding requirements. As such, EBX becomes a logical and convenient modality for delivery of intraoperative radiation therapy (IORT). We report 1-year results and clinical outcomes of a trial that utilizes EBX to deliver IORT for patients with early-stage breast cancer. Eleven patients were enrolled on an institutional review board (IRB)-approved protocol. Inclusion criteria were patient age >45 years, unifocal tumors with infiltrating ductal or ductal carcinoma in situ (DCIS) histology, tumors ≤3 cm, and uninvolved lymph nodes. Preloaded radiation plans were used to deliver radiation prescription dose of 20 Gy to the balloon surface. The mean time for radiation delivery was 22 min; the total mean procedure time was 1 h 39 min. All margins of excision were negative on final pathology. At mean follow-up of 12 months, overall cosmesis was excellent in 10 of 11 patients. No infection, fat necrosis, desquamation, rib fracture or cancer recurrence has been observed. There was no evidence of fibrosis at last follow-up. IORT utilizing EBX is emerging as a feasible, well-tolerated alternative to postsurgical APBI. Further research and longer follow-up data on EBX and other IORT methods are needed to establish the clinical efficacy and safety of this treatment.

  • intraoperative radiation therapy in the treatment of early stage breast cancer utilizing xoft axxent Electronic brachytherapy
    World Journal of Surgical Oncology, 2009
    Co-Authors: Adam Dickler, Olga Ivanov, Darius Francescatti
    Abstract:

    In an effort to overcome the barriers to BCT, alternative methods of delivering radiation therapy have been explored. APBI allows the radiation treatment to be accomplished in one week or less. XB is a form of balloon-based APBI that uses an Electronic Source generated by a mobile controller unit. Investigators have also explored IORT treatment that delivers a single fraction of radiation in the operating suite at the time of surgery. We report on the first patient treated with XB to deliver IORT. IORT treatment utilizing XB is feasible and can be accomplished with a total procedure time of approximately 2 hours. Further research on XB and other methods of IORT is needed to establish clinical efficacy and safety for patients with early-stage breast cancer.

James V Pellicane - One of the best experts on this subject based on the ideXlab platform.

  • twelve month follow up results of a trial utilizing axxent Electronic brachytherapy to deliver intraoperative radiation therapy for early stage breast cancer
    Annals of Surgical Oncology, 2011
    Co-Authors: Olga Ivanov, Adam Dickler, Bennett Y F Lum, James V Pellicane, Darius Francescatti
    Abstract:

    Accelerated partial breast irradiation (APBI) is emerging as a valid alternative to whole-breast radiation therapy (WBRT) in breast-conserving therapy (BCT) for early-stage breast cancer. Axxent Electronic brachytherapy (EBX) is a form of portable, balloon-based APBI that utilizes an Electronic Source of kilovoltage irradiation delivery with minimal shielding requirements. As such, EBX becomes a logical and convenient modality for delivery of intraoperative radiation therapy (IORT). We report 1-year results and clinical outcomes of a trial that utilizes EBX to deliver IORT for patients with early-stage breast cancer. Eleven patients were enrolled on an institutional review board (IRB)-approved protocol. Inclusion criteria were patient age >45 years, unifocal tumors with infiltrating ductal or ductal carcinoma in situ (DCIS) histology, tumors ≤3 cm, and uninvolved lymph nodes. Preloaded radiation plans were used to deliver radiation prescription dose of 20 Gy to the balloon surface. The mean time for radiation delivery was 22 min; the total mean procedure time was 1 h 39 min. All margins of excision were negative on final pathology. At mean follow-up of 12 months, overall cosmesis was excellent in 10 of 11 patients. No infection, fat necrosis, desquamation, rib fracture or cancer recurrence has been observed. There was no evidence of fibrosis at last follow-up. IORT utilizing EBX is emerging as a feasible, well-tolerated alternative to postsurgical APBI. Further research and longer follow-up data on EBX and other IORT methods are needed to establish the clinical efficacy and safety of this treatment.

Bennett Y F Lum - One of the best experts on this subject based on the ideXlab platform.

  • twelve month follow up results of a trial utilizing axxent Electronic brachytherapy to deliver intraoperative radiation therapy for early stage breast cancer
    Annals of Surgical Oncology, 2011
    Co-Authors: Olga Ivanov, Adam Dickler, Bennett Y F Lum, James V Pellicane, Darius Francescatti
    Abstract:

    Accelerated partial breast irradiation (APBI) is emerging as a valid alternative to whole-breast radiation therapy (WBRT) in breast-conserving therapy (BCT) for early-stage breast cancer. Axxent Electronic brachytherapy (EBX) is a form of portable, balloon-based APBI that utilizes an Electronic Source of kilovoltage irradiation delivery with minimal shielding requirements. As such, EBX becomes a logical and convenient modality for delivery of intraoperative radiation therapy (IORT). We report 1-year results and clinical outcomes of a trial that utilizes EBX to deliver IORT for patients with early-stage breast cancer. Eleven patients were enrolled on an institutional review board (IRB)-approved protocol. Inclusion criteria were patient age >45 years, unifocal tumors with infiltrating ductal or ductal carcinoma in situ (DCIS) histology, tumors ≤3 cm, and uninvolved lymph nodes. Preloaded radiation plans were used to deliver radiation prescription dose of 20 Gy to the balloon surface. The mean time for radiation delivery was 22 min; the total mean procedure time was 1 h 39 min. All margins of excision were negative on final pathology. At mean follow-up of 12 months, overall cosmesis was excellent in 10 of 11 patients. No infection, fat necrosis, desquamation, rib fracture or cancer recurrence has been observed. There was no evidence of fibrosis at last follow-up. IORT utilizing EBX is emerging as a feasible, well-tolerated alternative to postsurgical APBI. Further research and longer follow-up data on EBX and other IORT methods are needed to establish the clinical efficacy and safety of this treatment.