The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform

Hiroatsu Agata - One of the best experts on this subject based on the ideXlab platform.

  • suppressive effects of Elimination Diets on t cell responses to ovalbumin in hen s egg sensitive atopic dermatitis patients
    Clinical & Experimental Allergy, 1993
    Co-Authors: Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Hiroatsu Agata, Yasuhiro Suzuki, Nobuyuki Shimozawa, Shunji Tomatsu, Yukiji Yamada, Masao Takemura, Akio Noma
    Abstract:

    We investigated the effect of Elimination Diets on T cell responses to ovalbumin (OA) in hen's egg-sensitive atopic dermatitis (AD) patients. The proliferative responses of both peripheral blood mononuclear cells (PBMCs) and T cells with monocytes to OA decreased after Elimination Diets, but those to Candida albicans or phytohemagglutinin (PHA) did not decrease after Elimination Diets. The proliferative responses of CD4+ T cells with monocytes to OA decreased after Elimination Diets. In these patients, clinical symptoms of AD improved. These results indicate that T cells, especially CD4+ T cells, respond to food antigens in food-specific lymphocyte responses, and that Elimination Diets may be able to initiate reduction of the responsiveness of food-sensitive T cells, especially CD4+ T cells. Moreover, the surface marker phenotypes of the T cells responding to OA were analysed. Our results showed that CD4+CD45RA+ T cells tended to increase. The increase in circulating CD4+CD45RA+ T cells might function as systemic suppression against immune responses in the skin.

  • effect of Elimination Diets on food specific ige antibodies and lymphocyte proliferative responses to food antigens in atopic dermatitis patients exhibiting sensitivity to food allergens
    The Journal of Allergy and Clinical Immunology, 1993
    Co-Authors: Hiroatsu Agata, Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Tadao Orii
    Abstract:

    Abstract Peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD) selected as being sensitive to hen's egg or cow's milk responded to food antigens, ovalbumin, or bovine serum albumin, with significantly enhanced DNA synthesis compared with the DNA synthesis in PBMCs from nonatopic control subjects and food-sensitive patients with immediate symptoms. Patients were treated with Elimination Diets. Symptoms of AD had been in remission during Elimination Diets. The levels of specific IgE antibodies to hen's egg or cow's milk decreased during Elimination Diets in patients with positive radioallergosorbent test (RAST). In patients with negative RAST, specific IgE antibodies remained negative during Elimination Diets. The proliferative responses of PBMCs to food antigens also decreased during Elimination Diets in patients with proliferative responses before Elimination Diets. Taken together, specific IgE antibodies to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and positive BAST, and proliferative responses of PBMCs to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and proliferative responses of PBMCs. (J ALLERGY CLIN IMMUNOL 1993;91:668-79.)

  • Suppressive effects of Elimination Diets on T cell responses to ovalbumin in hen's egg‐sensitive atopic dermatitis patients
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1993
    Co-Authors: Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Hiroatsu Agata, Yasuhiro Suzuki, Nobuyuki Shimozawa, Shunji Tomatsu, Yukiji Yamada, Masao Takemura, Akio Noma
    Abstract:

    We investigated the effect of Elimination Diets on T cell responses to ovalbumin (OA) in hen's egg-sensitive atopic dermatitis (AD) patients. The proliferative responses of both peripheral blood mononuclear cells (PBMCs) and T cells with monocytes to OA decreased after Elimination Diets, but those to Candida albicans or phytohemagglutinin (PHA) did not decrease after Elimination Diets. The proliferative responses of CD4+ T cells with monocytes to OA decreased after Elimination Diets. In these patients, clinical symptoms of AD improved. These results indicate that T cells, especially CD4+ T cells, respond to food antigens in food-specific lymphocyte responses, and that Elimination Diets may be able to initiate reduction of the responsiveness of food-sensitive T cells, especially CD4+ T cells. Moreover, the surface marker phenotypes of the T cells responding to OA were analysed. Our results showed that CD4+CD45RA+ T cells tended to increase. The increase in circulating CD4+CD45RA+ T cells might function as systemic suppression against immune responses in the skin.

  • Effect of Elimination Diets on food-specific IgE antibodies and lymphocyte proliferative responses to food antigens in atopic dermatitis patients exhibiting sensitivity to food allergens
    The Journal of allergy and clinical immunology, 1993
    Co-Authors: Hiroatsu Agata, Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Tadao Orii
    Abstract:

    Peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD) selected as being sensitive to hen's egg or cow's milk responded to food antigens, ovalbumin, or bovine serum albumin, with significantly enhanced DNA synthesis compared with the DNA synthesis in PBMCs from nonatopic control subjects and food-sensitive patients with immediate symptoms. Patients were treated with Elimination Diets. Symptoms of AD had been in remission during Elimination Diets. The levels of specific IgE antibodies to hen's egg or cow's milk decreased during Elimination Diets in patients with positive radioallergosorbent test (RAST). In patients with negative RAST, specific IgE antibodies remained negative during Elimination Diets. The proliferative responses of PBMCs to food antigens also decreased during Elimination Diets in patients with proliferative responses before Elimination Diets. Taken together, specific IgE antibodies to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and positive RAST, and proliferative responses of PBMCs to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and proliferative responses of PBMCs.

Shinji Shinoda - One of the best experts on this subject based on the ideXlab platform.

  • suppressive effects of Elimination Diets on t cell responses to ovalbumin in hen s egg sensitive atopic dermatitis patients
    Clinical & Experimental Allergy, 1993
    Co-Authors: Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Hiroatsu Agata, Yasuhiro Suzuki, Nobuyuki Shimozawa, Shunji Tomatsu, Yukiji Yamada, Masao Takemura, Akio Noma
    Abstract:

    We investigated the effect of Elimination Diets on T cell responses to ovalbumin (OA) in hen's egg-sensitive atopic dermatitis (AD) patients. The proliferative responses of both peripheral blood mononuclear cells (PBMCs) and T cells with monocytes to OA decreased after Elimination Diets, but those to Candida albicans or phytohemagglutinin (PHA) did not decrease after Elimination Diets. The proliferative responses of CD4+ T cells with monocytes to OA decreased after Elimination Diets. In these patients, clinical symptoms of AD improved. These results indicate that T cells, especially CD4+ T cells, respond to food antigens in food-specific lymphocyte responses, and that Elimination Diets may be able to initiate reduction of the responsiveness of food-sensitive T cells, especially CD4+ T cells. Moreover, the surface marker phenotypes of the T cells responding to OA were analysed. Our results showed that CD4+CD45RA+ T cells tended to increase. The increase in circulating CD4+CD45RA+ T cells might function as systemic suppression against immune responses in the skin.

  • effect of Elimination Diets on food specific ige antibodies and lymphocyte proliferative responses to food antigens in atopic dermatitis patients exhibiting sensitivity to food allergens
    The Journal of Allergy and Clinical Immunology, 1993
    Co-Authors: Hiroatsu Agata, Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Tadao Orii
    Abstract:

    Abstract Peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD) selected as being sensitive to hen's egg or cow's milk responded to food antigens, ovalbumin, or bovine serum albumin, with significantly enhanced DNA synthesis compared with the DNA synthesis in PBMCs from nonatopic control subjects and food-sensitive patients with immediate symptoms. Patients were treated with Elimination Diets. Symptoms of AD had been in remission during Elimination Diets. The levels of specific IgE antibodies to hen's egg or cow's milk decreased during Elimination Diets in patients with positive radioallergosorbent test (RAST). In patients with negative RAST, specific IgE antibodies remained negative during Elimination Diets. The proliferative responses of PBMCs to food antigens also decreased during Elimination Diets in patients with proliferative responses before Elimination Diets. Taken together, specific IgE antibodies to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and positive BAST, and proliferative responses of PBMCs to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and proliferative responses of PBMCs. (J ALLERGY CLIN IMMUNOL 1993;91:668-79.)

  • Suppressive effects of Elimination Diets on T cell responses to ovalbumin in hen's egg‐sensitive atopic dermatitis patients
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1993
    Co-Authors: Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Hiroatsu Agata, Yasuhiro Suzuki, Nobuyuki Shimozawa, Shunji Tomatsu, Yukiji Yamada, Masao Takemura, Akio Noma
    Abstract:

    We investigated the effect of Elimination Diets on T cell responses to ovalbumin (OA) in hen's egg-sensitive atopic dermatitis (AD) patients. The proliferative responses of both peripheral blood mononuclear cells (PBMCs) and T cells with monocytes to OA decreased after Elimination Diets, but those to Candida albicans or phytohemagglutinin (PHA) did not decrease after Elimination Diets. The proliferative responses of CD4+ T cells with monocytes to OA decreased after Elimination Diets. In these patients, clinical symptoms of AD improved. These results indicate that T cells, especially CD4+ T cells, respond to food antigens in food-specific lymphocyte responses, and that Elimination Diets may be able to initiate reduction of the responsiveness of food-sensitive T cells, especially CD4+ T cells. Moreover, the surface marker phenotypes of the T cells responding to OA were analysed. Our results showed that CD4+CD45RA+ T cells tended to increase. The increase in circulating CD4+CD45RA+ T cells might function as systemic suppression against immune responses in the skin.

  • Effect of Elimination Diets on food-specific IgE antibodies and lymphocyte proliferative responses to food antigens in atopic dermatitis patients exhibiting sensitivity to food allergens
    The Journal of allergy and clinical immunology, 1993
    Co-Authors: Hiroatsu Agata, Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Tadao Orii
    Abstract:

    Peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD) selected as being sensitive to hen's egg or cow's milk responded to food antigens, ovalbumin, or bovine serum albumin, with significantly enhanced DNA synthesis compared with the DNA synthesis in PBMCs from nonatopic control subjects and food-sensitive patients with immediate symptoms. Patients were treated with Elimination Diets. Symptoms of AD had been in remission during Elimination Diets. The levels of specific IgE antibodies to hen's egg or cow's milk decreased during Elimination Diets in patients with positive radioallergosorbent test (RAST). In patients with negative RAST, specific IgE antibodies remained negative during Elimination Diets. The proliferative responses of PBMCs to food antigens also decreased during Elimination Diets in patients with proliferative responses before Elimination Diets. Taken together, specific IgE antibodies to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and positive RAST, and proliferative responses of PBMCs to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and proliferative responses of PBMCs.

Tadao Orii - One of the best experts on this subject based on the ideXlab platform.

  • effect of Elimination Diets on food specific ige antibodies and lymphocyte proliferative responses to food antigens in atopic dermatitis patients exhibiting sensitivity to food allergens
    The Journal of Allergy and Clinical Immunology, 1993
    Co-Authors: Hiroatsu Agata, Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Tadao Orii
    Abstract:

    Abstract Peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD) selected as being sensitive to hen's egg or cow's milk responded to food antigens, ovalbumin, or bovine serum albumin, with significantly enhanced DNA synthesis compared with the DNA synthesis in PBMCs from nonatopic control subjects and food-sensitive patients with immediate symptoms. Patients were treated with Elimination Diets. Symptoms of AD had been in remission during Elimination Diets. The levels of specific IgE antibodies to hen's egg or cow's milk decreased during Elimination Diets in patients with positive radioallergosorbent test (RAST). In patients with negative RAST, specific IgE antibodies remained negative during Elimination Diets. The proliferative responses of PBMCs to food antigens also decreased during Elimination Diets in patients with proliferative responses before Elimination Diets. Taken together, specific IgE antibodies to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and positive BAST, and proliferative responses of PBMCs to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and proliferative responses of PBMCs. (J ALLERGY CLIN IMMUNOL 1993;91:668-79.)

  • Effect of Elimination Diets on food-specific IgE antibodies and lymphocyte proliferative responses to food antigens in atopic dermatitis patients exhibiting sensitivity to food allergens
    The Journal of allergy and clinical immunology, 1993
    Co-Authors: Hiroatsu Agata, Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Tadao Orii
    Abstract:

    Peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD) selected as being sensitive to hen's egg or cow's milk responded to food antigens, ovalbumin, or bovine serum albumin, with significantly enhanced DNA synthesis compared with the DNA synthesis in PBMCs from nonatopic control subjects and food-sensitive patients with immediate symptoms. Patients were treated with Elimination Diets. Symptoms of AD had been in remission during Elimination Diets. The levels of specific IgE antibodies to hen's egg or cow's milk decreased during Elimination Diets in patients with positive radioallergosorbent test (RAST). In patients with negative RAST, specific IgE antibodies remained negative during Elimination Diets. The proliferative responses of PBMCs to food antigens also decreased during Elimination Diets in patients with proliferative responses before Elimination Diets. Taken together, specific IgE antibodies to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and positive RAST, and proliferative responses of PBMCs to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and proliferative responses of PBMCs.

Naomi Kondo - One of the best experts on this subject based on the ideXlab platform.

  • suppressive effects of Elimination Diets on t cell responses to ovalbumin in hen s egg sensitive atopic dermatitis patients
    Clinical & Experimental Allergy, 1993
    Co-Authors: Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Hiroatsu Agata, Yasuhiro Suzuki, Nobuyuki Shimozawa, Shunji Tomatsu, Yukiji Yamada, Masao Takemura, Akio Noma
    Abstract:

    We investigated the effect of Elimination Diets on T cell responses to ovalbumin (OA) in hen's egg-sensitive atopic dermatitis (AD) patients. The proliferative responses of both peripheral blood mononuclear cells (PBMCs) and T cells with monocytes to OA decreased after Elimination Diets, but those to Candida albicans or phytohemagglutinin (PHA) did not decrease after Elimination Diets. The proliferative responses of CD4+ T cells with monocytes to OA decreased after Elimination Diets. In these patients, clinical symptoms of AD improved. These results indicate that T cells, especially CD4+ T cells, respond to food antigens in food-specific lymphocyte responses, and that Elimination Diets may be able to initiate reduction of the responsiveness of food-sensitive T cells, especially CD4+ T cells. Moreover, the surface marker phenotypes of the T cells responding to OA were analysed. Our results showed that CD4+CD45RA+ T cells tended to increase. The increase in circulating CD4+CD45RA+ T cells might function as systemic suppression against immune responses in the skin.

  • effect of Elimination Diets on food specific ige antibodies and lymphocyte proliferative responses to food antigens in atopic dermatitis patients exhibiting sensitivity to food allergens
    The Journal of Allergy and Clinical Immunology, 1993
    Co-Authors: Hiroatsu Agata, Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Tadao Orii
    Abstract:

    Abstract Peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD) selected as being sensitive to hen's egg or cow's milk responded to food antigens, ovalbumin, or bovine serum albumin, with significantly enhanced DNA synthesis compared with the DNA synthesis in PBMCs from nonatopic control subjects and food-sensitive patients with immediate symptoms. Patients were treated with Elimination Diets. Symptoms of AD had been in remission during Elimination Diets. The levels of specific IgE antibodies to hen's egg or cow's milk decreased during Elimination Diets in patients with positive radioallergosorbent test (RAST). In patients with negative RAST, specific IgE antibodies remained negative during Elimination Diets. The proliferative responses of PBMCs to food antigens also decreased during Elimination Diets in patients with proliferative responses before Elimination Diets. Taken together, specific IgE antibodies to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and positive BAST, and proliferative responses of PBMCs to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and proliferative responses of PBMCs. (J ALLERGY CLIN IMMUNOL 1993;91:668-79.)

  • Suppressive effects of Elimination Diets on T cell responses to ovalbumin in hen's egg‐sensitive atopic dermatitis patients
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1993
    Co-Authors: Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Hiroatsu Agata, Yasuhiro Suzuki, Nobuyuki Shimozawa, Shunji Tomatsu, Yukiji Yamada, Masao Takemura, Akio Noma
    Abstract:

    We investigated the effect of Elimination Diets on T cell responses to ovalbumin (OA) in hen's egg-sensitive atopic dermatitis (AD) patients. The proliferative responses of both peripheral blood mononuclear cells (PBMCs) and T cells with monocytes to OA decreased after Elimination Diets, but those to Candida albicans or phytohemagglutinin (PHA) did not decrease after Elimination Diets. The proliferative responses of CD4+ T cells with monocytes to OA decreased after Elimination Diets. In these patients, clinical symptoms of AD improved. These results indicate that T cells, especially CD4+ T cells, respond to food antigens in food-specific lymphocyte responses, and that Elimination Diets may be able to initiate reduction of the responsiveness of food-sensitive T cells, especially CD4+ T cells. Moreover, the surface marker phenotypes of the T cells responding to OA were analysed. Our results showed that CD4+CD45RA+ T cells tended to increase. The increase in circulating CD4+CD45RA+ T cells might function as systemic suppression against immune responses in the skin.

  • Effect of Elimination Diets on food-specific IgE antibodies and lymphocyte proliferative responses to food antigens in atopic dermatitis patients exhibiting sensitivity to food allergens
    The Journal of allergy and clinical immunology, 1993
    Co-Authors: Hiroatsu Agata, Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Tadao Orii
    Abstract:

    Peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD) selected as being sensitive to hen's egg or cow's milk responded to food antigens, ovalbumin, or bovine serum albumin, with significantly enhanced DNA synthesis compared with the DNA synthesis in PBMCs from nonatopic control subjects and food-sensitive patients with immediate symptoms. Patients were treated with Elimination Diets. Symptoms of AD had been in remission during Elimination Diets. The levels of specific IgE antibodies to hen's egg or cow's milk decreased during Elimination Diets in patients with positive radioallergosorbent test (RAST). In patients with negative RAST, specific IgE antibodies remained negative during Elimination Diets. The proliferative responses of PBMCs to food antigens also decreased during Elimination Diets in patients with proliferative responses before Elimination Diets. Taken together, specific IgE antibodies to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and positive RAST, and proliferative responses of PBMCs to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and proliferative responses of PBMCs.

Osamu Fukutomi - One of the best experts on this subject based on the ideXlab platform.

  • suppressive effects of Elimination Diets on t cell responses to ovalbumin in hen s egg sensitive atopic dermatitis patients
    Clinical & Experimental Allergy, 1993
    Co-Authors: Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Hiroatsu Agata, Yasuhiro Suzuki, Nobuyuki Shimozawa, Shunji Tomatsu, Yukiji Yamada, Masao Takemura, Akio Noma
    Abstract:

    We investigated the effect of Elimination Diets on T cell responses to ovalbumin (OA) in hen's egg-sensitive atopic dermatitis (AD) patients. The proliferative responses of both peripheral blood mononuclear cells (PBMCs) and T cells with monocytes to OA decreased after Elimination Diets, but those to Candida albicans or phytohemagglutinin (PHA) did not decrease after Elimination Diets. The proliferative responses of CD4+ T cells with monocytes to OA decreased after Elimination Diets. In these patients, clinical symptoms of AD improved. These results indicate that T cells, especially CD4+ T cells, respond to food antigens in food-specific lymphocyte responses, and that Elimination Diets may be able to initiate reduction of the responsiveness of food-sensitive T cells, especially CD4+ T cells. Moreover, the surface marker phenotypes of the T cells responding to OA were analysed. Our results showed that CD4+CD45RA+ T cells tended to increase. The increase in circulating CD4+CD45RA+ T cells might function as systemic suppression against immune responses in the skin.

  • effect of Elimination Diets on food specific ige antibodies and lymphocyte proliferative responses to food antigens in atopic dermatitis patients exhibiting sensitivity to food allergens
    The Journal of Allergy and Clinical Immunology, 1993
    Co-Authors: Hiroatsu Agata, Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Tadao Orii
    Abstract:

    Abstract Peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD) selected as being sensitive to hen's egg or cow's milk responded to food antigens, ovalbumin, or bovine serum albumin, with significantly enhanced DNA synthesis compared with the DNA synthesis in PBMCs from nonatopic control subjects and food-sensitive patients with immediate symptoms. Patients were treated with Elimination Diets. Symptoms of AD had been in remission during Elimination Diets. The levels of specific IgE antibodies to hen's egg or cow's milk decreased during Elimination Diets in patients with positive radioallergosorbent test (RAST). In patients with negative RAST, specific IgE antibodies remained negative during Elimination Diets. The proliferative responses of PBMCs to food antigens also decreased during Elimination Diets in patients with proliferative responses before Elimination Diets. Taken together, specific IgE antibodies to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and positive BAST, and proliferative responses of PBMCs to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and proliferative responses of PBMCs. (J ALLERGY CLIN IMMUNOL 1993;91:668-79.)

  • Suppressive effects of Elimination Diets on T cell responses to ovalbumin in hen's egg‐sensitive atopic dermatitis patients
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1993
    Co-Authors: Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Hiroatsu Agata, Yasuhiro Suzuki, Nobuyuki Shimozawa, Shunji Tomatsu, Yukiji Yamada, Masao Takemura, Akio Noma
    Abstract:

    We investigated the effect of Elimination Diets on T cell responses to ovalbumin (OA) in hen's egg-sensitive atopic dermatitis (AD) patients. The proliferative responses of both peripheral blood mononuclear cells (PBMCs) and T cells with monocytes to OA decreased after Elimination Diets, but those to Candida albicans or phytohemagglutinin (PHA) did not decrease after Elimination Diets. The proliferative responses of CD4+ T cells with monocytes to OA decreased after Elimination Diets. In these patients, clinical symptoms of AD improved. These results indicate that T cells, especially CD4+ T cells, respond to food antigens in food-specific lymphocyte responses, and that Elimination Diets may be able to initiate reduction of the responsiveness of food-sensitive T cells, especially CD4+ T cells. Moreover, the surface marker phenotypes of the T cells responding to OA were analysed. Our results showed that CD4+CD45RA+ T cells tended to increase. The increase in circulating CD4+CD45RA+ T cells might function as systemic suppression against immune responses in the skin.

  • Effect of Elimination Diets on food-specific IgE antibodies and lymphocyte proliferative responses to food antigens in atopic dermatitis patients exhibiting sensitivity to food allergens
    The Journal of allergy and clinical immunology, 1993
    Co-Authors: Hiroatsu Agata, Shinji Shinoda, Naomi Kondo, Osamu Fukutomi, Tadao Orii
    Abstract:

    Peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD) selected as being sensitive to hen's egg or cow's milk responded to food antigens, ovalbumin, or bovine serum albumin, with significantly enhanced DNA synthesis compared with the DNA synthesis in PBMCs from nonatopic control subjects and food-sensitive patients with immediate symptoms. Patients were treated with Elimination Diets. Symptoms of AD had been in remission during Elimination Diets. The levels of specific IgE antibodies to hen's egg or cow's milk decreased during Elimination Diets in patients with positive radioallergosorbent test (RAST). In patients with negative RAST, specific IgE antibodies remained negative during Elimination Diets. The proliferative responses of PBMCs to food antigens also decreased during Elimination Diets in patients with proliferative responses before Elimination Diets. Taken together, specific IgE antibodies to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and positive RAST, and proliferative responses of PBMCs to food antigens are useful indexes of the effect of Elimination Diets in food-sensitive patients with AD and proliferative responses of PBMCs.