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Olaf Burkhardt - One of the best experts on this subject based on the ideXlab platform.

  • risk of underdosing of ampicillin sulbactam in patients with acute kidney injury undergoing extended daily dialysis a single case
    Nephrology Dialysis Transplantation, 2009
    Co-Authors: Jan T Kielstein, Johan M Lorenzen, Michael Broll, Volkhard Kaever, Carsten Hafer, Heike Burhenne, Olaf Burkhardt
    Abstract:

    The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. The normal kidneys eliminate ∼60% of ampicillin (371.39 Da) and sulbactam (255.22 Da). Concomitant with the decline in renal function, the terminal Elimination Half-Life increases from 1 up to 24 h in patients with ESRD. Patients on three times weekly low flux haemodialysis exhibit a Half-Life of 2.3 h on and 17.4 h off dialysis. In contrast, in the present observation the Elimination Half-Life in a single patient with acute kidney injury undergoing extended daily dialysis (EDD) with a polysulphone membrane was 1.5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD.

  • risk of underdosing of ampicillin sulbactam in patients with acute kidney injury undergoing extended daily dialysis a single case
    Nephrology Dialysis Transplantation, 2009
    Co-Authors: Jan T Kielstein, Johan M Lorenzen, Michael Broll, Volkhard Kaever, Carsten Hafer, Heike Burhenne, Olaf Burkhardt
    Abstract:

    The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. The normal kidneys eliminate approximately 60% of ampicillin (371.39 Da) and sulbactam (255.22 Da). Concomitant with the decline in renal function, the terminal Elimination Half-Life increases from 1 up to 24 h in patients with ESRD. Patients on three times weekly low flux haemodialysis exhibit a Half-Life of 2.3 h on and 17.4 h off dialysis. In contrast, in the present observation the Elimination Half-Life in a single patient with acute kidney injury undergoing extended daily dialysis (EDD) with a polysulphone membrane was 1.5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD.

Jan T Kielstein - One of the best experts on this subject based on the ideXlab platform.

  • risk of underdosing of ampicillin sulbactam in patients with acute kidney injury undergoing extended daily dialysis a single case
    Nephrology Dialysis Transplantation, 2009
    Co-Authors: Jan T Kielstein, Johan M Lorenzen, Michael Broll, Volkhard Kaever, Carsten Hafer, Heike Burhenne, Olaf Burkhardt
    Abstract:

    The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. The normal kidneys eliminate ∼60% of ampicillin (371.39 Da) and sulbactam (255.22 Da). Concomitant with the decline in renal function, the terminal Elimination Half-Life increases from 1 up to 24 h in patients with ESRD. Patients on three times weekly low flux haemodialysis exhibit a Half-Life of 2.3 h on and 17.4 h off dialysis. In contrast, in the present observation the Elimination Half-Life in a single patient with acute kidney injury undergoing extended daily dialysis (EDD) with a polysulphone membrane was 1.5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD.

  • risk of underdosing of ampicillin sulbactam in patients with acute kidney injury undergoing extended daily dialysis a single case
    Nephrology Dialysis Transplantation, 2009
    Co-Authors: Jan T Kielstein, Johan M Lorenzen, Michael Broll, Volkhard Kaever, Carsten Hafer, Heike Burhenne, Olaf Burkhardt
    Abstract:

    The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. The normal kidneys eliminate approximately 60% of ampicillin (371.39 Da) and sulbactam (255.22 Da). Concomitant with the decline in renal function, the terminal Elimination Half-Life increases from 1 up to 24 h in patients with ESRD. Patients on three times weekly low flux haemodialysis exhibit a Half-Life of 2.3 h on and 17.4 h off dialysis. In contrast, in the present observation the Elimination Half-Life in a single patient with acute kidney injury undergoing extended daily dialysis (EDD) with a polysulphone membrane was 1.5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD.

Michael Broll - One of the best experts on this subject based on the ideXlab platform.

  • risk of underdosing of ampicillin sulbactam in patients with acute kidney injury undergoing extended daily dialysis a single case
    Nephrology Dialysis Transplantation, 2009
    Co-Authors: Jan T Kielstein, Johan M Lorenzen, Michael Broll, Volkhard Kaever, Carsten Hafer, Heike Burhenne, Olaf Burkhardt
    Abstract:

    The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. The normal kidneys eliminate ∼60% of ampicillin (371.39 Da) and sulbactam (255.22 Da). Concomitant with the decline in renal function, the terminal Elimination Half-Life increases from 1 up to 24 h in patients with ESRD. Patients on three times weekly low flux haemodialysis exhibit a Half-Life of 2.3 h on and 17.4 h off dialysis. In contrast, in the present observation the Elimination Half-Life in a single patient with acute kidney injury undergoing extended daily dialysis (EDD) with a polysulphone membrane was 1.5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD.

  • risk of underdosing of ampicillin sulbactam in patients with acute kidney injury undergoing extended daily dialysis a single case
    Nephrology Dialysis Transplantation, 2009
    Co-Authors: Jan T Kielstein, Johan M Lorenzen, Michael Broll, Volkhard Kaever, Carsten Hafer, Heike Burhenne, Olaf Burkhardt
    Abstract:

    The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. The normal kidneys eliminate approximately 60% of ampicillin (371.39 Da) and sulbactam (255.22 Da). Concomitant with the decline in renal function, the terminal Elimination Half-Life increases from 1 up to 24 h in patients with ESRD. Patients on three times weekly low flux haemodialysis exhibit a Half-Life of 2.3 h on and 17.4 h off dialysis. In contrast, in the present observation the Elimination Half-Life in a single patient with acute kidney injury undergoing extended daily dialysis (EDD) with a polysulphone membrane was 1.5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD.

Johan M Lorenzen - One of the best experts on this subject based on the ideXlab platform.

  • risk of underdosing of ampicillin sulbactam in patients with acute kidney injury undergoing extended daily dialysis a single case
    Nephrology Dialysis Transplantation, 2009
    Co-Authors: Jan T Kielstein, Johan M Lorenzen, Michael Broll, Volkhard Kaever, Carsten Hafer, Heike Burhenne, Olaf Burkhardt
    Abstract:

    The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. The normal kidneys eliminate ∼60% of ampicillin (371.39 Da) and sulbactam (255.22 Da). Concomitant with the decline in renal function, the terminal Elimination Half-Life increases from 1 up to 24 h in patients with ESRD. Patients on three times weekly low flux haemodialysis exhibit a Half-Life of 2.3 h on and 17.4 h off dialysis. In contrast, in the present observation the Elimination Half-Life in a single patient with acute kidney injury undergoing extended daily dialysis (EDD) with a polysulphone membrane was 1.5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD.

  • risk of underdosing of ampicillin sulbactam in patients with acute kidney injury undergoing extended daily dialysis a single case
    Nephrology Dialysis Transplantation, 2009
    Co-Authors: Jan T Kielstein, Johan M Lorenzen, Michael Broll, Volkhard Kaever, Carsten Hafer, Heike Burhenne, Olaf Burkhardt
    Abstract:

    The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. The normal kidneys eliminate approximately 60% of ampicillin (371.39 Da) and sulbactam (255.22 Da). Concomitant with the decline in renal function, the terminal Elimination Half-Life increases from 1 up to 24 h in patients with ESRD. Patients on three times weekly low flux haemodialysis exhibit a Half-Life of 2.3 h on and 17.4 h off dialysis. In contrast, in the present observation the Elimination Half-Life in a single patient with acute kidney injury undergoing extended daily dialysis (EDD) with a polysulphone membrane was 1.5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD.

Volkhard Kaever - One of the best experts on this subject based on the ideXlab platform.

  • risk of underdosing of ampicillin sulbactam in patients with acute kidney injury undergoing extended daily dialysis a single case
    Nephrology Dialysis Transplantation, 2009
    Co-Authors: Jan T Kielstein, Johan M Lorenzen, Michael Broll, Volkhard Kaever, Carsten Hafer, Heike Burhenne, Olaf Burkhardt
    Abstract:

    The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. The normal kidneys eliminate ∼60% of ampicillin (371.39 Da) and sulbactam (255.22 Da). Concomitant with the decline in renal function, the terminal Elimination Half-Life increases from 1 up to 24 h in patients with ESRD. Patients on three times weekly low flux haemodialysis exhibit a Half-Life of 2.3 h on and 17.4 h off dialysis. In contrast, in the present observation the Elimination Half-Life in a single patient with acute kidney injury undergoing extended daily dialysis (EDD) with a polysulphone membrane was 1.5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD.

  • risk of underdosing of ampicillin sulbactam in patients with acute kidney injury undergoing extended daily dialysis a single case
    Nephrology Dialysis Transplantation, 2009
    Co-Authors: Jan T Kielstein, Johan M Lorenzen, Michael Broll, Volkhard Kaever, Carsten Hafer, Heike Burhenne, Olaf Burkhardt
    Abstract:

    The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. The normal kidneys eliminate approximately 60% of ampicillin (371.39 Da) and sulbactam (255.22 Da). Concomitant with the decline in renal function, the terminal Elimination Half-Life increases from 1 up to 24 h in patients with ESRD. Patients on three times weekly low flux haemodialysis exhibit a Half-Life of 2.3 h on and 17.4 h off dialysis. In contrast, in the present observation the Elimination Half-Life in a single patient with acute kidney injury undergoing extended daily dialysis (EDD) with a polysulphone membrane was 1.5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD.