The Experts below are selected from a list of 99 Experts worldwide ranked by ideXlab platform

Kanwaljit Chopra - One of the best experts on this subject based on the ideXlab platform.

  • Emblica Officinalis corrects functional biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido nitrosative stress mediated inflammatory cascade
    Phytotherapy Research, 2011
    Co-Authors: Vinod Tiwari, Anurag Kuhad, Kanwaljit Chopra
    Abstract:

    Diabetic neuropathy is one of the most common microvascular complications of diabetes mellitus which affects more than 50% of diabetic patients. Diabetic neuropathic pain is amongst the most difficult types of pain to treat mainly due to the lack of understanding of its etiology and inadequate relief with available drug therapy. The present study targeted oxidative stress mediated nerve damage in diabetic rats using an aqueous Extract of Emblica Officinalis, a potent natural antioxidant. Diabetic rats exhibited significantly decreased tail-flick latency in the tail-immersion test (thermal hyperalgesia) and decreased paw withdrawal threshold in both Randall-Selitto (mechanical hyperalgesia) and von-Frey hair test (mechanical allodynia). A decrease in the nociceptive threshold was accompanied by significantly increased oxidative stress, nitrite levels and cytokines (TNF-α, IL-1β and TGF-β1) both in the serum and sciatic nerve of diabetic rats. Treatment with the Emblica Officinalis aqueous Extract (250, 500 and 1000 mg/kg/day) significantly attenuated all the behavioral, biochemical and molecular alterations in a dose-dependent manner. The major finding of the study is that insulin alone corrected the hyperglycemia and partially reversed the pain response in diabetic rats. However, combination with Emblica Officinalis Extract not only attenuated the diabetic condition but also reversed neuropathic pain through modulation of oxidative–nitrosative stress in diabetic rats. Copyright © 2011 John Wiley & Sons, Ltd.

  • Emblica Officinalis Corrects Functional, Biochemical and Molecular Deficits in Experimental Diabetic Neuropathy by Targeting the Oxido‐nitrosative Stress Mediated Inflammatory Cascade
    Phytotherapy research : PTR, 2011
    Co-Authors: Vinod Tiwari, Anurag Kuhad, Kanwaljit Chopra
    Abstract:

    Diabetic neuropathy is one of the most common microvascular complications of diabetes mellitus which affects more than 50% of diabetic patients. Diabetic neuropathic pain is amongst the most difficult types of pain to treat mainly due to the lack of understanding of its etiology and inadequate relief with available drug therapy. The present study targeted oxidative stress mediated nerve damage in diabetic rats using an aqueous Extract of Emblica Officinalis, a potent natural antioxidant. Diabetic rats exhibited significantly decreased tail-flick latency in the tail-immersion test (thermal hyperalgesia) and decreased paw withdrawal threshold in both Randall-Selitto (mechanical hyperalgesia) and von-Frey hair test (mechanical allodynia). A decrease in the nociceptive threshold was accompanied by significantly increased oxidative stress, nitrite levels and cytokines (TNF-α, IL-1β and TGF-β1) both in the serum and sciatic nerve of diabetic rats. Treatment with the Emblica Officinalis aqueous Extract (250, 500 and 1000 mg/kg/day) significantly attenuated all the behavioral, biochemical and molecular alterations in a dose-dependent manner. The major finding of the study is that insulin alone corrected the hyperglycemia and partially reversed the pain response in diabetic rats. However, combination with Emblica Officinalis Extract not only attenuated the diabetic condition but also reversed neuropathic pain through modulation of oxidative–nitrosative stress in diabetic rats. Copyright © 2011 John Wiley & Sons, Ltd.

Vinod Tiwari - One of the best experts on this subject based on the ideXlab platform.

  • Emblica Officinalis corrects functional biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido nitrosative stress mediated inflammatory cascade
    Phytotherapy Research, 2011
    Co-Authors: Vinod Tiwari, Anurag Kuhad, Kanwaljit Chopra
    Abstract:

    Diabetic neuropathy is one of the most common microvascular complications of diabetes mellitus which affects more than 50% of diabetic patients. Diabetic neuropathic pain is amongst the most difficult types of pain to treat mainly due to the lack of understanding of its etiology and inadequate relief with available drug therapy. The present study targeted oxidative stress mediated nerve damage in diabetic rats using an aqueous Extract of Emblica Officinalis, a potent natural antioxidant. Diabetic rats exhibited significantly decreased tail-flick latency in the tail-immersion test (thermal hyperalgesia) and decreased paw withdrawal threshold in both Randall-Selitto (mechanical hyperalgesia) and von-Frey hair test (mechanical allodynia). A decrease in the nociceptive threshold was accompanied by significantly increased oxidative stress, nitrite levels and cytokines (TNF-α, IL-1β and TGF-β1) both in the serum and sciatic nerve of diabetic rats. Treatment with the Emblica Officinalis aqueous Extract (250, 500 and 1000 mg/kg/day) significantly attenuated all the behavioral, biochemical and molecular alterations in a dose-dependent manner. The major finding of the study is that insulin alone corrected the hyperglycemia and partially reversed the pain response in diabetic rats. However, combination with Emblica Officinalis Extract not only attenuated the diabetic condition but also reversed neuropathic pain through modulation of oxidative–nitrosative stress in diabetic rats. Copyright © 2011 John Wiley & Sons, Ltd.

  • Emblica Officinalis Corrects Functional, Biochemical and Molecular Deficits in Experimental Diabetic Neuropathy by Targeting the Oxido‐nitrosative Stress Mediated Inflammatory Cascade
    Phytotherapy research : PTR, 2011
    Co-Authors: Vinod Tiwari, Anurag Kuhad, Kanwaljit Chopra
    Abstract:

    Diabetic neuropathy is one of the most common microvascular complications of diabetes mellitus which affects more than 50% of diabetic patients. Diabetic neuropathic pain is amongst the most difficult types of pain to treat mainly due to the lack of understanding of its etiology and inadequate relief with available drug therapy. The present study targeted oxidative stress mediated nerve damage in diabetic rats using an aqueous Extract of Emblica Officinalis, a potent natural antioxidant. Diabetic rats exhibited significantly decreased tail-flick latency in the tail-immersion test (thermal hyperalgesia) and decreased paw withdrawal threshold in both Randall-Selitto (mechanical hyperalgesia) and von-Frey hair test (mechanical allodynia). A decrease in the nociceptive threshold was accompanied by significantly increased oxidative stress, nitrite levels and cytokines (TNF-α, IL-1β and TGF-β1) both in the serum and sciatic nerve of diabetic rats. Treatment with the Emblica Officinalis aqueous Extract (250, 500 and 1000 mg/kg/day) significantly attenuated all the behavioral, biochemical and molecular alterations in a dose-dependent manner. The major finding of the study is that insulin alone corrected the hyperglycemia and partially reversed the pain response in diabetic rats. However, combination with Emblica Officinalis Extract not only attenuated the diabetic condition but also reversed neuropathic pain through modulation of oxidative–nitrosative stress in diabetic rats. Copyright © 2011 John Wiley & Sons, Ltd.

Sushanta K Banerjee - One of the best experts on this subject based on the ideXlab platform.

  • Emblica Officinalis Extract induces autophagy and inhibits human ovarian cancer cell proliferation angiogenesis growth of mouse xenograft tumors
    PLOS ONE, 2013
    Co-Authors: Chris Papasian, Shane T Hentges, Snigdha Banerjee, Inamul Haque, Sushanta K Banerjee
    Abstract:

    Patients with ovarian cancer (OC) may be treated with surgery, chemotherapy and/or radiation therapy, although none of these strategies are very effective. Several plant-based natural products/dietary supplements, including Extracts from EmblicaOfficinalis (Amla), have demonstrated potent anti-neoplastic properties. In this study we determined that Amla Extract (AE) has anti-proliferative effects on OC cells under both in vitro and in vivo conditions. We also determined the anti-proliferative effects one of the components of AE, quercetin, on OC cells under in vitro conditions. AE did not induce apoptotic cell death, but did significantly increase the expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions. Quercetin also increased the expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions. AE also significantly reduced the expression of several angiogenic genes, including hypoxia-inducible factor 1α (HIF-1α) in OVCAR3 cells. AE acted synergistically with cisplatin to reduce cell proliferation and increase expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions. AE also had anti-proliferative effects and induced the expression of the autophagic proteins beclin1 and LC3B-II in mouse xenograft tumors. Additionally, AE reduced endothelial cell antigen - CD31 positive blood vessels and HIF-1α expression in mouse xenograft tumors. Together, these studies indicate that AE inhibits OC cell growth both in vitro and in vivo possibly via inhibition of angiogenesis and activation of autophagy in OC. Thus AE may prove useful as an alternative or adjunct therapeutic approach in helping to fight OC.

  • Emblica Officinalis Extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors
    2013
    Co-Authors: Chris Papasian, Shane T Hentges, Snigdha Banerjee, Inamul Haque, Sushanta K Banerjee
    Abstract:

    Patients with ovarian cancer (OC) may be treated with surgery, chemotherapy and/or radiation therapy, although none of these strategies are very effective. Several plant-based natural products/dietary supplements, including Extracts from Emblica Officinalis (Amla), have demonstrated potent anti-neoplastic properties. In this study we determined that Amla Extract (AE) has anti-proliferative effects on OC cells under both in vitro and in vivo conditions. We also determined the anti-proliferative effects one of the components of AE, quercetin, on OC cells under in vitro conditions. AE did not induce apoptotic cell death, but did significantly increase the expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions. Quercetin also increased the expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions. AE also significantly reduced the expression of several angiogenic genes, including hypoxia-inducible factor 1α (HIF-1α) in OVCAR3 cells. AE acted synergistically with cisplatin to reduce cell proliferation and increase expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions. AE also had anti-proliferative effects and induced the expression of the autophagic proteins beclin1 and LC3B-II in mouse xenograft tumors. Additionally, AE reduced endothelial cell antigen – CD31 positive bloo

Anurag Kuhad - One of the best experts on this subject based on the ideXlab platform.

  • Emblica Officinalis corrects functional biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido nitrosative stress mediated inflammatory cascade
    Phytotherapy Research, 2011
    Co-Authors: Vinod Tiwari, Anurag Kuhad, Kanwaljit Chopra
    Abstract:

    Diabetic neuropathy is one of the most common microvascular complications of diabetes mellitus which affects more than 50% of diabetic patients. Diabetic neuropathic pain is amongst the most difficult types of pain to treat mainly due to the lack of understanding of its etiology and inadequate relief with available drug therapy. The present study targeted oxidative stress mediated nerve damage in diabetic rats using an aqueous Extract of Emblica Officinalis, a potent natural antioxidant. Diabetic rats exhibited significantly decreased tail-flick latency in the tail-immersion test (thermal hyperalgesia) and decreased paw withdrawal threshold in both Randall-Selitto (mechanical hyperalgesia) and von-Frey hair test (mechanical allodynia). A decrease in the nociceptive threshold was accompanied by significantly increased oxidative stress, nitrite levels and cytokines (TNF-α, IL-1β and TGF-β1) both in the serum and sciatic nerve of diabetic rats. Treatment with the Emblica Officinalis aqueous Extract (250, 500 and 1000 mg/kg/day) significantly attenuated all the behavioral, biochemical and molecular alterations in a dose-dependent manner. The major finding of the study is that insulin alone corrected the hyperglycemia and partially reversed the pain response in diabetic rats. However, combination with Emblica Officinalis Extract not only attenuated the diabetic condition but also reversed neuropathic pain through modulation of oxidative–nitrosative stress in diabetic rats. Copyright © 2011 John Wiley & Sons, Ltd.

  • Emblica Officinalis Corrects Functional, Biochemical and Molecular Deficits in Experimental Diabetic Neuropathy by Targeting the Oxido‐nitrosative Stress Mediated Inflammatory Cascade
    Phytotherapy research : PTR, 2011
    Co-Authors: Vinod Tiwari, Anurag Kuhad, Kanwaljit Chopra
    Abstract:

    Diabetic neuropathy is one of the most common microvascular complications of diabetes mellitus which affects more than 50% of diabetic patients. Diabetic neuropathic pain is amongst the most difficult types of pain to treat mainly due to the lack of understanding of its etiology and inadequate relief with available drug therapy. The present study targeted oxidative stress mediated nerve damage in diabetic rats using an aqueous Extract of Emblica Officinalis, a potent natural antioxidant. Diabetic rats exhibited significantly decreased tail-flick latency in the tail-immersion test (thermal hyperalgesia) and decreased paw withdrawal threshold in both Randall-Selitto (mechanical hyperalgesia) and von-Frey hair test (mechanical allodynia). A decrease in the nociceptive threshold was accompanied by significantly increased oxidative stress, nitrite levels and cytokines (TNF-α, IL-1β and TGF-β1) both in the serum and sciatic nerve of diabetic rats. Treatment with the Emblica Officinalis aqueous Extract (250, 500 and 1000 mg/kg/day) significantly attenuated all the behavioral, biochemical and molecular alterations in a dose-dependent manner. The major finding of the study is that insulin alone corrected the hyperglycemia and partially reversed the pain response in diabetic rats. However, combination with Emblica Officinalis Extract not only attenuated the diabetic condition but also reversed neuropathic pain through modulation of oxidative–nitrosative stress in diabetic rats. Copyright © 2011 John Wiley & Sons, Ltd.

Mandava V. Rao - One of the best experts on this subject based on the ideXlab platform.