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P. K. Goyal - One of the best experts on this subject based on the ideXlab platform.
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Fruit Extract of Emblica Officinalis (Amla) Protects Radiation Induced Biochemical Lesions In The Brain of Swiss Albino Mice
Annals of Neurosciences, 2006Co-Authors: Inder Singh, Abhilasha Sharma, Archana Jindal, Dhanraj Soyal, P. K. GoyalAbstract:The alterations in enzymatic and biochemical activities were investigated in the brain of Swiss albino mice, with (experimental) or without (control) fruit extract before exposure to 5 Gy gamma radiation. The value of serum acid phosphatase activity were significantly higher in the irradiated group throughout the experiments compared to normal. However, this activity in Emblica Officinalis pretreated irradiated animals showed a significant decline over untreated irradiated animals at all the autopsy intervals and attained the normal value by day 20th of treatment conversely, a marked decrease in serum alkaline phosphatase activity was noted in both the irradiated groups, but in the Emblica Officinalis pretreated group an elevation in protein and cholesterol levels was observed. Furthermore, Emblica Officinalis inhibited lipid peroxidation and increased glutathione (GSH) level in brain. doi; 10.5214/ans.0972.7531.2006.130302
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Chemopreventive action of Emblica Officinalis on skin carcinogenesis in mice.
Asian Pacific journal of cancer prevention : APJCP, 2005Co-Authors: Garima Sancheti, Archana Jindal, Rimpu Kumari, P. K. GoyalAbstract:Chemoprevention with food phytochemicals is currently regarded as one of the most important strategies for cancer control. Emblica Officinalis (Family: Euphorbiaceae) indigenous to India, is valued for its unique tannins and flavanoids, which contain very powerful antioxidant properties. The inhibition of tumor incidences by fruit extract of this plant has been evaluated on two-stage process of skin carcinogenesis in Swiss albino mice, induced by a single application of 7, 12-dimethyabenz(a)anthrecene (100 microg / 100 microl acetone), and two weeks later, promoted by repeated application of croton oil (1% in acetone/thrice a week) till the end of the experiment (16 weeks). The tumor incidence, tumor yield, tumor burdon and cumulative number of papillomas were found to be higher in the control (without EO treatment) as compared to experimental animals (EO treated). The differences in the values of the results of experimental groups were statistically analysed and found to be significant in comparison to the control group (p< 0.05). The present study demonstrates the chemopreventive potential of Emblica Officinalis fruit extract on DMBA induced skin tumorigenesis in Swiss albino mice.
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Radioprotection of Swiss albino mice by Emblica Officinalis
Phytotherapy research : PTR, 2005Co-Authors: Inder Singh, Abhilasha Sharma, Vandana Nunia, P. K. GoyalAbstract:The fruit pulp of Emblica Officinalis (EO) is an important drug used in Indian systems of medicine for several diseases and as a tonic. In view of its multifarious uses, the plant extract (aqueous) was tested for its radioprotective properties against sublethal gamma radiation (9 Gy) in Swiss albino mice. Animals were divided into two groups and irradiated with gamma radiation externally, with or without EO extract, which was given orally at different doses before irradiation. The dose of fruit pulp extract found to be most effective against radiation was 100 mg/kg b.wt. This dose increased the survival time and reduced the mortality rate of mice significantly. Furthermore, body weight loss in EO administered irradiated animals was significantly less in comparison with animals who were given radiation only.
Inder Singh - One of the best experts on this subject based on the ideXlab platform.
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Fruit Extract of Emblica Officinalis (Amla) Protects Radiation Induced Biochemical Lesions In The Brain of Swiss Albino Mice
Annals of Neurosciences, 2006Co-Authors: Inder Singh, Abhilasha Sharma, Archana Jindal, Dhanraj Soyal, P. K. GoyalAbstract:The alterations in enzymatic and biochemical activities were investigated in the brain of Swiss albino mice, with (experimental) or without (control) fruit extract before exposure to 5 Gy gamma radiation. The value of serum acid phosphatase activity were significantly higher in the irradiated group throughout the experiments compared to normal. However, this activity in Emblica Officinalis pretreated irradiated animals showed a significant decline over untreated irradiated animals at all the autopsy intervals and attained the normal value by day 20th of treatment conversely, a marked decrease in serum alkaline phosphatase activity was noted in both the irradiated groups, but in the Emblica Officinalis pretreated group an elevation in protein and cholesterol levels was observed. Furthermore, Emblica Officinalis inhibited lipid peroxidation and increased glutathione (GSH) level in brain. doi; 10.5214/ans.0972.7531.2006.130302
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Radioprotection of Swiss albino mice by Emblica Officinalis
Phytotherapy research : PTR, 2005Co-Authors: Inder Singh, Abhilasha Sharma, Vandana Nunia, P. K. GoyalAbstract:The fruit pulp of Emblica Officinalis (EO) is an important drug used in Indian systems of medicine for several diseases and as a tonic. In view of its multifarious uses, the plant extract (aqueous) was tested for its radioprotective properties against sublethal gamma radiation (9 Gy) in Swiss albino mice. Animals were divided into two groups and irradiated with gamma radiation externally, with or without EO extract, which was given orally at different doses before irradiation. The dose of fruit pulp extract found to be most effective against radiation was 100 mg/kg b.wt. This dose increased the survival time and reduced the mortality rate of mice significantly. Furthermore, body weight loss in EO administered irradiated animals was significantly less in comparison with animals who were given radiation only.
Abhilasha Sharma - One of the best experts on this subject based on the ideXlab platform.
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Fruit Extract of Emblica Officinalis (Amla) Protects Radiation Induced Biochemical Lesions In The Brain of Swiss Albino Mice
Annals of Neurosciences, 2006Co-Authors: Inder Singh, Abhilasha Sharma, Archana Jindal, Dhanraj Soyal, P. K. GoyalAbstract:The alterations in enzymatic and biochemical activities were investigated in the brain of Swiss albino mice, with (experimental) or without (control) fruit extract before exposure to 5 Gy gamma radiation. The value of serum acid phosphatase activity were significantly higher in the irradiated group throughout the experiments compared to normal. However, this activity in Emblica Officinalis pretreated irradiated animals showed a significant decline over untreated irradiated animals at all the autopsy intervals and attained the normal value by day 20th of treatment conversely, a marked decrease in serum alkaline phosphatase activity was noted in both the irradiated groups, but in the Emblica Officinalis pretreated group an elevation in protein and cholesterol levels was observed. Furthermore, Emblica Officinalis inhibited lipid peroxidation and increased glutathione (GSH) level in brain. doi; 10.5214/ans.0972.7531.2006.130302
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Radioprotection of Swiss albino mice by Emblica Officinalis
Phytotherapy research : PTR, 2005Co-Authors: Inder Singh, Abhilasha Sharma, Vandana Nunia, P. K. GoyalAbstract:The fruit pulp of Emblica Officinalis (EO) is an important drug used in Indian systems of medicine for several diseases and as a tonic. In view of its multifarious uses, the plant extract (aqueous) was tested for its radioprotective properties against sublethal gamma radiation (9 Gy) in Swiss albino mice. Animals were divided into two groups and irradiated with gamma radiation externally, with or without EO extract, which was given orally at different doses before irradiation. The dose of fruit pulp extract found to be most effective against radiation was 100 mg/kg b.wt. This dose increased the survival time and reduced the mortality rate of mice significantly. Furthermore, body weight loss in EO administered irradiated animals was significantly less in comparison with animals who were given radiation only.
Archana Jindal - One of the best experts on this subject based on the ideXlab platform.
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Fruit Extract of Emblica Officinalis (Amla) Protects Radiation Induced Biochemical Lesions In The Brain of Swiss Albino Mice
Annals of Neurosciences, 2006Co-Authors: Inder Singh, Abhilasha Sharma, Archana Jindal, Dhanraj Soyal, P. K. GoyalAbstract:The alterations in enzymatic and biochemical activities were investigated in the brain of Swiss albino mice, with (experimental) or without (control) fruit extract before exposure to 5 Gy gamma radiation. The value of serum acid phosphatase activity were significantly higher in the irradiated group throughout the experiments compared to normal. However, this activity in Emblica Officinalis pretreated irradiated animals showed a significant decline over untreated irradiated animals at all the autopsy intervals and attained the normal value by day 20th of treatment conversely, a marked decrease in serum alkaline phosphatase activity was noted in both the irradiated groups, but in the Emblica Officinalis pretreated group an elevation in protein and cholesterol levels was observed. Furthermore, Emblica Officinalis inhibited lipid peroxidation and increased glutathione (GSH) level in brain. doi; 10.5214/ans.0972.7531.2006.130302
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Chemopreventive action of Emblica Officinalis on skin carcinogenesis in mice.
Asian Pacific journal of cancer prevention : APJCP, 2005Co-Authors: Garima Sancheti, Archana Jindal, Rimpu Kumari, P. K. GoyalAbstract:Chemoprevention with food phytochemicals is currently regarded as one of the most important strategies for cancer control. Emblica Officinalis (Family: Euphorbiaceae) indigenous to India, is valued for its unique tannins and flavanoids, which contain very powerful antioxidant properties. The inhibition of tumor incidences by fruit extract of this plant has been evaluated on two-stage process of skin carcinogenesis in Swiss albino mice, induced by a single application of 7, 12-dimethyabenz(a)anthrecene (100 microg / 100 microl acetone), and two weeks later, promoted by repeated application of croton oil (1% in acetone/thrice a week) till the end of the experiment (16 weeks). The tumor incidence, tumor yield, tumor burdon and cumulative number of papillomas were found to be higher in the control (without EO treatment) as compared to experimental animals (EO treated). The differences in the values of the results of experimental groups were statistically analysed and found to be significant in comparison to the control group (p< 0.05). The present study demonstrates the chemopreventive potential of Emblica Officinalis fruit extract on DMBA induced skin tumorigenesis in Swiss albino mice.
Tamanna Jahangir - One of the best experts on this subject based on the ideXlab platform.
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Emblica Officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats.
Journal of ethnopharmacology, 2008Co-Authors: Sarwat Sultana, Salahuddin Ahmed, Tamanna JahangirAbstract:Abstract Introduction Emblica Officinalis L. commonly known as gooseberry, Phyllanthus Emblica, Emblica, Indian gooseberry, amla is used in Indian system of medicine for the treatment of liver ailments. Aim and Objectives In the present study, we report that it ameliorates the carcinogenic response as it reverses the histopathological changes and reduces the number of γ-GT-positive foci induced by Solt Farber protocol in the liver of Wistar rats. Materials and Methods Tumors were induced by initiation with diethylnitrosoamine (DEN) (200 mg/kg body wt., i.p.) followed by promotion with 2-acetylaminoflourine (2-AAF) (0.02%, w/w in diet) for continuous 6 weeks and the animals were subjected to partial hepatectomy on day 21 of initiation. Results Pretreatment with defatted methanolic fruit extract (100 and 200 mg/kg b.w.) of Emblica Officinalis showed significant partial recovery of pathological manifestations as compared to DEN and 2-AAF-treated group animals (p Conclusion Emblica Officinalis has the potential to suppress carcinogen-induced response in rat liver.