The Experts below are selected from a list of 23280 Experts worldwide ranked by ideXlab platform
Wai Kin Victor Chan - One of the best experts on this subject based on the ideXlab platform.
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interaction metric of Emergent Behaviors in agent based simulation
Winter Simulation Conference, 2011Co-Authors: Wai Kin Victor ChanAbstract:Agent-based simulation (ABS) has been a popular tool in various science and engineering domains. Simulating Emergent Behavior is one main usage of ABS. This paper investigates the use of interaction statistics as a metric for detecting Emergent Behaviors from ABS. An Emergent Behavior arises if this interaction metric deviates from normality.
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agent based simulation tutorial simulation of Emergent Behavior and differences between agent based simulation and discrete event simulation
Winter Simulation Conference, 2010Co-Authors: Wai Kin Victor Chan, Young Jun Son, Charles M MacalAbstract:This tutorial demonstrates the use of agent-based simulation (ABS) in modeling Emergent Behaviors. We first introduce key concepts of ABS by using two simple examples: the Game of Life and the Boids models. We illustrate agent-based modeling issues and simulation of Emergent Behaviors by using examples in social networks, auction-type markets, emergency evacuation, crowd Behavior under normal situations, biology, material science, chemistry, and archaeology. Finally, we discuss the relationship between ABS and other simulation methodologies and outline some research challenges in ABS.
Keith A Crutcher - One of the best experts on this subject based on the ideXlab platform.
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segregated neural explants exhibit co oriented asymmetric neurite outgrowth
PLOS ONE, 2019Co-Authors: David B Pettigrew, Curtis B Dobson, Lori G Isaacson, Eric C Leuthardt, Heather N Lilley, Georgette L Suidan, Keith A CrutcherAbstract:: Explants of embryonic chick sympathetic and sensory ganglia were found to exhibit asymmetric radial outgrowth of neurites under standard culture conditions with or without exogenous Nerve Growth Factor [NGF]. Opposing sides of an explant exhibited: a) differences in neurite length and, b) differences in neurite morphology. Strikingly, this asymmetry exhibited co-orientation among segregated, neighboring explants. The underlying mechanism(s) of the asymmetry and its co-orientation are not known but appear to depend on cell clustering because dissociated sympathetic neurons do not exhibit co-orientation whereas re-aggregated clusters of cells do. This Emergent Behavior may be similar to the community effect described in other cell types. If a similar phenomenon exists in the embryo, or in maturity, it may contribute to the establishment of proper orientation of neurite outgrowth during development and/or injury-induced neuronal plasticity.
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segregated neural explants exhibit co oriented asymmetric neurite outgrowth
bioRxiv, 2019Co-Authors: David B Pettigrew, Curtis B Dobson, Lori G Isaacson, Eric C Leuthardt, Heather N Lilley, Georgette L Suidan, Keith A CrutcherAbstract:Abstract Explants of embryonic chick sympathetic and sensory ganglia were found to exhibit asymmetric radial outgrowth of neurites under standard culture conditions with or without exogenous Nerve Growth Factor [NGF]. Opposing sides of an explant exhibited: a] differences in neurite length and, b] differences in terminal morphology. Strikingly, this asymmetry exhibited co-orientation among segregated, neighboring explants. The underlying mechanism[s] of the asymmetry and its co-orientation have not been discovered but appears to depend on cell clustering because dissociated sympathetic neurons do not exhibit co-orientation whereas re-aggregated clusters of cells do. This Emergent Behavior may be similar to the community effect described in other cell types. If a similar phenomenon exists in the embryo, or in maturity, it may contribute to the establishment of proper orientation of neurite outgrowth during development and/or injury-induced neuronal plasticity.
Charles M Macal - One of the best experts on this subject based on the ideXlab platform.
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agent based simulation tutorial simulation of Emergent Behavior and differences between agent based simulation and discrete event simulation
Winter Simulation Conference, 2010Co-Authors: Wai Kin Victor Chan, Young Jun Son, Charles M MacalAbstract:This tutorial demonstrates the use of agent-based simulation (ABS) in modeling Emergent Behaviors. We first introduce key concepts of ABS by using two simple examples: the Game of Life and the Boids models. We illustrate agent-based modeling issues and simulation of Emergent Behaviors by using examples in social networks, auction-type markets, emergency evacuation, crowd Behavior under normal situations, biology, material science, chemistry, and archaeology. Finally, we discuss the relationship between ABS and other simulation methodologies and outline some research challenges in ABS.
David B Pettigrew - One of the best experts on this subject based on the ideXlab platform.
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segregated neural explants exhibit co oriented asymmetric neurite outgrowth
PLOS ONE, 2019Co-Authors: David B Pettigrew, Curtis B Dobson, Lori G Isaacson, Eric C Leuthardt, Heather N Lilley, Georgette L Suidan, Keith A CrutcherAbstract:: Explants of embryonic chick sympathetic and sensory ganglia were found to exhibit asymmetric radial outgrowth of neurites under standard culture conditions with or without exogenous Nerve Growth Factor [NGF]. Opposing sides of an explant exhibited: a) differences in neurite length and, b) differences in neurite morphology. Strikingly, this asymmetry exhibited co-orientation among segregated, neighboring explants. The underlying mechanism(s) of the asymmetry and its co-orientation are not known but appear to depend on cell clustering because dissociated sympathetic neurons do not exhibit co-orientation whereas re-aggregated clusters of cells do. This Emergent Behavior may be similar to the community effect described in other cell types. If a similar phenomenon exists in the embryo, or in maturity, it may contribute to the establishment of proper orientation of neurite outgrowth during development and/or injury-induced neuronal plasticity.
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segregated neural explants exhibit co oriented asymmetric neurite outgrowth
bioRxiv, 2019Co-Authors: David B Pettigrew, Curtis B Dobson, Lori G Isaacson, Eric C Leuthardt, Heather N Lilley, Georgette L Suidan, Keith A CrutcherAbstract:Abstract Explants of embryonic chick sympathetic and sensory ganglia were found to exhibit asymmetric radial outgrowth of neurites under standard culture conditions with or without exogenous Nerve Growth Factor [NGF]. Opposing sides of an explant exhibited: a] differences in neurite length and, b] differences in terminal morphology. Strikingly, this asymmetry exhibited co-orientation among segregated, neighboring explants. The underlying mechanism[s] of the asymmetry and its co-orientation have not been discovered but appears to depend on cell clustering because dissociated sympathetic neurons do not exhibit co-orientation whereas re-aggregated clusters of cells do. This Emergent Behavior may be similar to the community effect described in other cell types. If a similar phenomenon exists in the embryo, or in maturity, it may contribute to the establishment of proper orientation of neurite outgrowth during development and/or injury-induced neuronal plasticity.
De Vuyst Luc - One of the best experts on this subject based on the ideXlab platform.
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Data from: Integrated culturing, modeling and transcriptomics uncovers complex interactions and Emergent Behavior in a three-species synthetic gut community
2018Co-Authors: D'hoe Kevin, Vet Stefan, Faust Karoline, Moens Frédéric, Falony Gwen, Gonze Didier, Lloréns-rico Verónica, Gelens Lendert, Danckaert Jan, De Vuyst LucAbstract:Whereas the composition of the human gut microbiome is well resolved, predictive understanding is still lacking. Here, we followed a bottom-up strategy to explore human gut community dynamics: we established a synthetic community composed of three representative human gut isolates (Roseburia intestinalis L1-82, Faecalibacterium prausnitzii A2-165 and Blautia hydrogenotrophica S5a33) and explored their interactions under well-controlled conditions in vitro. Systematic mono- and pair-wise fermentation experiments confirmed competition for fructose and cross-feeding of formate. We quantified with a mechanistic model how well tri-culture dynamics was predicted from mono-culture data. With the model as reference, we demonstrated that strains grown in co-culture behaved differently than in mono-culture and confirmed their altered Behavior at the transcriptional level. In addition, we showed with replicate tri-cultures and simulations that dominance in tri-culture sensitively depended on initial conditions. Our work has important implications for gut microbial community modeling as well as ecological interaction detection from batch cultures
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Integrated culturing, modeling and transcriptomics uncovers complex interactions and Emergent Behavior in a three-species synthetic gut community
'eLife Sciences Publications Ltd', 2018Co-Authors: D'hoe Kevin, Vet Stefan, Faust Karoline, Falony Gwen, Gonze Didier, Gelens Lendert, Danckaert Jan, Moens Frederic, Llorens-rico Veronica, De Vuyst LucAbstract:The composition of the human gut microbiome is well resolved, but predictive understanding of its dynamics is still lacking. Here, we followed a bottom-up strategy to explore human gut community dynamics: we established a synthetic community composed of three representative human gut isolates (Roseburia intestinalis L1-82, Faecalibacterium prausnitzii A2-165 and Blautia hydrogenotrophica S5a33) and explored their interactions under well-controlled conditions in vitro. Systematic mono- and pair-wise fermentation experiments confirmed competition for fructose and cross-feeding of formate. We quantified with a mechanistic model how well tri-culture dynamics was predicted from mono-culture data. With the model as reference, we demonstrated that strains grown in co-culture behaved differently than those in mono-culture and confirmed their altered Behavior at the transcriptional level. In addition, we showed with replicate tri-cultures and simulations that dominance in tri-culture sensitively depends on the initial conditions. Our work has important implications for gut microbial community modeling as well as for ecological interaction detection from batch cultures.status: publishe
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Integrated culturing, modeling and transcriptomics uncovers complex interactions and Emergent Behavior in a three-species synthetic gut community
'eLife Sciences Publications Ltd', 2018Co-Authors: D’hoe Kevin, Vet Stefan, Faust Karoline, Falony Gwen, Gonze Didier, Gelens Lendert, Danckaert Jan, Moens Frederic, Llorens-rico Veronica, De Vuyst LucAbstract:The composition of the human gut microbiome is well resolved, but predictive understanding of its dynamics is still lacking. Here, we followed a bottom-up strategy to explore human gut community dynamics: we established a synthetic community composed of three representative human gut isolates (Roseburia intestinalis L1-82, Faecalibacterium prausnitzii A2-165 and Blautia hydrogenotrophica S5a33) and explored their interactions under well-controlled conditions in vitro. Systematic mono-and pair-wise fermentation experiments confirmed competition for fructose and cross-feeding of formate. We quantified with a mechanistic model how well tri-culture dynamics was predicted from mono-culture data. With the model as reference, we demonstrated that strains grown in co-culture behaved differently than those in mono-culture and confirmed their altered Behavior at the transcriptional level. In addition, we showed with replicate tri-cultures and simulations that dominance in tri-culture sensitively depends on the initial conditions. Our work has important implications for gut microbial community modeling as well as for ecological interaction detection from batch cultures.SCOPUS: ar.jinfo:eu-repo/semantics/publishe