The Experts below are selected from a list of 1464 Experts worldwide ranked by ideXlab platform
Smi Choikwon - One of the best experts on this subject based on the ideXlab platform.
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poststroke Emotional disturbances and a tryptophan hydroxylase 2 gene polymorphism
Brain and behavior, 2018Co-Authors: Smi Choikwon, Sang-eun Jun, Ju Han Kim, Kyung Hee Cho, Hyun Wook Nah, Ha-sup Song, Jong S. KimAbstract:Objectives Emotional dysfunction is a common finding in stroke patients. Despite reports on serotonergic involvement in the etiology of poststroke Emotional dysfunction (PSED), the role of serotonin synthesizing tryptophan hydroxylase 2 (TPH2) genes in the development of PSED remains unclear. Methods Genotyping of TPH2 rs4641528 and rs10879355 was performed from genomic DNA of 383 stroke patients collected previously and stored at -70°C. Potential associations between TPH2 genes and poststroke depression (PSD), poststroke Emotional Incontinence (PSEI), and poststroke anger proneness (PSAP) were investigated 3 months poststroke. Results Among the 383 patients, 69 (18%) had PSD, 41 (11%) had PSEI, and 93 (24%) had PSAP. The TPH2 rs4641528 genotype frequencies differed significantly between patients with and without either PSD or PSEI, although no significant differences were found between the patients with and without PSAP. In multiple logistic regression analysis, PSD was related to the National Institutes of Health Stroke Scale (NIHSS) score at admission (95% confidence interval [CI]: 1.047-1.230, p < .01), modified Rankin scale score at 3 months (95% CI: 0.135-0.848, p < .05), and TPH2 rs4641528 C allele (95% CI: 1.039-5.631, p < .05), whereas PSEI was associated only with the NIHSS score at admission (95% CI: 1.053-1.259, p < .01) and the TPH2 rs4641528 C allele (95% CI: 1.029-11.678, p < .05). Conclusions Our findings suggest that the TPH2 rs4641528 C allele may play a role in the pathogenesis of PSD and PSEI but not PSAP in Korean stroke patients.
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poststroke depression and Emotional Incontinence factors related to acute and subacute stages
Neurology, 2012Co-Authors: Smi Choikwon, S Choi, H Song, Sunuck Kwon, Dongwha KangAbstract:Objectives: To investigate the characteristics and prevalence of poststroke depression (PSD) and poststroke Emotional Incontinence (PSEI) and the factors related to these conditions at admission and 3 months after stroke. Methods: We evaluated 508 consecutive patients with acute ischemic stroke for PSD and PSEI at admission and 3 months later. PSD was evaluated using the Beck Depression Inventory, and PSEI was evaluated using Kim9s criteria. Blood samples were collected and genotyped for the promoter region of the serotonin transporter protein (5-HTTLPR) and the number of tandem repeats within intron 2 (STin2 VNTR). Perceived social support (the ENRICHD Social Support Inventory) was also measured. Results: PSD and PSEI were present in 13.7% and 9.4% of patients, respectively, at admission and in 17.7% and 11.7%, respectively, at 3 months after stroke. Multivariate analyses showed that PSD at admission was associated with the NIH Stroke Scale score at admission ( p p p p = 0.022) was associated with PSEI at admission, whereas modified Rankin Scale score ( p = 0.019), STin2 VNTR ( p = 0.040), and low social support ( p = 0.042) were related to PSEI 3 months after stroke. Conclusions: Diverse factors such as neurologic dysfunction, lesion location, microbleeds, genetic traits, and social support are differently related to acute and subacute Emotional disturbances. Strategies to prevent or manage these problems should consider these differences.
Raed Hawa - One of the best experts on this subject based on the ideXlab platform.
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pathological laughing and crying post stroke liaison psychiatrist beware
Journal of Neuropsychiatry and Clinical Neurosciences, 2016Co-Authors: Arina Bingelien, Colin M Shapiro, Sanjeev Sockalingam, Raed HawaAbstract:Pathological laughing and crying (PLC) has been known by a number of different names, but the most widely used terms are “pseudobulbar affect,” “Emotional lability,” “Emotional Incontinence,” and “pathological laughing and crying.” The cardinal feature of PLC is a pathologically lowered threshold for the exhibition of behavioral responses that include laughter, crying, or both. An affected individual exhibits episodes of laughter and / or crying without an apparent motivating stimulus or in response to stimuli that would not have elicited such an Emotional response before the onset of their underlying neurologic disorder. Symptoms of PLC can be severe, and episodes can be persistent and unremitting. PLC is a clinical condition that occurs in patients with various neurological disorders. The majority of evidence relates to stroke patients. The review summarizes the available data about pharmacological and behavioral treatment efficiency for this condition. Furthermore the management of these patients adds a rich avenue to the future understanding of Emotional behavior.
Ioannis Evdokimidis - One of the best experts on this subject based on the ideXlab platform.
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duloxetine for pathological laughing and crying
The International Journal of Neuropsychopharmacology, 2009Co-Authors: Panagiotis Ferentinos, Thomas Paparrigopoulos, Michael Rentzos, Ioannis EvdokimidisAbstract:Pathological laughing and crying (PLC) is a condition characterized by frequent, sudden outbursts of uncontrollable crying and/or laughing that are disproportionate or incongruent to underlying feelings or external triggers (Wortzel et al. 2008). Alternative terms often used to describe this syndrome are pseudobulbar affect, Emotional Incontinence, Emotional or affective lability, organic or pathological Emotionalism and involuntary Emotional expression disorder. The condition is associated with various neurological disorders, such as stroke, multiple sclerosis, Parkinson's disease, traumatic brain injury, dementia and amyotrophic lateral sclerosis (ALS). PLC can be socially and occupationally disabling and is a source of distress for affected patients and their families. However, it is largely under-recognized or misdiagnosed in clinical settings. An important first step in the recognition and accurate measurement of PLC has been accomplished with the introduction of specific rating scales, such as the interviewer administered Pathological Laughter and Crying Scale validated for use with stroke victims (Robinson et al. 1993) and the self-report Center for Neurologic Study – Lability Scale (CNS-LS) validated for use with ALS and multiple sclerosis patients (Moore et al. …
Dongwha Kang - One of the best experts on this subject based on the ideXlab platform.
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poststroke depression and Emotional Incontinence factors related to acute and subacute stages
Neurology, 2012Co-Authors: Smi Choikwon, S Choi, H Song, Sunuck Kwon, Dongwha KangAbstract:Objectives: To investigate the characteristics and prevalence of poststroke depression (PSD) and poststroke Emotional Incontinence (PSEI) and the factors related to these conditions at admission and 3 months after stroke. Methods: We evaluated 508 consecutive patients with acute ischemic stroke for PSD and PSEI at admission and 3 months later. PSD was evaluated using the Beck Depression Inventory, and PSEI was evaluated using Kim9s criteria. Blood samples were collected and genotyped for the promoter region of the serotonin transporter protein (5-HTTLPR) and the number of tandem repeats within intron 2 (STin2 VNTR). Perceived social support (the ENRICHD Social Support Inventory) was also measured. Results: PSD and PSEI were present in 13.7% and 9.4% of patients, respectively, at admission and in 17.7% and 11.7%, respectively, at 3 months after stroke. Multivariate analyses showed that PSD at admission was associated with the NIH Stroke Scale score at admission ( p p p p = 0.022) was associated with PSEI at admission, whereas modified Rankin Scale score ( p = 0.019), STin2 VNTR ( p = 0.040), and low social support ( p = 0.042) were related to PSEI 3 months after stroke. Conclusions: Diverse factors such as neurologic dysfunction, lesion location, microbleeds, genetic traits, and social support are differently related to acute and subacute Emotional disturbances. Strategies to prevent or manage these problems should consider these differences.
Arina Bingelien - One of the best experts on this subject based on the ideXlab platform.
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pathological laughing and crying post stroke liaison psychiatrist beware
Journal of Neuropsychiatry and Clinical Neurosciences, 2016Co-Authors: Arina Bingelien, Colin M Shapiro, Sanjeev Sockalingam, Raed HawaAbstract:Pathological laughing and crying (PLC) has been known by a number of different names, but the most widely used terms are “pseudobulbar affect,” “Emotional lability,” “Emotional Incontinence,” and “pathological laughing and crying.” The cardinal feature of PLC is a pathologically lowered threshold for the exhibition of behavioral responses that include laughter, crying, or both. An affected individual exhibits episodes of laughter and / or crying without an apparent motivating stimulus or in response to stimuli that would not have elicited such an Emotional response before the onset of their underlying neurologic disorder. Symptoms of PLC can be severe, and episodes can be persistent and unremitting. PLC is a clinical condition that occurs in patients with various neurological disorders. The majority of evidence relates to stroke patients. The review summarizes the available data about pharmacological and behavioral treatment efficiency for this condition. Furthermore the management of these patients adds a rich avenue to the future understanding of Emotional behavior.