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Gregorovičová Martina - One of the best experts on this subject based on the ideXlab platform.
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Význam jednotlivých složek repelentní sekrece Graphosoma lineatum vůči různým druhům predátorů
Univerzita Karlova Přírodovědecká fakulta, 2016Co-Authors: Gregorovičová MartinaAbstract:The chemical defence of Heteroptera is based on the repellent secretion that is very complex and consists of dozens chemical compounds. Heteroptera have good ability to produce/store large amounts of chemical components. The repellent secretion of Graphosoma lineatum is composed of many chemicals, such as short-chained aldehydes, which may signal the unpalatability of the bug to its potential predators or be directly toxic for them. The thesis is aimed at the major components of defensive secretion of Graphosoma lineatum - aldehydes - as well as the whole metathoracic scent-glands secretion of Graphosoma lineatum. The aversive reactions of four selected predators were evaluated: (1) leopard gecko (Eublepharis macularius); (2) green lizard (Lacerta viridis); (3) great tit (Parus major) and (4) blue tit (Cyanistes caeruleus). The following major compounds of the repellent secretion were tested: (1) the mixture of three aldehydes: (E)-hex-2-Enal, (E)-oct-2-Enal, (E)-dec-2-Enal; (2) the mixture of three aldehydes and tridecane; (3) oxoaldehyde: (E)-4-oxohex-2-Enal; (4) extracted metathoracic scent-glands secretion of Graphosoma lineatum adults; (5) hexane as a non-polar solvent and (6) pyrazine: 2-isobutyl-3-methoxypyrazine in experiments with leopard geckos as a positive control for excluding the...The chemical defence of Heteroptera is based on the repellent secretion that is very complex and consists of dozens chemical compounds. Heteroptera have good ability to produce/store large amounts of chemical components. The repellent secretion of Graphosoma lineatum is composed of many chemicals, such as short-chained aldehydes, which may signal the unpalatability of the bug to its potential predators or be directly toxic for them. The thesis is aimed at the major components of defensive secretion of Graphosoma lineatum - aldehydes - as well as the whole metathoracic scent-glands secretion of Graphosoma lineatum. The aversive reactions of four selected predators were evaluated: (1) leopard gecko (Eublepharis macularius); (2) green lizard (Lacerta viridis); (3) great tit (Parus major) and (4) blue tit (Cyanistes caeruleus). The following major compounds of the repellent secretion were tested: (1) the mixture of three aldehydes: (E)-hex-2-Enal, (E)-oct-2-Enal, (E)-dec-2-Enal; (2) the mixture of three aldehydes and tridecane; (3) oxoaldehyde: (E)-4-oxohex-2-Enal; (4) extracted metathoracic scent-glands secretion of Graphosoma lineatum adults; (5) hexane as a non-polar solvent and (6) pyrazine: 2-isobutyl-3-methoxypyrazine in experiments with leopard geckos as a positive control for excluding the...Department of ZoologyKatedra zoologiePřírodovědecká fakultaFaculty of Scienc
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Role of individual chemical compounds of repellent secretion of Graphosoma lineatum towards different predator species
2016Co-Authors: Gregorovičová MartinaAbstract:The chemical defence of Heteroptera is based on the repellent secretion that is very complex and consists of dozens chemical compounds. Heteroptera have good ability to produce/store large amounts of chemical components. The repellent secretion of Graphosoma lineatum is composed of many chemicals, such as short-chained aldehydes, which may signal the unpalatability of the bug to its potential predators or be directly toxic for them. The thesis is aimed at the major components of defensive secretion of Graphosoma lineatum - aldehydes - as well as the whole metathoracic scent-glands secretion of Graphosoma lineatum. The aversive reactions of four selected predators were evaluated: (1) leopard gecko (Eublepharis macularius); (2) green lizard (Lacerta viridis); (3) great tit (Parus major) and (4) blue tit (Cyanistes caeruleus). The following major compounds of the repellent secretion were tested: (1) the mixture of three aldehydes: (E)-hex-2-Enal, (E)-oct-2-Enal, (E)-dec-2-Enal; (2) the mixture of three aldehydes and tridecane; (3) oxoaldehyde: (E)-4-oxohex-2-Enal; (4) extracted metathoracic scent-glands secretion of Graphosoma lineatum adults; (5) hexane as a non-polar solvent and (6) pyrazine: 2-isobutyl-3-methoxypyrazine in experiments with leopard geckos as a positive control for excluding the..
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Význam jednotlivých složek repelentní sekrece Graphosoma lineatum vůči různým druhům predátorů.
Univerzita Karlova Přírodovědecká fakulta, 2015Co-Authors: Gregorovičová MartinaAbstract:The chemical defence of Heteroptera is based on the repellent secretion that is very complex and consists of dozens chemical compounds. Heteroptera have good ability to produce/store large amounts of chemical components. The repellent secretion of Graphosoma lineatum is composed of many chemicals, such as short-chained aldehydes, which may signal the unpalatability of the bug to its potential predators or be directly toxic for them. The thesis is aimed at the major components of defensive secretion of Graphosoma lineatum - aldehydes - as well as the whole metathoracic scent-glands secretion of Graphosoma lineatum. The aversive reactions of four selected predators were evaluated: (1) leopard gecko (Eublepharis macularius); (2) green lizard (Lacerta viridis); (3) great tit (Parus major) and (4) blue tit (Cyanistes caeruleus). The following major compounds of the repellent secretion were tested: (1) the mixture of three aldehydes: (E)-hex-2-Enal, (E)-oct-2-Enal, (E)-dec-2-Enal; (2) the mixture of three aldehydes and tridecane; (3) oxoaldehyde: (E)-4-oxohex-2-Enal; (4) extracted metathoracic scent-glands secretion of Graphosoma lineatum adults; (5) hexane as a non-polar solvent and (6) pyrazine: 2-isobutyl-3-methoxypyrazine in experiments with leopard geckos as a positive control for excluding the...Skupina ploštice (Heteroptera) má vynikající schopnost produkovat/uchovávat velké množství chemických látek, jež tvo í základ jejich komplexní repelentní sekrece. Mezi nejlépe prostudované repelentní sekrece pat í sekrece Graphosoma lineatum skládající se z mnoha složek, které mohou p sobit jako iritanty nebo p ímo jako toxiny. Mezi hlavní chemické složky sekrece pat í aldehydy s krátkými et zci. Diserta ní práce se zam uje na hlavní chemické složky této repelentní sekrece - aldehydy - stejn jako na extrahovanou sekreci metathorakálních pachových žláz Graphosoma lineatum. Celkem byly testovány aversivní reakce ty vybraných druh predátor : (1) gekon ík no ní (Eublepharis macularius); (2) ješt rka zelená (Lacerta viridis); (3) sýkora ko adra (Parus major) a (4) sýkora mod inka (Cyanistes caeruleus). Vybrané druhy predátor byly konfrontovány s majoritními složkami obranné sekrece Graphosoma lineatum: (1) sm s t í aldehyd : (E)-hex-2-Enal, (E)-oct-2-Enal, (E)-dec-2-Enal; (2) sm s t chto t í aldehyd obohacená o tridekan; (3) oxoaldehyd: (E)-4-oxohex-2-Enal; (4) extrahovaná sekrece metathorakálních pachových žláz dosp lé Graphosoma lineatum; (5) hexan, jakožto nepolární rozpoušt dlo a (6) pyrazín: 2-isobutyl-3-methoxypyrazín u experiment s gekon íky no ními jako pozitivní kontrola k vylou ení efektu...Department of ZoologyKatedra zoologieFaculty of SciencePřírodovědecká fakult
Bruno De Meulenaer - One of the best experts on this subject based on the ideXlab platform.
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Behavior of Hexanal, (E)-Hex-2-Enal, 4-Hydroxyhex-2-Enal, and 4-Hydroxynon-2-Enal in Oil-in-Water Emulsions.
Journal of agricultural and food chemistry, 2020Co-Authors: Angelique Vandemoortele, Marie Simon, Arnaud Claes, Bruno De MeulenaerAbstract:The reactivity of hexanal, (E)-hex-2-Enal, 4-hydroxyhex-2-Enal, and 4-hydroxynon-2-Enal in oil-in-water emulsions and its respective compartments, in presence and absence of protein, was studied at...
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behavior of hexanal e hex 2 Enal 4 hydroxyhex 2 Enal and 4 hydroxynon 2 Enal in oil in water emulsions
Journal of Agricultural and Food Chemistry, 2020Co-Authors: Angelique Vandemoortele, Marie Simon, Arnaud Claes, Bruno De MeulenaerAbstract:The reactivity of hexanal, (E)-hex-2-Enal, 4-hydroxyhex-2-Enal, and 4-hydroxynon-2-Enal in oil-in-water emulsions and its respective compartments, in presence and absence of protein, was studied at 40 °C. In the presence of water, hexanal oxidized to hexanoic acid. In the presence of protein, an additional loss occurred, presumably as a result of adduct formation with cysteine. Similarly, (E)-hex-2-Enal oxidized to (E)-hex-2-enoic acid in the presence of water, the results suggested that also this acid is able to form adducts with proteins. 4-Hydroxyalk-2-Enals showed the highest reactivity in all models evaluated. Especially in protein containing systems, they were not detectable anymore or their initial concentration was seriously reduced. 4-Hydroxynon-2-Enal was the most reactive of the substances studied. The reactivity of the aldehydes was influenced by their partition within emulsions which remarkably was not correlated with their hydrophobicity. These findings need to be considered when using these aldehydes as lipid oxidation markers in foods.
Angelique Vandemoortele - One of the best experts on this subject based on the ideXlab platform.
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Behavior of Hexanal, (E)-Hex-2-Enal, 4-Hydroxyhex-2-Enal, and 4-Hydroxynon-2-Enal in Oil-in-Water Emulsions.
Journal of agricultural and food chemistry, 2020Co-Authors: Angelique Vandemoortele, Marie Simon, Arnaud Claes, Bruno De MeulenaerAbstract:The reactivity of hexanal, (E)-hex-2-Enal, 4-hydroxyhex-2-Enal, and 4-hydroxynon-2-Enal in oil-in-water emulsions and its respective compartments, in presence and absence of protein, was studied at...
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behavior of hexanal e hex 2 Enal 4 hydroxyhex 2 Enal and 4 hydroxynon 2 Enal in oil in water emulsions
Journal of Agricultural and Food Chemistry, 2020Co-Authors: Angelique Vandemoortele, Marie Simon, Arnaud Claes, Bruno De MeulenaerAbstract:The reactivity of hexanal, (E)-hex-2-Enal, 4-hydroxyhex-2-Enal, and 4-hydroxynon-2-Enal in oil-in-water emulsions and its respective compartments, in presence and absence of protein, was studied at 40 °C. In the presence of water, hexanal oxidized to hexanoic acid. In the presence of protein, an additional loss occurred, presumably as a result of adduct formation with cysteine. Similarly, (E)-hex-2-Enal oxidized to (E)-hex-2-enoic acid in the presence of water, the results suggested that also this acid is able to form adducts with proteins. 4-Hydroxyalk-2-Enals showed the highest reactivity in all models evaluated. Especially in protein containing systems, they were not detectable anymore or their initial concentration was seriously reduced. 4-Hydroxynon-2-Enal was the most reactive of the substances studied. The reactivity of the aldehydes was influenced by their partition within emulsions which remarkably was not correlated with their hydrophobicity. These findings need to be considered when using these aldehydes as lipid oxidation markers in foods.
Peter R Moore - One of the best experts on this subject based on the ideXlab platform.
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reoptimization of the organocatalyzed double aldol domino process to a key Enal intermediate and its application to the total synthesis of δ12 prostaglandin j3
Chemistry: A European Journal, 2018Co-Authors: Andrejs Pelss, Narasimhulu Gandhamsetty, James R Smith, Damien Mailhol, Mattia Silvi, Andrew J A Watson, Isabel Perezpowell, Sebastien Prevost, Nina Schutzenmeister, Peter R MooreAbstract:Re-investigation of the l-proline catalyzed double aldol cascade dimerization of succinaldehyde for the synthesis of a key bicyclic Enal intermediate, pertinent in the field of stereoselective prostaglandin synthesis, is reported. The yield of this process has been more than doubled, from 14 % to a 29 % isolated yield on a multi-gram scale (32 % NMR yield), through conducting a detailed study of the reaction solvent, temperature, and concentration, as well as a catalyst screen. The synthetic utility of this Enal intermediate has been further demonstrated through the total synthesis of Δ12 -prostaglandin J3 , a compound with known anti-leukemic properties.
Maarten L P Dirkx - One of the best experts on this subject based on the ideXlab platform.
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practical use of the extended no action level Enal correction protocol for breast cancer patients with implanted surgical clips
International Journal of Radiation Oncology Biology Physics, 2012Co-Authors: J Penninkhof, Ben J M Heijmen, S Quint, Margreet H A Baaijens, Maarten L P DirkxAbstract:Purpose To describe the practical use of the extended No Action Level (Enal) setup correction protocol for breast cancer patients with surgical clips and evaluate its impact on the setup accuracy of both tumor bed and whole breast during simultaneously integrated boost treatments. Methods and Materials For 80 patients, two orthogonal planar kilovoltage images and one megavoltage image (for the mediolateral beam) were acquired per fraction throughout the radiotherapy course. For setup correction, the Enal protocol was applied, based on registration of surgical clips in the lumpectomy cavity. Differences with respect to application of a No Action Level (NAL) protocol or no protocol were quantified for tumor bed and whole breast. The correlation between clip migration during the fractionated treatment and either the method of surgery or the time elapsed from last surgery was investigated. Results The distance of the clips to their center of mass (COM), averaged over all clips and patients, was reduced by 0.9 ± 1.2 mm (mean ± 1 SD). Clip migration was similar between the group of patients starting treatment within 100 days after surgery (median, 53 days) and the group starting afterward (median, 163 days) ( p = 0.20). Clip migration after conventional breast surgery (closing the breast superficially) or after lumpectomy with partial breast reconstructive techniques (sutured cavity). was not significantly different either ( p = 0.22). Application of Enal on clips resulted in residual systematic errors for the clips’ COM of less than 1 mm in each direction, whereas the setup of the breast was within about 2 mm of accuracy. Conclusions Surgical clips can be safely used for high-accuracy position verification and correction. Given compensation for time trends in the clips’ COM throughout the treatment course, Enal resulted in better setup accuracies for both tumor bed and whole breast than NAL.
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su gg t 02 clinical application of the Enal set up correction protocol to compensate for time trends in breast cancer treatments
Medical Physics, 2010Co-Authors: Maarten L P Dirkx, J Penninkhof, S Quint, Margreet H A Baaijens, Ben J M HeijmenAbstract:Purpose: Clinical evaluation of the extended NAL (Enal) set‐up protocol (deBoer2007) for breast cancer patients treated with an integrated boost technique. Method and Materials: For 80 breast cancer patients, two orthogonal planar kilovoltage images and one megavoltage image (for the medio‐lateral beam) were acquired per fraction throughout the treatment course (14 fractions on average). Based on registration of surgical clips in the lumpectomy cavity (4.3 on average) set‐up corrections were derived after the first three fractions and updated once a week thereafter using Enal. The stability of the clips during the fractionated treatment was derived. Using a t‐test the correlation between clip migration and either the method of surgery or the time elapsed from last surgery was quantified. The impact of the Enal protocol on the set‐up accuracy for both the tumor bed and the whole breast was evaluated. Results: During the fractionated treatment the mean distance between the clips and their center of mass (COM) reduced by 0.9 ± 1.2 mm (1 SD). The clip migration was not statistically different between patients treated within 100 days after surgery or afterwards (p=0.20). Compared to conventional breast surgery (closing the lumpectomy cavity superficially), clip migration after oncoplastic surgery (suturing the lumpectomy cavity) was slightly smaller, but not significantly different (p=0.13). Throughout the treatment course timetrends in the COM position of the clips >3mm were observed for 61% of the patients. Application of the Enal protocol on clips resulted in residual systematic errors for the tumor bed of <1 mm in each direction, while the whole breast was treated within about 2 mm accuracy. Conclusion: Surgical clips can safely be used for position verification and correction. By compensating for time trends, the Enal protocol resulted in better set‐up accuracies for both the tumor bed and the whole breast than the NAL protocol.