The Experts below are selected from a list of 348 Experts worldwide ranked by ideXlab platform

Jayanthi S Lea - One of the best experts on this subject based on the ideXlab platform.

  • malignant ovarian germ cell Tumor role of surgical staging and gonadal dysgenesis
    Gynecologic Oncology, 2014
    Co-Authors: Ken Yu Lin, Stefanie N Bryant, David Miller, Siobhan M Kehoe, Debra L Richardson, Jayanthi S Lea
    Abstract:

    Abstract Objective To evaluate the effect of comprehensive surgical staging and gonadal dysgenesis on the outcomes of patients with malignant ovarian germ cell Tumor. Methods We performed a retrospective review of patients with ovarian germ cell Tumors who were treated at our institution between 1976 and 2012. Results Malignant ovarian germ cell Tumors (MOGCTs) were identified in 50 females. The median age was 24years (range 13 to 49). Of all MOGCT patients, 42% had dysgerminoma, 20% immature teratoma, 16% Endodermal Sinus Tumor, and 22% mixed germ cell Tumor. Univariate analyses revealed that the lack of surgical staging (p=0.048) and Endodermal Sinus Tumor (p=0.0085) were associated with disease recurrence, while age at diagnosis, ethnicity, and stage of the disease were not. Multivariate analyses revealed that the lack of surgical staging (p=0.029) and Endodermal Sinus Tumor (p=0.016) were independently associated with disease recurrence. In addition, 7 patients (14%) had 46 XY karyotype, including 6 with pure dysgerminoma and 1 with mixed germ cell Tumor. Five had Swyer syndrome and 2 had complete androgen insensitivity syndrome. Concurrent gonadoblastoma was found in 5 of the patients. No difference was found in the mean age at presentation, stage distribution, or recurrence rate for MOGCT patients with or without XY phenotype. Conclusions Comprehensive surgical staging was associated with a lower rate of recurrence. Fourteen percent of phenotypic females with MOGCT and 29% of those with dysgerminoma had XY karyotype. The clinical outcome of these patients is similar to that of MOGCT patients with XX karyotype.

A Alhammadi - One of the best experts on this subject based on the ideXlab platform.

  • yolk sac Tumor of vagina a case report
    International Journal of Clinical and Experimental Pathology, 2015
    Co-Authors: A Alhumidi, Al Shaikh S, A Alhammadi
    Abstract:

    Malignant germ-cell Tumors (MGCT) are rare Tumors of childhood accounting for less than 3% of pediatric malignancies. Yolk sac (Endodermal Sinus) Tumor is one of the malignant germ cell Tumor that usually involves the gonads (ovaries and testes). Its occurrence in the vagina is extremely rare. We report a 6-months old girl presented with a vaginal mass diagnosed as a yolk sac Tumor. This diagnosis is confirmed by histopathologic examination, immunehistochemical studies as well as elevated serum alpha fetoprotein (AFP).

Pengcheng Wang - One of the best experts on this subject based on the ideXlab platform.

  • Expression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors
    2010
    Co-Authors: Lin Wang, Guangying Yuan, Xiaotian Chang, Yan Zhao, Pengcheng Wang
    Abstract:

    Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline. The current study focused on the expression of PADI4 in various subtypes of ovary cancers, and this study investigated the effects of estrogen on PADI4 expression in SKOV-3 cells that originated from ovary Tumors. We utilized immunohistochemistry, real-time PCR and western blotting to analyze the expression of PADI4 in the Tumor tissues and in the cell line that were cultured with estrodial-17β. PADI4 was detected in serious cystadenocarcinoma (n=39, positivity=100%), clear cell cancer (n=7, positivity = 100%), mucinous cystadenocarcinoma (n=6, positivity=100%), dysgerminoma (n=6, positivity=100%), squamous cell Tumor (n=6, positivity=100%), sibnet-ring cell carcinoma (n=6, positivity=100%), Endodermal Sinus Tumor (n=6, positivity=100%), germ cell Tumors (n=6, positivity=100%) and immature teratoma (n=6, positivity=100%). However, PADI4 was either not detected or detected at low levels in granulosa cell Tumor (n=6), malignant thecoma (n=6), ovarian cystadenoma (n=5) and normal ovarian tissue (n=11). For serious cystadenocarcinoma, all of the samples with hig

  • Expression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors
    International Journal of Biological Sciences, 2010
    Co-Authors: Lin Wang, Guangying Yuan, Xiaotian Chang, Yan Zhao, Pengcheng Wang
    Abstract:

    Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline. The current study focused on the expression of PADI4 in various subtypes of ovary cancers, and this study investigated the effects of estrogen on PADI4 expression in SKOV-3 cells that originated from ovary Tumors. We utilized immunohistochemistry, real-time PCR and western blotting to analyze the expression of PADI4 in the Tumor tissues and in the cell line that were cultured with estrodial-17β. PADI4 was detected in serious cystadenocarcinoma (n=39, positivity=100%), clear cell cancer (n=7, positivity= 100%), mucinous cystadenocarcinoma (n=6, positivity=100%), dysgerminoma (n=6, positivity=100%), squamous cell Tumor (n=6, positivity=100%), sibnet-ring cell carcinoma (n=6, positivity=100%), Endodermal Sinus Tumor (n=6, positivity=100%), germ cell Tumors (n=6, positivity=100%) and immature teratoma (n=6, positivity=100%). However, PADI4 was either not detected or detected at low levels in granulosa cell Tumor (n=6), malignant thecoma (n=6), ovarian cystadenoma (n=5) and normal ovarian tissue (n=11). For serious cystadenocarcinoma, all of the samples with high PADI4 expression belonged to the T1 and T2 stages of pTMN, whereas all of the samples that exhibited weak or moderate PADI4 expression belonged to the T3 and T4 stages. PADI4 was evenly distributed in the cytoplasm of Tumor cells of serious cystadenocarcinoma that were classified as being grade II and III by histopathological scoring. However, PADI4 showed granular cellular distribution in the Tumor tissues that were isolated from grade I cystadenocarcinoma. In addition, the PADI4 level was positively related with the ages of the patients that presented with serious adenocarcinoma (p=0.029). Real-time PCR and western blot analyses confirmed that PADI4 was expressed at higher levels in ovarian adenocarcinoma (n=8) compared to ovarian cystadenoma (n=5) (p< 0.05). The study also detected an increased level of PADI4 in SKOV-3 cells that were incubated with estrodial-17β in the range of 10-12 to 10-4M. The results suggest an important role for PADI4 in the Tumorigenesis of ovary cancers that are under the regulation of estrogen.

Juha Hernesniemi - One of the best experts on this subject based on the ideXlab platform.

  • unedited microneurosurgery of a mixed germ cell Tumor of the pineal region
    Surgical Neurology International, 2018
    Co-Authors: Joham Choquevelasquez, Juha Hernesniemi
    Abstract:

    Background Germ cell Tumors comprise a heterogeneous group of neoplasms, classified as germinomas and nongerminomatous germ cell Tumors based on clinicopathological features. The nongerminomatous group of Tumors includes embryonal carcinoma, Endodermal Sinus Tumor (yolk sac Tumor), choriocarcinoma, mature and immature teratoma, and mixed germ cell Tumors with more than one element. While germinomas are radiation-sensitive Tumors, all other Tumors have less response to radiotherapy, and it is suggested that gross total resection improves their overall survival and Tumor-free survival rates. Herein, we present the microsurgical management of a histologically confirmed mixed-germ cell of the pineal region. Case description A patient with a mixed germ cell Tumor underwent sitting praying position and midline supracerebellar infratentorial approach. After opening of the dura, a midline cerebellar vein was coagulated and cut, and the pineal region was accessed over the superior cerebellar surface. A tight reactive dorsal membrane of the quadrigeminal cistern was widely opened with subsequent evaluation of the neurovascular structures by intraoperative angiography. Under high microsurgical magnification between both basal veins, the dorsal wall of the fibrotic and solid Tumor was coagulated and opened aiming an internal debulking of the lesion. Water dissection and cotton dissection were useful tools to separate the lateral borders of the Tumor from the surroundings. Bipolar coagulation was helpful shrinking the Tumor as well. The superior borders of the lesion, firmly attached to the roof of the third ventricle, required a careful evaluation. Ring microforceps in the right hand and thumb-regulated suction tube in the left one allowed us to pull out the Tumor in a piece under soft and continuous traction with dissection of the cleavage plane. The superior attachment of the Tumor was coagulated and cut. Finally, bipolar coagulation and small pieces of surgicel ensured a proper hemostasis. Postoperatively, the patient had a partial gaze palsy that improved gradually. The patient underwent adjuvant radiochemotherapy and currently is alive, free of Tumor recurrence >12 years after surgery. Conclusion This unedited video offers all detailed aspects that a neurosurgeon as the senior author JH considers essential when performing an efficient and safe surgery for a mixed germ cell Tumor. Videolink http://surgicalneurologyint.com/videogallery/pineal-Tumor-5.

Omer Gunhan - One of the best experts on this subject based on the ideXlab platform.

  • extragonadal yolk sac Tumor in pelvic localization a case report and literature review
    Gynecologic Oncology, 2004
    Co-Authors: Murat Dede, Recai Pabuccu, Gokhan Yagci, Mufit Cemal Yenen, Umit Goktolga, Omer Gunhan
    Abstract:

    Abstract Background . Yolk sac Tumor (YST) is a rare neoplasm that usually arises in the testis or ovary. We report a case of extragonadal yolk sac Tumor located in the pelvic area. Case . A 33-year-old woman was admitted with a history of abdominal pain and distension. Transvaginal ultrasonography showed a 63 × 63-mm hyperechoic mass and pelvic computerized scanning reported a pelvic mass mimicking a subserous myoma. Exploration findings revealed an extragonadal mass and she was treated with left pelvic mass extirpation, bilateral ovarian wedge resection, and reconstruction. Pelvic, paraaortic lymph node dissection and total omentectomy were also added to the operation. Histological evaluation of the specimen exhibited typical patterns of Endodermal Sinus Tumor and stained for a-fetoprotein and cytokeratin. Four courses of bleomycin, etoposide, and cisplatin combination chemotherapy repeated every 3 weeks were added to therapy and she has remained free of disease for 6 months after completion of the therapy.