The Experts below are selected from a list of 2118 Experts worldwide ranked by ideXlab platform

Clive Sweet - One of the best experts on this subject based on the ideXlab platform.

Sheldo M Wolff - One of the best experts on this subject based on the ideXlab platform.

  • ciliary neurotrophic factor is an Endogenous Pyrogen
    Proceedings of the National Academy of Sciences of the United States of America, 1993
    Co-Authors: Leland Shapiro, Xixia Zhang, Randall G Rupp, Sheldo M Wolff
    Abstract:

    Abstract Fever is initiated by the action of polypeptide cytokines called Endogenous Pyrogens, which are produced by the host during inflammation, trauma, or infection and which elevate the thermoregulatory set point in the hypothalamus. Ciliary neurotrophic factor (CNTF) supports the differentiation and survival of central and peripheral neurons. We describe the activity of CNTF as intrinsically Pyrogenic in the rabbit. CNTF induced a monophasic fever which rose rapidly (within the first 12 min) following intravenous injection; CNTF fever was blocked by pretreatment with indomethacin. The fever induced by CNTF was not due to contaminating endotoxins. Increasing doses of CNTF resulted in prolongation of the fever, suggesting the subsequent induction of additional Endogenous Pyrogenic activity. After passive transfer of plasma obtained during CNTF-induced fever, Endogenous Pyrogen activity was not present in the circulation; CNTF also did not induce the Endogenous Pyrogens interleukin 1, tumor necrosis factor, or interleukin 6 in vitro. Nevertheless, a second Endogenous Pyrogen may originate within the central nervous system following the systemic injection of CNTF. Of the four Endogenous Pyrogens described to date (interleukin 1, tumor necrosis factor, interferon, and interleukin 6), CNTF, like interleukin 6, utilizes the cell-surface gp 130 signal-transduction apparatus.

Kenneth J Jakeman - One of the best experts on this subject based on the ideXlab platform.

Leland Shapiro - One of the best experts on this subject based on the ideXlab platform.

  • ciliary neurotrophic factor is an Endogenous Pyrogen
    Proceedings of the National Academy of Sciences of the United States of America, 1993
    Co-Authors: Leland Shapiro, Xixia Zhang, Randall G Rupp, Sheldo M Wolff
    Abstract:

    Abstract Fever is initiated by the action of polypeptide cytokines called Endogenous Pyrogens, which are produced by the host during inflammation, trauma, or infection and which elevate the thermoregulatory set point in the hypothalamus. Ciliary neurotrophic factor (CNTF) supports the differentiation and survival of central and peripheral neurons. We describe the activity of CNTF as intrinsically Pyrogenic in the rabbit. CNTF induced a monophasic fever which rose rapidly (within the first 12 min) following intravenous injection; CNTF fever was blocked by pretreatment with indomethacin. The fever induced by CNTF was not due to contaminating endotoxins. Increasing doses of CNTF resulted in prolongation of the fever, suggesting the subsequent induction of additional Endogenous Pyrogenic activity. After passive transfer of plasma obtained during CNTF-induced fever, Endogenous Pyrogen activity was not present in the circulation; CNTF also did not induce the Endogenous Pyrogens interleukin 1, tumor necrosis factor, or interleukin 6 in vitro. Nevertheless, a second Endogenous Pyrogen may originate within the central nervous system following the systemic injection of CNTF. Of the four Endogenous Pyrogens described to date (interleukin 1, tumor necrosis factor, interferon, and interleukin 6), CNTF, like interleukin 6, utilizes the cell-surface gp 130 signal-transduction apparatus.

H Smith - One of the best experts on this subject based on the ideXlab platform.