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William J Ledger - One of the best experts on this subject based on the ideXlab platform.

  • post partum Endomyometritis diagnosis and treatment a review
    Journal of Obstetrics and Gynaecology Research, 2003
    Co-Authors: William J Ledger
    Abstract:

    Over the past 80 years, obstetrical treatment strategies devised to control current problems have resulted in the emergence of new types of infection. These, in turn, have caused modifications in diagnostic techniques and treatment specifics. Currently, the two most obvious changes influencing post-partum infection care are shortened post-partum hospital care, and the widespread use of intra-partum antibiotics to prevent early onset Group B streptococcal sepsis in the newborn. In the present review, risk factors for post-partum infection are delineated and strategies for prophylaxis and treatment are given.

  • incidence of postpartum Endomyometritis following single dose antibiotic prophylaxis with either ampicillin sulbactam cefazolin or cefotetan in high risk cesarean section patients
    Infectious Diseases in Obstetrics & Gynecology, 1998
    Co-Authors: N Noyes, A S Berkeley, K S Freedman, William J Ledger
    Abstract:

    OBJECTIVE: To assess the efficacy of single-dose antibiotic prophylaxis against postpartum Endomyometritis in high-risk cesarean section patients. DESIGN: Patients were administered one of three single-dose antibiotic regimens following umbilical cord clamping after cesarean section delivery. SETTING: Prospective randomized trial at a university-based hospital. PATIENTS: The study evaluated 293 consenting women undergoing cesarean section who had either experienced labor for a duration of > or = 6 hr or rupture of amniotic membranes. MAIN OUTCOME MEASURES: Development of postpartum Endomyometritis. RESULTS: The incidence of postpartum Endomyometritis was 7/95 (7.4%) following the ampicillin/sulbactam regimen, 14/98 (14.3%) after the cefazolin regimen, and 11/99 (11.1%) after the cefotetan regimen. There was no significant difference in postpartum infection among the three study arms. In addition, the incidence of Endomyometritis in the three single-dose study arms was not higher than previously noted in studies where three doses of antibiotic were administered. CONCLUSION: Single-dose antibiotic prophylaxis should replace the standard triple-dose therapy for uninfected women undergoing cesarean section who are at risk for postoperative Endomyometritis. Ampicillin/sulbactam, cefazolin, and cefotetan are all reasonable antibiotic choices for single-dose therapy.

  • incidence of postpartum Endomyometritis followingsingle dose antibiotic prophylaxis with eitherampicillin sulbactam cefazolin or cefotetan inhigh risk cesarean section patients
    Infectious Diseases in Obstetrics & Gynecology, 1998
    Co-Authors: N Noyes, A S Berkeley, K S Freedman, William J Ledger
    Abstract:

    Objective: To assess the efficacy of Single-dose antibiotic prophylaxis against postpartum Endomyometritis in high-risk cesarean section patients.

N Noyes - One of the best experts on this subject based on the ideXlab platform.

A S Berkeley - One of the best experts on this subject based on the ideXlab platform.

John R. Ebright - One of the best experts on this subject based on the ideXlab platform.

K S Freedman - One of the best experts on this subject based on the ideXlab platform.