The Experts below are selected from a list of 91455 Experts worldwide ranked by ideXlab platform

R G Phelps - One of the best experts on this subject based on the ideXlab platform.

  • Photoinduced dermal pigmentation in patients taking tricyclic antidepressants: histology, electron microscopy, and Energy Dispersive Spectroscopy.
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M C Sicari, M Lebwohl, J Baral, P Wexler, R E Gordon, R G Phelps
    Abstract:

    Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy Dispersive Spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation.

  • Photoinduced dermal pigmentation in patients taking tricyclic antidepressants : Histology, electron microscopy, and Energy Dispersive Spectroscopy
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M C Sicari, M Lebwohl, J Baral, R E Gordon, Patricia S. Wexler, R G Phelps
    Abstract:

    Abstract Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy Dispersive Spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation. (J Am Acad Dermatol 1999;40:290-3.)

M C Sicari - One of the best experts on this subject based on the ideXlab platform.

  • Photoinduced dermal pigmentation in patients taking tricyclic antidepressants: histology, electron microscopy, and Energy Dispersive Spectroscopy.
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M C Sicari, M Lebwohl, J Baral, P Wexler, R E Gordon, R G Phelps
    Abstract:

    Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy Dispersive Spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation.

  • Photoinduced dermal pigmentation in patients taking tricyclic antidepressants : Histology, electron microscopy, and Energy Dispersive Spectroscopy
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M C Sicari, M Lebwohl, J Baral, R E Gordon, Patricia S. Wexler, R G Phelps
    Abstract:

    Abstract Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy Dispersive Spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation. (J Am Acad Dermatol 1999;40:290-3.)

R E Gordon - One of the best experts on this subject based on the ideXlab platform.

  • Determining the quantity and character of carotid artery embolic debris by electron microscopy and Energy Dispersive Spectroscopy
    Journal of vascular surgery, 2007
    Co-Authors: Brian G. Derubertis, R E Gordon, Rabih A. Chaer, Heather M. Bell, Robert L. Hynecek, Fred M. Pieracci, John K. Karwowski, K. Craig Kent, Peter L. Faries
    Abstract:

    Objectives Carotid artery angioplasty and stenting (CAS) is now routinely performed with embolic protection devices, yet little is known about the compositional characteristics of the captured embolic debris and whether the type or quantity of debris correlates with patient, lesion, or operator characteristics. This study examined the embolic debris generated during CAS using electron microscopy and Energy Dispersive Spectroscopy (EDS) for symptomatic and asymptomatic patients. Methods Between 2003 and 2005, CAS for carotid stenosis was performed in 175 patients. Cerebral protection devices were used in all but three cases. Sixty-four consecutive unselected microporous filters from procedures performed by a single vascular surgeon were obtained for analysis. Captured particulate debris within the protection devices was quantified (number and mean size of particles) by light microscopy for all filters. Twenty protection devices (9 symptomatic, 11 asymptomatic patients) were processed for electron microscopy and EDS to assess morphology, cellular composition, and calcium content of debris. Results Captured particulate matter was present in 49 filters (77%) and included particles measuring 200 to 500 μm in 72%, 500 to 1000 μm in 53%, and >1000 μm in 33%. The mean number of captured particles was 6.9, and mean size was 248 ± 150 μm. Univariate analysis revealed that sequential patient cohort and filter type were correlated with the number (but not size) of captured particles. The number of particles significantly decreased after the first cohort of 20 patients (11.5 particles) compared with the second (5.0 particles, P = .023) and third (5.2 particles, P = .029) cohorts. The type of captured debris ranged from sheets of damaged red blood cells without other components to clumps of recently activated platelets with early fibrin crosslinking to plaque debris coated with well-organized coalescing areas of platelet thrombus. Platelet activation was more common in symptomatic patients (78%) than asymptomatic patients (27%; P Conclusions Particulate embolic debris is released in most patients during CAS and can measure >1000 μm in one third of patients. The number of particles may decrease with increasing operator experience with CAS. Debris captured during CAS with embolic protection exhibits a range of cellular and acellular components on electron microscopy, with a higher prevalence of platelet activation evident in symptomatic patients.

  • Photoinduced dermal pigmentation in patients taking tricyclic antidepressants: histology, electron microscopy, and Energy Dispersive Spectroscopy.
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M C Sicari, M Lebwohl, J Baral, P Wexler, R E Gordon, R G Phelps
    Abstract:

    Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy Dispersive Spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation.

  • Photoinduced dermal pigmentation in patients taking tricyclic antidepressants : Histology, electron microscopy, and Energy Dispersive Spectroscopy
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M C Sicari, M Lebwohl, J Baral, R E Gordon, Patricia S. Wexler, R G Phelps
    Abstract:

    Abstract Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy Dispersive Spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation. (J Am Acad Dermatol 1999;40:290-3.)

M Lebwohl - One of the best experts on this subject based on the ideXlab platform.

  • Photoinduced dermal pigmentation in patients taking tricyclic antidepressants: histology, electron microscopy, and Energy Dispersive Spectroscopy.
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M C Sicari, M Lebwohl, J Baral, P Wexler, R E Gordon, R G Phelps
    Abstract:

    Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy Dispersive Spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation.

  • Photoinduced dermal pigmentation in patients taking tricyclic antidepressants : Histology, electron microscopy, and Energy Dispersive Spectroscopy
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M C Sicari, M Lebwohl, J Baral, R E Gordon, Patricia S. Wexler, R G Phelps
    Abstract:

    Abstract Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy Dispersive Spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation. (J Am Acad Dermatol 1999;40:290-3.)

J Baral - One of the best experts on this subject based on the ideXlab platform.

  • Photoinduced dermal pigmentation in patients taking tricyclic antidepressants: histology, electron microscopy, and Energy Dispersive Spectroscopy.
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M C Sicari, M Lebwohl, J Baral, P Wexler, R E Gordon, R G Phelps
    Abstract:

    Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy Dispersive Spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation.

  • Photoinduced dermal pigmentation in patients taking tricyclic antidepressants : Histology, electron microscopy, and Energy Dispersive Spectroscopy
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M C Sicari, M Lebwohl, J Baral, R E Gordon, Patricia S. Wexler, R G Phelps
    Abstract:

    Abstract Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy Dispersive Spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation. (J Am Acad Dermatol 1999;40:290-3.)