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Jochen Buchs - One of the best experts on this subject based on the ideXlab platform.

  • hydromechanical stress in shake flasks correlation for the maximum local Energy Dissipation rate
    Biotechnology and Bioengineering, 2006
    Co-Authors: Cyril P Peter, Yusuke Suzuki, Jochen Buchs
    Abstract:

    Shake flasks are widely used in biotechnological process research. Bioprocesses for which hydromechanical stress may become the rate controlling parameter include those where oils are applied as carbon sources, biotransformation of compounds with low solubility in the aqueous phase, or processes employing animal, plant, or filamentous microorganisms. In this study, the maximum local Energy Dissipation rate as the measure for hydromechanical stress is characterized in shake flasks by measuring the maximum stable drop size. The theoretical basis for the method is that the maximum stable drop diameter in a coalescence inhibited liquid/liquid dispersion is only a function of the maximum local Energy Dissipation rate and not of the dispersing apparatus. The maximum local Energy Dissipation rate is obtained by comparing the drop diameters in shake flasks to those in a stirred tank reactor. At the same volumetric power consumption, the maximum Energy Dissipation rate in shake flasks is about 10 times lower than in stirred tank reactors explaining the common observation of considerable differences in the morphology of hydromechanically sensitive cells between these two reactor types. At the same volumetric power consumption, the maximum local Energy Dissipation rate in baffled and in unbaffled shake flasks is very similar. A correlation is presented to quantify the maximum local Energy Dissipation rate in shake flasks as a function of the operating conditions. Non-negligible drop viscosity may be considered by known literature correlations. Further, from dispersion experiments a critical Reynolds number of about 60,000 is proposed for turbulent flow in unbaffled shake flasks. © 2006 Wiley Periodicals, Inc.

  • hydromechanical stress in shake flasks correlation for the maximum local Energy Dissipation rate
    Biotechnology and Bioengineering, 2006
    Co-Authors: Cyril P Peter, Yusuke Suzuki, Jochen Buchs
    Abstract:

    Shake flasks are widely used in biotechnological process research. Bioprocesses for which hydromechanical stress may become the rate controlling parameter include those where oils are applied as carbon sources, biotransformation of compounds with low solubility in the aqueous phase, or processes employing animal, plant, or filamentous microorganisms. In this study, the maximum local Energy Dissipation rate as the measure for hydromechanical stress is characterized in shake flasks by measuring the maximum stable drop size. The theoretical basis for the method is that the maximum stable drop diameter in a coalescence inhibited liquid/liquid dispersion is only a function of the maximum local Energy Dissipation rate and not of the dispersing apparatus. The maximum local Energy Dissipation rate is obtained by comparing the drop diameters in shake flasks to those in a stirred tank reactor. At the same volumetric power consumption, the maximum Energy Dissipation rate in shake flasks is about 10 times lower than in stirred tank reactors explaining the common observation of considerable differences in the morphology of hydromechanically sensitive cells between these two reactor types. At the same volumetric power consumption, the maximum local Energy Dissipation rate in baffled and in unbaffled shake flasks is very similar. A correlation is presented to quantify the maximum local Energy Dissipation rate in shake flasks as a function of the operating conditions. Non-negligible drop viscosity may be considered by known literature correlations. Further, from dispersion experiments a critical Reynolds number of about 60,000 is proposed for turbulent flow in unbaffled shake flasks.

Cyril P Peter - One of the best experts on this subject based on the ideXlab platform.

  • hydromechanical stress in shake flasks correlation for the maximum local Energy Dissipation rate
    Biotechnology and Bioengineering, 2006
    Co-Authors: Cyril P Peter, Yusuke Suzuki, Jochen Buchs
    Abstract:

    Shake flasks are widely used in biotechnological process research. Bioprocesses for which hydromechanical stress may become the rate controlling parameter include those where oils are applied as carbon sources, biotransformation of compounds with low solubility in the aqueous phase, or processes employing animal, plant, or filamentous microorganisms. In this study, the maximum local Energy Dissipation rate as the measure for hydromechanical stress is characterized in shake flasks by measuring the maximum stable drop size. The theoretical basis for the method is that the maximum stable drop diameter in a coalescence inhibited liquid/liquid dispersion is only a function of the maximum local Energy Dissipation rate and not of the dispersing apparatus. The maximum local Energy Dissipation rate is obtained by comparing the drop diameters in shake flasks to those in a stirred tank reactor. At the same volumetric power consumption, the maximum Energy Dissipation rate in shake flasks is about 10 times lower than in stirred tank reactors explaining the common observation of considerable differences in the morphology of hydromechanically sensitive cells between these two reactor types. At the same volumetric power consumption, the maximum local Energy Dissipation rate in baffled and in unbaffled shake flasks is very similar. A correlation is presented to quantify the maximum local Energy Dissipation rate in shake flasks as a function of the operating conditions. Non-negligible drop viscosity may be considered by known literature correlations. Further, from dispersion experiments a critical Reynolds number of about 60,000 is proposed for turbulent flow in unbaffled shake flasks. © 2006 Wiley Periodicals, Inc.

  • hydromechanical stress in shake flasks correlation for the maximum local Energy Dissipation rate
    Biotechnology and Bioengineering, 2006
    Co-Authors: Cyril P Peter, Yusuke Suzuki, Jochen Buchs
    Abstract:

    Shake flasks are widely used in biotechnological process research. Bioprocesses for which hydromechanical stress may become the rate controlling parameter include those where oils are applied as carbon sources, biotransformation of compounds with low solubility in the aqueous phase, or processes employing animal, plant, or filamentous microorganisms. In this study, the maximum local Energy Dissipation rate as the measure for hydromechanical stress is characterized in shake flasks by measuring the maximum stable drop size. The theoretical basis for the method is that the maximum stable drop diameter in a coalescence inhibited liquid/liquid dispersion is only a function of the maximum local Energy Dissipation rate and not of the dispersing apparatus. The maximum local Energy Dissipation rate is obtained by comparing the drop diameters in shake flasks to those in a stirred tank reactor. At the same volumetric power consumption, the maximum Energy Dissipation rate in shake flasks is about 10 times lower than in stirred tank reactors explaining the common observation of considerable differences in the morphology of hydromechanically sensitive cells between these two reactor types. At the same volumetric power consumption, the maximum local Energy Dissipation rate in baffled and in unbaffled shake flasks is very similar. A correlation is presented to quantify the maximum local Energy Dissipation rate in shake flasks as a function of the operating conditions. Non-negligible drop viscosity may be considered by known literature correlations. Further, from dispersion experiments a critical Reynolds number of about 60,000 is proposed for turbulent flow in unbaffled shake flasks.

Yusuke Suzuki - One of the best experts on this subject based on the ideXlab platform.

  • hydromechanical stress in shake flasks correlation for the maximum local Energy Dissipation rate
    Biotechnology and Bioengineering, 2006
    Co-Authors: Cyril P Peter, Yusuke Suzuki, Jochen Buchs
    Abstract:

    Shake flasks are widely used in biotechnological process research. Bioprocesses for which hydromechanical stress may become the rate controlling parameter include those where oils are applied as carbon sources, biotransformation of compounds with low solubility in the aqueous phase, or processes employing animal, plant, or filamentous microorganisms. In this study, the maximum local Energy Dissipation rate as the measure for hydromechanical stress is characterized in shake flasks by measuring the maximum stable drop size. The theoretical basis for the method is that the maximum stable drop diameter in a coalescence inhibited liquid/liquid dispersion is only a function of the maximum local Energy Dissipation rate and not of the dispersing apparatus. The maximum local Energy Dissipation rate is obtained by comparing the drop diameters in shake flasks to those in a stirred tank reactor. At the same volumetric power consumption, the maximum Energy Dissipation rate in shake flasks is about 10 times lower than in stirred tank reactors explaining the common observation of considerable differences in the morphology of hydromechanically sensitive cells between these two reactor types. At the same volumetric power consumption, the maximum local Energy Dissipation rate in baffled and in unbaffled shake flasks is very similar. A correlation is presented to quantify the maximum local Energy Dissipation rate in shake flasks as a function of the operating conditions. Non-negligible drop viscosity may be considered by known literature correlations. Further, from dispersion experiments a critical Reynolds number of about 60,000 is proposed for turbulent flow in unbaffled shake flasks. © 2006 Wiley Periodicals, Inc.

  • hydromechanical stress in shake flasks correlation for the maximum local Energy Dissipation rate
    Biotechnology and Bioengineering, 2006
    Co-Authors: Cyril P Peter, Yusuke Suzuki, Jochen Buchs
    Abstract:

    Shake flasks are widely used in biotechnological process research. Bioprocesses for which hydromechanical stress may become the rate controlling parameter include those where oils are applied as carbon sources, biotransformation of compounds with low solubility in the aqueous phase, or processes employing animal, plant, or filamentous microorganisms. In this study, the maximum local Energy Dissipation rate as the measure for hydromechanical stress is characterized in shake flasks by measuring the maximum stable drop size. The theoretical basis for the method is that the maximum stable drop diameter in a coalescence inhibited liquid/liquid dispersion is only a function of the maximum local Energy Dissipation rate and not of the dispersing apparatus. The maximum local Energy Dissipation rate is obtained by comparing the drop diameters in shake flasks to those in a stirred tank reactor. At the same volumetric power consumption, the maximum Energy Dissipation rate in shake flasks is about 10 times lower than in stirred tank reactors explaining the common observation of considerable differences in the morphology of hydromechanically sensitive cells between these two reactor types. At the same volumetric power consumption, the maximum local Energy Dissipation rate in baffled and in unbaffled shake flasks is very similar. A correlation is presented to quantify the maximum local Energy Dissipation rate in shake flasks as a function of the operating conditions. Non-negligible drop viscosity may be considered by known literature correlations. Further, from dispersion experiments a critical Reynolds number of about 60,000 is proposed for turbulent flow in unbaffled shake flasks.

Andrzej W. Pacek - One of the best experts on this subject based on the ideXlab platform.

  • flow pattern periodicity and Energy Dissipation in a batch rotor stator mixer
    Chemical Engineering Research & Design, 2008
    Co-Authors: Michael Baker, Andrzej W. Pacek
    Abstract:

    Abstract The flow pattern and the distribution of Energy Dissipation rate in a batch rotor–stator mixer have been investigated. Sliding mesh and standard k–ɛ turbulence model were employed to predict velocity and Energy Dissipation rate distributions verified experimentally by the Laser Doppler Anemometry measurements. The agreement between predicted and measured bulk flow field as well as the flow pattern of jets emerging from the stator holes was very good. Results showed that the periodicity of the jet can be related to the rotor's velocity and number of blades. The Energy balance based on measured velocity distribution indicated that about 70% of Energy is dissipated in close proximity to the mixing head. Both simulation and measurement showed that the jet velocity and flowrate through the holes were proportional to N while the Energy Dissipation rate scaled with N3.

Boris Jeremic - One of the best experts on this subject based on the ideXlab platform.

  • Energy Dissipation analysis of elastic plastic materials
    Computer Methods in Applied Mechanics and Engineering, 2018
    Co-Authors: Han Yang, Sumeet Kumar Sinha, Yuan Feng, David B Mccallen, Boris Jeremic
    Abstract:

    Abstract Presented is an Energy Dissipation analysis framework for granular material that is based on thermodynamics. Theoretical formulations are derived from the second law of thermodynamics, in conjunction with a few plausible assumptions on Energy transformation and Dissipation. The role of plastic free Energy is emphasized by a conceptual experiment showing its physical nature. Theoretical formulation is adapted in order to be applied in elastic–plastic finite element method (FEM) simulations. Developed methodology is verified through comparison of input work, stored Energy, and Energy Dissipation of the system. Separation of plastic work into plastic free Energy and Energy Dissipation removes a common mistake, made in a number of publications, where Energy Dissipation can attain negative values (Energy production) which is impossible.