The Experts below are selected from a list of 12207 Experts worldwide ranked by ideXlab platform
Lichun Lu - One of the best experts on this subject based on the ideXlab platform.
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poly propylene fumarate bone tissue Engineering Scaffold fabrication using stereolithography effects of resin formulations and laser parameters
Biomacromolecules, 2007Co-Authors: Shanfeng Wang, Erik L. Ritman, Michael J. Yaszemski, Lichun LuAbstract:Stereolithography using photo-cross-linkable polymeric biomaterials is an effective technique for fabricating highly complex three-dimensional (3D) Scaffolds with controlled microstructures for tissue Engineering applications. In this study, we have optimized the UV curable polymer solution composition and laser parameters for the stereolithography machine. Poly(propylene fumarate) (PPF) was used as the biomaterial, diethyl fumarate (DEF) was used as the solvent, and bisacrylphosphrine oxide (BAPO) was used as the photoinitiator. Three different weight ratios of PPF/DEF and BAPO contents were characterized by measuring the viscosities and thermal properties of the un-cross-linked solutions and the mechanical properties of the formed Scaffolds. After optimizing the resin composition by satisfying both the viscosity limitation and the mechanical requirement, laser parameters such as critical exposure (Ec) and penetration depth (Dp) were determined from the working curve and the relationship between laser sp...
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Poly(propylene fumarate) bone tissue Engineering Scaffold fabrication using stereolithography: Effects of resin formulations and laser parameters
Biomacromolecules, 2007Co-Authors: Kee Won Lee, Bradley C. Fox, Shanfeng Wang, Erik L. Ritman, Michael J. Yaszemski, Lichun LuAbstract:Stereolithography using photo-cross-linkable polymeric biomaterials is an effective technique for fabricating highly complex three-dimensional (3D) Scaffolds with controlled microstructures for tissue Engineering applications. In this study, we have optimized the UV curable polymer solution composition and laser parameters for the stereolithography machine. Poly(propylene fumarate) (PPF) was used as the biomaterial, diethyl fumarate (DEF) was used as the solvent, and bisacrylphosphrine oxide (BAPO) was used as the photoinitiator. Three different weight ratios of PPF/DEF and BAPO contents were characterized by measuring the viscosities and thermal properties of the un-cross-linked solutions and the mechanical properties of the formed Scaffolds. After optimizing the resin composition by satisfying both the viscosity limitation and the mechanical requirement, laser parameters such as critical exposure (Ec) and penetration depth (Dp) were determined from the working curve and the relationship between laser speed and energy by measuring the thickness of predesigned windows fabricated in stereolithography with different ranges of Ec and Dp. Three-dimensional Scaffolds with various pore sizes, pore shapes, and porosities were designed in computer-aided design (CAD) software and were fabricated in stereolithography. The fabricated Scaffolds were characterized by measuring external dimensions, porosities, mean pore sizes, and compressive moduli and were compared to the CAD models. Feature accuracy in the xy-plane was achieved and overcuring of the resin in z-axis was minimized. The stereolithographically fabricated Scaffolds with controlled microstructures can be useful in diverse tissue Engineering applications.
David J. Mooney - One of the best experts on this subject based on the ideXlab platform.
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hydrogels for tissue Engineering Scaffold design variables and applications
Biomaterials, 2003Co-Authors: Jeanie L. Drury, David J. MooneyAbstract:Abstract Polymer Scaffolds have many different functions in the field of tissue Engineering. They are applied as space filling agents, as delivery vehicles for bioactive molecules, and as three-dimensional structures that organize cells and present stimuli to direct the formation of a desired tissue. Much of the success of Scaffolds in these roles hinges on finding an appropriate material to address the critical physical, mass transport, and biological design variables inherent to each application. Hydrogels are an appealing Scaffold material because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, and may be delivered in a minimally invasive manner. Consequently, hydrogels have been utilized as Scaffold materials for drug and growth factor delivery, Engineering tissue replacements, and a variety of other applications.
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Hydrogels for tissue Engineering: Scaffold design variables and applications
Biomaterials, 2003Co-Authors: Jeanie L. Drury, David J. MooneyAbstract:Polymer Scaffolds have many different functions in the field of tissue Engineering. They are applied as space filling agents, as delivery vehicles for bioactive molecules, and as three-dimensional structures that organize cells and present stimuli to direct the formation of a desired tissue. Much of the success of Scaffolds in these roles hinges on finding an appropriate material to address the critical physical, mass transport, and biological design variables inherent to each application. Hydrogels are an appealing Scaffold material because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, and may be delivered in a minimally invasive manner. Consequently, hydrogels have been utilized as Scaffold materials for drug and growth factor delivery, Engineering tissue replacements, and a variety of other applications. © 2003 Elsevier Ltd. All rights reserved.
Shanfeng Wang - One of the best experts on this subject based on the ideXlab platform.
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poly propylene fumarate bone tissue Engineering Scaffold fabrication using stereolithography effects of resin formulations and laser parameters
Biomacromolecules, 2007Co-Authors: Shanfeng Wang, Erik L. Ritman, Michael J. Yaszemski, Lichun LuAbstract:Stereolithography using photo-cross-linkable polymeric biomaterials is an effective technique for fabricating highly complex three-dimensional (3D) Scaffolds with controlled microstructures for tissue Engineering applications. In this study, we have optimized the UV curable polymer solution composition and laser parameters for the stereolithography machine. Poly(propylene fumarate) (PPF) was used as the biomaterial, diethyl fumarate (DEF) was used as the solvent, and bisacrylphosphrine oxide (BAPO) was used as the photoinitiator. Three different weight ratios of PPF/DEF and BAPO contents were characterized by measuring the viscosities and thermal properties of the un-cross-linked solutions and the mechanical properties of the formed Scaffolds. After optimizing the resin composition by satisfying both the viscosity limitation and the mechanical requirement, laser parameters such as critical exposure (Ec) and penetration depth (Dp) were determined from the working curve and the relationship between laser sp...
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Poly(propylene fumarate) bone tissue Engineering Scaffold fabrication using stereolithography: Effects of resin formulations and laser parameters
Biomacromolecules, 2007Co-Authors: Kee Won Lee, Bradley C. Fox, Shanfeng Wang, Erik L. Ritman, Michael J. Yaszemski, Lichun LuAbstract:Stereolithography using photo-cross-linkable polymeric biomaterials is an effective technique for fabricating highly complex three-dimensional (3D) Scaffolds with controlled microstructures for tissue Engineering applications. In this study, we have optimized the UV curable polymer solution composition and laser parameters for the stereolithography machine. Poly(propylene fumarate) (PPF) was used as the biomaterial, diethyl fumarate (DEF) was used as the solvent, and bisacrylphosphrine oxide (BAPO) was used as the photoinitiator. Three different weight ratios of PPF/DEF and BAPO contents were characterized by measuring the viscosities and thermal properties of the un-cross-linked solutions and the mechanical properties of the formed Scaffolds. After optimizing the resin composition by satisfying both the viscosity limitation and the mechanical requirement, laser parameters such as critical exposure (Ec) and penetration depth (Dp) were determined from the working curve and the relationship between laser speed and energy by measuring the thickness of predesigned windows fabricated in stereolithography with different ranges of Ec and Dp. Three-dimensional Scaffolds with various pore sizes, pore shapes, and porosities were designed in computer-aided design (CAD) software and were fabricated in stereolithography. The fabricated Scaffolds were characterized by measuring external dimensions, porosities, mean pore sizes, and compressive moduli and were compared to the CAD models. Feature accuracy in the xy-plane was achieved and overcuring of the resin in z-axis was minimized. The stereolithographically fabricated Scaffolds with controlled microstructures can be useful in diverse tissue Engineering applications.
Michael J. Yaszemski - One of the best experts on this subject based on the ideXlab platform.
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poly propylene fumarate bone tissue Engineering Scaffold fabrication using stereolithography effects of resin formulations and laser parameters
Biomacromolecules, 2007Co-Authors: Shanfeng Wang, Erik L. Ritman, Michael J. Yaszemski, Lichun LuAbstract:Stereolithography using photo-cross-linkable polymeric biomaterials is an effective technique for fabricating highly complex three-dimensional (3D) Scaffolds with controlled microstructures for tissue Engineering applications. In this study, we have optimized the UV curable polymer solution composition and laser parameters for the stereolithography machine. Poly(propylene fumarate) (PPF) was used as the biomaterial, diethyl fumarate (DEF) was used as the solvent, and bisacrylphosphrine oxide (BAPO) was used as the photoinitiator. Three different weight ratios of PPF/DEF and BAPO contents were characterized by measuring the viscosities and thermal properties of the un-cross-linked solutions and the mechanical properties of the formed Scaffolds. After optimizing the resin composition by satisfying both the viscosity limitation and the mechanical requirement, laser parameters such as critical exposure (Ec) and penetration depth (Dp) were determined from the working curve and the relationship between laser sp...
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Poly(propylene fumarate) bone tissue Engineering Scaffold fabrication using stereolithography: Effects of resin formulations and laser parameters
Biomacromolecules, 2007Co-Authors: Kee Won Lee, Bradley C. Fox, Shanfeng Wang, Erik L. Ritman, Michael J. Yaszemski, Lichun LuAbstract:Stereolithography using photo-cross-linkable polymeric biomaterials is an effective technique for fabricating highly complex three-dimensional (3D) Scaffolds with controlled microstructures for tissue Engineering applications. In this study, we have optimized the UV curable polymer solution composition and laser parameters for the stereolithography machine. Poly(propylene fumarate) (PPF) was used as the biomaterial, diethyl fumarate (DEF) was used as the solvent, and bisacrylphosphrine oxide (BAPO) was used as the photoinitiator. Three different weight ratios of PPF/DEF and BAPO contents were characterized by measuring the viscosities and thermal properties of the un-cross-linked solutions and the mechanical properties of the formed Scaffolds. After optimizing the resin composition by satisfying both the viscosity limitation and the mechanical requirement, laser parameters such as critical exposure (Ec) and penetration depth (Dp) were determined from the working curve and the relationship between laser speed and energy by measuring the thickness of predesigned windows fabricated in stereolithography with different ranges of Ec and Dp. Three-dimensional Scaffolds with various pore sizes, pore shapes, and porosities were designed in computer-aided design (CAD) software and were fabricated in stereolithography. The fabricated Scaffolds were characterized by measuring external dimensions, porosities, mean pore sizes, and compressive moduli and were compared to the CAD models. Feature accuracy in the xy-plane was achieved and overcuring of the resin in z-axis was minimized. The stereolithographically fabricated Scaffolds with controlled microstructures can be useful in diverse tissue Engineering applications.
Erik L. Ritman - One of the best experts on this subject based on the ideXlab platform.
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poly propylene fumarate bone tissue Engineering Scaffold fabrication using stereolithography effects of resin formulations and laser parameters
Biomacromolecules, 2007Co-Authors: Shanfeng Wang, Erik L. Ritman, Michael J. Yaszemski, Lichun LuAbstract:Stereolithography using photo-cross-linkable polymeric biomaterials is an effective technique for fabricating highly complex three-dimensional (3D) Scaffolds with controlled microstructures for tissue Engineering applications. In this study, we have optimized the UV curable polymer solution composition and laser parameters for the stereolithography machine. Poly(propylene fumarate) (PPF) was used as the biomaterial, diethyl fumarate (DEF) was used as the solvent, and bisacrylphosphrine oxide (BAPO) was used as the photoinitiator. Three different weight ratios of PPF/DEF and BAPO contents were characterized by measuring the viscosities and thermal properties of the un-cross-linked solutions and the mechanical properties of the formed Scaffolds. After optimizing the resin composition by satisfying both the viscosity limitation and the mechanical requirement, laser parameters such as critical exposure (Ec) and penetration depth (Dp) were determined from the working curve and the relationship between laser sp...
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Poly(propylene fumarate) bone tissue Engineering Scaffold fabrication using stereolithography: Effects of resin formulations and laser parameters
Biomacromolecules, 2007Co-Authors: Kee Won Lee, Bradley C. Fox, Shanfeng Wang, Erik L. Ritman, Michael J. Yaszemski, Lichun LuAbstract:Stereolithography using photo-cross-linkable polymeric biomaterials is an effective technique for fabricating highly complex three-dimensional (3D) Scaffolds with controlled microstructures for tissue Engineering applications. In this study, we have optimized the UV curable polymer solution composition and laser parameters for the stereolithography machine. Poly(propylene fumarate) (PPF) was used as the biomaterial, diethyl fumarate (DEF) was used as the solvent, and bisacrylphosphrine oxide (BAPO) was used as the photoinitiator. Three different weight ratios of PPF/DEF and BAPO contents were characterized by measuring the viscosities and thermal properties of the un-cross-linked solutions and the mechanical properties of the formed Scaffolds. After optimizing the resin composition by satisfying both the viscosity limitation and the mechanical requirement, laser parameters such as critical exposure (Ec) and penetration depth (Dp) were determined from the working curve and the relationship between laser speed and energy by measuring the thickness of predesigned windows fabricated in stereolithography with different ranges of Ec and Dp. Three-dimensional Scaffolds with various pore sizes, pore shapes, and porosities were designed in computer-aided design (CAD) software and were fabricated in stereolithography. The fabricated Scaffolds were characterized by measuring external dimensions, porosities, mean pore sizes, and compressive moduli and were compared to the CAD models. Feature accuracy in the xy-plane was achieved and overcuring of the resin in z-axis was minimized. The stereolithographically fabricated Scaffolds with controlled microstructures can be useful in diverse tissue Engineering applications.