The Experts below are selected from a list of 669 Experts worldwide ranked by ideXlab platform
Dip Hosp Clin Pharm Pract - One of the best experts on this subject based on the ideXlab platform.
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a guide to Enteral Drug Administration in palliative care
Journal of Pain and Symptom Management, 1999Co-Authors: Peter J Gilbar, Dip Hosp Clin Pharm PractAbstract:Abstract Enteral feeding is indicated in patients unable to ingest sufficient nutrients but whose gastrointestinal function is adequate for digestion and absorption. Indications in palliative care include patients with radical esophageal surgery, upper gastrointestinal tract obstruction, anorexia, and dysphagia. As the oral route is the preferred method of palliative Drug delivery, the Enteral feeding tube can become an important tool for Drug Administration. A number of questions must be asked before a Drug is considered for Enteral Administration. Firstly, is the Drug in a suitable dosage form for Administration? If not, can a different dosage form (or Drug) be substituted or can the physical form of the original product be altered? Secondly, is the Drug compatible with the Enteral feed? Finally, are there any complicating factors that may affect Drug absorption or clearance? This review attempts to answer these questions, provide easily understood guidelines for the successful Enteral Administration of medications, and discuss clinical implications for palliative care.
Peter J Gilbar - One of the best experts on this subject based on the ideXlab platform.
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a guide to Enteral Drug Administration in palliative care
Journal of Pain and Symptom Management, 1999Co-Authors: Peter J Gilbar, Dip Hosp Clin Pharm PractAbstract:Abstract Enteral feeding is indicated in patients unable to ingest sufficient nutrients but whose gastrointestinal function is adequate for digestion and absorption. Indications in palliative care include patients with radical esophageal surgery, upper gastrointestinal tract obstruction, anorexia, and dysphagia. As the oral route is the preferred method of palliative Drug delivery, the Enteral feeding tube can become an important tool for Drug Administration. A number of questions must be asked before a Drug is considered for Enteral Administration. Firstly, is the Drug in a suitable dosage form for Administration? If not, can a different dosage form (or Drug) be substituted or can the physical form of the original product be altered? Secondly, is the Drug compatible with the Enteral feed? Finally, are there any complicating factors that may affect Drug absorption or clearance? This review attempts to answer these questions, provide easily understood guidelines for the successful Enteral Administration of medications, and discuss clinical implications for palliative care.
F Fante - One of the best experts on this subject based on the ideXlab platform.
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Original Article Refinement of a macaque transplantation model: application
2016Co-Authors: F Fante, N Baldan, M Boldrin, Lucrezia Furian, Dino Sgarabotto, F Besenzon, D Ramon, G M De Benedictis, L Ravarotto, E CozziAbstract:of a subcutaneous port as a means for long-term Enteral Drug Administration and nutritional supplementatio
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refinement of a macaque transplantation model application of a subcutaneous port as a means for long term Enteral Drug Administration and nutritional supplementation
Laboratory Animals, 2012Co-Authors: F Fante, N Baldan, M Boldrin, Lucrezia Furian, Dino Sgarabotto, F Besenzon, D Ramon, Licia Ravarotto, Giulia Maria De Benedictis, Emanuele CozziAbstract:A new application of a device enabling the long-term Enteral Administration of Drugs or nutritional supplementation was developed for implementing in research entailing the use of macaques (Macaca fascicularis). After implanting a subcutaneous port, a surgically-placed gastrostomy (SPG) was completed to afford access to the gastric lumen and enable the Administration of substances. In this study, the device was left in place for a period ranging between two and 12 months in macaques (n ¼ 16). In five cases, the SPG was used successfully for 8‐12 months, until the experimental endpoint was reached. In six cases, the SPG had to be removed earlier due to local infection at the implant site, which promptly regressed after the SPG was removed and antibiotic treatment was administered. One SPG-implanted macaque was euthanized for reasons unrelated to the SPG or the xenotransplantation procedure. In four cases, the SPG was implanted without any complications but has yet to be used to administer substances to the animals. From an ethical standpoint, the SPG device described here minimizes the forced handling of macaques otherwise needed for the oral Administration of viscous or unpalatable substances by gavage. The device thus represents an effective refinement that fully complies with the tenet of the ‘3 Rs’ that should be considered by primate centres exposing non-human primates to the long-term daily Administration of substances by oral gavage.
N Baldan - One of the best experts on this subject based on the ideXlab platform.
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Original Article Refinement of a macaque transplantation model: application
2016Co-Authors: F Fante, N Baldan, M Boldrin, Lucrezia Furian, Dino Sgarabotto, F Besenzon, D Ramon, G M De Benedictis, L Ravarotto, E CozziAbstract:of a subcutaneous port as a means for long-term Enteral Drug Administration and nutritional supplementatio
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refinement of a macaque transplantation model application of a subcutaneous port as a means for long term Enteral Drug Administration and nutritional supplementation
Laboratory Animals, 2012Co-Authors: F Fante, N Baldan, M Boldrin, Lucrezia Furian, Dino Sgarabotto, F Besenzon, D Ramon, Licia Ravarotto, Giulia Maria De Benedictis, Emanuele CozziAbstract:A new application of a device enabling the long-term Enteral Administration of Drugs or nutritional supplementation was developed for implementing in research entailing the use of macaques (Macaca fascicularis). After implanting a subcutaneous port, a surgically-placed gastrostomy (SPG) was completed to afford access to the gastric lumen and enable the Administration of substances. In this study, the device was left in place for a period ranging between two and 12 months in macaques (n ¼ 16). In five cases, the SPG was used successfully for 8‐12 months, until the experimental endpoint was reached. In six cases, the SPG had to be removed earlier due to local infection at the implant site, which promptly regressed after the SPG was removed and antibiotic treatment was administered. One SPG-implanted macaque was euthanized for reasons unrelated to the SPG or the xenotransplantation procedure. In four cases, the SPG was implanted without any complications but has yet to be used to administer substances to the animals. From an ethical standpoint, the SPG device described here minimizes the forced handling of macaques otherwise needed for the oral Administration of viscous or unpalatable substances by gavage. The device thus represents an effective refinement that fully complies with the tenet of the ‘3 Rs’ that should be considered by primate centres exposing non-human primates to the long-term daily Administration of substances by oral gavage.
M Boldrin - One of the best experts on this subject based on the ideXlab platform.
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Original Article Refinement of a macaque transplantation model: application
2016Co-Authors: F Fante, N Baldan, M Boldrin, Lucrezia Furian, Dino Sgarabotto, F Besenzon, D Ramon, G M De Benedictis, L Ravarotto, E CozziAbstract:of a subcutaneous port as a means for long-term Enteral Drug Administration and nutritional supplementatio
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refinement of a macaque transplantation model application of a subcutaneous port as a means for long term Enteral Drug Administration and nutritional supplementation
Laboratory Animals, 2012Co-Authors: F Fante, N Baldan, M Boldrin, Lucrezia Furian, Dino Sgarabotto, F Besenzon, D Ramon, Licia Ravarotto, Giulia Maria De Benedictis, Emanuele CozziAbstract:A new application of a device enabling the long-term Enteral Administration of Drugs or nutritional supplementation was developed for implementing in research entailing the use of macaques (Macaca fascicularis). After implanting a subcutaneous port, a surgically-placed gastrostomy (SPG) was completed to afford access to the gastric lumen and enable the Administration of substances. In this study, the device was left in place for a period ranging between two and 12 months in macaques (n ¼ 16). In five cases, the SPG was used successfully for 8‐12 months, until the experimental endpoint was reached. In six cases, the SPG had to be removed earlier due to local infection at the implant site, which promptly regressed after the SPG was removed and antibiotic treatment was administered. One SPG-implanted macaque was euthanized for reasons unrelated to the SPG or the xenotransplantation procedure. In four cases, the SPG was implanted without any complications but has yet to be used to administer substances to the animals. From an ethical standpoint, the SPG device described here minimizes the forced handling of macaques otherwise needed for the oral Administration of viscous or unpalatable substances by gavage. The device thus represents an effective refinement that fully complies with the tenet of the ‘3 Rs’ that should be considered by primate centres exposing non-human primates to the long-term daily Administration of substances by oral gavage.