The Experts below are selected from a list of 24813 Experts worldwide ranked by ideXlab platform
H. K. Geiss - One of the best experts on this subject based on the ideXlab platform.
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Varying linezolid susceptibility of vancomycin-resistant Enterococcus faecium isolates during therapy: a case report
The Journal of antimicrobial chemotherapy, 2005Co-Authors: Stefanie Swoboda, Stefan Fritz, M. E. Martignoni, Rita Feldhues, Torsten Hoppe-tichy, Markus W. Büchler, H. K. GeissAbstract:Objectives: Linezolid is an oxazolidinone antibiotic used in the treatment of infections caused by vancomycin-resistant enterococci. Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. Patient and methods: We present clinical details and susceptibility data from multiple Enterococcus faecium strains isolated from a liver transplant patient over 13 months. MICs of linezolid, vancomycin and quinupristin/dalfopristin were determined using Etest. Molecular typing was performed by pulsedfield gel electrophoresis. Domain V of the 23S rRNA gene in the vancomycin-resistant Enterococcus faecium was amplified. Linezolid concentrations were analysed by HPLC. Results: We report the emergence of resistance to linezolid in a vancomycin-resistant Enterococcus faecium during linezolid treatment. After discontinuation of the linezolid therapy, the isolate reverted to susceptibility. However, after re-administration of linezolid the vancomycin-resistant Enterococcus faecium became resistant to linezolid again. The isolates that were resistant to linezolid had a G2576T mutation in their 23S rDNA. Conclusion: We describe a clinical case that shows the shift of a vancomycin-resistant Enterococcus faecium from linezolid resistance to susceptibility and then back to resistance again related to linezolid therapy.
Åsa Melhus - One of the best experts on this subject based on the ideXlab platform.
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The Initial Epidemiology of a Major Clonal Outbreak Caused by VanB-Carrying Enterococcus faecium Clone ST192
2018Co-Authors: Gustaf Starlander, Christian Tellgren-roth, Susanne Sütterlin, Åsa MelhusAbstract:The Initial Epidemiology of a Major Clonal Outbreak Caused by VanB-Carrying Enterococcus faecium Clone ST192
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Fatal acquisition of vanD gene during vancomycin treatment of septicaemia caused by Enterococcus faecium
The Journal of hospital infection, 2016Co-Authors: Gustaf Starlander, Christian Tellgren-roth, Åsa MelhusAbstract:Fatal acquisition of vanD gene during vancomycin treatment of septicaemia caused by Enterococcus faecium
Nancy Khardori - One of the best experts on this subject based on the ideXlab platform.
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Treatment of central nervous system infection by vancomycin-resistant Enterococcus faecium
Diagnostic microbiology and infectious disease, 2003Co-Authors: Termkiat Kanchanapoom, Janak Koirala, James Goodrich, Edem Agamah, Nancy KhardoriAbstract:Enterococci are uncommon causes of CNS infection. We describe a case of ventriculitis and Ommaya reservoir infection due to vancomycin-resistant Enterococcus faecium successfully treated with the combination of i.v. quinupristin/dalfopristin and i.v. linezolid. The patient deteriorated after receiving three dosages of intraventricular quinupristin/dalfopristin. He recovered after discontinuation of intraventricular quinupristin/dalfopristin.
Lisa Saiman - One of the best experts on this subject based on the ideXlab platform.
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Linezolid treatment of vancomycin-resistant Enterococcus faecium ventriculitis
The Pediatric infectious disease journal, 2002Co-Authors: Philip L. Graham, Krow Ampofo, Lisa SaimanAbstract:The successful treatment of a 7-month-old infant with shunt-associated ventriculitis caused by vancomycin-resistant Enterococcus faecium is presented. Linezolid was administered intravenously every 8 h; children have a greater volume of distribution and total body clearance than adults and therefore require more frequent dosing. The patient tolerated the therapy without adverse effects.
David J Nisbe - One of the best experts on this subject based on the ideXlab platform.
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methylsulfonylmethane exhibits bacteriostatic inhibition of vancomycin resistant Enterococcus faecium in vitro
Microbial Drug Resistance, 2020Co-Authors: T L Poole, Rodney Enjami, Kenneth J Genovese, David J NisbeAbstract:The aim of this study was to evaluate the antibacterial properties of methylsulfonylmethane (MSM) on vancomycin-resistant Enterococcus faecium (VRE). Bacterial proliferation was measured spectropho...