The Experts below are selected from a list of 8520 Experts worldwide ranked by ideXlab platform
Utpal Tatu - One of the best experts on this subject based on the ideXlab platform.
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recurrent fever promotes plasmodium falciparum development in human erythrocytes
Journal of Biological Chemistry, 2004Co-Authors: Soundara Raghavan Pavithra, Gowrishankar Banumathy, Omana Joy, Varsha Singh, Utpal TatuAbstract:The human malarial parasite Plasmodium falciparum (Pf) is exposed to wide temperature fluctuations during its life cycle, ranging from 25 °C in the mosquito vector and 37 °C in humans to 41 °C during febrile episodes in the patient. The repeated occurrence of fever at regular intervals is a characteristic of human malaria. We have examined the influence of repeated exposure to elevated temperatures encountered during fever on the intraerythrocytic development of the parasite. Using flow cytometry, we show that repeated exposure to temperatures mimicking febrile episodes promotes parasite development in human erythrocytes. Heat shock-mediated cytoprotection and growth promotion is dependent on the heat shock protein 90 (PfHsp90) multi-chaperone complex. Inhibition of PfHsp90 function using geldanamycin attenuates temperature-dependent progression from the ring to the trophozoite stage. Geldanamycin inhibits parasite development by disrupting the Pf- Hsp90 complex consisting of PfHsp70, PfPP5, and tubulin,among other proteins. While explaining the contribution of febrile episodes to the pathogenesis of malaria, our results implicate temperature as an important Environmental Cue used by the parasite to coordinate its development in humans.
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recurrent fever promotes plasmodium falciparum development in human erythrocytes
Journal of Biological Chemistry, 2004Co-Authors: Soundara Raghavan Pavithra, Gowrishankar Banumathy, Omana Joy, Varsha Singh, Utpal TatuAbstract:The human malarial parasite Plasmodium falciparum (Pf) is exposed to wide temperature fluctuations during its life cycle, ranging from 25 degrees C in the mosquito vector and 37 degrees C in humans to 41 degrees C during febrile episodes in the patient. The repeated occurrence of fever at regular intervals is a characteristic of human malaria. We have examined the influence of repeated exposure to elevated temperatures encountered during fever on the intraerythrocytic development of the parasite. Using flow cytometry, we show that repeated exposure to temperatures mimicking febrile episodes promotes parasite development in human erythrocytes. Heat shock-mediated cytoprotection and growth promotion is dependent on the heat shock protein 90 (PfHsp90) multi-chaperone complex. Inhibition of PfHsp90 function using geldanamycin attenuates temperature-dependent progression from the ring to the trophozoite stage. Geldanamycin inhibits parasite development by disrupting the PfHsp90 complex consisting of PfHsp70, PfPP5, and tubulin, among other proteins. While explaining the contribution of febrile episodes to the pathogenesis of malaria, our results implicate temperature as an important Environmental Cue used by the parasite to coordinate its development in humans.
Soundara Raghavan Pavithra - One of the best experts on this subject based on the ideXlab platform.
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recurrent fever promotes plasmodium falciparum development in human erythrocytes
Journal of Biological Chemistry, 2004Co-Authors: Soundara Raghavan Pavithra, Gowrishankar Banumathy, Omana Joy, Varsha Singh, Utpal TatuAbstract:The human malarial parasite Plasmodium falciparum (Pf) is exposed to wide temperature fluctuations during its life cycle, ranging from 25 °C in the mosquito vector and 37 °C in humans to 41 °C during febrile episodes in the patient. The repeated occurrence of fever at regular intervals is a characteristic of human malaria. We have examined the influence of repeated exposure to elevated temperatures encountered during fever on the intraerythrocytic development of the parasite. Using flow cytometry, we show that repeated exposure to temperatures mimicking febrile episodes promotes parasite development in human erythrocytes. Heat shock-mediated cytoprotection and growth promotion is dependent on the heat shock protein 90 (PfHsp90) multi-chaperone complex. Inhibition of PfHsp90 function using geldanamycin attenuates temperature-dependent progression from the ring to the trophozoite stage. Geldanamycin inhibits parasite development by disrupting the Pf- Hsp90 complex consisting of PfHsp70, PfPP5, and tubulin,among other proteins. While explaining the contribution of febrile episodes to the pathogenesis of malaria, our results implicate temperature as an important Environmental Cue used by the parasite to coordinate its development in humans.
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recurrent fever promotes plasmodium falciparum development in human erythrocytes
Journal of Biological Chemistry, 2004Co-Authors: Soundara Raghavan Pavithra, Gowrishankar Banumathy, Omana Joy, Varsha Singh, Utpal TatuAbstract:The human malarial parasite Plasmodium falciparum (Pf) is exposed to wide temperature fluctuations during its life cycle, ranging from 25 degrees C in the mosquito vector and 37 degrees C in humans to 41 degrees C during febrile episodes in the patient. The repeated occurrence of fever at regular intervals is a characteristic of human malaria. We have examined the influence of repeated exposure to elevated temperatures encountered during fever on the intraerythrocytic development of the parasite. Using flow cytometry, we show that repeated exposure to temperatures mimicking febrile episodes promotes parasite development in human erythrocytes. Heat shock-mediated cytoprotection and growth promotion is dependent on the heat shock protein 90 (PfHsp90) multi-chaperone complex. Inhibition of PfHsp90 function using geldanamycin attenuates temperature-dependent progression from the ring to the trophozoite stage. Geldanamycin inhibits parasite development by disrupting the PfHsp90 complex consisting of PfHsp70, PfPP5, and tubulin, among other proteins. While explaining the contribution of febrile episodes to the pathogenesis of malaria, our results implicate temperature as an important Environmental Cue used by the parasite to coordinate its development in humans.
Daryl P Shanley - One of the best experts on this subject based on the ideXlab platform.
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the predictive adaptive response modeling the life history evolution of the butterfly bicyclus anynana in seasonal environments
The American Naturalist, 2013Co-Authors: Joost Van Den Heuvel, Marjo Saastamoinen, Bas J Zwaan, Thomas B. L. Kirkwood, Paul M. Brakefield, Daryl P ShanleyAbstract:Abstract A predictive adaptive response (PAR) is a type of developmental plasticity where the response to an Environmental Cue is not immediately advantageous but instead is later in life. The PAR is a way for organisms to maximize fitness in varying environments. Insects living in seasonal environments are valuable model systems for testing the existence and form of PAR. Previous manipulations of the larval and the adult environments of the butterfly Bicyclus anynana have shown that individuals that were food restricted during the larval stage coped better with forced flight during the adult stage compared to those with optimal conditions in the larval stage. Here, we describe a state-dependent energy allocation model, which we use to test whether such a response to food restriction could be adaptive in nature where this butterfly exhibits seasonal cycles. The results from the model confirm the responses obtained in our previous experimental work and show how such an outcome was facilitated by resource a...
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The predictive adaptive response: modeling the life-history evolution of the butterfly Bicyclus anynana in seasonal environments.
The American Naturalist, 2013Co-Authors: Joost Van Den Heuvel, Marjo Saastamoinen, Bas J Zwaan, Thomas B. L. Kirkwood, Paul M. Brakefield, Daryl P ShanleyAbstract:A predictive adaptive response (PAR) is a type of developmental plasticity where the response to an Environmental Cue is not immediately advantageous but instead is later in life. The PAR is a way for organisms to maximize fitness in varying environments. Insects living in seasonal environments are valuable model systems for testing the existence and form of PAR. Previous manipulations of the larval and the adult environments of the butterfly Bicyclus anynana have shown that individuals that were food restricted during the larval stage coped better with forced flight during the adult stage compared to those with optimal conditions in the larval stage. Here, we describe a state-dependent energy allocation model, which we use to test whether such a response to food restriction could be adaptive in nature where this butterfly exhibits seasonal cycles. The results from the model confirm the responses obtained in our previous experimental work and show how such an outcome was facilitated by resource allocation patterns to the thorax during the pupal stage. We conclude that for B. anynana, early-stage Cues can direct development toward a better adapted phenotype later in life and, therefore, that a PAR has evolved in this species.
Omana Joy - One of the best experts on this subject based on the ideXlab platform.
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recurrent fever promotes plasmodium falciparum development in human erythrocytes
Journal of Biological Chemistry, 2004Co-Authors: Soundara Raghavan Pavithra, Gowrishankar Banumathy, Omana Joy, Varsha Singh, Utpal TatuAbstract:The human malarial parasite Plasmodium falciparum (Pf) is exposed to wide temperature fluctuations during its life cycle, ranging from 25 °C in the mosquito vector and 37 °C in humans to 41 °C during febrile episodes in the patient. The repeated occurrence of fever at regular intervals is a characteristic of human malaria. We have examined the influence of repeated exposure to elevated temperatures encountered during fever on the intraerythrocytic development of the parasite. Using flow cytometry, we show that repeated exposure to temperatures mimicking febrile episodes promotes parasite development in human erythrocytes. Heat shock-mediated cytoprotection and growth promotion is dependent on the heat shock protein 90 (PfHsp90) multi-chaperone complex. Inhibition of PfHsp90 function using geldanamycin attenuates temperature-dependent progression from the ring to the trophozoite stage. Geldanamycin inhibits parasite development by disrupting the Pf- Hsp90 complex consisting of PfHsp70, PfPP5, and tubulin,among other proteins. While explaining the contribution of febrile episodes to the pathogenesis of malaria, our results implicate temperature as an important Environmental Cue used by the parasite to coordinate its development in humans.
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recurrent fever promotes plasmodium falciparum development in human erythrocytes
Journal of Biological Chemistry, 2004Co-Authors: Soundara Raghavan Pavithra, Gowrishankar Banumathy, Omana Joy, Varsha Singh, Utpal TatuAbstract:The human malarial parasite Plasmodium falciparum (Pf) is exposed to wide temperature fluctuations during its life cycle, ranging from 25 degrees C in the mosquito vector and 37 degrees C in humans to 41 degrees C during febrile episodes in the patient. The repeated occurrence of fever at regular intervals is a characteristic of human malaria. We have examined the influence of repeated exposure to elevated temperatures encountered during fever on the intraerythrocytic development of the parasite. Using flow cytometry, we show that repeated exposure to temperatures mimicking febrile episodes promotes parasite development in human erythrocytes. Heat shock-mediated cytoprotection and growth promotion is dependent on the heat shock protein 90 (PfHsp90) multi-chaperone complex. Inhibition of PfHsp90 function using geldanamycin attenuates temperature-dependent progression from the ring to the trophozoite stage. Geldanamycin inhibits parasite development by disrupting the PfHsp90 complex consisting of PfHsp70, PfPP5, and tubulin, among other proteins. While explaining the contribution of febrile episodes to the pathogenesis of malaria, our results implicate temperature as an important Environmental Cue used by the parasite to coordinate its development in humans.
Gowrishankar Banumathy - One of the best experts on this subject based on the ideXlab platform.
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recurrent fever promotes plasmodium falciparum development in human erythrocytes
Journal of Biological Chemistry, 2004Co-Authors: Soundara Raghavan Pavithra, Gowrishankar Banumathy, Omana Joy, Varsha Singh, Utpal TatuAbstract:The human malarial parasite Plasmodium falciparum (Pf) is exposed to wide temperature fluctuations during its life cycle, ranging from 25 °C in the mosquito vector and 37 °C in humans to 41 °C during febrile episodes in the patient. The repeated occurrence of fever at regular intervals is a characteristic of human malaria. We have examined the influence of repeated exposure to elevated temperatures encountered during fever on the intraerythrocytic development of the parasite. Using flow cytometry, we show that repeated exposure to temperatures mimicking febrile episodes promotes parasite development in human erythrocytes. Heat shock-mediated cytoprotection and growth promotion is dependent on the heat shock protein 90 (PfHsp90) multi-chaperone complex. Inhibition of PfHsp90 function using geldanamycin attenuates temperature-dependent progression from the ring to the trophozoite stage. Geldanamycin inhibits parasite development by disrupting the Pf- Hsp90 complex consisting of PfHsp70, PfPP5, and tubulin,among other proteins. While explaining the contribution of febrile episodes to the pathogenesis of malaria, our results implicate temperature as an important Environmental Cue used by the parasite to coordinate its development in humans.
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recurrent fever promotes plasmodium falciparum development in human erythrocytes
Journal of Biological Chemistry, 2004Co-Authors: Soundara Raghavan Pavithra, Gowrishankar Banumathy, Omana Joy, Varsha Singh, Utpal TatuAbstract:The human malarial parasite Plasmodium falciparum (Pf) is exposed to wide temperature fluctuations during its life cycle, ranging from 25 degrees C in the mosquito vector and 37 degrees C in humans to 41 degrees C during febrile episodes in the patient. The repeated occurrence of fever at regular intervals is a characteristic of human malaria. We have examined the influence of repeated exposure to elevated temperatures encountered during fever on the intraerythrocytic development of the parasite. Using flow cytometry, we show that repeated exposure to temperatures mimicking febrile episodes promotes parasite development in human erythrocytes. Heat shock-mediated cytoprotection and growth promotion is dependent on the heat shock protein 90 (PfHsp90) multi-chaperone complex. Inhibition of PfHsp90 function using geldanamycin attenuates temperature-dependent progression from the ring to the trophozoite stage. Geldanamycin inhibits parasite development by disrupting the PfHsp90 complex consisting of PfHsp70, PfPP5, and tubulin, among other proteins. While explaining the contribution of febrile episodes to the pathogenesis of malaria, our results implicate temperature as an important Environmental Cue used by the parasite to coordinate its development in humans.