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Thomas Heberer - One of the best experts on this subject based on the ideXlab platform.

  • human health risk assessment hhra for Environmental Development and transfer of antibiotic resistance
    Environmental Health Perspectives, 2013
    Co-Authors: Nicholas J Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer
    Abstract:

    Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens. Methods: The authors participated in a workshop held 4–8 March 2012 in Quebec, Canada, to define the scope and objectives of an Environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of Environmental-resistance-Development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. Discussion: Various novel aspects to traditional risk assessments were identified to enable an assessment of Environmental antibiotic resistance. These include a) accounting for an added selective pressure on the Environmental resistome that, over time, allows for Development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant Environmental “hot spot” compartments; and c) modifying traditional dose–response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that Environmental aspects of antibiotic-resistance Development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of Environmental antibiotic resistance that informs risk managers. Citation: Ashbolt NJ, Amezquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schonfeld J, Silley P, Snape JR, Van den Eede C, Topp E. 2013. Human health risk assessment (HHRA) for Environmental Development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001; http://dx.doi.org/10.1289/ehp.1206316

  • human health risk assessment hhra for Environmental Development and transfer of antibiotic resistance
    Environmental Health Perspectives, 2013
    Co-Authors: Nicholas J Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer
    Abstract:

    Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens. Methods: The authors participated in a workshop held 4–8 March 2012 in Quebec, Canada, to define the scope and objectives of an Environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of Environmental-resistance-Development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. Discussion: Various novel aspects to traditional risk assessments were identified to enable an assessment of Environmental antibiotic resistance. These include a) accounting for an added selective pressure on the Environmental resistome that, over time, allows for Development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant Environmental “hot spot” compartments; and c) modifying traditional dose–response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that Environmental aspects of antibiotic-resistance Development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of Environmental antibiotic resistance that informs risk managers. Citation: Ashbolt NJ, Amezquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schonfeld J, Silley P, Snape JR, Van den Eede C, Topp E. 2013. Human health risk assessment (HHRA) for Environmental Development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001; http://dx.doi.org/10.1289/ehp.1206316

Nicholas J Ashbolt - One of the best experts on this subject based on the ideXlab platform.

  • human health risk assessment hhra for Environmental Development and transfer of antibiotic resistance
    Environmental Health Perspectives, 2013
    Co-Authors: Nicholas J Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer
    Abstract:

    Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens. Methods: The authors participated in a workshop held 4–8 March 2012 in Quebec, Canada, to define the scope and objectives of an Environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of Environmental-resistance-Development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. Discussion: Various novel aspects to traditional risk assessments were identified to enable an assessment of Environmental antibiotic resistance. These include a) accounting for an added selective pressure on the Environmental resistome that, over time, allows for Development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant Environmental “hot spot” compartments; and c) modifying traditional dose–response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that Environmental aspects of antibiotic-resistance Development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of Environmental antibiotic resistance that informs risk managers. Citation: Ashbolt NJ, Amezquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schonfeld J, Silley P, Snape JR, Van den Eede C, Topp E. 2013. Human health risk assessment (HHRA) for Environmental Development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001; http://dx.doi.org/10.1289/ehp.1206316

  • human health risk assessment hhra for Environmental Development and transfer of antibiotic resistance
    Environmental Health Perspectives, 2013
    Co-Authors: Nicholas J Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer
    Abstract:

    Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens. Methods: The authors participated in a workshop held 4–8 March 2012 in Quebec, Canada, to define the scope and objectives of an Environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of Environmental-resistance-Development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. Discussion: Various novel aspects to traditional risk assessments were identified to enable an assessment of Environmental antibiotic resistance. These include a) accounting for an added selective pressure on the Environmental resistome that, over time, allows for Development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant Environmental “hot spot” compartments; and c) modifying traditional dose–response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that Environmental aspects of antibiotic-resistance Development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of Environmental antibiotic resistance that informs risk managers. Citation: Ashbolt NJ, Amezquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schonfeld J, Silley P, Snape JR, Van den Eede C, Topp E. 2013. Human health risk assessment (HHRA) for Environmental Development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001; http://dx.doi.org/10.1289/ehp.1206316

William H Gaze - One of the best experts on this subject based on the ideXlab platform.

  • human health risk assessment hhra for Environmental Development and transfer of antibiotic resistance
    Environmental Health Perspectives, 2013
    Co-Authors: Nicholas J Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer
    Abstract:

    Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens. Methods: The authors participated in a workshop held 4–8 March 2012 in Quebec, Canada, to define the scope and objectives of an Environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of Environmental-resistance-Development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. Discussion: Various novel aspects to traditional risk assessments were identified to enable an assessment of Environmental antibiotic resistance. These include a) accounting for an added selective pressure on the Environmental resistome that, over time, allows for Development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant Environmental “hot spot” compartments; and c) modifying traditional dose–response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that Environmental aspects of antibiotic-resistance Development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of Environmental antibiotic resistance that informs risk managers. Citation: Ashbolt NJ, Amezquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schonfeld J, Silley P, Snape JR, Van den Eede C, Topp E. 2013. Human health risk assessment (HHRA) for Environmental Development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001; http://dx.doi.org/10.1289/ehp.1206316

  • human health risk assessment hhra for Environmental Development and transfer of antibiotic resistance
    Environmental Health Perspectives, 2013
    Co-Authors: Nicholas J Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer
    Abstract:

    Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens. Methods: The authors participated in a workshop held 4–8 March 2012 in Quebec, Canada, to define the scope and objectives of an Environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of Environmental-resistance-Development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. Discussion: Various novel aspects to traditional risk assessments were identified to enable an assessment of Environmental antibiotic resistance. These include a) accounting for an added selective pressure on the Environmental resistome that, over time, allows for Development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant Environmental “hot spot” compartments; and c) modifying traditional dose–response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that Environmental aspects of antibiotic-resistance Development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of Environmental antibiotic resistance that informs risk managers. Citation: Ashbolt NJ, Amezquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schonfeld J, Silley P, Snape JR, Van den Eede C, Topp E. 2013. Human health risk assessment (HHRA) for Environmental Development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001; http://dx.doi.org/10.1289/ehp.1206316

Rita Finley - One of the best experts on this subject based on the ideXlab platform.

  • human health risk assessment hhra for Environmental Development and transfer of antibiotic resistance
    Environmental Health Perspectives, 2013
    Co-Authors: Nicholas J Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer
    Abstract:

    Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens. Methods: The authors participated in a workshop held 4–8 March 2012 in Quebec, Canada, to define the scope and objectives of an Environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of Environmental-resistance-Development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. Discussion: Various novel aspects to traditional risk assessments were identified to enable an assessment of Environmental antibiotic resistance. These include a) accounting for an added selective pressure on the Environmental resistome that, over time, allows for Development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant Environmental “hot spot” compartments; and c) modifying traditional dose–response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that Environmental aspects of antibiotic-resistance Development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of Environmental antibiotic resistance that informs risk managers. Citation: Ashbolt NJ, Amezquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schonfeld J, Silley P, Snape JR, Van den Eede C, Topp E. 2013. Human health risk assessment (HHRA) for Environmental Development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001; http://dx.doi.org/10.1289/ehp.1206316

  • human health risk assessment hhra for Environmental Development and transfer of antibiotic resistance
    Environmental Health Perspectives, 2013
    Co-Authors: Nicholas J Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer
    Abstract:

    Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens. Methods: The authors participated in a workshop held 4–8 March 2012 in Quebec, Canada, to define the scope and objectives of an Environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of Environmental-resistance-Development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. Discussion: Various novel aspects to traditional risk assessments were identified to enable an assessment of Environmental antibiotic resistance. These include a) accounting for an added selective pressure on the Environmental resistome that, over time, allows for Development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant Environmental “hot spot” compartments; and c) modifying traditional dose–response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that Environmental aspects of antibiotic-resistance Development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of Environmental antibiotic resistance that informs risk managers. Citation: Ashbolt NJ, Amezquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schonfeld J, Silley P, Snape JR, Van den Eede C, Topp E. 2013. Human health risk assessment (HHRA) for Environmental Development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001; http://dx.doi.org/10.1289/ehp.1206316

Anja Coors - One of the best experts on this subject based on the ideXlab platform.

  • human health risk assessment hhra for Environmental Development and transfer of antibiotic resistance
    Environmental Health Perspectives, 2013
    Co-Authors: Nicholas J Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer
    Abstract:

    Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens. Methods: The authors participated in a workshop held 4–8 March 2012 in Quebec, Canada, to define the scope and objectives of an Environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of Environmental-resistance-Development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. Discussion: Various novel aspects to traditional risk assessments were identified to enable an assessment of Environmental antibiotic resistance. These include a) accounting for an added selective pressure on the Environmental resistome that, over time, allows for Development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant Environmental “hot spot” compartments; and c) modifying traditional dose–response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that Environmental aspects of antibiotic-resistance Development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of Environmental antibiotic resistance that informs risk managers. Citation: Ashbolt NJ, Amezquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schonfeld J, Silley P, Snape JR, Van den Eede C, Topp E. 2013. Human health risk assessment (HHRA) for Environmental Development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001; http://dx.doi.org/10.1289/ehp.1206316

  • human health risk assessment hhra for Environmental Development and transfer of antibiotic resistance
    Environmental Health Perspectives, 2013
    Co-Authors: Nicholas J Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer
    Abstract:

    Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens. Methods: The authors participated in a workshop held 4–8 March 2012 in Quebec, Canada, to define the scope and objectives of an Environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of Environmental-resistance-Development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. Discussion: Various novel aspects to traditional risk assessments were identified to enable an assessment of Environmental antibiotic resistance. These include a) accounting for an added selective pressure on the Environmental resistome that, over time, allows for Development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant Environmental “hot spot” compartments; and c) modifying traditional dose–response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that Environmental aspects of antibiotic-resistance Development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of Environmental antibiotic resistance that informs risk managers. Citation: Ashbolt NJ, Amezquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DG, McEwen SA, Ryan JJ, Schonfeld J, Silley P, Snape JR, Van den Eede C, Topp E. 2013. Human health risk assessment (HHRA) for Environmental Development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001; http://dx.doi.org/10.1289/ehp.1206316