The Experts below are selected from a list of 52977 Experts worldwide ranked by ideXlab platform
Matthew J Budoff - One of the best experts on this subject based on the ideXlab platform.
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abstract mp82 the effect of nicotinic acetylcholine receptor genes chrna3 5 on thoracic aortic calcium is mediated by smoking
Circulation, 2016Co-Authors: Sharon M Lutz, G L Kinney, Kendra A Young, Katherine A Pratte, Lindsey M Duca, Marilyn G Foreman, Terri H Beaty, Ed Silverman, Matthew J Budoff, John E. HokansonAbstract:Introduction: Coronary artery calcium (CAC) and thoracic aortic calcium (TAC), markers of subclinical atherosclerosis, have been shown to strongly correlate with the amount of atheromatous plaque and subsequently predict future coronary disease events and mortality. CAC and TAC are complex heritable traits with both genetic and Environmental Risk Factors such as cigarette smoking. We investigated the role of smoking, a key Environmental Risk Factor, as a mediator of the genetic Risk of subclinical atherosclerosis in the COPDGene study. Hypothesis: We hypothesized that smoking will mediate a portion of the genome-wide significant SNPs with subclinical atherosclerosis as measured by TAC and CAC. Methods: We performed genome wide genotyping of common and rare variants in COPDGene, a study of 10,192 current and former smokers with at least 10 pack-years of smoking history. CAC and TAC were measured using high dose, inspiration chest CT scans, following an established protocol in 8,739 individuals (6,150 non-H...
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Abstract MP82: The Effect of Nicotinic Acetylcholine Receptor Genes CHRNA3/5 on Thoracic Aortic Calcium is Mediated by Smoking
Circulation, 2016Co-Authors: Sharon M Lutz, G L Kinney, Kendra A Young, Katherine A Pratte, Lindsey M Duca, Marilyn G Foreman, Terri H Beaty, Ed Silverman, Matthew J BudoffAbstract:Introduction: Coronary artery calcium (CAC) and thoracic aortic calcium (TAC), markers of subclinical atherosclerosis, have been shown to strongly correlate with the amount of atheromatous plaque and subsequently predict future coronary disease events and mortality. CAC and TAC are complex heritable traits with both genetic and Environmental Risk Factors such as cigarette smoking. We investigated the role of smoking, a key Environmental Risk Factor, as a mediator of the genetic Risk of subclinical atherosclerosis in the COPDGene study. Hypothesis: We hypothesized that smoking will mediate a portion of the genome-wide significant SNPs with subclinical atherosclerosis as measured by TAC and CAC. Methods: We performed genome wide genotyping of common and rare variants in COPDGene, a study of 10,192 current and former smokers with at least 10 pack-years of smoking history. CAC and TAC were measured using high dose, inspiration chest CT scans, following an established protocol in 8,739 individuals (6,150 non-H...
Robert Plomin - One of the best experts on this subject based on the ideXlab platform.
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negative parental discipline conduct problems and callous unemotional traits monozygotic twin differences study
British Journal of Psychiatry, 2009Co-Authors: Essi Viding, Nathalie M. G. Fontaine, Bonamy R. Oliver, Robert PlominAbstract:Negative parental discipline is associated with increased Risk of conduct problems. 1 Children who grow up in the same family can face markedly different parental discipline 2 and previous data using the monozygotic (MZ) twin differences design confirm that differences in negative parental discipline are a non-shared Environmental Risk Factor associated with differences in the level of concurrent conduct problems. 3 Longitudinal MZ twin differences data also suggest that maternal negative emotional attitudes towards children at age 5 may be a causal Environmental Factor for the development of subsequent conduct problems at age 7. 4 To our knowledge, no research to date has used the MZ twin differences design to assess whether differences in negative parental discipline represent a possible causal Environmental Factor for the development of conduct problems. Moreover, no MZ twin differences studies have been conducted to assess whether negative parental discipline is a non-shared Environmental Factor contributing to the development of callous–unemotional traits. Callous–unemotional traits are a well-documented temperamental
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Negative parental discipline, conduct problems and callous–unemotional traits: monozygotic twin differences study
The British journal of psychiatry : the journal of mental science, 2009Co-Authors: Essi Viding, Nathalie M. G. Fontaine, Bonamy R. Oliver, Robert PlominAbstract:Negative parental discipline is associated with increased Risk of conduct problems. 1 Children who grow up in the same family can face markedly different parental discipline 2 and previous data using the monozygotic (MZ) twin differences design confirm that differences in negative parental discipline are a non-shared Environmental Risk Factor associated with differences in the level of concurrent conduct problems. 3 Longitudinal MZ twin differences data also suggest that maternal negative emotional attitudes towards children at age 5 may be a causal Environmental Factor for the development of subsequent conduct problems at age 7. 4 To our knowledge, no research to date has used the MZ twin differences design to assess whether differences in negative parental discipline represent a possible causal Environmental Factor for the development of conduct problems. Moreover, no MZ twin differences studies have been conducted to assess whether negative parental discipline is a non-shared Environmental Factor contributing to the development of callous–unemotional traits. Callous–unemotional traits are a well-documented temperamental
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reading exposure a largely Environmental Risk Factor with Environmentally mediated effects on reading performance in the primary school years
Journal of Child Psychology and Psychiatry, 2007Co-Authors: Nicole Harlaar, Philip S Dale, Robert PlominAbstract:Background: It is widely believed that there are reciprocal links between reading achievement and reading exposure: children who read more do better at reading, and reading achievement itself promotes reading. We tested the hypotheses that these links arise because children's genetically influenced reading performance is correlated with their leisure-time reading exposure, and reading exposure, in turn, may have an Environmentally mediated effect on later reading performance. Method: The sample consisted of 3039 twin pairs from the UK Twins Early Development Study (TEDS). Reading exposure was assessed at age 10 using the Author Recognition Test (ART). Reading performance was assessed at ages 7 and 12 using the Test of Word Reading Efficiency (TOWRE). Results: ART scores were moderately correlated with TOWRE scores at ages 7 and 12. Shared Environmental variance in 7-year TOWRE performance accounted for most of the contribution made by 7-year TOWRE scores to the prediction of 10-year ART scores. Genetic influences on ART scores were modest, but this genetic variance almost completely reflected genetic variance in 7-year TOWRE scores. After controlling for genetic and Environmental influences that overlapped between 7-year TOWRE and 10-year ART scores, there was evidence for a separate link between 10-year ART and 12-year TOWRE that was due to shared Environmental influences. Conclusions: Genetic influences on early reading achievement contribute to later propensities to seek out reading experiences that might, in turn, reciprocally influence reading achievement through shared Environmental paths.
Sharon M Lutz - One of the best experts on this subject based on the ideXlab platform.
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abstract mp82 the effect of nicotinic acetylcholine receptor genes chrna3 5 on thoracic aortic calcium is mediated by smoking
Circulation, 2016Co-Authors: Sharon M Lutz, G L Kinney, Kendra A Young, Katherine A Pratte, Lindsey M Duca, Marilyn G Foreman, Terri H Beaty, Ed Silverman, Matthew J Budoff, John E. HokansonAbstract:Introduction: Coronary artery calcium (CAC) and thoracic aortic calcium (TAC), markers of subclinical atherosclerosis, have been shown to strongly correlate with the amount of atheromatous plaque and subsequently predict future coronary disease events and mortality. CAC and TAC are complex heritable traits with both genetic and Environmental Risk Factors such as cigarette smoking. We investigated the role of smoking, a key Environmental Risk Factor, as a mediator of the genetic Risk of subclinical atherosclerosis in the COPDGene study. Hypothesis: We hypothesized that smoking will mediate a portion of the genome-wide significant SNPs with subclinical atherosclerosis as measured by TAC and CAC. Methods: We performed genome wide genotyping of common and rare variants in COPDGene, a study of 10,192 current and former smokers with at least 10 pack-years of smoking history. CAC and TAC were measured using high dose, inspiration chest CT scans, following an established protocol in 8,739 individuals (6,150 non-H...
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Abstract MP82: The Effect of Nicotinic Acetylcholine Receptor Genes CHRNA3/5 on Thoracic Aortic Calcium is Mediated by Smoking
Circulation, 2016Co-Authors: Sharon M Lutz, G L Kinney, Kendra A Young, Katherine A Pratte, Lindsey M Duca, Marilyn G Foreman, Terri H Beaty, Ed Silverman, Matthew J BudoffAbstract:Introduction: Coronary artery calcium (CAC) and thoracic aortic calcium (TAC), markers of subclinical atherosclerosis, have been shown to strongly correlate with the amount of atheromatous plaque and subsequently predict future coronary disease events and mortality. CAC and TAC are complex heritable traits with both genetic and Environmental Risk Factors such as cigarette smoking. We investigated the role of smoking, a key Environmental Risk Factor, as a mediator of the genetic Risk of subclinical atherosclerosis in the COPDGene study. Hypothesis: We hypothesized that smoking will mediate a portion of the genome-wide significant SNPs with subclinical atherosclerosis as measured by TAC and CAC. Methods: We performed genome wide genotyping of common and rare variants in COPDGene, a study of 10,192 current and former smokers with at least 10 pack-years of smoking history. CAC and TAC were measured using high dose, inspiration chest CT scans, following an established protocol in 8,739 individuals (6,150 non-H...
John E. Hokanson - One of the best experts on this subject based on the ideXlab platform.
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abstract mp82 the effect of nicotinic acetylcholine receptor genes chrna3 5 on thoracic aortic calcium is mediated by smoking
Circulation, 2016Co-Authors: Sharon M Lutz, G L Kinney, Kendra A Young, Katherine A Pratte, Lindsey M Duca, Marilyn G Foreman, Terri H Beaty, Ed Silverman, Matthew J Budoff, John E. HokansonAbstract:Introduction: Coronary artery calcium (CAC) and thoracic aortic calcium (TAC), markers of subclinical atherosclerosis, have been shown to strongly correlate with the amount of atheromatous plaque and subsequently predict future coronary disease events and mortality. CAC and TAC are complex heritable traits with both genetic and Environmental Risk Factors such as cigarette smoking. We investigated the role of smoking, a key Environmental Risk Factor, as a mediator of the genetic Risk of subclinical atherosclerosis in the COPDGene study. Hypothesis: We hypothesized that smoking will mediate a portion of the genome-wide significant SNPs with subclinical atherosclerosis as measured by TAC and CAC. Methods: We performed genome wide genotyping of common and rare variants in COPDGene, a study of 10,192 current and former smokers with at least 10 pack-years of smoking history. CAC and TAC were measured using high dose, inspiration chest CT scans, following an established protocol in 8,739 individuals (6,150 non-H...
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Epidemiology, radiology, and genetics of nicotine dependence in COPD
Respiratory Research, 2011Co-Authors: Craig P. Hersh, George R. Washko, John E. Hokanson, David A. Lynch, John D. Newell, James Murphy, James D. Crapo, Edwin K. SilvermanAbstract:Background: Cigarette smoking is the principal Environmental Risk Factor for developing COPD, and nicotine dependence strongly influences smoking behavior. This study was performed to elucidate the relationship between nicotine dependence, genetic susceptibility to nicotine dependence, and volumetric CT findings in smokers. Methods: Current smokers with COPD (GOLD stage ≥ 2) or normal spirometry were analyzed from the COPDGene Study, a prospective observational study. Nicotine dependence was determined by the Fagerstrom test for nicotine dependence (FTND). Volumetric CT acquisitions measuring the percent of emphysema on inspiratory CT (% of lung
Ed Silverman - One of the best experts on this subject based on the ideXlab platform.
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abstract mp82 the effect of nicotinic acetylcholine receptor genes chrna3 5 on thoracic aortic calcium is mediated by smoking
Circulation, 2016Co-Authors: Sharon M Lutz, G L Kinney, Kendra A Young, Katherine A Pratte, Lindsey M Duca, Marilyn G Foreman, Terri H Beaty, Ed Silverman, Matthew J Budoff, John E. HokansonAbstract:Introduction: Coronary artery calcium (CAC) and thoracic aortic calcium (TAC), markers of subclinical atherosclerosis, have been shown to strongly correlate with the amount of atheromatous plaque and subsequently predict future coronary disease events and mortality. CAC and TAC are complex heritable traits with both genetic and Environmental Risk Factors such as cigarette smoking. We investigated the role of smoking, a key Environmental Risk Factor, as a mediator of the genetic Risk of subclinical atherosclerosis in the COPDGene study. Hypothesis: We hypothesized that smoking will mediate a portion of the genome-wide significant SNPs with subclinical atherosclerosis as measured by TAC and CAC. Methods: We performed genome wide genotyping of common and rare variants in COPDGene, a study of 10,192 current and former smokers with at least 10 pack-years of smoking history. CAC and TAC were measured using high dose, inspiration chest CT scans, following an established protocol in 8,739 individuals (6,150 non-H...
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Abstract MP82: The Effect of Nicotinic Acetylcholine Receptor Genes CHRNA3/5 on Thoracic Aortic Calcium is Mediated by Smoking
Circulation, 2016Co-Authors: Sharon M Lutz, G L Kinney, Kendra A Young, Katherine A Pratte, Lindsey M Duca, Marilyn G Foreman, Terri H Beaty, Ed Silverman, Matthew J BudoffAbstract:Introduction: Coronary artery calcium (CAC) and thoracic aortic calcium (TAC), markers of subclinical atherosclerosis, have been shown to strongly correlate with the amount of atheromatous plaque and subsequently predict future coronary disease events and mortality. CAC and TAC are complex heritable traits with both genetic and Environmental Risk Factors such as cigarette smoking. We investigated the role of smoking, a key Environmental Risk Factor, as a mediator of the genetic Risk of subclinical atherosclerosis in the COPDGene study. Hypothesis: We hypothesized that smoking will mediate a portion of the genome-wide significant SNPs with subclinical atherosclerosis as measured by TAC and CAC. Methods: We performed genome wide genotyping of common and rare variants in COPDGene, a study of 10,192 current and former smokers with at least 10 pack-years of smoking history. CAC and TAC were measured using high dose, inspiration chest CT scans, following an established protocol in 8,739 individuals (6,150 non-H...