The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Joseph E. Dohar - One of the best experts on this subject based on the ideXlab platform.
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Laryngeal Cleft and Eosinophilic Gastroenteritis
2016Co-Authors: Nira A. Goldstein, Philip E. Putnam, Joseph E. DoharAbstract:Although laryngotracheoesophageal clefts are often found in association with other welldescribed anomalies, we know of no previous reported association with Eosinophilic Gastroenteritis, a disorder of unknown etiology characterized by Eosinophilic infiltration of the gastrointestinal tract. We treated 2 children who had laryngeal clefts and Eosinophilic Gastroenteritis. Since the esophageal inflammatory changes found in Eosinophilic Gastroenteritis may persist despite aggressive therapy, management of the laryngotracheoesophageal clefts is more complicated. The diagnosis of Eosinophilic Gastroenteritis should not be overlooked in patients with laryngotracheoesophageal clefts and warrants prompt referral to a pediatric gastroenterologist. Arch Otolaryngol Head Neck Surg. 2000;126:227-230 Laryngotracheoesophageal clefts (LTECs) are uncommon congenital abnormalities that may be difficult to diagnose. Although there are numerous well-documented associated anomalies, we know of no previous report of an association with Eosinophilic Gastroenteritis (EG), a disorder of unknown cause characterized by Eosinophilic infiltration of the gastrointestinal tract. We describe 2 patients examined at Children’s Hospital of Pittsburgh, Pittsburgh, Pa, within a 1-year period who had both disorders. The presence of EG may complicate management of LTECs.
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Laryngeal Cleft and Eosinophilic Gastroenteritis: Report of 2 Cases
Archives of otolaryngology--head & neck surgery, 2000Co-Authors: Nira A. Goldstein, Philip E. Putnam, Joseph E. DoharAbstract:Although laryngotracheoesophageal clefts are often found in association with other well-described anomalies, we know of no previous reported association with Eosinophilic Gastroenteritis, a disorder of unknown etiology characterized by Eosinophilic infiltration of the gastrointestinal tract. We treated 2 children who had laryngeal clefts and Eosinophilic Gastroenteritis. Since the esophageal inflammatory changes found in Eosinophilic Gastroenteritis may persist despite aggressive therapy, management of the laryngotracheoesophageal clefts is more complicated. The diagnosis of Eosinophilic Gastroenteritis should not be overlooked in patients with laryngotracheoesophageal clefts and warrants prompt referral to a pediatric gastroenterologist.
Nicholas J. Talley - One of the best experts on this subject based on the ideXlab platform.
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Eosinophilic Gastroenteritis
Current Gastroenterology Reports, 2002Co-Authors: Rahim Daneshjoo, Nicholas J. TalleyAbstract:Eosinophilic Gastroenteritis is a rare gastrointestinal (GI) disorder of undetermined cause characterized by infiltration of eosinophils in the GI tract. Eosinophils accumulate in tissues and may release highly cytotoxic granular proteins, which cause severe tissue damage characteristic of Eosinophilic Gastroenteritis. Eotaxin may play a role in the recruitment of eosinophils into tissue in combination with chemoattractants and cytokines, including interleukin 3 and 5 and granulocyte-macrophage colony-stimulating factor. Food allergy, especially in children, can be a triggering factor, and an amino acid-based diet may be helpful. Accumulation of eosinophils in the gut is a common feature in food-induced GI disorders that can be regulated through a complex molecular network involving Th2 cells, various cytokines, and chemokines. Eosinophilic Gastroenteritis has a wide spectrum of clinical presentation depending on the site of involvement. It may be confused with irritable bowel syndrome or dyspepsia and, rarely, mimics pancreatitis or appendicitis. Diagnosis is important and is usually made by a pathologist. Eosinophilic Gastroenteritis is a treatable disease; patients generally respond to steroid therapy, although relapse is common. Non-enteric-coated budesonide, a locally acting corticosteroid with little risk of adrenal suppression, may be substituted, although more experience is needed. Promising new drugs for Eosinophilic Gastroenteritis include montelukast, a selective leukotriene receptor antagonist, and suplaplast tosilate, a selective Th2 cytokine inhibitor with inhibitory effects on allergy-induced Eosinophilic infiltration and IgE production. Although it is likely a separate disease, more experience has accumulated, and an elimination or specific amino acid-based diet appears to be helpful in treatment.
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Dyspepsia due to Eosinophilic Gastroenteritis.
Digestive diseases and sciences, 1997Co-Authors: S. J. Kalantar, R. Marks, J. R. Lambert, D. Badov, Nicholas J. TalleyAbstract:Classical Eosinophilic Gastroenteritis is a rare disease but may be misdiagnosed in clinical practice. We report Eosinophilic Gastroenteritis that was diagnosed in six patients (four males and two females; mean age 31.5 years) using standard criteria (presence of gastrointestinal symptoms, a predominant Eosinophilic infiltrate on biopsy, and exclusion of other causes of eosinophilia). All had gastric mucosal disease and presented with dyspepsia. The median duration of symptoms prior to diagnosis was three months (range five weeks to 13 years). Epigastric pain or discomfort was the most common symptom (100%) followed by anorexia, nausea, and vomiting (67%, 67% and 33%, respectively). None had diarrhea. Half the patients had a history of allergy, while 67% had peripheral eosinophilia. All responded to oral steroids within two months; one third needed to continue on a small dose of maintenance steroids to remain in remission. A high degree of suspicion and biopsy at upper endoscopy is necessary for diagnosis of this rare disease.
Nira A. Goldstein - One of the best experts on this subject based on the ideXlab platform.
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Laryngeal Cleft and Eosinophilic Gastroenteritis
2016Co-Authors: Nira A. Goldstein, Philip E. Putnam, Joseph E. DoharAbstract:Although laryngotracheoesophageal clefts are often found in association with other welldescribed anomalies, we know of no previous reported association with Eosinophilic Gastroenteritis, a disorder of unknown etiology characterized by Eosinophilic infiltration of the gastrointestinal tract. We treated 2 children who had laryngeal clefts and Eosinophilic Gastroenteritis. Since the esophageal inflammatory changes found in Eosinophilic Gastroenteritis may persist despite aggressive therapy, management of the laryngotracheoesophageal clefts is more complicated. The diagnosis of Eosinophilic Gastroenteritis should not be overlooked in patients with laryngotracheoesophageal clefts and warrants prompt referral to a pediatric gastroenterologist. Arch Otolaryngol Head Neck Surg. 2000;126:227-230 Laryngotracheoesophageal clefts (LTECs) are uncommon congenital abnormalities that may be difficult to diagnose. Although there are numerous well-documented associated anomalies, we know of no previous report of an association with Eosinophilic Gastroenteritis (EG), a disorder of unknown cause characterized by Eosinophilic infiltration of the gastrointestinal tract. We describe 2 patients examined at Children’s Hospital of Pittsburgh, Pittsburgh, Pa, within a 1-year period who had both disorders. The presence of EG may complicate management of LTECs.
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Laryngeal Cleft and Eosinophilic Gastroenteritis: Report of 2 Cases
Archives of otolaryngology--head & neck surgery, 2000Co-Authors: Nira A. Goldstein, Philip E. Putnam, Joseph E. DoharAbstract:Although laryngotracheoesophageal clefts are often found in association with other well-described anomalies, we know of no previous reported association with Eosinophilic Gastroenteritis, a disorder of unknown etiology characterized by Eosinophilic infiltration of the gastrointestinal tract. We treated 2 children who had laryngeal clefts and Eosinophilic Gastroenteritis. Since the esophageal inflammatory changes found in Eosinophilic Gastroenteritis may persist despite aggressive therapy, management of the laryngotracheoesophageal clefts is more complicated. The diagnosis of Eosinophilic Gastroenteritis should not be overlooked in patients with laryngotracheoesophageal clefts and warrants prompt referral to a pediatric gastroenterologist.
Tsangen Wang - One of the best experts on this subject based on the ideXlab platform.
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• CLINICAL RESEARCH • Eosinophilic Gastroenteritis: Clinical experience with 15 patients
2015Co-Authors: Mingjen Chen, Shouchuan Shih, Tsangen Wang, Cheng-hsin Chu, Shee-chan LinAbstract:AIM: To evaluate the clinic features of Eosinophilic Gastroenteritis and examine the diagnosis, treatment, long-term outcome of this disease. METHODS: Charts with a diagnosis of Eosinophilic Gastroenteritis from 1984 to 2002 at Mackay Memorial Hospital were reviewed retrospectively. There were 15 patients diagnosed with Eosinophilic Gastroenteritis. The diagnosis was established in 13 by histologic evaluation of endoscopic biopsy or operative specimen and in 2 by radiologic imaging and the presence of Eosinophilic ascites. RESULTS: All the patients had gastrointestinal symptoms and 12 (80 %) had hypereosinophilia (absolute eosinophil count 1 008 to 31 360/cm3). The most common symptoms were abdominal pain and diarrhea. Five of the 15 patient
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Eosinophilic Gastroenteritis clinical experience with 15 patients
World Journal of Gastroenterology, 2003Co-Authors: Mingjen Chen, Shouchuan Shih, Tsangen WangAbstract:AIM: To evaluate the clinic features of Eosinophilic Gastroenteritis and examine the diagnosis, treatment, long-term outcome of this disease. METHODS: Charts with a diagnosis of Eosinophilic Gastroenteritis from 1984 to 2002 at Mackay Memorial Hospital were reviewed retrospectively. There were 15 patients diagnosed with Eosinophilic Gastroenteritis. The diagnosis was established in 13 by histologic evaluation of endoscopic biopsy or operative specimen and in 2 by radiologic imaging and the presence of Eosinophilic ascites. RESULTS: All the patients had gastrointestinal symptoms and 12 (80%) had hypereosinophilia (absolute eosinophil count 1008 to 31360/cm3). The most common symptoms were abdominal pain and diarrhea. Five of the 15 patients had a history of allergy. Seven patients had involvement of the mucosa, 2 of muscularis, and 6 of subserosa. One with a history of seafood allergy was successfully treated with an elimination diet. Another patient improved spontaneously after fasting for several days. The remaining 13 patients were treated with oral prednisolone, 10 to 40 mg/day initially, which was then tapered. The symptoms in all the patients subsided within two weeks. Eleven of the 15 patients were followed up for more than 12 months (12 to 104 months, mean 48.7), of whom 5 had relapses after discontinuing steroids (13 episodes). Two of these patients required long-term maintenance oral prednisolone (5 to 10 mg/day). CONCLUSION: Eosinophilic Gastroenteritis is a rare condition of unclear etiology characterized by relapses and remissions. Short courses of corticosteroids are the mainstay of treatment, although some patients with relapsing disease require long-term low-dose steroids.
Mingjen Chen - One of the best experts on this subject based on the ideXlab platform.
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• CLINICAL RESEARCH • Eosinophilic Gastroenteritis: Clinical experience with 15 patients
2015Co-Authors: Mingjen Chen, Shouchuan Shih, Tsangen Wang, Cheng-hsin Chu, Shee-chan LinAbstract:AIM: To evaluate the clinic features of Eosinophilic Gastroenteritis and examine the diagnosis, treatment, long-term outcome of this disease. METHODS: Charts with a diagnosis of Eosinophilic Gastroenteritis from 1984 to 2002 at Mackay Memorial Hospital were reviewed retrospectively. There were 15 patients diagnosed with Eosinophilic Gastroenteritis. The diagnosis was established in 13 by histologic evaluation of endoscopic biopsy or operative specimen and in 2 by radiologic imaging and the presence of Eosinophilic ascites. RESULTS: All the patients had gastrointestinal symptoms and 12 (80 %) had hypereosinophilia (absolute eosinophil count 1 008 to 31 360/cm3). The most common symptoms were abdominal pain and diarrhea. Five of the 15 patient
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Eosinophilic Gastroenteritis clinical experience with 15 patients
World Journal of Gastroenterology, 2003Co-Authors: Mingjen Chen, Shouchuan Shih, Tsangen WangAbstract:AIM: To evaluate the clinic features of Eosinophilic Gastroenteritis and examine the diagnosis, treatment, long-term outcome of this disease. METHODS: Charts with a diagnosis of Eosinophilic Gastroenteritis from 1984 to 2002 at Mackay Memorial Hospital were reviewed retrospectively. There were 15 patients diagnosed with Eosinophilic Gastroenteritis. The diagnosis was established in 13 by histologic evaluation of endoscopic biopsy or operative specimen and in 2 by radiologic imaging and the presence of Eosinophilic ascites. RESULTS: All the patients had gastrointestinal symptoms and 12 (80%) had hypereosinophilia (absolute eosinophil count 1008 to 31360/cm3). The most common symptoms were abdominal pain and diarrhea. Five of the 15 patients had a history of allergy. Seven patients had involvement of the mucosa, 2 of muscularis, and 6 of subserosa. One with a history of seafood allergy was successfully treated with an elimination diet. Another patient improved spontaneously after fasting for several days. The remaining 13 patients were treated with oral prednisolone, 10 to 40 mg/day initially, which was then tapered. The symptoms in all the patients subsided within two weeks. Eleven of the 15 patients were followed up for more than 12 months (12 to 104 months, mean 48.7), of whom 5 had relapses after discontinuing steroids (13 episodes). Two of these patients required long-term maintenance oral prednisolone (5 to 10 mg/day). CONCLUSION: Eosinophilic Gastroenteritis is a rare condition of unclear etiology characterized by relapses and remissions. Short courses of corticosteroids are the mainstay of treatment, although some patients with relapsing disease require long-term low-dose steroids.