The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform

Evan S Dellon - One of the best experts on this subject based on the ideXlab platform.

  • distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy
    Modern Pathology, 2015
    Co-Authors: Evan S Dellon, Olga Speck, Kimberly Woodward, Nicholas J Shaheen, Shannon Covey, Spencer Rusin, John T Woosley
    Abstract:

    The variability of Eosinophilic infiltrates in Eosinophilic esophagitis is not well described. This study aimed to determine the distribution of esophageal eosinophilia and the utility of histologic cut-points for Eosinophilic esophagitis diagnosis in subjects undergoing endoscopy. We performed a prospective study of adults undergoing outpatient endoscopy. Research protocol esophageal biopsies were obtained from all subjects. Incident cases of Eosinophilic esophagitis were diagnosed per consensus guidelines. Biopsies were interpreted following a validated protocol, and maximum eosinophil counts (eosinophils per high-power field; eos/hpf) were determined. Histologic analyses were performed on a per-patient, per-biopsy, and per-hpf basis. There were 213 patients, yielding 923 esophageal biopsies with 4588 hpfs. Overall, 48 patients (23%), 165 biopsy fragments (18%), and 449 hpfs (10%) had ≥15 eos/hpf; most subjects had no or low levels of eosinophils. In the Eosinophilic esophagitis cases, 119 biopsy fragments (63%) and 332 hpfs (36%) had ≥15 eos/hpf. There was a mean 104-fold difference between the lowest and highest hpf eosinophil count for the Eosinophilic esophagitis patients; 85% of the biopsies from Eosinophilic esophagitis cases also had at least one hpf with <15 eos/hpf. The cut-point of 15 eos/hpf had a sensitivity of 100% and a specificity of 96% for diagnosis of Eosinophilic esophagitis. In conclusion, most patients have little to no esophageal eosinophilia. In patients with Eosinophilic esophagitis, there was marked variability in the eosinophil counts by biopsy and by hpf within a given biopsy. Additionally, the 15 eos/hpf cut-point was highly sensitive and specific for Eosinophilic esophagitis. Multiple esophageal biopsies from different locations should be obtained to optimize Eosinophilic esophagitis diagnosis.

  • clinical and endoscopic characteristics do not reliably differentiate ppi responsive esophageal eosinophilia and Eosinophilic esophagitis in patients undergoing upper endoscopy a prospective cohort study
    The American Journal of Gastroenterology, 2013
    Co-Authors: Evan S Dellon, Olga Speck, Kimberly Woodward, Jessica H Gebhart, Ryan D Madanick, Sidney Levinson, Karen J Fritchie, John T Woosley, Nicholas J Shaheen
    Abstract:

    Clinical and Endoscopic Characteristics do Not Reliably Differentiate PPI-Responsive Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients Undergoing Upper Endoscopy: A Prospective Cohort Study

  • acg clinical guideline evidenced based approach to the diagnosis and management of esophageal eosinophilia and Eosinophilic esophagitis eoe
    The American Journal of Gastroenterology, 2013
    Co-Authors: Evan S Dellon, Nirmala Gonsalves, Ikuo Hirano, Glenn T Furuta, Chris A Liacouras, David A Katzka
    Abstract:

    5Esophageal eosinophilia and Eosinophilic esophagitis (EoE) are increasingly recognized and prevalent conditions, which now represent common clinical problems encountered by gastroenterologists, pathologists, and allergists. The study of EoE has become a dynamic fi eld with an evolving understanding of the pathogenesis, diagnosis, and treatment. Although there are limited data supporting management decisions, clinical parameters are needed to guide the care of patients with Eosinophilic ‐ esophageal disorders. In this evidence-based review, recommendations developed by adult and pediatric gastroenterologists are provided for the evaluation and management of these patients. New terminology is emphasized, particularly the concepts of esophageal eosinophilia and proton-pump inhibitor-responsive esophageal eosinophilia (PPI-REE) as entities distinct from EoE.

Nicholas J Shaheen - One of the best experts on this subject based on the ideXlab platform.

  • distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy
    Modern Pathology, 2015
    Co-Authors: Evan S Dellon, Olga Speck, Kimberly Woodward, Nicholas J Shaheen, Shannon Covey, Spencer Rusin, John T Woosley
    Abstract:

    The variability of Eosinophilic infiltrates in Eosinophilic esophagitis is not well described. This study aimed to determine the distribution of esophageal eosinophilia and the utility of histologic cut-points for Eosinophilic esophagitis diagnosis in subjects undergoing endoscopy. We performed a prospective study of adults undergoing outpatient endoscopy. Research protocol esophageal biopsies were obtained from all subjects. Incident cases of Eosinophilic esophagitis were diagnosed per consensus guidelines. Biopsies were interpreted following a validated protocol, and maximum eosinophil counts (eosinophils per high-power field; eos/hpf) were determined. Histologic analyses were performed on a per-patient, per-biopsy, and per-hpf basis. There were 213 patients, yielding 923 esophageal biopsies with 4588 hpfs. Overall, 48 patients (23%), 165 biopsy fragments (18%), and 449 hpfs (10%) had ≥15 eos/hpf; most subjects had no or low levels of eosinophils. In the Eosinophilic esophagitis cases, 119 biopsy fragments (63%) and 332 hpfs (36%) had ≥15 eos/hpf. There was a mean 104-fold difference between the lowest and highest hpf eosinophil count for the Eosinophilic esophagitis patients; 85% of the biopsies from Eosinophilic esophagitis cases also had at least one hpf with <15 eos/hpf. The cut-point of 15 eos/hpf had a sensitivity of 100% and a specificity of 96% for diagnosis of Eosinophilic esophagitis. In conclusion, most patients have little to no esophageal eosinophilia. In patients with Eosinophilic esophagitis, there was marked variability in the eosinophil counts by biopsy and by hpf within a given biopsy. Additionally, the 15 eos/hpf cut-point was highly sensitive and specific for Eosinophilic esophagitis. Multiple esophageal biopsies from different locations should be obtained to optimize Eosinophilic esophagitis diagnosis.

  • clinical and endoscopic characteristics do not reliably differentiate ppi responsive esophageal eosinophilia and Eosinophilic esophagitis in patients undergoing upper endoscopy a prospective cohort study
    The American Journal of Gastroenterology, 2013
    Co-Authors: Evan S Dellon, Olga Speck, Kimberly Woodward, Jessica H Gebhart, Ryan D Madanick, Sidney Levinson, Karen J Fritchie, John T Woosley, Nicholas J Shaheen
    Abstract:

    Clinical and Endoscopic Characteristics do Not Reliably Differentiate PPI-Responsive Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients Undergoing Upper Endoscopy: A Prospective Cohort Study

John T Woosley - One of the best experts on this subject based on the ideXlab platform.

  • distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy
    Modern Pathology, 2015
    Co-Authors: Evan S Dellon, Olga Speck, Kimberly Woodward, Nicholas J Shaheen, Shannon Covey, Spencer Rusin, John T Woosley
    Abstract:

    The variability of Eosinophilic infiltrates in Eosinophilic esophagitis is not well described. This study aimed to determine the distribution of esophageal eosinophilia and the utility of histologic cut-points for Eosinophilic esophagitis diagnosis in subjects undergoing endoscopy. We performed a prospective study of adults undergoing outpatient endoscopy. Research protocol esophageal biopsies were obtained from all subjects. Incident cases of Eosinophilic esophagitis were diagnosed per consensus guidelines. Biopsies were interpreted following a validated protocol, and maximum eosinophil counts (eosinophils per high-power field; eos/hpf) were determined. Histologic analyses were performed on a per-patient, per-biopsy, and per-hpf basis. There were 213 patients, yielding 923 esophageal biopsies with 4588 hpfs. Overall, 48 patients (23%), 165 biopsy fragments (18%), and 449 hpfs (10%) had ≥15 eos/hpf; most subjects had no or low levels of eosinophils. In the Eosinophilic esophagitis cases, 119 biopsy fragments (63%) and 332 hpfs (36%) had ≥15 eos/hpf. There was a mean 104-fold difference between the lowest and highest hpf eosinophil count for the Eosinophilic esophagitis patients; 85% of the biopsies from Eosinophilic esophagitis cases also had at least one hpf with <15 eos/hpf. The cut-point of 15 eos/hpf had a sensitivity of 100% and a specificity of 96% for diagnosis of Eosinophilic esophagitis. In conclusion, most patients have little to no esophageal eosinophilia. In patients with Eosinophilic esophagitis, there was marked variability in the eosinophil counts by biopsy and by hpf within a given biopsy. Additionally, the 15 eos/hpf cut-point was highly sensitive and specific for Eosinophilic esophagitis. Multiple esophageal biopsies from different locations should be obtained to optimize Eosinophilic esophagitis diagnosis.

  • clinical and endoscopic characteristics do not reliably differentiate ppi responsive esophageal eosinophilia and Eosinophilic esophagitis in patients undergoing upper endoscopy a prospective cohort study
    The American Journal of Gastroenterology, 2013
    Co-Authors: Evan S Dellon, Olga Speck, Kimberly Woodward, Jessica H Gebhart, Ryan D Madanick, Sidney Levinson, Karen J Fritchie, John T Woosley, Nicholas J Shaheen
    Abstract:

    Clinical and Endoscopic Characteristics do Not Reliably Differentiate PPI-Responsive Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients Undergoing Upper Endoscopy: A Prospective Cohort Study

Olga Speck - One of the best experts on this subject based on the ideXlab platform.

  • distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy
    Modern Pathology, 2015
    Co-Authors: Evan S Dellon, Olga Speck, Kimberly Woodward, Nicholas J Shaheen, Shannon Covey, Spencer Rusin, John T Woosley
    Abstract:

    The variability of Eosinophilic infiltrates in Eosinophilic esophagitis is not well described. This study aimed to determine the distribution of esophageal eosinophilia and the utility of histologic cut-points for Eosinophilic esophagitis diagnosis in subjects undergoing endoscopy. We performed a prospective study of adults undergoing outpatient endoscopy. Research protocol esophageal biopsies were obtained from all subjects. Incident cases of Eosinophilic esophagitis were diagnosed per consensus guidelines. Biopsies were interpreted following a validated protocol, and maximum eosinophil counts (eosinophils per high-power field; eos/hpf) were determined. Histologic analyses were performed on a per-patient, per-biopsy, and per-hpf basis. There were 213 patients, yielding 923 esophageal biopsies with 4588 hpfs. Overall, 48 patients (23%), 165 biopsy fragments (18%), and 449 hpfs (10%) had ≥15 eos/hpf; most subjects had no or low levels of eosinophils. In the Eosinophilic esophagitis cases, 119 biopsy fragments (63%) and 332 hpfs (36%) had ≥15 eos/hpf. There was a mean 104-fold difference between the lowest and highest hpf eosinophil count for the Eosinophilic esophagitis patients; 85% of the biopsies from Eosinophilic esophagitis cases also had at least one hpf with <15 eos/hpf. The cut-point of 15 eos/hpf had a sensitivity of 100% and a specificity of 96% for diagnosis of Eosinophilic esophagitis. In conclusion, most patients have little to no esophageal eosinophilia. In patients with Eosinophilic esophagitis, there was marked variability in the eosinophil counts by biopsy and by hpf within a given biopsy. Additionally, the 15 eos/hpf cut-point was highly sensitive and specific for Eosinophilic esophagitis. Multiple esophageal biopsies from different locations should be obtained to optimize Eosinophilic esophagitis diagnosis.

  • clinical and endoscopic characteristics do not reliably differentiate ppi responsive esophageal eosinophilia and Eosinophilic esophagitis in patients undergoing upper endoscopy a prospective cohort study
    The American Journal of Gastroenterology, 2013
    Co-Authors: Evan S Dellon, Olga Speck, Kimberly Woodward, Jessica H Gebhart, Ryan D Madanick, Sidney Levinson, Karen J Fritchie, John T Woosley, Nicholas J Shaheen
    Abstract:

    Clinical and Endoscopic Characteristics do Not Reliably Differentiate PPI-Responsive Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients Undergoing Upper Endoscopy: A Prospective Cohort Study

Kimberly Woodward - One of the best experts on this subject based on the ideXlab platform.

  • distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy
    Modern Pathology, 2015
    Co-Authors: Evan S Dellon, Olga Speck, Kimberly Woodward, Nicholas J Shaheen, Shannon Covey, Spencer Rusin, John T Woosley
    Abstract:

    The variability of Eosinophilic infiltrates in Eosinophilic esophagitis is not well described. This study aimed to determine the distribution of esophageal eosinophilia and the utility of histologic cut-points for Eosinophilic esophagitis diagnosis in subjects undergoing endoscopy. We performed a prospective study of adults undergoing outpatient endoscopy. Research protocol esophageal biopsies were obtained from all subjects. Incident cases of Eosinophilic esophagitis were diagnosed per consensus guidelines. Biopsies were interpreted following a validated protocol, and maximum eosinophil counts (eosinophils per high-power field; eos/hpf) were determined. Histologic analyses were performed on a per-patient, per-biopsy, and per-hpf basis. There were 213 patients, yielding 923 esophageal biopsies with 4588 hpfs. Overall, 48 patients (23%), 165 biopsy fragments (18%), and 449 hpfs (10%) had ≥15 eos/hpf; most subjects had no or low levels of eosinophils. In the Eosinophilic esophagitis cases, 119 biopsy fragments (63%) and 332 hpfs (36%) had ≥15 eos/hpf. There was a mean 104-fold difference between the lowest and highest hpf eosinophil count for the Eosinophilic esophagitis patients; 85% of the biopsies from Eosinophilic esophagitis cases also had at least one hpf with <15 eos/hpf. The cut-point of 15 eos/hpf had a sensitivity of 100% and a specificity of 96% for diagnosis of Eosinophilic esophagitis. In conclusion, most patients have little to no esophageal eosinophilia. In patients with Eosinophilic esophagitis, there was marked variability in the eosinophil counts by biopsy and by hpf within a given biopsy. Additionally, the 15 eos/hpf cut-point was highly sensitive and specific for Eosinophilic esophagitis. Multiple esophageal biopsies from different locations should be obtained to optimize Eosinophilic esophagitis diagnosis.

  • clinical and endoscopic characteristics do not reliably differentiate ppi responsive esophageal eosinophilia and Eosinophilic esophagitis in patients undergoing upper endoscopy a prospective cohort study
    The American Journal of Gastroenterology, 2013
    Co-Authors: Evan S Dellon, Olga Speck, Kimberly Woodward, Jessica H Gebhart, Ryan D Madanick, Sidney Levinson, Karen J Fritchie, John T Woosley, Nicholas J Shaheen
    Abstract:

    Clinical and Endoscopic Characteristics do Not Reliably Differentiate PPI-Responsive Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients Undergoing Upper Endoscopy: A Prospective Cohort Study