The Experts below are selected from a list of 909 Experts worldwide ranked by ideXlab platform

C.b. Vicentini - One of the best experts on this subject based on the ideXlab platform.

  • mannan changes induced by 3 methyl 5 aminoisoxazole 4 thiocyanate a new azole derivative on Epidermophyton Floccosum
    2002
    Co-Authors: Donatella Mares, Carlo Romagnoli, A. Bruni, B Tosi, R Benvegnu, C.b. Vicentini
    Abstract:

    The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate, a new azole derivative, was studied on the dermatophyte Epidermophyton Floccosum. The compound strongly inhibited the in vitro growth of two different strains of the fungus and even induced profound morphogenetic anomalies. Optical and electron microscopy showed that such treatment targets the endomembrane system, particularly the plasmalemma, causing abnormal extrusion of the wall mannans. This results in improper arrangement of the different parietal materials; the walls are thus weak and subject to subapical rupture which terminates cell growth and elongation of the hypha. The morphological results and the preliminary biochemical data on fungal sterols suggest that this compound employs an action mechanism similar to that of other azoles used in therapy.

  • mannan changes induced by 3 methyl 5 aminoisoxazole 4 thiocyanate a new azole derivative on Epidermophyton Floccosum
    2002
    Co-Authors: D. Mares, Carlo Romagnoli, A. Bruni, B Tosi, R Benvegnu, C.b. Vicentini
    Abstract:

    The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate, a new azole derivative, was studied on the dermatophyte Epidermophyton Floccosum. The compound strongly inhibited the in vitro growth of two different strains of the fungus and even induced profound morphogenetic anomalies. Optical and electron microscopy showed that such treatment targets the endomembrane system, particularly the plasmalemma, causing abnormal extrusion of the wall mannans. This results in improper arrangement of the different parietal materials; the walls are thus weak and subject to subapical rupture which terminates cell growth and elongation of the hypha. The morphological results and the preliminary biochemical data on fungal sterols suggest that this compound employs an action mechanism similar to that of other azoles used in therapy.

  • Antifungal activity of 5 new synthetic compounds vs. Trichophyton rubrum and Epidermophyton Floccosum
    2002
    Co-Authors: C. Romagnoli, D. Mares, A. Bruni, E. Andreotti, M. Manfrini, C.b. Vicentini
    Abstract:

    The antifungal activity of five new synthetic compounds was evaluated on two dermatophytes: Epidermophyton Floccosum and Trichophyton rubrum . The data showed that the imidazo-pyrazole and pyrazolo-thiazoles were not particularly effective, while the two pyrazole-thiocyanates proved highly active on both fungi. The most active 5-amino-3-methyl-1-phenylpyrazolo-4-thiocyanate was chosen to perform SEM and TEM morphological studies on both fungi. Both SEM and TEM observations revealed interesting alterations on the two dermatophytes, particularly involving the endomembrane system.

Arquínigo Lavado, Denisse Katherine - One of the best experts on this subject based on the ideXlab platform.

  • Efecto antimicótico del aceite esencial de Eucalyptus globulus sobre Trichophyton rubrum, Microsporum canis y Epidermophyton Floccosum, comparado con Clotrimazol
    2019
    Co-Authors: Arquínigo Lavado, Denisse Katherine
    Abstract:

    Este estudio se realizó con el objetivo de evaluar el efecto antimicótico del aceite esencial de Eucalyptus globulus sobre Trichophyton rubrum, Microsporum canis y Epidermophyton Floccosum, comparado con Clotrimazol, in vitro. Se planteó un diseño experimental que tuvo como muestra 10 cultivos de cada uno de los dermatofitos. El aceite esencial se obtuvo por arrastre con vapor de agua y se utilizó al 100%. Se evaluó el efecto del aceite esencial de Eucalyptus globulus in vitro, mediante el método de difusión con pozos en agar Sabouraud. Los resultados muestran que el aceite esencial de Eucalyptus globulus tuvo mayor efecto sobre Microsporum canis, con halo de inhibición de 19,6 mm. El análisis con la prueba de t de student indicó que existe diferencia altamente significativa (p

  • Efecto antimicótico del aceite esencial de Eucalyptus globulus sobre Trichophyton rubrum, Microsporum canis y Epidermophyton Floccosum, comparado con Clotrimazol
    2019
    Co-Authors: Arquínigo Lavado, Denisse Katherine
    Abstract:

    TesisTrujilloEscuela Académico Profesional de MedicinaEnfermedades Infecciosas y TransmisiblesEste estudio se realizó con el objetivo de evaluar el efecto antimicótico del aceite esencial de Eucalyptus globulus sobre Trichophyton rubrum, Microsporum canis y Epidermophyton Floccosum, comparado con Clotrimazol, in vitro. Se planteó un diseño experimental que tuvo como muestra 10 cultivos de cada uno de los dermatofitos. El aceite esencial se obtuvo por arrastre con vapor de agua y se utilizó al 100%. Se evaluó el efecto del aceite esencial de Eucalyptus globulus in vitro, mediante el método de difusión con pozos en agar Sabouraud. Los resultados muestran que el aceite esencial de Eucalyptus globulus tuvo mayor efecto sobre Microsporum canis, con halo de inhibición de 19,6 mm. El análisis con la prueba de t de student indicó que existe diferencia altamente significativa (p

A. Bruni - One of the best experts on this subject based on the ideXlab platform.

  • mannan changes induced by 3 methyl 5 aminoisoxazole 4 thiocyanate a new azole derivative on Epidermophyton Floccosum
    2002
    Co-Authors: Donatella Mares, Carlo Romagnoli, A. Bruni, B Tosi, R Benvegnu, C.b. Vicentini
    Abstract:

    The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate, a new azole derivative, was studied on the dermatophyte Epidermophyton Floccosum. The compound strongly inhibited the in vitro growth of two different strains of the fungus and even induced profound morphogenetic anomalies. Optical and electron microscopy showed that such treatment targets the endomembrane system, particularly the plasmalemma, causing abnormal extrusion of the wall mannans. This results in improper arrangement of the different parietal materials; the walls are thus weak and subject to subapical rupture which terminates cell growth and elongation of the hypha. The morphological results and the preliminary biochemical data on fungal sterols suggest that this compound employs an action mechanism similar to that of other azoles used in therapy.

  • mannan changes induced by 3 methyl 5 aminoisoxazole 4 thiocyanate a new azole derivative on Epidermophyton Floccosum
    2002
    Co-Authors: D. Mares, Carlo Romagnoli, A. Bruni, B Tosi, R Benvegnu, C.b. Vicentini
    Abstract:

    The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate, a new azole derivative, was studied on the dermatophyte Epidermophyton Floccosum. The compound strongly inhibited the in vitro growth of two different strains of the fungus and even induced profound morphogenetic anomalies. Optical and electron microscopy showed that such treatment targets the endomembrane system, particularly the plasmalemma, causing abnormal extrusion of the wall mannans. This results in improper arrangement of the different parietal materials; the walls are thus weak and subject to subapical rupture which terminates cell growth and elongation of the hypha. The morphological results and the preliminary biochemical data on fungal sterols suggest that this compound employs an action mechanism similar to that of other azoles used in therapy.

  • Antifungal activity of 5 new synthetic compounds vs. Trichophyton rubrum and Epidermophyton Floccosum
    2002
    Co-Authors: C. Romagnoli, D. Mares, A. Bruni, E. Andreotti, M. Manfrini, C.b. Vicentini
    Abstract:

    The antifungal activity of five new synthetic compounds was evaluated on two dermatophytes: Epidermophyton Floccosum and Trichophyton rubrum . The data showed that the imidazo-pyrazole and pyrazolo-thiazoles were not particularly effective, while the two pyrazole-thiocyanates proved highly active on both fungi. The most active 5-amino-3-methyl-1-phenylpyrazolo-4-thiocyanate was chosen to perform SEM and TEM morphological studies on both fungi. Both SEM and TEM observations revealed interesting alterations on the two dermatophytes, particularly involving the endomembrane system.

Carlo Romagnoli - One of the best experts on this subject based on the ideXlab platform.

  • Antidermatophytic activity of pyrazolo[3,4-c]isothiazoles: a preliminary approach on 4-chlorophenyl derivative for evaluation of mutagenic and clastogenic effects on bacteria and human chromosomes in vitro.
    2011
    Co-Authors: Damiano Rossi, Donatella Mares, Carlo Romagnoli, Elisa Andreotti, Stefano Manfredini, Chiara Beatrice Vicentini
    Abstract:

    The antifungal activity of eight pyrazolo[3,4-c]isothiazole derivatives was evaluated on five dermatophytes: three were of an anthropophilic species (i.e., Epidermophyton Floccosum, Trichophyton rubrum, and Trichophyton tonsurans) and two were of a geophilic species (i.e., Microsporum gypseum and Nannizzia cajetani). The new compounds proved to be unlikely effective in inhibiting the growth of the different strains. In general, the fungi parasitic on man were more sensitive than the geophilic species. This fact can be positive for a possible practical-therapeutic utilization of this class of compounds. To verify their possible use against fungi of medical interest, the most interesting substance at low doses, 6-(4-chlorophenyl)-4-methyl-6H-pyrazolo[3,4-c]isothiazol-3-amine, was chosen to perform in vitro genotoxicity tests using the following: Salmonella/microsome test (SAL), sister chromatid excange test (SCE), cytokinesis-blocked micronucleus test (CBMN), and its improvement (Ara-C/CBMN). The compound s...

  • mannan changes induced by 3 methyl 5 aminoisoxazole 4 thiocyanate a new azole derivative on Epidermophyton Floccosum
    2002
    Co-Authors: D. Mares, Carlo Romagnoli, A. Bruni, B Tosi, R Benvegnu, C.b. Vicentini
    Abstract:

    The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate, a new azole derivative, was studied on the dermatophyte Epidermophyton Floccosum. The compound strongly inhibited the in vitro growth of two different strains of the fungus and even induced profound morphogenetic anomalies. Optical and electron microscopy showed that such treatment targets the endomembrane system, particularly the plasmalemma, causing abnormal extrusion of the wall mannans. This results in improper arrangement of the different parietal materials; the walls are thus weak and subject to subapical rupture which terminates cell growth and elongation of the hypha. The morphological results and the preliminary biochemical data on fungal sterols suggest that this compound employs an action mechanism similar to that of other azoles used in therapy.

  • mannan changes induced by 3 methyl 5 aminoisoxazole 4 thiocyanate a new azole derivative on Epidermophyton Floccosum
    2002
    Co-Authors: Donatella Mares, Carlo Romagnoli, A. Bruni, B Tosi, R Benvegnu, C.b. Vicentini
    Abstract:

    The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate, a new azole derivative, was studied on the dermatophyte Epidermophyton Floccosum. The compound strongly inhibited the in vitro growth of two different strains of the fungus and even induced profound morphogenetic anomalies. Optical and electron microscopy showed that such treatment targets the endomembrane system, particularly the plasmalemma, causing abnormal extrusion of the wall mannans. This results in improper arrangement of the different parietal materials; the walls are thus weak and subject to subapical rupture which terminates cell growth and elongation of the hypha. The morphological results and the preliminary biochemical data on fungal sterols suggest that this compound employs an action mechanism similar to that of other azoles used in therapy.

R Benvegnu - One of the best experts on this subject based on the ideXlab platform.

  • mannan changes induced by 3 methyl 5 aminoisoxazole 4 thiocyanate a new azole derivative on Epidermophyton Floccosum
    2002
    Co-Authors: D. Mares, Carlo Romagnoli, A. Bruni, B Tosi, R Benvegnu, C.b. Vicentini
    Abstract:

    The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate, a new azole derivative, was studied on the dermatophyte Epidermophyton Floccosum. The compound strongly inhibited the in vitro growth of two different strains of the fungus and even induced profound morphogenetic anomalies. Optical and electron microscopy showed that such treatment targets the endomembrane system, particularly the plasmalemma, causing abnormal extrusion of the wall mannans. This results in improper arrangement of the different parietal materials; the walls are thus weak and subject to subapical rupture which terminates cell growth and elongation of the hypha. The morphological results and the preliminary biochemical data on fungal sterols suggest that this compound employs an action mechanism similar to that of other azoles used in therapy.

  • mannan changes induced by 3 methyl 5 aminoisoxazole 4 thiocyanate a new azole derivative on Epidermophyton Floccosum
    2002
    Co-Authors: Donatella Mares, Carlo Romagnoli, A. Bruni, B Tosi, R Benvegnu, C.b. Vicentini
    Abstract:

    The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate, a new azole derivative, was studied on the dermatophyte Epidermophyton Floccosum. The compound strongly inhibited the in vitro growth of two different strains of the fungus and even induced profound morphogenetic anomalies. Optical and electron microscopy showed that such treatment targets the endomembrane system, particularly the plasmalemma, causing abnormal extrusion of the wall mannans. This results in improper arrangement of the different parietal materials; the walls are thus weak and subject to subapical rupture which terminates cell growth and elongation of the hypha. The morphological results and the preliminary biochemical data on fungal sterols suggest that this compound employs an action mechanism similar to that of other azoles used in therapy.