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Pragya Singhal - One of the best experts on this subject based on the ideXlab platform.

  • (Shatavari mandoor and Pippali ghrita) in Parinama Shoola Vis-à-vis Acid Peptic Disorders Research Article 1. Clinical Registrar / Asst. Professor (Kayachikitsa),
    2016
    Co-Authors: Ch. Brahm, Pragya Singhal, Prakash Ayurved, Charak Sansthan, Khera Dabar, New Delhi, Khera Dabar Najafgarh
    Abstract:

    Background: : Acid peptic disease is the condition in which there is either excessive secretion of acid and pepsin or a weakened stomach mucosal defence, which is responsible for damage to the delicate mucosa and the lining of the stomach, oesophagus and duodenum resulting in ulceration.Parinama shoola in Ayurveda is comparable with Acid peptic disease. Aim of study: The Aim of the study is to evaluate and compare the effect of indigenous compound drugs (Shatavari mandoor and Pippali ghrita) in uncomplicated cases of Parinam shoola. Methods: This is a prospective, open labelled, randomised clinical tr ial. A total of 31 patients suggestive of features of Parinama Shoola (acid peptic disorder) were enrolled and were randomly divided in two groups- 12 patients were enrolled in group A and were given trial drug Shatavari mandoor,19 patients were enrolled in group B and were given trial drug Pippali ghrita. Duration of study was 3 months. Results: Individually both groups showed statistically significant improvement in clinical symptoms i.e. pain in abdomen, Epigastric Burning, nausea, flatulence, loss of appetite and constipation (p<0.01), but the mean reduction in the symptoms of group A (Shatavari mandoor group) is more than group B (Pippali ghrita group). Conclusion: Both tr ial drugs are effective in the treatment of Parinama shoola. Shatavari mandoor is more effective in the treatment of Parinam shoola in comparison to Pippali ghrita

  • A Comparative clinical study to evaluate the effect of Indigenous compound drugs (Shatavari mandoor and Pippali ghrita) in Parinama Shoola Vis-à-vis Acid Peptic Disorders
    International Journal of Ayurvedic Medicine, 2015
    Co-Authors: Pragya Singhal
    Abstract:

    Background: : Acid peptic disease is the condition in which there is either excessive secretion of acid and pepsin or a weakened stomach mucosal defence, which is responsible for damage to the delicate mucosa and the lining of the stomach, oesophagus and duodenum resulting in ulceration.Parinama shoola in Ayurveda is comparable with Acid peptic disease.Aim of study: The Aim of the study is to evaluate and compare the effect of indigenous compound drugs (Shatavari mandoor and Pippali ghrita) in uncomplicated cases of Parinam shoola.Methods:  This is a prospective, open labelled, randomised clinical trial. A total of 31 patients suggestive of features of Parinama Shoola (acid peptic disorder) were enrolled and were randomly divided in two groups- 12 patients were enrolled in group A and were given trial drug Shatavari mandoor,19 patients were enrolled in group B and were given trial drug Pippali ghrita. Duration of study was 3 months.Results: Individually both groups showed statistically significant improvement in clinical symptoms i.e. pain in abdomen, Epigastric Burning, nausea, flatulence, loss of appetite and constipation (p

Jan Tack - One of the best experts on this subject based on the ideXlab platform.

  • The use of pictograms improves symptom evaluation by patients with functional dyspepsia
    Alimentary pharmacology & therapeutics, 2014
    Co-Authors: Jan Tack, Hanne Vanheel, Tim Vanuytsel, Lieselot Holvoet, Florencia Carbone, A. Vandenberghe
    Abstract:

    Summary Background No validated patient-reported outcome (PRO) measure exists for functional dyspepsia (FD) assessment. Verbal descriptions of different upper abdominal symptoms may be poorly distinguishable to patients. Aim To investigate whether understanding of FD symptoms is enhanced by pictograms symbolising the nature of the symptoms, besides verbal descriptors. Methods Consecutive FD patients were randomised to fill out a questionnaire assessing nineupper gastrointestinal symptoms (post-prandial fullness, early satiation, Epigastric pain, Epigastric Burning, bloating centred in the upper abdomen, nausea, vomiting, heartburn, regurgitation) with or without accompanying pictograms. Symptoms were rated for frequency and severity (0–5), and patients also identified the most bothersome symptom. Subsequently, in-depth history was taken by an expert clinician, who filled out the same symptom ratings. Concordance between patient and clinician ratings was quantified using chi-square and kappa statistics. Results Content validity of pictograms was first confirmed by 15 FD patients. Next, 76 patients (52 women, age 42.2 ± 1.9) were randomised to questionnaires with or without pictograms. The concordance with clinician's assessment as gold standard rose from 36 without to 48% for questions with pictograms (P 

  • Postprandial symptoms originating from the stomach in functional dyspepsia.
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2013
    Co-Authors: Hanne Vanheel, Tim Vanuytsel, L. Van Oudenhove, R. Farré, Kristin Verbeke, Jan Tack
    Abstract:

    Background Functional dyspepsia (FD) is characterized by chronic Epigastric symptoms. The stomach has been held responsible for the generation of symptoms, but the latest reports have pointed out that also the duodenum can be implicated in the pathophysiology. The aim of this study was to elucidate which dyspeptic symptoms originate from the stomach and/or from the small intestine after a meal. Methods Two hundred eighty-four FD patients underwent a gastric emptying breath test. Breath samples were taken and the intensity of six dyspeptic symptoms (fullness, bloating, belching, nausea, Epigastric Burning, and Epigastric pain) was scored before a meal and at 15 min intervals for a period of 240 min postprandially. Time curves of each symptom were analyzed and severity scores during the gastric and the intestinal phase were compared. Key Results Time curves of fullness, bloating, belching, and nausea displayed a significant negative slope, while symptom severity of Epigastric Burning and Epigastric pain did not decrease over time. Numerical analysis revealed that scores for fullness, bloating, and belching were higher during the gastric phase compared with the intestinal phase. On the other hand, intensities of nausea, Epigastric Burning, and Epigastric pain were similar during both phases. Conclusions & Inferences Intensities of fullness, bloating, and belching decrease with food moving from the stomach to the small intestine indicating that the stomach plays a crucial role in the generation of these symptoms. In contrast, the symptom severity of Epigastric Burning and Epigastric pain persists with progression of food to the small intestine.

  • Tu2093 Distinction Between Gastric and Small Intestinal Symptoms After a Meal in Patients With Functional Dyspepsia
    Gastroenterology, 2013
    Co-Authors: Hanne Vanheel, Tim Vanuytsel, R. Farré, Kristin Verbeke, Lukas Van Oudenhove, Jan Tack
    Abstract:

    Background: Functional dyspepsia (FD) is a common disorder of gastrointestinal function characterized by chronic Epigastric symptoms. Traditionally, the stomach has been held responsible for the generation of symptoms. The latest reports, however, have pointed out that also the duodenum can be implicated in the pathophysiology of FD. The aim was to analyze the time course of dyspeptic symptoms after a meal in FD patients and to elucidate which symptoms specifically originate from the stomach and/or from the small intestine. Methods: Gastric emptying rate for solids was determined in 308 FD patients fulfilling Rome II criteria (87 men, mean age 42±1 years) using the 14C-octanoic acid breath test. Breath samples were taken before a meal and at 15 min intervals for a period of 240 min postprandially. At each breath sampling, the patients were asked to grade the intensity (03) of 6 symptoms (Epigastric pain, postprandial fullness, bloating, nausea, Epigastric Burning and belching). Gastric half emptying time (t1/2) was calculated from the breath samples to determine the gastric phase and the small intestinal phase per individual. The gastric period was defined as the time interval between time point 15 min and t1/2; the small intestinal phase was defined as the time interval between 3*t1/2 (stomach emptied 87.5%) and the end of the measurement. For each symptom, the average of the severity scores during the gastric and the small intestinal phase was calculated and compared using a paired Student's t test. Data are given as mean±SEM. In addition, time curves of each symptom were analyzed from time point 30 min until 240 min using mixed models with linear effects of time as a continuous independent variable. Results: 161 patients (49 men, mean age 43±1 years) had a t1/2,75min and hence, both a gastric and small intestinal phase during the 4h test period. Numerical analysis revealed that scores for bloating, fullness and belching were higher during the gastric phase compared with the small intestinal phase, while intensities of Epigastric pain, Burning and nausea were similar for the gastric and small intestinal phase (Table 1). This was further supported by the results of the time curves (Table 2). Fullness, bloating, belching and nausea displayed a significant negative slope, indicating a decrease in symptoms with progression of food from the stomach into the small intestine. Symptom severity of Burning and pain showed no decrease, indicating that these symptoms persist with food moving to the small intestine. Conclusion: These data suggest that the stomach as well as the small intestine contribute to the generation of postprandial symptoms in FD patients. Bloating, fullness and belching seem to originate mainly from the stomach; while symptoms of Epigastric Burning, pain and nausea seem to be driven by both stomach and small intestine. Table 1

  • Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in man.
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2009
    Co-Authors: Sébastien Kindt, Robin Vos, Kathleen Blondeau, Jan Tack
    Abstract:

    Heartburn is the most typical gastro-oesophageal reflux disease (GERD) symptom. The transient receptor potential vanilloid receptor-1 (TRPV(1)) is a candidate mediator of heartburn. Exposure of TRPV(1) to capsaicin is characterized by activation, followed by desensitization. Our aim was to investigate the effect of intra-oesophageal capsaicin instillation on oesophageal symptom perception (activation) and on sensitivity to oesophageal acid perfusion and oesophageal balloon distention (desensitization). In a first protocol (n = 10), saline or capsaicin solution were instilled in the mid-oesophagus and symptoms were rated at 5-min intervals for 60 min. In a second study (n = 10), oesophageal 0.1 N hydrochloric acid perfusion was performed 60 min after pretreatment with saline, low or high dose capsaicin. In a third study (n = 10), sensitivity to oesophageal balloon distention was determined before and at 30-min intervals up to 90 min after pretreatment with saline, low or high dose capsaicin. Areas under the curve (AUC) for symptom intensities under different conditions were calculated and compared with Kruskal-Wallis test. Oesophageal capsaicin instillation induced transient symptoms of retrosternal and Epigastric Burning in a dose-dependent fashion. After oesophageal capsaicin or saline instillation, there was no difference in symptom pattern and intensities induced by oesophageal acid perfusion. After oesophageal capsaicin or saline instillation, sensitivity to oesophageal balloon distention and oesophageal compliance were not significantly altered. Oesophageal instillation of the TRPV(1) receptor agonist capsaicin induces symptoms of retrosternal and Epigastric Burning in a dose-dependent fashion. Pretreatment with capsaicin does not desensitize the oesophagus to acid perfusion or to balloon distention.

  • Prolonged duodenal acid perfusion and dyspeptic symptom occurrence in healthy volunteers
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2009
    Co-Authors: M Di Stefano, Tim Vanuytsel, Rita Vos, Jozef Janssens, Jan Tack
    Abstract:

    The pathophysiology of functional dyspepsia (FD) is unknown and several mechanisms associated with specific symptom patterns have been recently proposed. Increased duodenal acid exposure has been supposed to be associated with nausea, but recently an increase of severity of several dyspeptic symptoms was noted in a subset of dyspeptic patients. As its pathogenetic role is still unclear, we evaluated an involvement of duodenal acid exposure in symptom generation by inducing a hyperacidity status of the duodenum. Twelve young adult healthy volunteers in a randomized, double-blind protocol, underwent duodenal acid (0.2 N, 5 mL min )1 ) or saline perfusion, antropyloroduodenal manometry and duodenal pH monitoring both during fasting and postprandially. Every 15 min, severity of discomfort, fullness, bloat- ing, belching, nausea, heartburn, Epigastric Burning, satiety and pain were evaluated by visual analogue scale. During acid perfusion, symptom scores for dis- comfort, bloating, nausea, Epigastric Burning were significantly higher (P < 0.01) compared to saline. Postprandial antral motility index was lower (2.96 ± 1.8 vs 3.62 ± 1.8, P = 0.01) and jejunal motility index higher (4.87 ± 1.0 vs 4.37 ± 1.4, P = 0.01) during acid perfusion. Occurrence and duration of phases III of the migrating motor complex showed no difference. Duodenal acid perfusion causes a sensitization to dyspeptic symptoms and induces antral hypomotility and jejunal hypercontractility. Through these mecha- nisms, increased duodenal acid exposure may play a role in the pathophysiology of FD symptoms.

René-marc Flipo - One of the best experts on this subject based on the ideXlab platform.

  • Upper gastrointestinal symptoms in patients treated with nonsteroidal anti-inflammatory drugs: prevalence and impact--the COMPLAINS study.
    European journal of gastroenterology & hepatology, 2010
    Co-Authors: Gérard Thiéfin, Thierry Schaeverbeke, Philippe Barthélémy, Christine Soufflet, René-marc Flipo
    Abstract:

    Objectives To investigate the prevalence and type of upper gastrointestinal symptoms during nonsteroidal anti-inflammatory drug (NSAID) therapy, the impact of these symptoms on daily life and adherence to treatment and the concordance between physicians' and patients' assessments. Methods A sample of 1000 French rheumatologists was invited to participate in the study, of which 630 accepted. Participating physicians enrolled all patients above 18 years of age seen during a 1-week period who had been receiving daily NSAID treatment for at least 3 days (n=8 269 ). Data on gastrointestinal symptoms were collected using a standardized questionnaire. In the first two symptomatic patients seen by each physician, patient and physician questionnaires were used to investigate concordance between symptom evaluations. Results Two thousand seven hundred and ninety-nine patients (33.8%) reported upper gastrointestinal symptoms; of these, 1056 (12.8% of the total population) had acid reflux symptoms (heartburn and/or acid regurgitation). The most common symptoms were Epigastric Burning (17.3%) and Epigastric discomfort or pain (14.4%). Symptoms were less common with coxibs than with nonselective NSAIDs (26.4 vs. 35.4%, P

Raf Bisschops - One of the best experts on this subject based on the ideXlab platform.

  • M1210 Subgroups in Functional Dyspepsia: A Cluster Analysis Approach Based On the Interaction of Symptom Severity, Gastric Sensitivity and Psychosocial Factors
    Gastroenterology, 2009
    Co-Authors: Lukas Van Oudenhove, Rita Vos, Raf Bisschops, Joris Arts, Philip Caenepeel, Lieselot Holvoet, Dominiek De Wulf, Koen Demyttenaere, Jan Tack
    Abstract:

    Introduction: The Rome III consensus proposed to subdivide functional dyspepsia (FD) into Epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS), based on the symptom pattern (Tack et al, Gastroenterology 2006). The same consensus proposed to consider separate diagnostic categories for nausea/vomiting and for belching disorders. Aim: To empirically investigate the validity of this symptom-based subgrouping. Methods: In 705 consecutive tertiary care patients, clinically diagnosed with FD according to Rome II criteria, the severity of 8 FD symptoms (pain, fullness, bloating, early satiation, nausea, vomiting, belching & Epigastric Burning) was scored on a Likert scale [range: 0-3 (absent, mild, moderate, severe)]. First, hierarchical cluster analysis with Ward's clustering method was used to determine the most appropriate number of clusters for subsequent non-hierarchical cluster analysis. Second, non-hierarchical cluster analysis with full seed replacement was performed to determine the optimal cluster solution. Results: The median (IQR) score was 2 (0-2) for pain & early satiation, 2 (1-3) for fullness, 2 (1-2) for bloating, 1 (0-2) for nausea, belching & Epigastric Burning and 0 (0-1) for vomiting. Hierarchical cluster analysis suggested a 4 cluster solution, based on the R2 method. Non-hierarchical cluster analysis with 4 clusters on all 8 variables showed very low R2 values for the variable belching, indicating that it may no be sufficiently appropriate for forming clusters. Therefore, this variable was removed from the final analysis. Non-hierarchical cluster analysis with 4 clusters on the 7 remaining variables resulted in an overall R2 of 0.37, indicating considerable overlap between the clusters. Vomiting, pain and early satiation were found to be the most important variables separating the clusters, with R2 values of 0.67, 0.54 and 0.52, respectively. The first cluster was characterized by high early satiety, fullness & bloating and moderate pain (‘postprandial distress cluster'). The second cluster was characterized by high vomiting, nausea and fullness (‘nausea-vomiting cluster'). The third cluster was characterized by high pain (‘Epigastric pain cluster'). The fourth cluster was characterized by low scores on all symptoms (‘limited severity cluster'). Conclusion: The symptom-based subgroups from the Rome III criteria are supported by the present data which confirmed the existence of EPS and PDS subgroups and a nausea/vomiting cluster. On the other hand, another ‘low severity” subgroup was also identiefied and overlap between subgroups is considerable.

  • M1208 Symptom-Based Subgroups in Functional Dyspepsia: A Cluster Analysis Approach
    Gastroenterology, 2009
    Co-Authors: Lukas Van Oudenhove, Rita Vos, Raf Bisschops, Joris Arts, Philip Caenepeel, Lieselot Holvoet, Dominiek De Wulf, Koen Demyttenaere, Jan Tack
    Abstract:

    Introduction: The Rome III consensus proposed to subdivide functional dyspepsia (FD) into Epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS), based on the symptom pattern (Tack et al, Gastroenterology 2006). The same consensus proposed to consider separate diagnostic categories for nausea/vomiting and for belching disorders. Aim: To empirically investigate the validity of this symptom-based subgrouping. Methods: In 705 consecutive tertiary care patients, clinically diagnosed with FD according to Rome II criteria, the severity of 8 FD symptoms (pain, fullness, bloating, early satiation, nausea, vomiting, belching & Epigastric Burning) was scored on a Likert scale [range: 0-3 (absent, mild, moderate, severe)]. First, hierarchical cluster analysis with Ward's clustering method was used to determine the most appropriate number of clusters for subsequent non-hierarchical cluster analysis. Second, non-hierarchical cluster analysis with full seed replacement was performed to determine the optimal cluster solution. Results: The median (IQR) score was 2 (0-2) for pain & early satiation, 2 (1-3) for fullness, 2 (1-2) for bloating, 1 (0-2) for nausea, belching & Epigastric Burning and 0 (0-1) for vomiting. Hierarchical cluster analysis suggested a 4 cluster solution, based on the R2 method. Non-hierarchical cluster analysis with 4 clusters on all 8 variables showed very low R2 values for the variable belching, indicating that it may no be sufficiently appropriate for forming clusters. Therefore, this variable was removed from the final analysis. Non-hierarchical cluster analysis with 4 clusters on the 7 remaining variables resulted in an overall R2 of 0.37, indicating considerable overlap between the clusters. Vomiting, pain and early satiation were found to be the most important variables separating the clusters, with R2 values of 0.67, 0.54 and 0.52, respectively. The first cluster was characterized by high early satiety, fullness & bloating and moderate pain (‘postprandial distress cluster'). The second cluster was characterized by high vomiting, nausea and fullness (‘nausea-vomiting cluster'). The third cluster was characterized by high pain (‘Epigastric pain cluster'). The fourth cluster was characterized by low scores on all symptoms (‘limited severity cluster'). Conclusion: The symptom-based subgroups from the Rome III criteria are supported by the present data which confirmed the existence of EPS and PDS subgroups and a nausea/vomiting cluster. On the other hand, another ‘low severity” subgroup was also identiefied and overlap between subgroups is considerable.

  • 180 Different Time Course of PDS Versus EPS Functional Dyspepsia Symptoms After Ingestion of a Meal
    Gastroenterology, 2008
    Co-Authors: Jan Tack, Raf Bisschops, Joris Arts, Philip Caenepeel, Jozef Janssens
    Abstract:

    Background: According to the Rome III consensus, functional dyspepsia (FD), is subcategorized into Postprandial Distress Syndrome (PDS) and Epigastric Pain Syndrome (EPS). Relationship to ingestion of a meal has been proposed as a distinguishing feature of PDS (comprising early satiation and postprandial fullness) and not of EPS (comprising Epigastric pain and Burning). The aim of the present study was to study the time-course of different FD symptoms after ingestion of a standardized meal. FD patients underwent a 13C-octanoic acid gastric emptying breath test during which they were asked to score the severity (0-4) of 6 symptoms (pain, fullness, bloating, nausea, Epigastric Burning and belching) at each sampling point (every 15 min for 4 hrs postprandially). For each symptom, a meal-related severity score was obtained by adding scores at all time-points. Different curve models were evaluated for goodness of fit of the time after the meal vs. symptom intensity based on the lowest sum of squared errors (SSE). Results: 218 consecutive FD patients (149 women, age 39±1) participated in the study. Meal ingestion was associated with a significant increase in intensity of each symptom at 15 min, and this remained significant throughout the 4 study hours. Meal-related symptom score was highest for fullness (23.2±1.3) and bloating (18.8±1.2), followed by belching (14.8±1.0) and Epigastric pain (14.4±1.2) and lowest for nausea (13.0±1.1) and Epigastric Burning (9.7±1.0). Curve fitting revealed two different patterns. For postprandial fullness, a power law curve with exponential cutoff (y=C*x(T)*e(-x/K)+d) provided the best fit (SSE 0.005, C=0.383; T=-0.336; K=139.937; d=0.647). The same curve type also provided the best fit for bloating (SSE 0.002, C=0.217; T=-0.455; K=112.917; d=0.535), for nausea (SSE 0.008, C=0.042; T=-0.685; K=99.842; d=0.497), and for belching (SSE 0.005, C=0.233; T=-0.404; K=108.262; d=0.403). For Epigastric pain, a sigmoid curve (y=a/(1.0+e(-(x-b)/c))+d) provided the best fit (SSE 0.037, a=-0.846; b= 7.029; c=-8.730; d=1.040). The same curve type also provided the best fit for Epigastric Burning (SSE 0.026, a=-0.646; b=2.938, c=-15.215, d=0.613). Conclusion: In FD patients, Epigastric pain and Burning follow a different pattern and time course after a standardized meal compared to fullness, bloating, nausea and belching. The different types of curve that best approximate these respective time courses do not depend on symptom intensity, and suggest different underlying pathophysiological mechanisms. The observations and curve fitting support the Rome III subdivision of FD into EPS versus PDS.

  • Influence of ghrelin on gastric emptying and meal‐related symptoms in idiopathic gastroparesis
    Alimentary pharmacology & therapeutics, 2005
    Co-Authors: Jan Tack, Kristin Verbeke, Jozef Janssens, Raf Bisschops, Inge Depoortere, Theo L. Peeters
    Abstract:

    Summary Background : Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor, is released from the stomach. Animal studies suggest that ghrelin stimulates gastrointestinal motor activity. Aim : To investigate the influence of ghrelin on gastric emptying rate and meal-related symptoms in idiopathic gastroparesis. Methods : In six patients with idiopathic gastroparesis, a breath test was used to measure gastric emptying rates (t1/2) for solids and liquids after administration of saline or ghrelin 40 μg/30 min in a double-blind, randomized fashion. At each breath sampling, the patient was asked to grade the intensity of six different symptoms (Epigastric pain, bloating, postprandial fullness, nausea, belching and Epigastric Burning) and these were added to obtain meal-related symptom severity score. Results : Ghrelin significantly enhanced liquid emptying (t1/2: 86 ± 7 vs. 53 ± 6 min, P = 0.02) and tended to enhance solid emptying (144 ± 45 vs. 98 ± 15 min, P = 0.06). Ghrelin pre-treatment significantly decreased cumulative meal-related symptom score (196 ± 30 vs. 136 ± 23, P = 0.04) and individual scores for fullness (55 ± 8 vs. 39 ± 8, P = 0.02), and for pain (40 ± 8 vs. 16 ± 5, P 

Zhou Ya-bin - One of the best experts on this subject based on the ideXlab platform.

  • Clinical study of Wangshi Baochi Pill on children with functional dyspepsia
    China Journal of Traditional Chinese Medicine and Pharmacy, 2014
    Co-Authors: Zhou Ya-bin
    Abstract:

    Objective: To evaluate the clinical effects of Wangshi Baochi Pill for children with functional dyspepsia(FD) by randomized controlled clinical trial. Methods: According to the proportion of 2∶1, 150 cases of children with FD were randomly divided into 100 cases of Wangshi Baochi Pill treatment group and 50 cases of domperidone oral liquid control group. After accepted the treatment for 4 weeks, the two groups were evaluated by the symptoms of postprandial fullness, early satiety, abdominal pain, Epigastric Burning, reduction of appetite, food intake and belching. Results: There was a statistically signii cant dif erence for Wangshi Baochi Pill treatment group in improving the symptoms of postprandial fullness, early satiety, abdominal pain, appetite and belching, compared with before treatment(P0.05). There was no dif erence in restoring gastrointestinal motility between Wangshi Baochi Pill treatment group and domperidone oral liquid group, while a signii cant dif erence in improving appetite(P0.05). The total effective rate of Wangshi Baochi Pill group was 83% in improving appetite, while the domperidone oral liquid group was 68%. Conclusion: Wangshi Banchi Pill has signii cant clinical effects on the treatment ofchildren with functional dyspepsia. The pharmacological mechanisms of Wangshi Banchi Pill in improving gastrointestinal motility needed further research.

  • Clinical Observation on “Wangshi Baochi Pill”for Children with Functional Dyspepsia
    2013
    Co-Authors: Zhou Ya-bin
    Abstract:

    Objective: To evaluate the clinical effect of "Wangshi Baochi Pill"for children with functional dyspepsia( FD). Methods: One hundred and fifty children with FD were randomly divided into the treatment group( 100 cases) and control group( 50 cases) according to 2 ∶ 1 ratio. The treatment group was treated by"Wangshi Baochi Pill"and the control group was treated by domperidone oral liquid,with a course of 28 days. The changes of main clinical symptoms,such as postprandial fullness and discomfort,early satiety,Epigastric pain,Epigastric Burning,reduction of food intake,eructation, and the clinical effects were evaluated. Results: After treatment,the total effective rates of treatment group and control group were 83% and 68% respectively,and the effect of treatment group was better than that of the control group( P 0. 05). After treatment,the symptoms of postprandial fullness,early satiety,Epigastric pain,reduction of food intake and eructation were significantly alleviated in treatment group( P 0. 05),the symptoms of postprandial fullness,early satiety,reduction of food intake and eructation were significantly relieved in control group( P 0. 05),and the improvement of the reduction of food intake in treatment group was better than that in control group( P 0. 05). Conclusion: "Wangshi Baochi Pill"has good effect in the treatment of FD for children.