The Experts below are selected from a list of 1212 Experts worldwide ranked by ideXlab platform
Serge Jothy - One of the best experts on this subject based on the ideXlab platform.
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clinicopathological relevance of the association between gastrointestinal and sebaceous neoplasms the muir torre syndrome
Human Pathology, 1995Co-Authors: Francois Paraf, Denis Sasseville, Kevin A Watters, Steven A Narod, Ophira Ginsburg, Henry Shibata, Serge JothyAbstract:The association between sebaceous neoplasms of the skin and visceral cancers, known as Muir-Torre syndrome, is described in three patients, including one with an extensive history of cancer in his family. The first patient, a 54-year-old man, developed multiple sebaceous adenomas, Epitheliomas, and carcinomas in association with a colonic carcinoma 6 years after cardiac transplantation. Family history in this patient disclosed colon cancer in 17 relatives. The second patient was a 51-year-old man who had recurrent adenocarcinoma of the sigmoid colon, adenocarcinoma arising in Barrett's esophagus, and sebaceous Epithelioma during a period of 15 years. The third patient was a 90-year-old man with a sebaceous adenoma followed 5 months later by adenocarcinoma of the sigmoid colon with liver metastases. Muir-Torre syndrome in 129 other patients published in the literature is reviewed. Although it is a rare disease, Muir-Torre syndrome requires recognition because skin lesions may be the first sign of the syndrome and this may lead to early diagnosis of associated visceral cancers. Moreover, because this syndrome appears to be inherited, family members should be screened for visceral cancer, especially colorectal adenocarcinoma.
Douglas Torre - One of the best experts on this subject based on the ideXlab platform.
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The Muir-Torre syndrome: A 25-year retrospect
Journal of the American Academy of Dermatology, 1995Co-Authors: Robert A. Schwartz, Douglas TorreAbstract:The Torre or Muir-Torre syndrome consists of certain types of sebaceous neoplasms of the skin, with or without keratoacanthomas, and one or more low-grade visceral malignancies in the absence of other predisposing factors. The sebaceous tumors are relatively uncommon or rare: sebaceous adenoma, sebaceous Epithelioma, basal cell Epithelioma with sebaceous differentiation, and sebaceous carcinoma. Sebaceous hyperplasia and hamartomas such as nevus sebaceus of Jadassohn, with or without a sebaceous Epithelioma within it, are not a defining part of this syndrome. Sebaceous hyperplasia is common in elderly light-complexioned people with or without this syndrome. Nevus sebaceus of Jadassohn is not rare and is predisposed to the development of other neoplasms within it, including occasionally a sebaceous Epithelioma. Colonic polyps are frequently present. Muir-Torre syndrome requires recognition because affected patients are at risk of multiple primary malignancies. The skin lesions may be the first sign of this syndrome, although more often its cutaneous signs follow the diagnosis of at least the first visceral malignancy. The Muir-Torre syndrome portends the greater possibility of a favorable prognosis than might be anticipated otherwise because the visceral cancers are usually low-grade malignancies. However, they are often multiple, so identifying such patients will affect their management in a few ways. Because these indolent visceral malignancies tend to permit prolonged survival, even metastatic disease may respond well to aggressive surgical treatment. The sebaceous cancers in this syndrome, like the visceral malignancies, are less aggressive than their counterparts unassociated with this syndrome. Because this syndrome is inherited in an autosomal dominant manner, identifying one patient means delineating an entire family, which should be investigated. This syndrome may be caused by a defective mismatch DNA repair gene.
Hiroshi Shimizu - One of the best experts on this subject based on the ideXlab platform.
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reticulated acanthoma with sebaceous differentiation
European Journal of Dermatology, 2017Co-Authors: Shinichi Nakazato, Teruki Yanagi, Yuka Inamura, Shinya Kitamura, Hiroo Hata, Yasuyuki Fujita, Takashi Anan, Masaru Honma, Hiroshi ShimizuAbstract:Reticulated acanthoma with sebaceous differentiation (RASD) is a rare benign sebaceous tumour that is histopathologically characterized by basaloid cell proliferation in a plate-like configuration, underlain by sebaceous glands [1]. It was first described as “superficial Epithelioma with sebaceous differentiation” (SESD) [2]. Since the term “Epithelioma” is likely to be confused with malignancy, RASD was proposed as a new designation by Steffen and Ackerman [3]. Based on the lack of apocrine [...]
Francois Paraf - One of the best experts on this subject based on the ideXlab platform.
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clinicopathological relevance of the association between gastrointestinal and sebaceous neoplasms the muir torre syndrome
Human Pathology, 1995Co-Authors: Francois Paraf, Denis Sasseville, Kevin A Watters, Steven A Narod, Ophira Ginsburg, Henry Shibata, Serge JothyAbstract:The association between sebaceous neoplasms of the skin and visceral cancers, known as Muir-Torre syndrome, is described in three patients, including one with an extensive history of cancer in his family. The first patient, a 54-year-old man, developed multiple sebaceous adenomas, Epitheliomas, and carcinomas in association with a colonic carcinoma 6 years after cardiac transplantation. Family history in this patient disclosed colon cancer in 17 relatives. The second patient was a 51-year-old man who had recurrent adenocarcinoma of the sigmoid colon, adenocarcinoma arising in Barrett's esophagus, and sebaceous Epithelioma during a period of 15 years. The third patient was a 90-year-old man with a sebaceous adenoma followed 5 months later by adenocarcinoma of the sigmoid colon with liver metastases. Muir-Torre syndrome in 129 other patients published in the literature is reviewed. Although it is a rare disease, Muir-Torre syndrome requires recognition because skin lesions may be the first sign of the syndrome and this may lead to early diagnosis of associated visceral cancers. Moreover, because this syndrome appears to be inherited, family members should be screened for visceral cancer, especially colorectal adenocarcinoma.
Robert A. Schwartz - One of the best experts on this subject based on the ideXlab platform.
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The Muir-Torre syndrome: A 25-year retrospect
Journal of the American Academy of Dermatology, 1995Co-Authors: Robert A. Schwartz, Douglas TorreAbstract:The Torre or Muir-Torre syndrome consists of certain types of sebaceous neoplasms of the skin, with or without keratoacanthomas, and one or more low-grade visceral malignancies in the absence of other predisposing factors. The sebaceous tumors are relatively uncommon or rare: sebaceous adenoma, sebaceous Epithelioma, basal cell Epithelioma with sebaceous differentiation, and sebaceous carcinoma. Sebaceous hyperplasia and hamartomas such as nevus sebaceus of Jadassohn, with or without a sebaceous Epithelioma within it, are not a defining part of this syndrome. Sebaceous hyperplasia is common in elderly light-complexioned people with or without this syndrome. Nevus sebaceus of Jadassohn is not rare and is predisposed to the development of other neoplasms within it, including occasionally a sebaceous Epithelioma. Colonic polyps are frequently present. Muir-Torre syndrome requires recognition because affected patients are at risk of multiple primary malignancies. The skin lesions may be the first sign of this syndrome, although more often its cutaneous signs follow the diagnosis of at least the first visceral malignancy. The Muir-Torre syndrome portends the greater possibility of a favorable prognosis than might be anticipated otherwise because the visceral cancers are usually low-grade malignancies. However, they are often multiple, so identifying such patients will affect their management in a few ways. Because these indolent visceral malignancies tend to permit prolonged survival, even metastatic disease may respond well to aggressive surgical treatment. The sebaceous cancers in this syndrome, like the visceral malignancies, are less aggressive than their counterparts unassociated with this syndrome. Because this syndrome is inherited in an autosomal dominant manner, identifying one patient means delineating an entire family, which should be investigated. This syndrome may be caused by a defective mismatch DNA repair gene.