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Julie H Tsai - One of the best experts on this subject based on the ideXlab platform.

  • Vogt–Koyanagi–Harada disease in Hispanic patients
    International Ophthalmology, 2007
    Co-Authors: Somsiri Sukavatcharin, Julie H Tsai
    Abstract:

    Purpose To describe the clinical features of Vogt–Koyanagi–Harada disease (VKH) in Hispanic patients. Methods Retrospective review of the records of 48 Hispanic patients diagnosed with VKH. The patients were divided into two groups: patients in the early phase of VKH ( n  = 11) were those who presented within 1 month after the onset of symptoms; patients in the late or chronic VKH phase ( n  = 37) were those who presented 6 months after onset of symptoms. Demographic data, clinical features, complications and initial and final visual acuity for each patient were recorded. Results All 11 patients in early phase VKH presented with bilateral uveitis (100%). Meningismus was noted in six cases and auditory disturbances in three. Ocular findings for these 11 patients included exudative retinal detachment in ten patients (91%) and marked optic disc edema in one patient. In the late phase VKH, ocular findings included sunset glow fundus in 26 patients (70%), peripheral nummular scars in 27 (73%), and retinal pigment Epithelium Hyperplasia in seven (19%). Extraocular manifestations noted in this group of patients included vitiligo in four, poliosis in six, and alopecia in five; auditory disturbances were found in four patients. The visual acuity improved in 60–70% of the patients after treatment with corticosteroids alone or in combination with immunosuppressive agents. Conclusion Hispanic patients with VKH often present without extraocular changes during early phase of the disease. However, once the disease evolves into the chronic phase, integumentary system involvement may become apparent in some patients.

  • Vogt-Koyanagi-Harada disease in Hispanic patients.
    International ophthalmology, 2007
    Co-Authors: Somsiri Sukavatcharin, Julie H Tsai
    Abstract:

    To describe the clinical features of Vogt-Koyanagi-Harada disease (VKH) in Hispanic patients. Retrospective review of the records of 48 Hispanic patients diagnosed with VKH. The patients were divided into two groups: patients in the early phase of VKH (n = 11) were those who presented within 1 month after the onset of symptoms; patients in the late or chronic VKH phase (n = 37) were those who presented 6 months after onset of symptoms. Demographic data, clinical features, complications and initial and final visual acuity for each patient were recorded. All 11 patients in early phase VKH presented with bilateral uveitis (100%). Meningismus was noted in six cases and auditory disturbances in three. Ocular findings for these 11 patients included exudative retinal detachment in ten patients (91%) and marked optic disc edema in one patient. In the late phase VKH, ocular findings included sunset glow fundus in 26 patients (70%), peripheral nummular scars in 27 (73%), and retinal pigment Epithelium Hyperplasia in seven (19%). Extraocular manifestations noted in this group of patients included vitiligo in four, poliosis in six, and alopecia in five; auditory disturbances were found in four patients. The visual acuity improved in 60-70% of the patients after treatment with corticosteroids alone or in combination with immunosuppressive agents. Hispanic patients with VKH often present without extraocular changes during early phase of the disease. However, once the disease evolves into the chronic phase, integumentary system involvement may become apparent in some patients.

Panagiotis Kanavaros - One of the best experts on this subject based on the ideXlab platform.

  • The in vivo cell kinetics in breast carcinogenesis
    Breast Cancer Research, 2001
    Co-Authors: Niki J. Agnantis, Sevasti Kamina, P. Zagorianakou, A. Demou, A Katsaraki, Roberto Agresti, Elda Tagliabue, Panagiotis Kanavaros, Cristina Ghirelli
    Abstract:

    Background Disruption of the balance between apoptosis and proliferation is considered to be an important factor in the development and progression of tumours. In the present study we determined the in vivo cell kinetics along the spectrum of apparently normal Epithelium, Hyperplasia, preinvasive lesions and invasive carcinoma, in breast tissues affected by fibrocystic changes in which preinvasive and/or invasive lesions developed, as a model of breast carcinogenesis.

  • In vivo cell kinetics in breast carcinogenesis
    Breast Cancer Research, 2001
    Co-Authors: Niki J. Agnantis, Sevasti Kamina, P. Zagorianakou, A. Demou, A Katsaraki, Panagiotis Kanavaros
    Abstract:

    Background Disruption of the balance between apoptosis and proliferation is considered to be an important factor in the development and progression of tumours. In the present study we determined the in vivo cell kinetics along the spectrum of apparently normal Epithelium, Hyperplasia, preinvasive lesions and invasive carcinoma, in breast tissues affected by fibrocystic changes in which preinvasive and/or invasive lesions developed, as a model of breast carcinogenesis. Materials and methods A total of 32 areas of apparently normal Epithelium and 135 ductal proliferative and neoplastic lesions were studied. More than one epithelial lesion per case were analyzed. The apoptotic index (AI) and the proliferative index (PI) were expressed as the percentage of TdT-mediated dUTP-nick end-labelling (TUNEL) and Ki-67-positive cells, respectively. The PI/AI (P/A index) was calculated for each case. Results The AIs and PIs were significantly higher in Hyperplasia than in apparently normal Epithelium ( P = 0.04 and P = 0.0005, respectively), in atypical Hyperplasia than in Hyperplasia ( P = 0.01 and P = 0.04, respectively) and in invasive carcinoma than in in situ carcinoma ( P < 0.001 and P < 0.001, respectively). The two indices were similar in atypical Hyperplasia and in in situ carcinoma. The P/A index increased significantly from normal Epithelium to Hyperplasia ( P = 0.01) and from preinvasive lesions to invasive carcinoma ( P = 0.04) whereas it was decreased (non-significantly) from Hyperplasia to preinvasive lesions. A strong positive correlation between the AIs and the PIs was found ( r = 0.83, P < 0.001). Conclusion These findings suggest accelerating cell turnover along the continuum of breast carcinogenesis. Atypical Hyperplasias and in situ carcinomas might be kinetically similar lesions. In the transition from normal Epithelium to Hyperplasia and from preinvasive lesions to invasive carcinoma the net growth of epithelial cells results from a growth imbalance in favour of proliferation. In the transition from Hyperplasia to preinvasive lesions there is an imbalance in favour of apoptosis.

Somsiri Sukavatcharin - One of the best experts on this subject based on the ideXlab platform.

  • Vogt–Koyanagi–Harada disease in Hispanic patients
    International Ophthalmology, 2007
    Co-Authors: Somsiri Sukavatcharin, Julie H Tsai
    Abstract:

    Purpose To describe the clinical features of Vogt–Koyanagi–Harada disease (VKH) in Hispanic patients. Methods Retrospective review of the records of 48 Hispanic patients diagnosed with VKH. The patients were divided into two groups: patients in the early phase of VKH ( n  = 11) were those who presented within 1 month after the onset of symptoms; patients in the late or chronic VKH phase ( n  = 37) were those who presented 6 months after onset of symptoms. Demographic data, clinical features, complications and initial and final visual acuity for each patient were recorded. Results All 11 patients in early phase VKH presented with bilateral uveitis (100%). Meningismus was noted in six cases and auditory disturbances in three. Ocular findings for these 11 patients included exudative retinal detachment in ten patients (91%) and marked optic disc edema in one patient. In the late phase VKH, ocular findings included sunset glow fundus in 26 patients (70%), peripheral nummular scars in 27 (73%), and retinal pigment Epithelium Hyperplasia in seven (19%). Extraocular manifestations noted in this group of patients included vitiligo in four, poliosis in six, and alopecia in five; auditory disturbances were found in four patients. The visual acuity improved in 60–70% of the patients after treatment with corticosteroids alone or in combination with immunosuppressive agents. Conclusion Hispanic patients with VKH often present without extraocular changes during early phase of the disease. However, once the disease evolves into the chronic phase, integumentary system involvement may become apparent in some patients.

  • Vogt-Koyanagi-Harada disease in Hispanic patients.
    International ophthalmology, 2007
    Co-Authors: Somsiri Sukavatcharin, Julie H Tsai
    Abstract:

    To describe the clinical features of Vogt-Koyanagi-Harada disease (VKH) in Hispanic patients. Retrospective review of the records of 48 Hispanic patients diagnosed with VKH. The patients were divided into two groups: patients in the early phase of VKH (n = 11) were those who presented within 1 month after the onset of symptoms; patients in the late or chronic VKH phase (n = 37) were those who presented 6 months after onset of symptoms. Demographic data, clinical features, complications and initial and final visual acuity for each patient were recorded. All 11 patients in early phase VKH presented with bilateral uveitis (100%). Meningismus was noted in six cases and auditory disturbances in three. Ocular findings for these 11 patients included exudative retinal detachment in ten patients (91%) and marked optic disc edema in one patient. In the late phase VKH, ocular findings included sunset glow fundus in 26 patients (70%), peripheral nummular scars in 27 (73%), and retinal pigment Epithelium Hyperplasia in seven (19%). Extraocular manifestations noted in this group of patients included vitiligo in four, poliosis in six, and alopecia in five; auditory disturbances were found in four patients. The visual acuity improved in 60-70% of the patients after treatment with corticosteroids alone or in combination with immunosuppressive agents. Hispanic patients with VKH often present without extraocular changes during early phase of the disease. However, once the disease evolves into the chronic phase, integumentary system involvement may become apparent in some patients.

Niki J. Agnantis - One of the best experts on this subject based on the ideXlab platform.

  • The in vivo cell kinetics in breast carcinogenesis
    Breast Cancer Research, 2001
    Co-Authors: Niki J. Agnantis, Sevasti Kamina, P. Zagorianakou, A. Demou, A Katsaraki, Roberto Agresti, Elda Tagliabue, Panagiotis Kanavaros, Cristina Ghirelli
    Abstract:

    Background Disruption of the balance between apoptosis and proliferation is considered to be an important factor in the development and progression of tumours. In the present study we determined the in vivo cell kinetics along the spectrum of apparently normal Epithelium, Hyperplasia, preinvasive lesions and invasive carcinoma, in breast tissues affected by fibrocystic changes in which preinvasive and/or invasive lesions developed, as a model of breast carcinogenesis.

  • In vivo cell kinetics in breast carcinogenesis
    Breast Cancer Research, 2001
    Co-Authors: Niki J. Agnantis, Sevasti Kamina, P. Zagorianakou, A. Demou, A Katsaraki, Panagiotis Kanavaros
    Abstract:

    Background Disruption of the balance between apoptosis and proliferation is considered to be an important factor in the development and progression of tumours. In the present study we determined the in vivo cell kinetics along the spectrum of apparently normal Epithelium, Hyperplasia, preinvasive lesions and invasive carcinoma, in breast tissues affected by fibrocystic changes in which preinvasive and/or invasive lesions developed, as a model of breast carcinogenesis. Materials and methods A total of 32 areas of apparently normal Epithelium and 135 ductal proliferative and neoplastic lesions were studied. More than one epithelial lesion per case were analyzed. The apoptotic index (AI) and the proliferative index (PI) were expressed as the percentage of TdT-mediated dUTP-nick end-labelling (TUNEL) and Ki-67-positive cells, respectively. The PI/AI (P/A index) was calculated for each case. Results The AIs and PIs were significantly higher in Hyperplasia than in apparently normal Epithelium ( P = 0.04 and P = 0.0005, respectively), in atypical Hyperplasia than in Hyperplasia ( P = 0.01 and P = 0.04, respectively) and in invasive carcinoma than in in situ carcinoma ( P < 0.001 and P < 0.001, respectively). The two indices were similar in atypical Hyperplasia and in in situ carcinoma. The P/A index increased significantly from normal Epithelium to Hyperplasia ( P = 0.01) and from preinvasive lesions to invasive carcinoma ( P = 0.04) whereas it was decreased (non-significantly) from Hyperplasia to preinvasive lesions. A strong positive correlation between the AIs and the PIs was found ( r = 0.83, P < 0.001). Conclusion These findings suggest accelerating cell turnover along the continuum of breast carcinogenesis. Atypical Hyperplasias and in situ carcinomas might be kinetically similar lesions. In the transition from normal Epithelium to Hyperplasia and from preinvasive lesions to invasive carcinoma the net growth of epithelial cells results from a growth imbalance in favour of proliferation. In the transition from Hyperplasia to preinvasive lesions there is an imbalance in favour of apoptosis.

Sevasti Kamina - One of the best experts on this subject based on the ideXlab platform.

  • The in vivo cell kinetics in breast carcinogenesis
    Breast Cancer Research, 2001
    Co-Authors: Niki J. Agnantis, Sevasti Kamina, P. Zagorianakou, A. Demou, A Katsaraki, Roberto Agresti, Elda Tagliabue, Panagiotis Kanavaros, Cristina Ghirelli
    Abstract:

    Background Disruption of the balance between apoptosis and proliferation is considered to be an important factor in the development and progression of tumours. In the present study we determined the in vivo cell kinetics along the spectrum of apparently normal Epithelium, Hyperplasia, preinvasive lesions and invasive carcinoma, in breast tissues affected by fibrocystic changes in which preinvasive and/or invasive lesions developed, as a model of breast carcinogenesis.

  • In vivo cell kinetics in breast carcinogenesis
    Breast Cancer Research, 2001
    Co-Authors: Niki J. Agnantis, Sevasti Kamina, P. Zagorianakou, A. Demou, A Katsaraki, Panagiotis Kanavaros
    Abstract:

    Background Disruption of the balance between apoptosis and proliferation is considered to be an important factor in the development and progression of tumours. In the present study we determined the in vivo cell kinetics along the spectrum of apparently normal Epithelium, Hyperplasia, preinvasive lesions and invasive carcinoma, in breast tissues affected by fibrocystic changes in which preinvasive and/or invasive lesions developed, as a model of breast carcinogenesis. Materials and methods A total of 32 areas of apparently normal Epithelium and 135 ductal proliferative and neoplastic lesions were studied. More than one epithelial lesion per case were analyzed. The apoptotic index (AI) and the proliferative index (PI) were expressed as the percentage of TdT-mediated dUTP-nick end-labelling (TUNEL) and Ki-67-positive cells, respectively. The PI/AI (P/A index) was calculated for each case. Results The AIs and PIs were significantly higher in Hyperplasia than in apparently normal Epithelium ( P = 0.04 and P = 0.0005, respectively), in atypical Hyperplasia than in Hyperplasia ( P = 0.01 and P = 0.04, respectively) and in invasive carcinoma than in in situ carcinoma ( P < 0.001 and P < 0.001, respectively). The two indices were similar in atypical Hyperplasia and in in situ carcinoma. The P/A index increased significantly from normal Epithelium to Hyperplasia ( P = 0.01) and from preinvasive lesions to invasive carcinoma ( P = 0.04) whereas it was decreased (non-significantly) from Hyperplasia to preinvasive lesions. A strong positive correlation between the AIs and the PIs was found ( r = 0.83, P < 0.001). Conclusion These findings suggest accelerating cell turnover along the continuum of breast carcinogenesis. Atypical Hyperplasias and in situ carcinomas might be kinetically similar lesions. In the transition from normal Epithelium to Hyperplasia and from preinvasive lesions to invasive carcinoma the net growth of epithelial cells results from a growth imbalance in favour of proliferation. In the transition from Hyperplasia to preinvasive lesions there is an imbalance in favour of apoptosis.