The Experts below are selected from a list of 255 Experts worldwide ranked by ideXlab platform
Brian P Eyden - One of the best experts on this subject based on the ideXlab platform.
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Nodular Erythema Elevatum Diutinum mimicking cutaneous neoplasms
Histopathology, 1997Co-Authors: Jonathan H Shanks, Saumitra S Banerjee, P W Bishop, J M Pearson, Brian P EydenAbstract:Aims: We describe the cutaneous pseudoneoplastic lesions in two patients with nodular Erythema Elevatum Diutinum, a rare chronic disorder in which polymorph nuclear fragmentation (leukocytoclasis) is present within dermal nodules showing spindle cells and fibrosis. In both cases diagnostic difficulty was encountered clinically and pathologically and various benign and malignant neoplasms were considered in the differential diagnosis. Methods and results: Immunohistochemically the spindle cells were negative for CAM5.2, AE1/3, S100 protein and desmin (D33). They were positive for vimentin and focally positive for CD34 and α-smooth muscle actin. Some of the spindle cells were positive for Mac 387 and KP1(CD68). By electron microscopy, the lesions were shown to consist of fibroblasts/myofibroblasts and fusiform macrophages. Conclusions: Increased awareness of the features described will help to avoid misdiagnosis as a neoplastic process.
Giampiero Girolomoni - One of the best experts on this subject based on the ideXlab platform.
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Papular neutrophilic dermatosis and Erythema Elevatum Diutinum following erythropoietin therapy in a patient with myelodysplastic syndrome.
Acta dermato-venereologica, 2003Co-Authors: Emanuela Gubinelli, Barbara Cocuroccia, Marcello Fazio, Giorgio Annessi, Giampiero GirolomoniAbstract:A 65-year-old man with refractory anaemia with an excess of blasts developed an Erythematous papular eruption symmetrically distributed on the legs and trunk 3 months after initiation of erythropoietin therapy. The lesions showed a dense neutrophilic infiltrate in the absence of leucocytoclastic vasculitis, and did not fit the criteria of a well-defined neutrophilic dermatosis. Concomitant with the rapid resolution of these skin lesions following erythropoietin discontinuation, typical lesions of Erythema Elevatum Diutinum arose on the extensor surface of the fingers, knees and elbows, which responded to a brief course of dapsone treatment. Although typical and atypical neutrophilic dermatoses have been reported in patients with haematological disorders, they have also been associated with the use of drugs, in particular granulocyte colony-stimulating factor. To our knowledge this is the first report of unclassified neutrophilic dermatosis and Erythema Elevatum Diutinum occurring following the administration of erythropoietin.
Rasheed Ahmad - One of the best experts on this subject based on the ideXlab platform.
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Primary Surgical Treatment of Erythema Elevatum Diutinum.
The Journal of hand surgery, 2018Co-Authors: Shannon L. Ahmad, Matthew Delarosa, William B. Kleinman, Rasheed AhmadAbstract:Erythema Elevatum Diutinum (EED) is a rare skin disease caused an Arthrus-type immunological reaction to antigen with immune complex deposition in the cutaneous microvasculature, which leads to tissue damage secondary to the effects of complement and leukocytes. It presents as brown or red cutaneous nodules, papules, or plaques, often on the extensor surfaces of the hands, knees, or elbows. Onset usually occurs in the fourth to sixth decades but possibly younger in patients with human immunodeficiency virus. Medical treatment is usually successful; however, surgical treatment can be used when chemotherapy fails. We present a case of a 29-year-old man with EED treated with excision and skin grafting.
Jonathan H Shanks - One of the best experts on this subject based on the ideXlab platform.
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Nodular Erythema Elevatum Diutinum mimicking cutaneous neoplasms
Histopathology, 1997Co-Authors: Jonathan H Shanks, Saumitra S Banerjee, P W Bishop, J M Pearson, Brian P EydenAbstract:Aims: We describe the cutaneous pseudoneoplastic lesions in two patients with nodular Erythema Elevatum Diutinum, a rare chronic disorder in which polymorph nuclear fragmentation (leukocytoclasis) is present within dermal nodules showing spindle cells and fibrosis. In both cases diagnostic difficulty was encountered clinically and pathologically and various benign and malignant neoplasms were considered in the differential diagnosis. Methods and results: Immunohistochemically the spindle cells were negative for CAM5.2, AE1/3, S100 protein and desmin (D33). They were positive for vimentin and focally positive for CD34 and α-smooth muscle actin. Some of the spindle cells were positive for Mac 387 and KP1(CD68). By electron microscopy, the lesions were shown to consist of fibroblasts/myofibroblasts and fusiform macrophages. Conclusions: Increased awareness of the features described will help to avoid misdiagnosis as a neoplastic process.
Emanuela Gubinelli - One of the best experts on this subject based on the ideXlab platform.
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Papular neutrophilic dermatosis and Erythema Elevatum Diutinum following erythropoietin therapy in a patient with myelodysplastic syndrome.
Acta dermato-venereologica, 2003Co-Authors: Emanuela Gubinelli, Barbara Cocuroccia, Marcello Fazio, Giorgio Annessi, Giampiero GirolomoniAbstract:A 65-year-old man with refractory anaemia with an excess of blasts developed an Erythematous papular eruption symmetrically distributed on the legs and trunk 3 months after initiation of erythropoietin therapy. The lesions showed a dense neutrophilic infiltrate in the absence of leucocytoclastic vasculitis, and did not fit the criteria of a well-defined neutrophilic dermatosis. Concomitant with the rapid resolution of these skin lesions following erythropoietin discontinuation, typical lesions of Erythema Elevatum Diutinum arose on the extensor surface of the fingers, knees and elbows, which responded to a brief course of dapsone treatment. Although typical and atypical neutrophilic dermatoses have been reported in patients with haematological disorders, they have also been associated with the use of drugs, in particular granulocyte colony-stimulating factor. To our knowledge this is the first report of unclassified neutrophilic dermatosis and Erythema Elevatum Diutinum occurring following the administration of erythropoietin.