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M Leinonen - One of the best experts on this subject based on the ideXlab platform.
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white blood cells c reactive protein and Erythrocyte Sedimentation Rate in pneumococcal pneumonia in children
European Respiratory Journal, 1997Co-Authors: Matti Korppi, Tarja Heiskanenkosma, M LeinonenAbstract:We evaluated the applicability of C-reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), white blood cell count (WBC), and absolute neutrophil count (ANC), in the screening of pneumococcal (PNC) pneumonia in children. In 1981-1982, 161 children were treated for radiologically verified community-acquired pneumonia in the hospital during a period of 12 months. The Streptococcus pneumoniae aetiology of infection was studied by antigen, antibody and immune complex assays in acute and convalescent sera. In acute blood samples, CRP was measured by the immunonephelometric method, ESR by the Westergren method, WBC using an automatic cell counter, and thereafter the ANC was calculated after microscopic examination of peripheral smears. CRP and ESR were significantly higher in patients with alveolar (n=53) than in those with interstitial (n=108) pneumonia. CRP, ESR and ANC were significantly higher in PNC (n=29) than in viral (n=23) pneumonia. The values in mixed PNC and viral infections (n=17) were approximately midway between PNC and viral cases. All cases with serologic evidence of S. pneumoniae aetiology were combined (n=46) for calculation of diagnostic parameters. When a cut-off limit of 60 mg x L(-1) was used, CRP had a sensitivity of 26% and a specificity of 83% in the screening of PNC pneumonia. We conclude that C-reactive protein and Erythrocyte Sedimentation Rate have a limited capacity to differentiate between pneumococcal and nonpneumococcal pneumonia. C-reactive protein is recommended as the first-line method of screening, and the value of 60 mg x L(-1) as the cut-off limit.
Matti Korppi - One of the best experts on this subject based on the ideXlab platform.
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white blood cells c reactive protein and Erythrocyte Sedimentation Rate in pneumococcal pneumonia in children
European Respiratory Journal, 1997Co-Authors: Matti Korppi, Tarja Heiskanenkosma, M LeinonenAbstract:We evaluated the applicability of C-reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), white blood cell count (WBC), and absolute neutrophil count (ANC), in the screening of pneumococcal (PNC) pneumonia in children. In 1981-1982, 161 children were treated for radiologically verified community-acquired pneumonia in the hospital during a period of 12 months. The Streptococcus pneumoniae aetiology of infection was studied by antigen, antibody and immune complex assays in acute and convalescent sera. In acute blood samples, CRP was measured by the immunonephelometric method, ESR by the Westergren method, WBC using an automatic cell counter, and thereafter the ANC was calculated after microscopic examination of peripheral smears. CRP and ESR were significantly higher in patients with alveolar (n=53) than in those with interstitial (n=108) pneumonia. CRP, ESR and ANC were significantly higher in PNC (n=29) than in viral (n=23) pneumonia. The values in mixed PNC and viral infections (n=17) were approximately midway between PNC and viral cases. All cases with serologic evidence of S. pneumoniae aetiology were combined (n=46) for calculation of diagnostic parameters. When a cut-off limit of 60 mg x L(-1) was used, CRP had a sensitivity of 26% and a specificity of 83% in the screening of PNC pneumonia. We conclude that C-reactive protein and Erythrocyte Sedimentation Rate have a limited capacity to differentiate between pneumococcal and nonpneumococcal pneumonia. C-reactive protein is recommended as the first-line method of screening, and the value of 60 mg x L(-1) as the cut-off limit.
Mario Plebani - One of the best experts on this subject based on the ideXlab platform.
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Erythrocyte Sedimentation Rate and c reactive protein in acute inflammation
American Journal of Clinical Pathology, 2019Co-Authors: Ivana Lapic, Andrea Padoan, Dania Bozzato, Mario PlebaniAbstract:OBJECTIVES To assess the diagnostic accuracy of Erythrocyte Sedimentation Rate (ESR) and C-reactive protein (CRP) in acute inflammation. METHODS PubMed and Scopus were searched and eligible articles were screened for methodologic quality using the Quality Assessment of the Diagnostic Accuracy Studies-Revised. Meta-analysis with calculation of pooled sensitivity (Se), specificity (Sp), and summary area under the curve (SAUC) was performed. RESULTS Twenty-nine studies were eligible. Se and Sp were 0.78 and 0.68 (SAUC = 0.80) for ESR in orthopedic infections and 0.79 and 0.70 (SAUC = 0.81) for CRP. For the diagnosis of other various inflammatory conditions, CRP had a superior diagnostic accuracy, with a Se of 0.86, Sp of 0.67, and SAUC of 0.86 compared with a Se of 0.77, Sp of 0.59, and SAUC of 0.75 for ESR. Heterogeneity among studies was elevated. Combined use of ESR and CRP yielded higher diagnostic accuracy. CONCLUSIONS Despite observed heterogeneity among studies, ESR and CRP have a similar diagnostic accuracy in assessment of inflammation, especially in orthopedic conditions.
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Erythrocyte Sedimentation Rate use of fresh blood for quality control
American Journal of Clinical Pathology, 2002Co-Authors: Mario Plebani, Elisa PivaAbstract:The Erythrocyte Sedimentation Rate (ESR) remains the most widely used laboratory test for monitoring the course of infections, inflammatory diseases, and some types of cancer. Several test methods have been developed recently, and as a result the safety and reliability of ESR testing procedures have improved. The method recommended by the International Council for Standardization in Haematology and the National Committee for Clinical Laboratory Standards for ESR measurement is based on the traditional Westergren method, using EDTA-anticoagulated samples without dilution. In clinical laboratories, reliable methods for calibration and the use of appropriate control materials are required for monitoring the accuracy and precision of the routine method. We describe and evaluate a procedure for achieving the daily quality control of ESR and for establishing the limits of agreement between working and reference methods. Data from routine patient samples were used to calculate the daily cumulative mean and to monitor its reproducibility over time. Finally, to monitor analytic performance, a comparison was made between results from the measurement of ESR in specimens stored at 4°C for 24 hours and results obtained in fresh samples.
Frederick Wolfe - One of the best experts on this subject based on the ideXlab platform.
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the many myths of Erythrocyte Sedimentation Rate and c reactive protein
The Journal of Rheumatology, 2009Co-Authors: Frederick WolfeAbstract:In 2004 Ward analyzed 63 rheumatoid arthritis (RA) clinical trial studies with 90 active disease modifying antirheumatic drug treatment arms and demonstRated that Erythrocyte Sedimentation Rate (ESR) was more sensitive to change than C-reactive protein (CRP) at 12 weeks and 24 weeks of treatment, with mean effect size differences of 0.09 to 0.11 units1. It is puzzling that Crowson, et al, authors from the Mayo Clinic and Centocor, address the issues of ESR versus CRP again, and with correlation analyses2. If we get their point, it is that it doesn’t matter which test is used in a clinical trial as they are both about as effective (or ineffective). This conclusion comes primarily from finding similar levels of correlation between swollen joint count and ESR and CRP, and through analysis … Address correspondence to Dr. Wolfe. E-mail: fwolfe{at}arthritis-research.org
Tarja Heiskanenkosma - One of the best experts on this subject based on the ideXlab platform.
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white blood cells c reactive protein and Erythrocyte Sedimentation Rate in pneumococcal pneumonia in children
European Respiratory Journal, 1997Co-Authors: Matti Korppi, Tarja Heiskanenkosma, M LeinonenAbstract:We evaluated the applicability of C-reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), white blood cell count (WBC), and absolute neutrophil count (ANC), in the screening of pneumococcal (PNC) pneumonia in children. In 1981-1982, 161 children were treated for radiologically verified community-acquired pneumonia in the hospital during a period of 12 months. The Streptococcus pneumoniae aetiology of infection was studied by antigen, antibody and immune complex assays in acute and convalescent sera. In acute blood samples, CRP was measured by the immunonephelometric method, ESR by the Westergren method, WBC using an automatic cell counter, and thereafter the ANC was calculated after microscopic examination of peripheral smears. CRP and ESR were significantly higher in patients with alveolar (n=53) than in those with interstitial (n=108) pneumonia. CRP, ESR and ANC were significantly higher in PNC (n=29) than in viral (n=23) pneumonia. The values in mixed PNC and viral infections (n=17) were approximately midway between PNC and viral cases. All cases with serologic evidence of S. pneumoniae aetiology were combined (n=46) for calculation of diagnostic parameters. When a cut-off limit of 60 mg x L(-1) was used, CRP had a sensitivity of 26% and a specificity of 83% in the screening of PNC pneumonia. We conclude that C-reactive protein and Erythrocyte Sedimentation Rate have a limited capacity to differentiate between pneumococcal and nonpneumococcal pneumonia. C-reactive protein is recommended as the first-line method of screening, and the value of 60 mg x L(-1) as the cut-off limit.