The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Andrew M Kropinski - One of the best experts on this subject based on the ideXlab platform.
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taxonomic reassessment of N4 like viruses using comparative genomics and proteomics suggests a new subfamily enquartavirinae
Archives of Virology, 2015Co-Authors: Johannes Wittmann, Jochen Klumpp, Andrea Moreno I Switt, Abdelbaset Yagubi, Hans Wolfgang Ackermann, Martin Wiedmann, Antonet M Svircev, John H E Nash, Andrew M KropinskiAbstract:The GenBank database currently contains sequence data for 33 N4-like viruses, with only one, Escherichia Phage N4, being formally recognized by the ICTV. The genus N4likevirus is uniquely characterized by that fact that its members possess an extremely large, virion-associated RNA polymerase. Using a variety of proteomic, genomic and phylogenetic tools, we have demonstrated that the N4-like Phages are not monophyletic and that N4 is actually a genomic orphan. We propose to create four new genera: “G7cvirus” (consisting of Phages G7C, IME11, KBNP21, vB_EcoP_PhAPEC5, vB_EcoP_PhAPEC7, Bp4, EC1-UPM and pSb-1), “Lit1virus” (LIT1, PA26 and vB_PaeP_C2-10_Ab09), “Sp58virus” (SP058 and SP076), and “Dss3virus” (DSS3φ2 and EE36φ1). We propose that coliPhage N4, the members of “G7cvirus”, Erwinia Phage Ea9-2, and Achromobacter Phage JWAlpha should be considered members of the same subfamily, which we tentatively call the “Enquartavirinae”.
Johannes Wittmann - One of the best experts on this subject based on the ideXlab platform.
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taxonomic reassessment of N4 like viruses using comparative genomics and proteomics suggests a new subfamily enquartavirinae
Archives of Virology, 2015Co-Authors: Johannes Wittmann, Jochen Klumpp, Andrea Moreno I Switt, Abdelbaset Yagubi, Hans Wolfgang Ackermann, Martin Wiedmann, Antonet M Svircev, John H E Nash, Andrew M KropinskiAbstract:The GenBank database currently contains sequence data for 33 N4-like viruses, with only one, Escherichia Phage N4, being formally recognized by the ICTV. The genus N4likevirus is uniquely characterized by that fact that its members possess an extremely large, virion-associated RNA polymerase. Using a variety of proteomic, genomic and phylogenetic tools, we have demonstrated that the N4-like Phages are not monophyletic and that N4 is actually a genomic orphan. We propose to create four new genera: “G7cvirus” (consisting of Phages G7C, IME11, KBNP21, vB_EcoP_PhAPEC5, vB_EcoP_PhAPEC7, Bp4, EC1-UPM and pSb-1), “Lit1virus” (LIT1, PA26 and vB_PaeP_C2-10_Ab09), “Sp58virus” (SP058 and SP076), and “Dss3virus” (DSS3φ2 and EE36φ1). We propose that coliPhage N4, the members of “G7cvirus”, Erwinia Phage Ea9-2, and Achromobacter Phage JWAlpha should be considered members of the same subfamily, which we tentatively call the “Enquartavirinae”.
Adriaenssens Evelien - One of the best experts on this subject based on the ideXlab platform.
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From orphan Phage to a proposed new family–the diversity of N4-like viruses
'MDPI AG', 2020Co-Authors: Wittmann Johannes, Turner Dann, Millard Andrew, Mahadevan Padmanabhan, Kropinski Andrew, Adriaenssens EvelienAbstract:Escherichia Phage N4 was isolated in 1966 in Italy and has remained a genomic orphan for a long time. It encodes an extremely large virion-associated RNA polymerase unique for bacterial viruses that became characteristic for this group. In recent years, due to new and relatively inexpensive sequencing techniques the number of publicly available Phage genome sequences expanded rapidly. This revealed new members of the N4-like Phage group, from 33 members in 2015 to 115 N4-like viruses in 2020. Using new technologies and methods for classification, the Bacterial and Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV) has moved the classification and taxonomy of bacterial viruses from mere morphological approaches to genomic and proteomic methods. The analysis of 115 N4-like genomes resulted in a huge reassessment of this group and the proposal of a new family “Schitoviridae”, including eight subfamilies and numerous new genera
Abdelbaset Yagubi - One of the best experts on this subject based on the ideXlab platform.
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taxonomic reassessment of N4 like viruses using comparative genomics and proteomics suggests a new subfamily enquartavirinae
Archives of Virology, 2015Co-Authors: Johannes Wittmann, Jochen Klumpp, Andrea Moreno I Switt, Abdelbaset Yagubi, Hans Wolfgang Ackermann, Martin Wiedmann, Antonet M Svircev, John H E Nash, Andrew M KropinskiAbstract:The GenBank database currently contains sequence data for 33 N4-like viruses, with only one, Escherichia Phage N4, being formally recognized by the ICTV. The genus N4likevirus is uniquely characterized by that fact that its members possess an extremely large, virion-associated RNA polymerase. Using a variety of proteomic, genomic and phylogenetic tools, we have demonstrated that the N4-like Phages are not monophyletic and that N4 is actually a genomic orphan. We propose to create four new genera: “G7cvirus” (consisting of Phages G7C, IME11, KBNP21, vB_EcoP_PhAPEC5, vB_EcoP_PhAPEC7, Bp4, EC1-UPM and pSb-1), “Lit1virus” (LIT1, PA26 and vB_PaeP_C2-10_Ab09), “Sp58virus” (SP058 and SP076), and “Dss3virus” (DSS3φ2 and EE36φ1). We propose that coliPhage N4, the members of “G7cvirus”, Erwinia Phage Ea9-2, and Achromobacter Phage JWAlpha should be considered members of the same subfamily, which we tentatively call the “Enquartavirinae”.
John H E Nash - One of the best experts on this subject based on the ideXlab platform.
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taxonomic reassessment of N4 like viruses using comparative genomics and proteomics suggests a new subfamily enquartavirinae
Archives of Virology, 2015Co-Authors: Johannes Wittmann, Jochen Klumpp, Andrea Moreno I Switt, Abdelbaset Yagubi, Hans Wolfgang Ackermann, Martin Wiedmann, Antonet M Svircev, John H E Nash, Andrew M KropinskiAbstract:The GenBank database currently contains sequence data for 33 N4-like viruses, with only one, Escherichia Phage N4, being formally recognized by the ICTV. The genus N4likevirus is uniquely characterized by that fact that its members possess an extremely large, virion-associated RNA polymerase. Using a variety of proteomic, genomic and phylogenetic tools, we have demonstrated that the N4-like Phages are not monophyletic and that N4 is actually a genomic orphan. We propose to create four new genera: “G7cvirus” (consisting of Phages G7C, IME11, KBNP21, vB_EcoP_PhAPEC5, vB_EcoP_PhAPEC7, Bp4, EC1-UPM and pSb-1), “Lit1virus” (LIT1, PA26 and vB_PaeP_C2-10_Ab09), “Sp58virus” (SP058 and SP076), and “Dss3virus” (DSS3φ2 and EE36φ1). We propose that coliPhage N4, the members of “G7cvirus”, Erwinia Phage Ea9-2, and Achromobacter Phage JWAlpha should be considered members of the same subfamily, which we tentatively call the “Enquartavirinae”.