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Örs Péter Horváth - One of the best experts on this subject based on the ideXlab platform.

  • GastroEsophageal Reflux Disease Might Induce Certain—Supposedly Adaptive—Changes in the Esophagus: A Hypothesis
    Digestive Diseases and Sciences, 2018
    Co-Authors: Laura Bognár, András Vereczkei, András Papp, Gábor Jancsó, Örs Péter Horváth
    Abstract:

    Background The increasing prevalence of GERD has become a major concern due to its major health and economic impacts. Beyond the typical unpleasant symptoms, reflux can also be the source of severe, potentially life-threatening complications, such as aspiration. Aim Our aim was to support our hypothesis that the human body may in some cases develop various protective mechanisms to prevent these conditions. Methods Based on our experiences and review of the literature, we investigated the potential adaptive nature of seven reflux complications (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter, Zenker’s diverticulum, Schatzki’s ring, Esophageal Web, and Barrett’s esophagus). Results Patients with progressive GERD may develop diverse structural and functional Esophageal changes that narrow the lumen of the esophagus and therefore reduce the risk of regurgitation and protect the upper aerodigestive tract from aspiration. The functional changes (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter) seem to be adaptive reactions aimed at easing the unpleasant symptoms and reducing acid regurgitation. The structural changes (Schatzki’s ring, Esophageal Web) result in very similar outcomes, but we consider these are rather secondary consequences and not real adaptive mechanisms. Barrett’s esophagus is a special form of adaptive protection. In these cases, patients report significant relief of their previous heartburn as Barrett’s esophagus develops because of the replacement of the normal squamous epithelium of the esophagus by acid-resistant metaplastic epithelium. Conclusion We believe that GERD may induce different self-protective reactions in the esophagus that result in reduced acid regurgitation or decreased reflux symptoms.

  • GastroEsophageal Reflux Disease Might Induce Certain-Supposedly Adaptive-Changes in the Esophagus: A Hypothesis.
    Digestive diseases and sciences, 2018
    Co-Authors: Laura Bognár, András Vereczkei, András Papp, Gábor Jancsó, Örs Péter Horváth
    Abstract:

    The increasing prevalence of GERD has become a major concern due to its major health and economic impacts. Beyond the typical unpleasant symptoms, reflux can also be the source of severe, potentially life-threatening complications, such as aspiration. Our aim was to support our hypothesis that the human body may in some cases develop various protective mechanisms to prevent these conditions. Based on our experiences and review of the literature, we investigated the potential adaptive nature of seven reflux complications (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter, Zenker’s diverticulum, Schatzki’s ring, Esophageal Web, and Barrett’s esophagus). Patients with progressive GERD may develop diverse structural and functional Esophageal changes that narrow the lumen of the esophagus and therefore reduce the risk of regurgitation and protect the upper aerodigestive tract from aspiration. The functional changes (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter) seem to be adaptive reactions aimed at easing the unpleasant symptoms and reducing acid regurgitation. The structural changes (Schatzki’s ring, Esophageal Web) result in very similar outcomes, but we consider these are rather secondary consequences and not real adaptive mechanisms. Barrett’s esophagus is a special form of adaptive protection. In these cases, patients report significant relief of their previous heartburn as Barrett’s esophagus develops because of the replacement of the normal squamous epithelium of the esophagus by acid-resistant metaplastic epithelium. We believe that GERD may induce different self-protective reactions in the esophagus that result in reduced acid regurgitation or decreased reflux symptoms.

Laura Bognár - One of the best experts on this subject based on the ideXlab platform.

  • GastroEsophageal Reflux Disease Might Induce Certain—Supposedly Adaptive—Changes in the Esophagus: A Hypothesis
    Digestive Diseases and Sciences, 2018
    Co-Authors: Laura Bognár, András Vereczkei, András Papp, Gábor Jancsó, Örs Péter Horváth
    Abstract:

    Background The increasing prevalence of GERD has become a major concern due to its major health and economic impacts. Beyond the typical unpleasant symptoms, reflux can also be the source of severe, potentially life-threatening complications, such as aspiration. Aim Our aim was to support our hypothesis that the human body may in some cases develop various protective mechanisms to prevent these conditions. Methods Based on our experiences and review of the literature, we investigated the potential adaptive nature of seven reflux complications (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter, Zenker’s diverticulum, Schatzki’s ring, Esophageal Web, and Barrett’s esophagus). Results Patients with progressive GERD may develop diverse structural and functional Esophageal changes that narrow the lumen of the esophagus and therefore reduce the risk of regurgitation and protect the upper aerodigestive tract from aspiration. The functional changes (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter) seem to be adaptive reactions aimed at easing the unpleasant symptoms and reducing acid regurgitation. The structural changes (Schatzki’s ring, Esophageal Web) result in very similar outcomes, but we consider these are rather secondary consequences and not real adaptive mechanisms. Barrett’s esophagus is a special form of adaptive protection. In these cases, patients report significant relief of their previous heartburn as Barrett’s esophagus develops because of the replacement of the normal squamous epithelium of the esophagus by acid-resistant metaplastic epithelium. Conclusion We believe that GERD may induce different self-protective reactions in the esophagus that result in reduced acid regurgitation or decreased reflux symptoms.

  • GastroEsophageal Reflux Disease Might Induce Certain-Supposedly Adaptive-Changes in the Esophagus: A Hypothesis.
    Digestive diseases and sciences, 2018
    Co-Authors: Laura Bognár, András Vereczkei, András Papp, Gábor Jancsó, Örs Péter Horváth
    Abstract:

    The increasing prevalence of GERD has become a major concern due to its major health and economic impacts. Beyond the typical unpleasant symptoms, reflux can also be the source of severe, potentially life-threatening complications, such as aspiration. Our aim was to support our hypothesis that the human body may in some cases develop various protective mechanisms to prevent these conditions. Based on our experiences and review of the literature, we investigated the potential adaptive nature of seven reflux complications (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter, Zenker’s diverticulum, Schatzki’s ring, Esophageal Web, and Barrett’s esophagus). Patients with progressive GERD may develop diverse structural and functional Esophageal changes that narrow the lumen of the esophagus and therefore reduce the risk of regurgitation and protect the upper aerodigestive tract from aspiration. The functional changes (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter) seem to be adaptive reactions aimed at easing the unpleasant symptoms and reducing acid regurgitation. The structural changes (Schatzki’s ring, Esophageal Web) result in very similar outcomes, but we consider these are rather secondary consequences and not real adaptive mechanisms. Barrett’s esophagus is a special form of adaptive protection. In these cases, patients report significant relief of their previous heartburn as Barrett’s esophagus develops because of the replacement of the normal squamous epithelium of the esophagus by acid-resistant metaplastic epithelium. We believe that GERD may induce different self-protective reactions in the esophagus that result in reduced acid regurgitation or decreased reflux symptoms.

Kartar Singh - One of the best experts on this subject based on the ideXlab platform.

  • Recurrent Multiple Cervical Esophageal Webs: An Unusual Presentation of Celiac Disease
    Gastroenterology research, 2009
    Co-Authors: Usha Dutta, Abdul Khaliq, Mohd Talha Noor, Rakesh Kochhar, Kartar Singh
    Abstract:

    Although the association of celiac disease with Esophageal Web has been reported earlier, in this case patient presented with persistent dysphagia. Upper gastrointestinal endoscopy revealed multiple Esophageal Webs which were recurring despite endoscopic dilatation. Diagnosis and treatment of underlying celiac disease led to long term improvement.

  • Cervical Esophageal Web and celiac disease
    Journal of Gastroenterology and Hepatology, 2008
    Co-Authors: Saroj K. Sinha, Birinder Nagi, Chander Kamal Nain, Harsh P. Udawat, Kk Prasad, Reena Das, Kartar Singh
    Abstract:

    Background and Aim:  There is paucity of prospective data on association between cervical Esophageal Webs and celiac disease. It is not clear whether all patients with cervical Esophageal Web need screening for celiac disease. Hence, the present study was carried out to determine the association of cervical Esophageal Web with celiac disease. Methods:  This prospective study included consecutive patients with symptomatic cervical Esophageal Web diagnosed over a period of 4.5 years. Tissue transglutaminase antibody was measured in serum of each patient. Patients with elevated tissue transglutaminase antibody titer were subjected to esophagogastroduodenoscopy and biopsies were obtained from the descending duodenum to look for histological changes of celiac disease. Esophageal Web was treated with bougie dilatation. Celiac disease was diagnosed on the basis of elevated tissue transglutaminase antibody and suggestive duodenal histology. Results:  Twenty one patients were diagnosed to have cervical Esophageal Web. Eighteen (85.7%) had evidence of iron deficiency. Five (23.8%) patients with cervical Esophageal Web fulfilled criteria for diagnosis of celiac disease. All five had evidence of iron deficiency. None of these patients gave a history of chronic diarrhea. All patients were treated with bougie dilatation. Patients with celiac disease were advised of a gluten-free diet. All five celiac disease patients are free of dysphagia without recurrence after a mean follow up of 10 months (range: 3 to 16 months). Conclusions:  There is association between cervical Esophageal Web and celiac disease. All adult patients with cervical Esophageal Web and iron deficiency need screening for celiac disease even in the absence of chronic diarrhea.

  • Cervical Esophageal Web and celiac disease.
    Journal of gastroenterology and hepatology, 2008
    Co-Authors: Saroj Kant Sinha, Birinder Nagi, Chander Kamal Nain, Harsh P. Udawat, Reena Das, Kaushal Kishore Prasad, Kartar Singh
    Abstract:

    There is paucity of prospective data on association between cervical Esophageal Webs and celiac disease. It is not clear whether all patients with cervical Esophageal Web need screening for celiac disease. Hence, the present study was carried out to determine the association of cervical Esophageal Web with celiac disease. This prospective study included consecutive patients with symptomatic cervical Esophageal Web diagnosed over a period of 4.5 years. Tissue transglutaminase antibody was measured in serum of each patient. Patients with elevated tissue transglutaminase antibody titer were subjected to esophagogastroduodenoscopy and biopsies were obtained from the descending duodenum to look for histological changes of celiac disease. Esophageal Web was treated with bougie dilatation. Celiac disease was diagnosed on the basis of elevated tissue transglutaminase antibody and suggestive duodenal histology. Twenty one patients were diagnosed to have cervical Esophageal Web. Eighteen (85.7%) had evidence of iron deficiency. Five (23.8%) patients with cervical Esophageal Web fulfilled criteria for diagnosis of celiac disease. All five had evidence of iron deficiency. None of these patients gave a history of chronic diarrhea. All patients were treated with bougie dilatation. Patients with celiac disease were advised of a gluten-free diet. All five celiac disease patients are free of dysphagia without recurrence after a mean follow up of 10 months (range: 3 to 16 months). There is association between cervical Esophageal Web and celiac disease. All adult patients with cervical Esophageal Web and iron deficiency need screening for celiac disease even in the absence of chronic diarrhea.

András Papp - One of the best experts on this subject based on the ideXlab platform.

  • GastroEsophageal Reflux Disease Might Induce Certain—Supposedly Adaptive—Changes in the Esophagus: A Hypothesis
    Digestive Diseases and Sciences, 2018
    Co-Authors: Laura Bognár, András Vereczkei, András Papp, Gábor Jancsó, Örs Péter Horváth
    Abstract:

    Background The increasing prevalence of GERD has become a major concern due to its major health and economic impacts. Beyond the typical unpleasant symptoms, reflux can also be the source of severe, potentially life-threatening complications, such as aspiration. Aim Our aim was to support our hypothesis that the human body may in some cases develop various protective mechanisms to prevent these conditions. Methods Based on our experiences and review of the literature, we investigated the potential adaptive nature of seven reflux complications (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter, Zenker’s diverticulum, Schatzki’s ring, Esophageal Web, and Barrett’s esophagus). Results Patients with progressive GERD may develop diverse structural and functional Esophageal changes that narrow the lumen of the esophagus and therefore reduce the risk of regurgitation and protect the upper aerodigestive tract from aspiration. The functional changes (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter) seem to be adaptive reactions aimed at easing the unpleasant symptoms and reducing acid regurgitation. The structural changes (Schatzki’s ring, Esophageal Web) result in very similar outcomes, but we consider these are rather secondary consequences and not real adaptive mechanisms. Barrett’s esophagus is a special form of adaptive protection. In these cases, patients report significant relief of their previous heartburn as Barrett’s esophagus develops because of the replacement of the normal squamous epithelium of the esophagus by acid-resistant metaplastic epithelium. Conclusion We believe that GERD may induce different self-protective reactions in the esophagus that result in reduced acid regurgitation or decreased reflux symptoms.

  • GastroEsophageal Reflux Disease Might Induce Certain-Supposedly Adaptive-Changes in the Esophagus: A Hypothesis.
    Digestive diseases and sciences, 2018
    Co-Authors: Laura Bognár, András Vereczkei, András Papp, Gábor Jancsó, Örs Péter Horváth
    Abstract:

    The increasing prevalence of GERD has become a major concern due to its major health and economic impacts. Beyond the typical unpleasant symptoms, reflux can also be the source of severe, potentially life-threatening complications, such as aspiration. Our aim was to support our hypothesis that the human body may in some cases develop various protective mechanisms to prevent these conditions. Based on our experiences and review of the literature, we investigated the potential adaptive nature of seven reflux complications (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter, Zenker’s diverticulum, Schatzki’s ring, Esophageal Web, and Barrett’s esophagus). Patients with progressive GERD may develop diverse structural and functional Esophageal changes that narrow the lumen of the esophagus and therefore reduce the risk of regurgitation and protect the upper aerodigestive tract from aspiration. The functional changes (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter) seem to be adaptive reactions aimed at easing the unpleasant symptoms and reducing acid regurgitation. The structural changes (Schatzki’s ring, Esophageal Web) result in very similar outcomes, but we consider these are rather secondary consequences and not real adaptive mechanisms. Barrett’s esophagus is a special form of adaptive protection. In these cases, patients report significant relief of their previous heartburn as Barrett’s esophagus develops because of the replacement of the normal squamous epithelium of the esophagus by acid-resistant metaplastic epithelium. We believe that GERD may induce different self-protective reactions in the esophagus that result in reduced acid regurgitation or decreased reflux symptoms.

András Vereczkei - One of the best experts on this subject based on the ideXlab platform.

  • GastroEsophageal Reflux Disease Might Induce Certain—Supposedly Adaptive—Changes in the Esophagus: A Hypothesis
    Digestive Diseases and Sciences, 2018
    Co-Authors: Laura Bognár, András Vereczkei, András Papp, Gábor Jancsó, Örs Péter Horváth
    Abstract:

    Background The increasing prevalence of GERD has become a major concern due to its major health and economic impacts. Beyond the typical unpleasant symptoms, reflux can also be the source of severe, potentially life-threatening complications, such as aspiration. Aim Our aim was to support our hypothesis that the human body may in some cases develop various protective mechanisms to prevent these conditions. Methods Based on our experiences and review of the literature, we investigated the potential adaptive nature of seven reflux complications (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter, Zenker’s diverticulum, Schatzki’s ring, Esophageal Web, and Barrett’s esophagus). Results Patients with progressive GERD may develop diverse structural and functional Esophageal changes that narrow the lumen of the esophagus and therefore reduce the risk of regurgitation and protect the upper aerodigestive tract from aspiration. The functional changes (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter) seem to be adaptive reactions aimed at easing the unpleasant symptoms and reducing acid regurgitation. The structural changes (Schatzki’s ring, Esophageal Web) result in very similar outcomes, but we consider these are rather secondary consequences and not real adaptive mechanisms. Barrett’s esophagus is a special form of adaptive protection. In these cases, patients report significant relief of their previous heartburn as Barrett’s esophagus develops because of the replacement of the normal squamous epithelium of the esophagus by acid-resistant metaplastic epithelium. Conclusion We believe that GERD may induce different self-protective reactions in the esophagus that result in reduced acid regurgitation or decreased reflux symptoms.

  • GastroEsophageal Reflux Disease Might Induce Certain-Supposedly Adaptive-Changes in the Esophagus: A Hypothesis.
    Digestive diseases and sciences, 2018
    Co-Authors: Laura Bognár, András Vereczkei, András Papp, Gábor Jancsó, Örs Péter Horváth
    Abstract:

    The increasing prevalence of GERD has become a major concern due to its major health and economic impacts. Beyond the typical unpleasant symptoms, reflux can also be the source of severe, potentially life-threatening complications, such as aspiration. Our aim was to support our hypothesis that the human body may in some cases develop various protective mechanisms to prevent these conditions. Based on our experiences and review of the literature, we investigated the potential adaptive nature of seven reflux complications (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter, Zenker’s diverticulum, Schatzki’s ring, Esophageal Web, and Barrett’s esophagus). Patients with progressive GERD may develop diverse structural and functional Esophageal changes that narrow the lumen of the esophagus and therefore reduce the risk of regurgitation and protect the upper aerodigestive tract from aspiration. The functional changes (hypertensive lower Esophageal sphincter, achalasia, hypertensive upper Esophageal sphincter) seem to be adaptive reactions aimed at easing the unpleasant symptoms and reducing acid regurgitation. The structural changes (Schatzki’s ring, Esophageal Web) result in very similar outcomes, but we consider these are rather secondary consequences and not real adaptive mechanisms. Barrett’s esophagus is a special form of adaptive protection. In these cases, patients report significant relief of their previous heartburn as Barrett’s esophagus develops because of the replacement of the normal squamous epithelium of the esophagus by acid-resistant metaplastic epithelium. We believe that GERD may induce different self-protective reactions in the esophagus that result in reduced acid regurgitation or decreased reflux symptoms.