The Experts below are selected from a list of 6903 Experts worldwide ranked by ideXlab platform
Pichlmaier H - One of the best experts on this subject based on the ideXlab platform.
-
Surgical therapy of esophageal Carcinoma: the influence of surgical approach and esophageal resection on cardiopulmonary function.
European Journal of Cardio-Thoracic Surgery, 1997Co-Authors: Christoph A. Jacobi, H. U. Zieren, Joachim M. Müller, Pichlmaier HAbstract:Objective: The effects of the different surgical approaches (transhiatal esophagectomy and right-sided transthoracic esophagectomy) on perioperative cardiopulmonary function in the surgical treatment of esophageal Carcinoma are discussed controversially and have not yet been evaluated. Methods: In a prospective randomized study including 32 patients, we investigated the effects of the surgical approach (blunt dissection (n = 16) versus transthoracic en-bloc resection (EB) (n=16)) in the treatment of Esophagus Carcinoma on perioperative cardiopulmonary function. The following parameters were measured in all patients: cardiac index (CI), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary artery pressure (MPAP), pulmonary capillary wedge pressure (PCWP), intrapulmonary shunt (QS/QT), arterio-alveolar (aaDO 2 ), arterio-venous oxygen pressure difference (avDO 2 ), and blood gas analyses. Time of measurement were: after induction of anesthesia, beginning and end of Esophagus resection, end of surgery, 1h postoperatively, and then every 12 h until the third postoperative day. Results: Compared to blunt dissection, en-bloc esophagectomy was found to be associated with a transient deterioration of pulmonary function during one-lung ventilation in the left-lateral position, which could already be compensated for during the intervention. No other significant differences in cardiopulmonary effects were seen between the two surgical techniques. The incidence of postoperative complications was identical in both groups. Conclusions: The results of our study show that en-bloc resection is only associated with an increased intraoperative pulmonary strain that is completely compensated during the operation and that there is no difference in cardiopulmonary functions between the two techniques in the postoperative course.
Christoph A. Jacobi - One of the best experts on this subject based on the ideXlab platform.
-
Surgical therapy of esophageal Carcinoma: the influence of surgical approach and esophageal resection on cardiopulmonary function.
European Journal of Cardio-Thoracic Surgery, 1997Co-Authors: Christoph A. Jacobi, H. U. Zieren, Joachim M. Müller, Pichlmaier HAbstract:Objective: The effects of the different surgical approaches (transhiatal esophagectomy and right-sided transthoracic esophagectomy) on perioperative cardiopulmonary function in the surgical treatment of esophageal Carcinoma are discussed controversially and have not yet been evaluated. Methods: In a prospective randomized study including 32 patients, we investigated the effects of the surgical approach (blunt dissection (n = 16) versus transthoracic en-bloc resection (EB) (n=16)) in the treatment of Esophagus Carcinoma on perioperative cardiopulmonary function. The following parameters were measured in all patients: cardiac index (CI), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary artery pressure (MPAP), pulmonary capillary wedge pressure (PCWP), intrapulmonary shunt (QS/QT), arterio-alveolar (aaDO 2 ), arterio-venous oxygen pressure difference (avDO 2 ), and blood gas analyses. Time of measurement were: after induction of anesthesia, beginning and end of Esophagus resection, end of surgery, 1h postoperatively, and then every 12 h until the third postoperative day. Results: Compared to blunt dissection, en-bloc esophagectomy was found to be associated with a transient deterioration of pulmonary function during one-lung ventilation in the left-lateral position, which could already be compensated for during the intervention. No other significant differences in cardiopulmonary effects were seen between the two surgical techniques. The incidence of postoperative complications was identical in both groups. Conclusions: The results of our study show that en-bloc resection is only associated with an increased intraoperative pulmonary strain that is completely compensated during the operation and that there is no difference in cardiopulmonary functions between the two techniques in the postoperative course.
Qimin Zhan - One of the best experts on this subject based on the ideXlab platform.
-
overexpression of cyclin b1 in human esophageal squamous cell Carcinoma cells induces tumor cell invasive growth and metastasis
Carcinogenesis, 2008Co-Authors: Yongmei Song, Chunling Zhao, Lijia Dong, Liyan Xue, Zhen Huang, Tong Tong, Zhuan Zhou, Amei Chen, Zhihua Yang, Qimin ZhanAbstract:Cyclin B1, a key component in the control of cell cycle progression from G(2) to M phase, has been implicated in tumorigenesis and the development of malignancy. However, the underlying mechanism by which cyclin B1 acts as an important oncogenic molecule remains largely unknown. Here we show that ectopic expression of cyclin B1 promotes cell proliferation, enhances cell motility and migration and results in increased ability of cells extravasating through the capillary endothelium. Interestingly, isogenic esophageal squamous cell Carcinoma (ESCC) cells overexpressing cyclin B1 reveal strong invasive growth and high potential of metastasis to lung in xenograft mice. Suppression of cyclin B1 expression via small interfering RNA approach in high-metastatic Esophagus Carcinoma cells specifically inhibits their ability to metastasize from the primary ESCC to lung. Notably, altered expression of epithelial markers and mesenchymal markers were observed in the cells overexpressing cyclin B1, suggesting that cyclin B1 contributes to metastasis probably by promoting an epithelial-mesenchymal transition. These results establish a mechanistic link between cyclin B1 and ESCC metastasis and provide novel insight into understanding of cyclin B1 in the development of ESCC malignancy.
Masatoshi Tagawa - One of the best experts on this subject based on the ideXlab platform.
-
increased infectivity of adenovirus type 5 bearing type 11 or type 35 fibers to human esophageal and oral Carcinoma cells
Oncology Reports, 2005Co-Authors: Hisanori Takenobu, Osamu Shimozato, Kiyoko Kawamura, Yoshinori Nimura, Naohiko Seki, Katsuhiro Uzawa, Hideki Tanzawa, Hideaki Shimada, Takenori Ochiai, Masatoshi TagawaAbstract:Esophageal and oral Carcinomas are relatively resistant to adenovirus serotype 5 (Ad5)-mediated gene transfer, primarily because expression of the cellular receptors for Ad5, the coxsackievirus and adenovirus receptor, is often dowunregulated in these types of tumor. The types of Ad in which the receptor expression is not suppressed in tumors are therefore better vectors for gene transfer into tumors. CD46, a cellular receptor for Ad subtype B2, such as Ad11 and Ad35, is well expressed in a number of esophageal and oral tumor cells. Since the infectivity of Ad to target cells is mainly influenced by the interaction between their fibers and the cellular receptors, we examined the infectivity of chimeric Ad5, whose fiber structure was substituted with that of type 11 or 35 (Ad5/11 or Ad5/35), to 6 human oral and 11 Esophagus Carcinoma cells. We found that the chimeric Ad, in particular Ad5/35, infected more effectively than Ad5 in all the tumors tested. However, the efficacy of Ad5/35- and Ad5/11-mediated transduction was not correlated with the expression level of CD46 or CD80/86, a cellular receptor of the Ad subtype B1, in the target cells. These data suggest that the Ad subtype B2 are suitable vectors of gene transfer for human squamous cell Carcinomas of the upper gastrointestinal tract, and that the infectivity of the Ad subtype B2 can possibly be regulated by other receptors besides CD46.
Joachim M. Müller - One of the best experts on this subject based on the ideXlab platform.
-
Surgical therapy of esophageal Carcinoma: the influence of surgical approach and esophageal resection on cardiopulmonary function.
European Journal of Cardio-Thoracic Surgery, 1997Co-Authors: Christoph A. Jacobi, H. U. Zieren, Joachim M. Müller, Pichlmaier HAbstract:Objective: The effects of the different surgical approaches (transhiatal esophagectomy and right-sided transthoracic esophagectomy) on perioperative cardiopulmonary function in the surgical treatment of esophageal Carcinoma are discussed controversially and have not yet been evaluated. Methods: In a prospective randomized study including 32 patients, we investigated the effects of the surgical approach (blunt dissection (n = 16) versus transthoracic en-bloc resection (EB) (n=16)) in the treatment of Esophagus Carcinoma on perioperative cardiopulmonary function. The following parameters were measured in all patients: cardiac index (CI), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary artery pressure (MPAP), pulmonary capillary wedge pressure (PCWP), intrapulmonary shunt (QS/QT), arterio-alveolar (aaDO 2 ), arterio-venous oxygen pressure difference (avDO 2 ), and blood gas analyses. Time of measurement were: after induction of anesthesia, beginning and end of Esophagus resection, end of surgery, 1h postoperatively, and then every 12 h until the third postoperative day. Results: Compared to blunt dissection, en-bloc esophagectomy was found to be associated with a transient deterioration of pulmonary function during one-lung ventilation in the left-lateral position, which could already be compensated for during the intervention. No other significant differences in cardiopulmonary effects were seen between the two surgical techniques. The incidence of postoperative complications was identical in both groups. Conclusions: The results of our study show that en-bloc resection is only associated with an increased intraoperative pulmonary strain that is completely compensated during the operation and that there is no difference in cardiopulmonary functions between the two techniques in the postoperative course.