The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Alexandre B M Da Silveira - One of the best experts on this subject based on the ideXlab platform.
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characterization of enteroglial cells and denervation process in chagasic patients with and without megaEsophagus
Human Pathology, 2010Co-Authors: Rodolfo Duarte Nascimento, Andre De Souza Lisboa, Alexandre B M Da Silveira, Debora Davila Reis, Michelle A R Freitas, Rodrigo Correa Oliveira, Ricardo Toshio Fujiwara, Sheila Jorge AdadAbstract:Chagas disease is caused by infestation with the parasite Trypanosoma cruzi, and some patients who are serologically positive develop chronic megaEsophagus, whereas others are symptom-free. Gastrointestinal form of Chagas disease involves an inflammatory invasion of the enteric plexuses and degeneration of enteric neurons and previous works related that enteroglial cells would be involved in enteric inflammatory responses. Because of this, the aims of this study were to determine the relation of enteroglial cells with the denervation process in chagasic patients with and without megaEsophagus and seronegative individuals. Our results indicated that the innervation of the esophageal muscle was substantially reduced in patients with megaEsophagus, but asymptomatic seropositive subjects were not different to seronegative controls. Besides, patients with megaEsophagus had significant decreased of enteroglial cells labeled with S-100 and glial fibrillary acidic protein, whereas patients without megaEsophagus presented an increased of both labels. We believe that enteroglial cells would operate a mechanism of defense in the enteric nervous system against the Trypanosoma cruzi infection, which could prevent the organ denervation and preserve the Esophagus Function.
Ricardo Toshio Fujiwara - One of the best experts on this subject based on the ideXlab platform.
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characterization of enteroglial cells and denervation process in chagasic patients with and without megaEsophagus
Human Pathology, 2010Co-Authors: Rodolfo Duarte Nascimento, Andre De Souza Lisboa, Alexandre B M Da Silveira, Debora Davila Reis, Michelle A R Freitas, Rodrigo Correa Oliveira, Ricardo Toshio Fujiwara, Sheila Jorge AdadAbstract:Chagas disease is caused by infestation with the parasite Trypanosoma cruzi, and some patients who are serologically positive develop chronic megaEsophagus, whereas others are symptom-free. Gastrointestinal form of Chagas disease involves an inflammatory invasion of the enteric plexuses and degeneration of enteric neurons and previous works related that enteroglial cells would be involved in enteric inflammatory responses. Because of this, the aims of this study were to determine the relation of enteroglial cells with the denervation process in chagasic patients with and without megaEsophagus and seronegative individuals. Our results indicated that the innervation of the esophageal muscle was substantially reduced in patients with megaEsophagus, but asymptomatic seropositive subjects were not different to seronegative controls. Besides, patients with megaEsophagus had significant decreased of enteroglial cells labeled with S-100 and glial fibrillary acidic protein, whereas patients without megaEsophagus presented an increased of both labels. We believe that enteroglial cells would operate a mechanism of defense in the enteric nervous system against the Trypanosoma cruzi infection, which could prevent the organ denervation and preserve the Esophagus Function.
Rodolfo Duarte Nascimento - One of the best experts on this subject based on the ideXlab platform.
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characterization of enteroglial cells and denervation process in chagasic patients with and without megaEsophagus
Human Pathology, 2010Co-Authors: Rodolfo Duarte Nascimento, Andre De Souza Lisboa, Alexandre B M Da Silveira, Debora Davila Reis, Michelle A R Freitas, Rodrigo Correa Oliveira, Ricardo Toshio Fujiwara, Sheila Jorge AdadAbstract:Chagas disease is caused by infestation with the parasite Trypanosoma cruzi, and some patients who are serologically positive develop chronic megaEsophagus, whereas others are symptom-free. Gastrointestinal form of Chagas disease involves an inflammatory invasion of the enteric plexuses and degeneration of enteric neurons and previous works related that enteroglial cells would be involved in enteric inflammatory responses. Because of this, the aims of this study were to determine the relation of enteroglial cells with the denervation process in chagasic patients with and without megaEsophagus and seronegative individuals. Our results indicated that the innervation of the esophageal muscle was substantially reduced in patients with megaEsophagus, but asymptomatic seropositive subjects were not different to seronegative controls. Besides, patients with megaEsophagus had significant decreased of enteroglial cells labeled with S-100 and glial fibrillary acidic protein, whereas patients without megaEsophagus presented an increased of both labels. We believe that enteroglial cells would operate a mechanism of defense in the enteric nervous system against the Trypanosoma cruzi infection, which could prevent the organ denervation and preserve the Esophagus Function.
Zheng Jiya - One of the best experts on this subject based on the ideXlab platform.
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the association of gastroesophageal reflux disease with Esophagus Function and gastrointestinal hormones
Zhejiang Journal of Preventive Medicine, 2005Co-Authors: Zheng JiyaAbstract:] Objective To find out the association between the levels of plasma gastrin and motilin and the Functional defect of lower esophageal sphincter (LES) in the children with Gastroesophageal Reflux Disease (GERD), so as to explore the pathogenesis of children GERD. Methods The detection on the pressure in esophageal lumen was carried out in 30 children with pathological gastric acid reflux (groupⅠ), who had been diagnosed according to the obvious symptom of gastroesophageal reflux and the dynamic monitoring on the pH value in 24 hours in Esophagus, including the lower esophageal sphincter length (LESL), lower esophageal sphincter pressure (LESP), transient lower esophageal sphincter relax (TLESR) and barrier pressure (BP). Meanwhile the concentration of gastrin and motilin were measured. Group Ⅱ and control group were set up to be compared. Results There were significant differences between groupⅠand groupⅡon LESP and BP. Compared with groupⅡ, the occurrence of TLESR was significantly increased in groupⅠ. Otherwise, the gastrin concentration in plasma decreased in groupⅠwhile the motilin increased, but the differences in both were not significant. Conclusions TLESR and the decrease of LESP and BP play an important role in the occurrence of GERD. There is few change in the gastrin concentration of GERD children, therefore, the reflux of acid is resulted from the decrease of defensive mechanism resisting against the reflux, but not from the increase of gastric acid secretion.
Andre De Souza Lisboa - One of the best experts on this subject based on the ideXlab platform.
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characterization of enteroglial cells and denervation process in chagasic patients with and without megaEsophagus
Human Pathology, 2010Co-Authors: Rodolfo Duarte Nascimento, Andre De Souza Lisboa, Alexandre B M Da Silveira, Debora Davila Reis, Michelle A R Freitas, Rodrigo Correa Oliveira, Ricardo Toshio Fujiwara, Sheila Jorge AdadAbstract:Chagas disease is caused by infestation with the parasite Trypanosoma cruzi, and some patients who are serologically positive develop chronic megaEsophagus, whereas others are symptom-free. Gastrointestinal form of Chagas disease involves an inflammatory invasion of the enteric plexuses and degeneration of enteric neurons and previous works related that enteroglial cells would be involved in enteric inflammatory responses. Because of this, the aims of this study were to determine the relation of enteroglial cells with the denervation process in chagasic patients with and without megaEsophagus and seronegative individuals. Our results indicated that the innervation of the esophageal muscle was substantially reduced in patients with megaEsophagus, but asymptomatic seropositive subjects were not different to seronegative controls. Besides, patients with megaEsophagus had significant decreased of enteroglial cells labeled with S-100 and glial fibrillary acidic protein, whereas patients without megaEsophagus presented an increased of both labels. We believe that enteroglial cells would operate a mechanism of defense in the enteric nervous system against the Trypanosoma cruzi infection, which could prevent the organ denervation and preserve the Esophagus Function.