The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Francesca Pala - One of the best experts on this subject based on the ideXlab platform.
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a distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero posterior patterning of Esophagus striated Muscle
eLife, 2019Co-Authors: Glenda Comai, Eglantine Heude, Sebastian Mella, Sylvain Paisant, Francesca PalaAbstract:: In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the Esophagus that permits food ingestion and swallowing. Masticatory and Esophagus striated Muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated Muscles as they are established in the absence of a primary skeletal Muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to MET/HGF signaling for antero-posterior migration of Esophagus Muscle progenitors, where Hgf ligand is expressed in adjacent smooth Muscle cells. These observations highlight the functional relevance of a smooth and striated Muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulates Esophagus myogenesis and identify distinct genetic signatures that can be used as framework to interpret pathologies arising within CPM derivatives.
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a distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero posterior patterning of Esophagus striated Muscle
bioRxiv, 2019Co-Authors: Glenda Comai, Eglantine Heude, Sebastian Mella, Sylvain Paisant, Francesca PalaAbstract:SUMMARY In most vertebrates, the upper digestive tract is composed of muscularised jaws linked to the Esophagus that permit food uptake and swallowing. Masticatory and Esophagus striated Muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated Muscles as they are established in the absence of a primary skeletal Muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to Met/HGF signalling for antero-posterior migration of Esophagus Muscle progenitors, where HGF ligand is expressed in adjacent smooth Muscle cells. These observations highlight the functional relevance of a smooth and striated Muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulate Esophagus myogenesis and identify distinct genetic signatures that can be used as a framework to interpret pathologies arising within CPM derivatives.
Glenda Comai - One of the best experts on this subject based on the ideXlab platform.
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a distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero posterior patterning of Esophagus striated Muscle
eLife, 2019Co-Authors: Glenda Comai, Eglantine Heude, Sebastian Mella, Sylvain Paisant, Francesca PalaAbstract:: In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the Esophagus that permits food ingestion and swallowing. Masticatory and Esophagus striated Muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated Muscles as they are established in the absence of a primary skeletal Muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to MET/HGF signaling for antero-posterior migration of Esophagus Muscle progenitors, where Hgf ligand is expressed in adjacent smooth Muscle cells. These observations highlight the functional relevance of a smooth and striated Muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulates Esophagus myogenesis and identify distinct genetic signatures that can be used as framework to interpret pathologies arising within CPM derivatives.
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a distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero posterior patterning of Esophagus striated Muscle
bioRxiv, 2019Co-Authors: Glenda Comai, Eglantine Heude, Sebastian Mella, Sylvain Paisant, Francesca PalaAbstract:SUMMARY In most vertebrates, the upper digestive tract is composed of muscularised jaws linked to the Esophagus that permit food uptake and swallowing. Masticatory and Esophagus striated Muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated Muscles as they are established in the absence of a primary skeletal Muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to Met/HGF signalling for antero-posterior migration of Esophagus Muscle progenitors, where HGF ligand is expressed in adjacent smooth Muscle cells. These observations highlight the functional relevance of a smooth and striated Muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulate Esophagus myogenesis and identify distinct genetic signatures that can be used as a framework to interpret pathologies arising within CPM derivatives.
Eglantine Heude - One of the best experts on this subject based on the ideXlab platform.
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a distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero posterior patterning of Esophagus striated Muscle
eLife, 2019Co-Authors: Glenda Comai, Eglantine Heude, Sebastian Mella, Sylvain Paisant, Francesca PalaAbstract:: In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the Esophagus that permits food ingestion and swallowing. Masticatory and Esophagus striated Muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated Muscles as they are established in the absence of a primary skeletal Muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to MET/HGF signaling for antero-posterior migration of Esophagus Muscle progenitors, where Hgf ligand is expressed in adjacent smooth Muscle cells. These observations highlight the functional relevance of a smooth and striated Muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulates Esophagus myogenesis and identify distinct genetic signatures that can be used as framework to interpret pathologies arising within CPM derivatives.
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a distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero posterior patterning of Esophagus striated Muscle
bioRxiv, 2019Co-Authors: Glenda Comai, Eglantine Heude, Sebastian Mella, Sylvain Paisant, Francesca PalaAbstract:SUMMARY In most vertebrates, the upper digestive tract is composed of muscularised jaws linked to the Esophagus that permit food uptake and swallowing. Masticatory and Esophagus striated Muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated Muscles as they are established in the absence of a primary skeletal Muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to Met/HGF signalling for antero-posterior migration of Esophagus Muscle progenitors, where HGF ligand is expressed in adjacent smooth Muscle cells. These observations highlight the functional relevance of a smooth and striated Muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulate Esophagus myogenesis and identify distinct genetic signatures that can be used as a framework to interpret pathologies arising within CPM derivatives.
Sebastian Mella - One of the best experts on this subject based on the ideXlab platform.
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a distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero posterior patterning of Esophagus striated Muscle
eLife, 2019Co-Authors: Glenda Comai, Eglantine Heude, Sebastian Mella, Sylvain Paisant, Francesca PalaAbstract:: In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the Esophagus that permits food ingestion and swallowing. Masticatory and Esophagus striated Muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated Muscles as they are established in the absence of a primary skeletal Muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to MET/HGF signaling for antero-posterior migration of Esophagus Muscle progenitors, where Hgf ligand is expressed in adjacent smooth Muscle cells. These observations highlight the functional relevance of a smooth and striated Muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulates Esophagus myogenesis and identify distinct genetic signatures that can be used as framework to interpret pathologies arising within CPM derivatives.
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a distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero posterior patterning of Esophagus striated Muscle
bioRxiv, 2019Co-Authors: Glenda Comai, Eglantine Heude, Sebastian Mella, Sylvain Paisant, Francesca PalaAbstract:SUMMARY In most vertebrates, the upper digestive tract is composed of muscularised jaws linked to the Esophagus that permit food uptake and swallowing. Masticatory and Esophagus striated Muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated Muscles as they are established in the absence of a primary skeletal Muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to Met/HGF signalling for antero-posterior migration of Esophagus Muscle progenitors, where HGF ligand is expressed in adjacent smooth Muscle cells. These observations highlight the functional relevance of a smooth and striated Muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulate Esophagus myogenesis and identify distinct genetic signatures that can be used as a framework to interpret pathologies arising within CPM derivatives.
Sylvain Paisant - One of the best experts on this subject based on the ideXlab platform.
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a distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero posterior patterning of Esophagus striated Muscle
eLife, 2019Co-Authors: Glenda Comai, Eglantine Heude, Sebastian Mella, Sylvain Paisant, Francesca PalaAbstract:: In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the Esophagus that permits food ingestion and swallowing. Masticatory and Esophagus striated Muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated Muscles as they are established in the absence of a primary skeletal Muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to MET/HGF signaling for antero-posterior migration of Esophagus Muscle progenitors, where Hgf ligand is expressed in adjacent smooth Muscle cells. These observations highlight the functional relevance of a smooth and striated Muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulates Esophagus myogenesis and identify distinct genetic signatures that can be used as framework to interpret pathologies arising within CPM derivatives.
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a distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero posterior patterning of Esophagus striated Muscle
bioRxiv, 2019Co-Authors: Glenda Comai, Eglantine Heude, Sebastian Mella, Sylvain Paisant, Francesca PalaAbstract:SUMMARY In most vertebrates, the upper digestive tract is composed of muscularised jaws linked to the Esophagus that permit food uptake and swallowing. Masticatory and Esophagus striated Muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated Muscles as they are established in the absence of a primary skeletal Muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to Met/HGF signalling for antero-posterior migration of Esophagus Muscle progenitors, where HGF ligand is expressed in adjacent smooth Muscle cells. These observations highlight the functional relevance of a smooth and striated Muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulate Esophagus myogenesis and identify distinct genetic signatures that can be used as a framework to interpret pathologies arising within CPM derivatives.