The Experts below are selected from a list of 297 Experts worldwide ranked by ideXlab platform

Richard J. Servatius - One of the best experts on this subject based on the ideXlab platform.

  • Estrus Cycle stage modifies the presentation of stress-induced startle suppression in female Sprague–Dawley rats
    Physiology & Behavior, 2008
    Co-Authors: Kevin D. Beck, Xilu Jiao, Tara P. Cominski, Richard J. Servatius
    Abstract:

    Tailshock stress causes transient reductions in startle reactivity, associative learning and open field activity in female rats in an ovarian hormone dependent manner. Others have shown estrogen modulation of associative learning by testing across the Estrus Cycle and pharmacological manipulations. Here we tested whether stress-induced suppression of startle reactivity can be attributed to circulating ovarian hormones. Female rats were tracked across the Estrus Cycle and subjected to the stressor (2 h periodic tailshock) the morning of diEstrus, proEstrus, Estrus, or metEstrus. Startle reactivity was tested 2 h following the cessation of the tailshock. Using a multi-stimulus protocol, we determined there were differences in startle sensitivity and responsivity. Following stressor exposure, Estrus females exhibited reduced startle responsivity. In contrast, diEstrus females exhibited increased sensitivity to the lowest acoustic stimulus. The results are discussed with respect to ovarian hormone regulation of the immune system and sensory reactivity during and following trauma that may lead to different abnormal behaviors in females in the wake of traumatic stress.

  • Estrus Cycle stage modifies the presentation of stress-induced startle suppression in female Sprague-Dawley rats.
    Physiology & behavior, 2008
    Co-Authors: Kevin D. Beck, Xilu Jiao, Tara P. Cominski, Richard J. Servatius
    Abstract:

    Tailshock stress causes transient reductions in startle reactivity, associative learning and open field activity in female rats in an ovarian hormone dependent manner. Others have shown estrogen modulation of associative learning by testing across the Estrus Cycle and pharmacological manipulations. Here we tested whether stress-induced suppression of startle reactivity can be attributed to circulating ovarian hormones. Female rats were tracked across the Estrus Cycle and subjected to the stressor (2 h periodic tailshock) the morning of diEstrus, proEstrus, Estrus, or metEstrus. Startle reactivity was tested 2 h following the cessation of the tailshock. Using a multi-stimulus protocol, we determined there were differences in startle sensitivity and responsivity. Following stressor exposure, Estrus females exhibited reduced startle responsivity. In contrast, diEstrus females exhibited increased sensitivity to the lowest acoustic stimulus. The results are discussed with respect to ovarian hormone regulation of the immune system and sensory reactivity during and following trauma that may lead to different abnormal behaviors in females in the wake of traumatic stress.

Kevin D. Beck - One of the best experts on this subject based on the ideXlab platform.

  • Estrus Cycle stage modifies the presentation of stress-induced startle suppression in female Sprague–Dawley rats
    Physiology & Behavior, 2008
    Co-Authors: Kevin D. Beck, Xilu Jiao, Tara P. Cominski, Richard J. Servatius
    Abstract:

    Tailshock stress causes transient reductions in startle reactivity, associative learning and open field activity in female rats in an ovarian hormone dependent manner. Others have shown estrogen modulation of associative learning by testing across the Estrus Cycle and pharmacological manipulations. Here we tested whether stress-induced suppression of startle reactivity can be attributed to circulating ovarian hormones. Female rats were tracked across the Estrus Cycle and subjected to the stressor (2 h periodic tailshock) the morning of diEstrus, proEstrus, Estrus, or metEstrus. Startle reactivity was tested 2 h following the cessation of the tailshock. Using a multi-stimulus protocol, we determined there were differences in startle sensitivity and responsivity. Following stressor exposure, Estrus females exhibited reduced startle responsivity. In contrast, diEstrus females exhibited increased sensitivity to the lowest acoustic stimulus. The results are discussed with respect to ovarian hormone regulation of the immune system and sensory reactivity during and following trauma that may lead to different abnormal behaviors in females in the wake of traumatic stress.

  • Estrus Cycle stage modifies the presentation of stress-induced startle suppression in female Sprague-Dawley rats.
    Physiology & behavior, 2008
    Co-Authors: Kevin D. Beck, Xilu Jiao, Tara P. Cominski, Richard J. Servatius
    Abstract:

    Tailshock stress causes transient reductions in startle reactivity, associative learning and open field activity in female rats in an ovarian hormone dependent manner. Others have shown estrogen modulation of associative learning by testing across the Estrus Cycle and pharmacological manipulations. Here we tested whether stress-induced suppression of startle reactivity can be attributed to circulating ovarian hormones. Female rats were tracked across the Estrus Cycle and subjected to the stressor (2 h periodic tailshock) the morning of diEstrus, proEstrus, Estrus, or metEstrus. Startle reactivity was tested 2 h following the cessation of the tailshock. Using a multi-stimulus protocol, we determined there were differences in startle sensitivity and responsivity. Following stressor exposure, Estrus females exhibited reduced startle responsivity. In contrast, diEstrus females exhibited increased sensitivity to the lowest acoustic stimulus. The results are discussed with respect to ovarian hormone regulation of the immune system and sensory reactivity during and following trauma that may lead to different abnormal behaviors in females in the wake of traumatic stress.

Tara P. Cominski - One of the best experts on this subject based on the ideXlab platform.

  • Estrus Cycle stage modifies the presentation of stress-induced startle suppression in female Sprague–Dawley rats
    Physiology & Behavior, 2008
    Co-Authors: Kevin D. Beck, Xilu Jiao, Tara P. Cominski, Richard J. Servatius
    Abstract:

    Tailshock stress causes transient reductions in startle reactivity, associative learning and open field activity in female rats in an ovarian hormone dependent manner. Others have shown estrogen modulation of associative learning by testing across the Estrus Cycle and pharmacological manipulations. Here we tested whether stress-induced suppression of startle reactivity can be attributed to circulating ovarian hormones. Female rats were tracked across the Estrus Cycle and subjected to the stressor (2 h periodic tailshock) the morning of diEstrus, proEstrus, Estrus, or metEstrus. Startle reactivity was tested 2 h following the cessation of the tailshock. Using a multi-stimulus protocol, we determined there were differences in startle sensitivity and responsivity. Following stressor exposure, Estrus females exhibited reduced startle responsivity. In contrast, diEstrus females exhibited increased sensitivity to the lowest acoustic stimulus. The results are discussed with respect to ovarian hormone regulation of the immune system and sensory reactivity during and following trauma that may lead to different abnormal behaviors in females in the wake of traumatic stress.

  • Estrus Cycle stage modifies the presentation of stress-induced startle suppression in female Sprague-Dawley rats.
    Physiology & behavior, 2008
    Co-Authors: Kevin D. Beck, Xilu Jiao, Tara P. Cominski, Richard J. Servatius
    Abstract:

    Tailshock stress causes transient reductions in startle reactivity, associative learning and open field activity in female rats in an ovarian hormone dependent manner. Others have shown estrogen modulation of associative learning by testing across the Estrus Cycle and pharmacological manipulations. Here we tested whether stress-induced suppression of startle reactivity can be attributed to circulating ovarian hormones. Female rats were tracked across the Estrus Cycle and subjected to the stressor (2 h periodic tailshock) the morning of diEstrus, proEstrus, Estrus, or metEstrus. Startle reactivity was tested 2 h following the cessation of the tailshock. Using a multi-stimulus protocol, we determined there were differences in startle sensitivity and responsivity. Following stressor exposure, Estrus females exhibited reduced startle responsivity. In contrast, diEstrus females exhibited increased sensitivity to the lowest acoustic stimulus. The results are discussed with respect to ovarian hormone regulation of the immune system and sensory reactivity during and following trauma that may lead to different abnormal behaviors in females in the wake of traumatic stress.

Xilu Jiao - One of the best experts on this subject based on the ideXlab platform.

  • Estrus Cycle stage modifies the presentation of stress-induced startle suppression in female Sprague–Dawley rats
    Physiology & Behavior, 2008
    Co-Authors: Kevin D. Beck, Xilu Jiao, Tara P. Cominski, Richard J. Servatius
    Abstract:

    Tailshock stress causes transient reductions in startle reactivity, associative learning and open field activity in female rats in an ovarian hormone dependent manner. Others have shown estrogen modulation of associative learning by testing across the Estrus Cycle and pharmacological manipulations. Here we tested whether stress-induced suppression of startle reactivity can be attributed to circulating ovarian hormones. Female rats were tracked across the Estrus Cycle and subjected to the stressor (2 h periodic tailshock) the morning of diEstrus, proEstrus, Estrus, or metEstrus. Startle reactivity was tested 2 h following the cessation of the tailshock. Using a multi-stimulus protocol, we determined there were differences in startle sensitivity and responsivity. Following stressor exposure, Estrus females exhibited reduced startle responsivity. In contrast, diEstrus females exhibited increased sensitivity to the lowest acoustic stimulus. The results are discussed with respect to ovarian hormone regulation of the immune system and sensory reactivity during and following trauma that may lead to different abnormal behaviors in females in the wake of traumatic stress.

  • Estrus Cycle stage modifies the presentation of stress-induced startle suppression in female Sprague-Dawley rats.
    Physiology & behavior, 2008
    Co-Authors: Kevin D. Beck, Xilu Jiao, Tara P. Cominski, Richard J. Servatius
    Abstract:

    Tailshock stress causes transient reductions in startle reactivity, associative learning and open field activity in female rats in an ovarian hormone dependent manner. Others have shown estrogen modulation of associative learning by testing across the Estrus Cycle and pharmacological manipulations. Here we tested whether stress-induced suppression of startle reactivity can be attributed to circulating ovarian hormones. Female rats were tracked across the Estrus Cycle and subjected to the stressor (2 h periodic tailshock) the morning of diEstrus, proEstrus, Estrus, or metEstrus. Startle reactivity was tested 2 h following the cessation of the tailshock. Using a multi-stimulus protocol, we determined there were differences in startle sensitivity and responsivity. Following stressor exposure, Estrus females exhibited reduced startle responsivity. In contrast, diEstrus females exhibited increased sensitivity to the lowest acoustic stimulus. The results are discussed with respect to ovarian hormone regulation of the immune system and sensory reactivity during and following trauma that may lead to different abnormal behaviors in females in the wake of traumatic stress.

Elias Eriksson - One of the best experts on this subject based on the ideXlab platform.

  • Association between Estrus Cycle-related aggression and tidal volume variability in female Wistar rats.
    Psychoneuroendocrinology, 2004
    Co-Authors: Lydia K Melchior, Marie Olsson, Kristina Annerbrink, Jan Hedner, Elias Eriksson
    Abstract:

    Premenstrual dysphoria is characterized by symptoms such as irritability and depressed mood, present during the luteal phase of the menstrual Cycle, and disappearing shortly after the onset of menstruation. Subjects with premenstrual dysphoria have previously been reported to display enhanced respiratory variability, and to experience anxiety when exposed to panicogens, such as CO2. In the present study, the possible influence of the Estrus Cycle and Estrus Cycle-related aggression on respiratory variability was investigated in female rats of the Wistar strain. The rats were subdivided into two groups: those displaying Estrus Cycle-related aggression, as evaluated using the resident intruder paradigm, and those not showing aggression throughout the Estrus Cycle. This model has been developed to serve as an animal model of premenstrual irritability. The former group was found to display higher tidal volume variability in diEstrus, as compared to the non-aggressive rats. There was no effect of Estrus Cycle phase on respiratory variability. These results are well in line with the clinical observation that women with premenstrual dysphoria display higher respiratory variability than controls, and the notion that respiratory variability is a parameter of interest in this context. In our opinion, they also strengthen the concept of this animal model as a model of premenstrual irritability.

  • Association between Estrus Cycle-related changes in respiration and Estrus Cycle-related aggression in outbred female Wistar rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002
    Co-Authors: Marie Olsson, Kristina Annerbrink, Lydia K Melchior, Jan Hedner, Elias Eriksson
    Abstract:

    Premenstrual dysphoric disorder is characterized by irritability surfacing during the luteal phase of the menstrual Cycle, and disappearing shortly after the onset of menstruation. Although the cardinal symptoms of premenstrual dysphoria are different from those of panic disorder, the two conditions share a number of traits indicating that they both may be associated with abnormalities in the regulation of respiration. Both subjects with panic disorder and subjects with premenstrual dysphoria are hence reported to display enhanced respiratory variability, and to experience anxiety when exposed to CO(2). In the present study, the possible influence of the Estrus Cycle on respiratory parameters in outbred female rats of the Wistar strain was investigated. Before being tested with respect to respiration, the rats were subdivided into two groups: those displaying Estrus Cycle-related variation in aggression, as evaluated using the resident intruder paradigm, and those not showing aggression throughout the Cycle. Whereas the former group was found to display higher respiratory rate during the diEstrus phase than during the proEstrus/Estrus phase, no Cycle-related variation in respiration was observed in animals not showing Cycle-related variation in aggression. The results support previous studies indicating that the Estrus Cycle exerts an influence on respiration, and suggest that rats prone to Cycle-related aggression are more sensitive also to the influence of hormonal cyclicity on respiration. The possible bearing of these findings for the aberration in respiration displayed by subjects with premenstrual dysphoria is discussed.