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Linan Cheng - One of the best experts on this subject based on the ideXlab platform.
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termination of second trimester pregnancy by mifepristone combined with misoprostol versus intra amniotic injection of Ethacridine Lactate rivanol a systematic review of chinese trials
Contraception, 2011Co-Authors: Aihua Fang, Qinfang Chen, Yongmei Huang, Oiuju Chen, Linan ChengAbstract:Abstract Background Mifepristone combined with misoprostol for second-trimester abortion (MM) and intra-amniotic injection of Ethacridine Lactate (EL; Rivanol®) are the common methods for termination of second-trimester pregnancy in China. The systematic review of relevant literature was conducted to evaluate the effectiveness and safety on termination of second-trimester pregnancy using MM, introduced in 1988 in China, versus the Chinese routinely used method since 1970 — EL. The review was conducted to evaluate mifepristone combined with the misoprostol versus intra-amniotic injection of Ethacridine Lactate in China for termination of second-trimester pregnancy with respect to efficacy, side effects, complications and so on. Study Design The Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, POPLINE, TOXLINE, World Health Organization–Department of Reproductive Health and Research, Chinese Biomedical Literature Database, Chinese Journal Full-text Database and Chinese Science & Technology Journal Database were systematically searched. Reference lists for English and Chinese-language reports (published from 1966 to 2008) were searched. All randomized controlled trials (RCTs) on second-trimester abortion by combination of mifepristone and misoprostol versus Ethacridine Lactate, which conducted in China, were analyzed. Trial quality was assessed, and data extraction was made independently by two reviewers. Results Fifteen original RCTs using MM versus EL were included. Three trials used oral misoprostol, six trials used vaginal misoprostol, and six trials used oral plus vaginal misoprostol. Failure rate of abortion was 2.0% to 5.9% in the MM group and 7.4% to 20.7% in the EL group. The incidence of postabortion curettage was similar in the two groups. The time of labor and hospitalization for abortion in the MM group were shorter compared with EL group. The blood loss within 2 h of abortion in the MM group was significantly less than that in the EL group, but the blood loss within 24 h of abortion was the same in both groups. More gastrointestinal side effects occurred with the MM regimen, whereas cervical injury occurred more often in the EL group. Conclusions Compared with the intra-amniotic injection of Ethacridine Lactate, mifepristone/misoprostol has a higher success rate and shorter time of labor with more gastrointestinal side effects for termination of second-trimester pregnancy.
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mifepristone combined with misoprostol versus intra amniotic injection of Ethacridine Lactate for the termination of second trimester pregnancy a prospective open label randomized clinical trial
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010Co-Authors: Qinfang Chen, Aihua Fang, Lanrong Zhang, Linan ChengAbstract:Abstract Objectives To compare the effectiveness and safety of mifepristone/misoprostol versus intra-amniotic injection of Ethacridine Lactate for the termination of second trimester pregnancy. Study design 210 women requesting voluntary termination of pregnancies at between 16 and 24 weeks of gestation were randomly assigned into two groups. Group 1 (MM) received a single oral dose of 200 mg mifepristone and, 36–48 h later, 400 μg of misoprostol vaginally, with up to three additional oral doses of 400 μg misoprostol every 12 h. Group 2 (EL) received an intra-amniotic injection of 100 mg Ethacridine Lactate. The primary outcome was successful abortion rate. Secondary outcomes included the difference in the induction-to-abortion interval and the frequency of adverse events. Results Both MM and EL regimens were effective, with successful abortion rates of 96.19% and 94.29%, respectively ( P = 0.746). The complete abortion rates were 68.57% and 70.48%, respectively. The induction-to-abortion interval was longer in the MM group than in the EL group (50.57 ± 6.80 h vs. 43.02 ± 8.74 h, respectively, P Conclusions Both MM and EL regimens were effective with high success rates and were safe for the termination of second trimester pregnancy.
Ismet Inan - One of the best experts on this subject based on the ideXlab platform.
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randomized study on the effect of adding oxytocin to Ethacridine Lactate or misoprostol for second trimester termination of pregnancy
Acta Obstetricia et Gynecologica Scandinavica, 2006Co-Authors: Sefa Kelekci, Evrim Erdemoglu, Ismet InanAbstract:Objective. To compare effectiveness of misoprostol and Ethacridine Lactate with or without oxytocin in second-trimester medical abortions.Subjects and methods. A randomized prospective study. A total of 388 women with genetic indications for termination of pregnancy at 13–24 weeks of gestation were recruited. Group I (n=85) were treated with extra-amniotic Ethacridine Lactate, 10 ml instilled per gestational week, to a maximum of 200 ml. Group II (n=93) were treated with misoprostol administered intravaginally (200 µg), followed by 100 µg of oral misoprostol 4 hourly for 24 h. Group III (n=102) were treated with a combination of ethacrine Lactate and oxytocin. An initial dose of 6 mU/min oxytocin was given, followed by additional 6 mU/min doses every 20 min. Group IV (n=96) were treated with a combination of misoprostol and oxytocin administered in a similar way as in group III. The main outcome measures were time to induce abortion, side effects, and failure/success rates.Results. The mean time to induce...
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comparison of Ethacridine Lactate and prostaglandin e2 in second trimester medical abortion
Acta Obstetricia et Gynecologica Scandinavica, 1997Co-Authors: Ismet Inan, Sefa Kelekci, Deniz YazarAbstract:Background. A comparison of Ethacridine Lactate and prostaglandin E2 (PGE2) with or without oxytocin infusion in second trimester medical abortion cases.Methods. A prospective study was performed on 151 women requiring second trimester medical abortions between 1989 and 1995. Patients were randomly assigned to PGE2 group (n= 30), Ethacridine Lactate group (n48), Ethacridine Lactate combined with oxytocin infusion group (n=49) and PGE2 combined with oxytocin infusion group (n=24). Rates of successful abortion (i.e., complete evacuation of fetal and placental tissxies from the uterus) within 24 hours for each group were determined and compared by x2 and the Student r-test.Results. Statistically significant difference concerning successful abortion rates was observed between Ethacridine Lactate and PGE2 groups, PGE2 and PGE2+oxytocin infusion groups, and Ethacridine Lactate+oxytocin infusion and PGE2 groups, while there was no significant difference between Ethacridine Lactate and Ethacridine Lactate+oxytoci...
Aihua Fang - One of the best experts on this subject based on the ideXlab platform.
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termination of second trimester pregnancy by mifepristone combined with misoprostol versus intra amniotic injection of Ethacridine Lactate rivanol a systematic review of chinese trials
Contraception, 2011Co-Authors: Aihua Fang, Qinfang Chen, Yongmei Huang, Oiuju Chen, Linan ChengAbstract:Abstract Background Mifepristone combined with misoprostol for second-trimester abortion (MM) and intra-amniotic injection of Ethacridine Lactate (EL; Rivanol®) are the common methods for termination of second-trimester pregnancy in China. The systematic review of relevant literature was conducted to evaluate the effectiveness and safety on termination of second-trimester pregnancy using MM, introduced in 1988 in China, versus the Chinese routinely used method since 1970 — EL. The review was conducted to evaluate mifepristone combined with the misoprostol versus intra-amniotic injection of Ethacridine Lactate in China for termination of second-trimester pregnancy with respect to efficacy, side effects, complications and so on. Study Design The Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, POPLINE, TOXLINE, World Health Organization–Department of Reproductive Health and Research, Chinese Biomedical Literature Database, Chinese Journal Full-text Database and Chinese Science & Technology Journal Database were systematically searched. Reference lists for English and Chinese-language reports (published from 1966 to 2008) were searched. All randomized controlled trials (RCTs) on second-trimester abortion by combination of mifepristone and misoprostol versus Ethacridine Lactate, which conducted in China, were analyzed. Trial quality was assessed, and data extraction was made independently by two reviewers. Results Fifteen original RCTs using MM versus EL were included. Three trials used oral misoprostol, six trials used vaginal misoprostol, and six trials used oral plus vaginal misoprostol. Failure rate of abortion was 2.0% to 5.9% in the MM group and 7.4% to 20.7% in the EL group. The incidence of postabortion curettage was similar in the two groups. The time of labor and hospitalization for abortion in the MM group were shorter compared with EL group. The blood loss within 2 h of abortion in the MM group was significantly less than that in the EL group, but the blood loss within 24 h of abortion was the same in both groups. More gastrointestinal side effects occurred with the MM regimen, whereas cervical injury occurred more often in the EL group. Conclusions Compared with the intra-amniotic injection of Ethacridine Lactate, mifepristone/misoprostol has a higher success rate and shorter time of labor with more gastrointestinal side effects for termination of second-trimester pregnancy.
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mifepristone combined with misoprostol versus intra amniotic injection of Ethacridine Lactate for the termination of second trimester pregnancy a prospective open label randomized clinical trial
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010Co-Authors: Qinfang Chen, Aihua Fang, Lanrong Zhang, Linan ChengAbstract:Abstract Objectives To compare the effectiveness and safety of mifepristone/misoprostol versus intra-amniotic injection of Ethacridine Lactate for the termination of second trimester pregnancy. Study design 210 women requesting voluntary termination of pregnancies at between 16 and 24 weeks of gestation were randomly assigned into two groups. Group 1 (MM) received a single oral dose of 200 mg mifepristone and, 36–48 h later, 400 μg of misoprostol vaginally, with up to three additional oral doses of 400 μg misoprostol every 12 h. Group 2 (EL) received an intra-amniotic injection of 100 mg Ethacridine Lactate. The primary outcome was successful abortion rate. Secondary outcomes included the difference in the induction-to-abortion interval and the frequency of adverse events. Results Both MM and EL regimens were effective, with successful abortion rates of 96.19% and 94.29%, respectively ( P = 0.746). The complete abortion rates were 68.57% and 70.48%, respectively. The induction-to-abortion interval was longer in the MM group than in the EL group (50.57 ± 6.80 h vs. 43.02 ± 8.74 h, respectively, P Conclusions Both MM and EL regimens were effective with high success rates and were safe for the termination of second trimester pregnancy.
Lili Huang - One of the best experts on this subject based on the ideXlab platform.
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mifepristone may shorten the induction to abortion time for termination of second trimester pregnancies by Ethacridine Lactate
Contraception, 2012Co-Authors: Yaling Zhuang, Xiuying Chen, Lili HuangAbstract:Abstract Background We reviewed our experience with adding mifepristone to the protocol for the termination of pregnancy up to 24 weeks of gestation by intra-amniotic Ethacridine Lactate. Study Design The study consisted of women who presented for the termination of a second-trimester pregnancy between August 2000 and July 2008. Results Of 1245 women who requested a termination of a second-trimester pregnancy, 744 women underwent the induction of abortion by intra-amniotic Ethacridine Lactate with mifepristone (mifepristone group), and 501 received intra-amniotic Ethacridine Lactate alone (control group). The proportion of women who delivered within 24 h was 25.94% in the mifepristone group and 10.18% in the control group (p Conclusion The addition of mifepristone to Ethacridine Lactate may shorten the induction-to-abortion time compared with the use of Ethacridine Lactate alone without increasing the number of complications.
Qinfang Chen - One of the best experts on this subject based on the ideXlab platform.
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termination of second trimester pregnancy by mifepristone combined with misoprostol versus intra amniotic injection of Ethacridine Lactate rivanol a systematic review of chinese trials
Contraception, 2011Co-Authors: Aihua Fang, Qinfang Chen, Yongmei Huang, Oiuju Chen, Linan ChengAbstract:Abstract Background Mifepristone combined with misoprostol for second-trimester abortion (MM) and intra-amniotic injection of Ethacridine Lactate (EL; Rivanol®) are the common methods for termination of second-trimester pregnancy in China. The systematic review of relevant literature was conducted to evaluate the effectiveness and safety on termination of second-trimester pregnancy using MM, introduced in 1988 in China, versus the Chinese routinely used method since 1970 — EL. The review was conducted to evaluate mifepristone combined with the misoprostol versus intra-amniotic injection of Ethacridine Lactate in China for termination of second-trimester pregnancy with respect to efficacy, side effects, complications and so on. Study Design The Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, POPLINE, TOXLINE, World Health Organization–Department of Reproductive Health and Research, Chinese Biomedical Literature Database, Chinese Journal Full-text Database and Chinese Science & Technology Journal Database were systematically searched. Reference lists for English and Chinese-language reports (published from 1966 to 2008) were searched. All randomized controlled trials (RCTs) on second-trimester abortion by combination of mifepristone and misoprostol versus Ethacridine Lactate, which conducted in China, were analyzed. Trial quality was assessed, and data extraction was made independently by two reviewers. Results Fifteen original RCTs using MM versus EL were included. Three trials used oral misoprostol, six trials used vaginal misoprostol, and six trials used oral plus vaginal misoprostol. Failure rate of abortion was 2.0% to 5.9% in the MM group and 7.4% to 20.7% in the EL group. The incidence of postabortion curettage was similar in the two groups. The time of labor and hospitalization for abortion in the MM group were shorter compared with EL group. The blood loss within 2 h of abortion in the MM group was significantly less than that in the EL group, but the blood loss within 24 h of abortion was the same in both groups. More gastrointestinal side effects occurred with the MM regimen, whereas cervical injury occurred more often in the EL group. Conclusions Compared with the intra-amniotic injection of Ethacridine Lactate, mifepristone/misoprostol has a higher success rate and shorter time of labor with more gastrointestinal side effects for termination of second-trimester pregnancy.
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mifepristone combined with misoprostol versus intra amniotic injection of Ethacridine Lactate for the termination of second trimester pregnancy a prospective open label randomized clinical trial
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010Co-Authors: Qinfang Chen, Aihua Fang, Lanrong Zhang, Linan ChengAbstract:Abstract Objectives To compare the effectiveness and safety of mifepristone/misoprostol versus intra-amniotic injection of Ethacridine Lactate for the termination of second trimester pregnancy. Study design 210 women requesting voluntary termination of pregnancies at between 16 and 24 weeks of gestation were randomly assigned into two groups. Group 1 (MM) received a single oral dose of 200 mg mifepristone and, 36–48 h later, 400 μg of misoprostol vaginally, with up to three additional oral doses of 400 μg misoprostol every 12 h. Group 2 (EL) received an intra-amniotic injection of 100 mg Ethacridine Lactate. The primary outcome was successful abortion rate. Secondary outcomes included the difference in the induction-to-abortion interval and the frequency of adverse events. Results Both MM and EL regimens were effective, with successful abortion rates of 96.19% and 94.29%, respectively ( P = 0.746). The complete abortion rates were 68.57% and 70.48%, respectively. The induction-to-abortion interval was longer in the MM group than in the EL group (50.57 ± 6.80 h vs. 43.02 ± 8.74 h, respectively, P Conclusions Both MM and EL regimens were effective with high success rates and were safe for the termination of second trimester pregnancy.