The Experts below are selected from a list of 2358 Experts worldwide ranked by ideXlab platform
Bin S Teh - One of the best experts on this subject based on the ideXlab platform.
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metastatic renal cell carcinoma to the nose and Ethmoid Sinus
2006Co-Authors: Mohammadbagher Ziari, Steven S Shen, Robert J Amato, Bin S TehAbstract:We report a rare case of metastatic renal cell carcinoma involving the nose and Ethmoid Sinus, 17 years after initial nephrectomy and diagnosis of Stage T1N0 clear cell renal cell carcinoma. The patient complained of nasal obstruction and epistaxis. Intensity-modulated radiotherapy (IMRT) was delivered using a higher-than-conventional daily fraction size concurrently with interferon and thalidomide. The patient achieved a complete response both clinically and by magnetic resonance imaging, without any side effects. Late and rare sites of recurrences and treatment options are discussed.
Milind N Naik - One of the best experts on this subject based on the ideXlab platform.
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entire lacrimal sac within the Ethmoid Sinus outcomes of powered endoscopic dacryocystorhinostomy
2016Co-Authors: Swati Singh, Milind N NaikAbstract:The aim of this study was to report the outcomes of powered endoscopic dacryocystorhinostomy (PEnDCR) in patients with lacrimal sac within the Sinus.Retrospective analysis was performed on all patients who underwent PEnDCR and were intraoperatively documented to have complete lacrimal sac in Sinus. Data collected included demographics, clinical presentations, associated lacrimal and nasal anomalies, intraoperative findings, intraoperative guidance, complications, postoperative ostium behavior, and anatomical and functional success. A minimum follow-up of 6 months postsurgery was considered for final analysis.A total of 17 eyes of 15 patients underwent PEnDCR using standard protocols, but with additional intraoperative guidance where required and careful maneuvering in the Ethmoid Sinus. The mean age of the patients was 37.2 (range 17-60) years. Of the unilateral cases, 69% (nine of 13) showed left-side predisposition; 80% of patients showed regurgitation on pressure over the lacrimal sac area. Associated lacrimal and nasal anomalies were observed in 13.3% (two of 15) and 40% (six of 15), respectively. At a mean follow-up of 6.6 months, anatomical and functional success were observed in 93.3% (14 of 15). One patient showed failure secondary to cicatricial closure of the ostium.An entire sac within an Ethmoid Sinus poses a surgical challenge. Good Sinus-surgery training, thorough knowledge of endoscopic anatomy, careful maneuvering, and use of intraoperative navigation guidance result in good outcomes with PEnDCR.
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entire lacrimal sac within the Ethmoid Sinus outcomes of powered endoscopic dacryocystorhinostomy
2016Co-Authors: Mohammad Javed Ali, Swati Singh, Milind N NaikAbstract:Background The aim of this study was to report the outcomes of powered endoscopic dacryocystorhinostomy (PEnDCR) in patients with lacrimal sac within the Sinus. Materials and methods Retrospective analysis was performed on all patients who underwent PEnDCR and were intraoperatively documented to have complete lacrimal sac in Sinus. Data collected included demographics, clinical presentations, associated lacrimal and nasal anomalies, intraoperative findings, intraoperative guidance, complications, postoperative ostium behavior, and anatomical and functional success. A minimum follow-up of 6 months postsurgery was considered for final analysis. Results A total of 17 eyes of 15 patients underwent PEnDCR using standard protocols, but with additional intraoperative guidance where required and careful maneuvering in the Ethmoid Sinus. The mean age of the patients was 37.2 (range 17-60) years. Of the unilateral cases, 69% (nine of 13) showed left-side predisposition; 80% of patients showed regurgitation on pressure over the lacrimal sac area. Associated lacrimal and nasal anomalies were observed in 13.3% (two of 15) and 40% (six of 15), respectively. At a mean follow-up of 6.6 months, anatomical and functional success were observed in 93.3% (14 of 15). One patient showed failure secondary to cicatricial closure of the ostium. Conclusion An entire sac within an Ethmoid Sinus poses a surgical challenge. Good Sinus-surgery training, thorough knowledge of endoscopic anatomy, careful maneuvering, and use of intraoperative navigation guidance result in good outcomes with PEnDCR.
Mohammadbagher Ziari - One of the best experts on this subject based on the ideXlab platform.
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metastatic renal cell carcinoma to the nose and Ethmoid Sinus
2006Co-Authors: Mohammadbagher Ziari, Steven S Shen, Robert J Amato, Bin S TehAbstract:We report a rare case of metastatic renal cell carcinoma involving the nose and Ethmoid Sinus, 17 years after initial nephrectomy and diagnosis of Stage T1N0 clear cell renal cell carcinoma. The patient complained of nasal obstruction and epistaxis. Intensity-modulated radiotherapy (IMRT) was delivered using a higher-than-conventional daily fraction size concurrently with interferon and thalidomide. The patient achieved a complete response both clinically and by magnetic resonance imaging, without any side effects. Late and rare sites of recurrences and treatment options are discussed.
Giulio Cantu - One of the best experts on this subject based on the ideXlab platform.
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tp53 status as guide for the management of Ethmoid Sinus intestinal type adenocarcinoma
2013Co-Authors: Paolo Bossi, Giulio Cantu, Rosalba Miceli, Luigi Mariani, Federica Perrone, Ester Orlandi, C Fallai, Laura D Locati, Barbara Cortelazzi, Pasquale QuattroneAbstract:summary Objective: Intestinal-type adenocarcinoma (ITAC) of the Ethmoid Sinus is a rare, occupational-related tumor. Optimal treatment consists of surgery and radiotherapy, while chemotherapy is still investigational. The molecular profile of ITAC is characterized by the occurrence of TP53 mutations associated with genotoxic agents such as wood dust. We investigated the role of p53 functionality in relation to the primary treatment. Materials and methods: We retrospectively reviewed 100 medical charts of consecutive patients with a first diagnosis of ITAC treated at our Institute; 74 patients were evaluable for TP53 analysis. Thirty (41%) were treated from 1991 to 2006 with craniofacial resection followed by radiotherapy (Group A), compared with 44 patients (59%) treated from 1996 to 2006 with cisplatin-based induction chemotherapy (PFL) followed by standard treatment (Group B). Results: Five-year OS in Group A was 42%, while in Group B it was 70% (p = 0.041); 5-year DFS in Group A was 40%, while in Group B it was 66%, (p = 0.009) (p = 0.061 and 0.003 at Cox multivariable OS and DFS analyses). Analyzing each group according to p53 functional status, only for Group B patients (who received preoperative chemotherapy) both OS and DFS were in favor of functional p53 (p = 0.023 and p = 0.010, respectively). No impact of p53 functional status as a biomarker was observed in Group A. Conclusions: Functional p53 may predict PFL-chemotherapy efficacy, offering a possible increase in survival when induction chemotherapy is given to a selected population. On the other hand, upcoming innovative approaches should be explored in the presence of non-functional p53.
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intestinal type adenocarcinoma of the Ethmoid Sinus in wood and leather workers a retrospective study of 153 cases
2011Co-Authors: Giulio Cantu, Luigi Mariani, Sarah Colombo, Madia Pompilio, C L Solero, Salvatore Lo Vullo, S Riccio, Federica Perrone, Paolo Formillo, Pasquale QuattroneAbstract:Background. The purpose of our study was to identify the role of work exposure to organic dusts in patients with malignant paranasal Sinus tumors. Methods. We analyzed all patients surgically treated for a malignant paranasal Sinus tumor at our institution between 1987 and 2006. All patients were specifically asked about their occupational history. The tumor site was classified as maxillary or Ethmoid Sinus. Adenocarcinomas were divided into intestinal type (ITAC) and non-ITAC. Results. The sample included 345 patients with Ethmoid Sinus and 301 maxillary Sinus. Regarding the Ethmoid Sinus, we found an exposure to organic dusts in 148 of 153 patients with ITAC, in 3 of 16 patients with non-ITAC adenocarcinoma, and in 10 of 176 patients with other tumors. Regarding the maxillary Sinus, we found an exposure in 1 of 20 patients with non-ITAC adenocarcinoma and in 4 of 281 patients with other histologies. Conclusion. Our study demonstrates that only Ethmoid ITACs have an indisputable relationship with the exposure to organic dusts. V
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survival for Ethmoid Sinus adenocarcinoma in european populations
2009Co-Authors: G Gatta, Gabriella Bimbi, Laura Ciccolallo, Giulia Zigon, Giulio CantuAbstract:Background. Adenocarcinoma of the Ethmoid Sinus is rare. EUROCARE data provide a good opportunity to study the survival of this rare disease in a population of continental size. Patients and methods. A total of 204 cases, age 15 to 99 years, diagnosed with primary Ethmoid Sinus adenocarcinoma between 1983 and 1994, were analyzed. The data were contributed by 22 population-based cancer registries from the nine countries participating in EUROCARE. Relative survival by sex, age, period
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lymph node metastases in malignant tumors of the paranasal Sinuses prognostic value and treatment
2008Co-Authors: Giulio Cantu, Gabriella Bimbi, Rosalba Miceli, Luigi Mariani, Sarah Colombo, Stefano Riccio, Massimo Squadrelli, Andrea Battisti, Madia Pompilio, Marco RossiAbstract:Objective To assess the frequency of nodal involvement and its prognostic value in malignant tumors of the paranasal Sinuses, particularly in maxillary Sinus squamous cell carcinoma. Design Retrospective review. Setting Tertiary cancer center. Patients The medical records of 704 consecutive patients surgically treated for malignant tumors of the paranasal Sinuses from January 1968 to March 2003 were reviewed. The tumors were staged according to American Joint Committee on Cancer–International Union Against Cancer 2002 classification. Only patients with clinically positive nodes underwent a neck dissection. Main Outcome Measures Lymph node metastases (at presentation or during follow-up, occurring alone, or with concurrent local recurrence and/or distant metastasis). Also analyzed were local recurrence (occurring alone or with concurrent distant metastasis), distant metastasis (occurring alone), and overall survival. Results The tumor site was the Ethmoid Sinus in 305 cases and maxillary Sinus in 399 cases. At baseline, 5 patients (1.6%) in the Ethmoid Sinus group and 33 (8.3%) in the maxillary Sinus group presented with positive nodes ( P P = .001). The highest incidence of node metastases was found in maxillary Sinus squamous cell carcinoma, particularly in T2 tumors. Five-year overall survival estimates were 45.3% for patients with N0 tumors and 0% for those with N+ (N1, N2, or N3) Ethmoid Sinus tumors, and 50.6% and 16.8%, respectively, for patients with maxillary Sinus tumors. Conclusions Lymph node metastases are a poor prognostic factor for patients with malignant tumors of the paranasal Sinuses. The incidence of these metastases is low, particularly in Ethmoid Sinus tumors. A prophylactic treatment of the neck in patients with N0 tumors (surgery or radiotherapy) might be considered in T2 squamous cell carcinoma of the maxillary Sinus and in undifferentiated carcinoma of the Ethmoid Sinus.
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adenocarcinoma of Ethmoid Sinus an occupational disease
2004Co-Authors: Gabriella Bimbi, G Gatta, S Riccio, Squadrelli M Saraceno, Lisa Licitra, Giulio CantuAbstract:Sinonasal tumours, particularly those of Ethmoidal origin, are rare neoplasms, of which adenocarcinoma is the most frequent histotype in Europe. The association between sinonasal malignancies and exposure to wood or leather dusts has been widely documented, however, the precise tumour site and histology has seldom been reported. In the present study, exposure to wood or leather dusts was investigated in 499 patients diagnosed with sinonasal tumours, who were treated at the Head and Neck Surgery Department of the National Cancer Institute of Milan, Italy, between 1987 and 2001. The original tumour site and histology were carefully assessed. Of the 499 patients evaluated, 249 had Ethmoidal tumours; 124 of which adenocarcinomas, affecting 115 males; 9 females. Of the males with adenocarcinoma, 90.4% had been exposed to wood or leather dusts; 16.3% of these had only been exposed for a short time and long before onset of the disease (median exposure 11 years; median latency 31 years). Of the remaining 125 patients with Ethmoidal tumours other than adenocarcinomas, only 2 (1.6%) had ever been exposed to these dusts. Non-Ethmoidal sinonasal tumours were seen in 250 cases; 17 of these (6.8%) were adenocarcinomas; no exposure to wood or leather dusts was reported in any of these patients. Ethmoid proved to be the sinonasal site affected by adenocarcinomas induced by exposure to wood or leather dusts. Even brief exposure, which may have occurred a very long time before onset of the disease, seems to be sufficient to increase the incidence of this tumour type. No significant correlation was observed between exposure and either non-Ethmoidal sinonasal neoplasms or Ethmoidal tumours other than adenocarcinomas.
Swati Singh - One of the best experts on this subject based on the ideXlab platform.
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entire lacrimal sac within the Ethmoid Sinus outcomes of powered endoscopic dacryocystorhinostomy
2016Co-Authors: Swati Singh, Milind N NaikAbstract:The aim of this study was to report the outcomes of powered endoscopic dacryocystorhinostomy (PEnDCR) in patients with lacrimal sac within the Sinus.Retrospective analysis was performed on all patients who underwent PEnDCR and were intraoperatively documented to have complete lacrimal sac in Sinus. Data collected included demographics, clinical presentations, associated lacrimal and nasal anomalies, intraoperative findings, intraoperative guidance, complications, postoperative ostium behavior, and anatomical and functional success. A minimum follow-up of 6 months postsurgery was considered for final analysis.A total of 17 eyes of 15 patients underwent PEnDCR using standard protocols, but with additional intraoperative guidance where required and careful maneuvering in the Ethmoid Sinus. The mean age of the patients was 37.2 (range 17-60) years. Of the unilateral cases, 69% (nine of 13) showed left-side predisposition; 80% of patients showed regurgitation on pressure over the lacrimal sac area. Associated lacrimal and nasal anomalies were observed in 13.3% (two of 15) and 40% (six of 15), respectively. At a mean follow-up of 6.6 months, anatomical and functional success were observed in 93.3% (14 of 15). One patient showed failure secondary to cicatricial closure of the ostium.An entire sac within an Ethmoid Sinus poses a surgical challenge. Good Sinus-surgery training, thorough knowledge of endoscopic anatomy, careful maneuvering, and use of intraoperative navigation guidance result in good outcomes with PEnDCR.
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entire lacrimal sac within the Ethmoid Sinus outcomes of powered endoscopic dacryocystorhinostomy
2016Co-Authors: Mohammad Javed Ali, Swati Singh, Milind N NaikAbstract:Background The aim of this study was to report the outcomes of powered endoscopic dacryocystorhinostomy (PEnDCR) in patients with lacrimal sac within the Sinus. Materials and methods Retrospective analysis was performed on all patients who underwent PEnDCR and were intraoperatively documented to have complete lacrimal sac in Sinus. Data collected included demographics, clinical presentations, associated lacrimal and nasal anomalies, intraoperative findings, intraoperative guidance, complications, postoperative ostium behavior, and anatomical and functional success. A minimum follow-up of 6 months postsurgery was considered for final analysis. Results A total of 17 eyes of 15 patients underwent PEnDCR using standard protocols, but with additional intraoperative guidance where required and careful maneuvering in the Ethmoid Sinus. The mean age of the patients was 37.2 (range 17-60) years. Of the unilateral cases, 69% (nine of 13) showed left-side predisposition; 80% of patients showed regurgitation on pressure over the lacrimal sac area. Associated lacrimal and nasal anomalies were observed in 13.3% (two of 15) and 40% (six of 15), respectively. At a mean follow-up of 6.6 months, anatomical and functional success were observed in 93.3% (14 of 15). One patient showed failure secondary to cicatricial closure of the ostium. Conclusion An entire sac within an Ethmoid Sinus poses a surgical challenge. Good Sinus-surgery training, thorough knowledge of endoscopic anatomy, careful maneuvering, and use of intraoperative navigation guidance result in good outcomes with PEnDCR.