The Experts below are selected from a list of 57135 Experts worldwide ranked by ideXlab platform
Silvana Torselli - One of the best experts on this subject based on the ideXlab platform.
-
Frequency of the ETV6-RUNX1, BCR-ABL1, TCF3-PBX1 and MLL-AFF1 fusion genes in Guatemalan Pediatric Acute Lymphoblastic Leukemia Patients and Its Ethnic Associations
Clinical Lymphoma Myeloma and Leukemia, 2015Co-Authors: Claudia Lorena Carranza Meléndez, Luisa Rosales, Mariana Herrera, Lilian Granados, Damaris Tinti, Swuanny Villagran, Mauricio Villegas, Federico Antillon, Silvana TorselliAbstract:Fusion genes involved in acute lymphoblastic leukemia (ALL) occur mostly due to genetic and environmental factors, and only a limited number of studies have reported any Ethnic Influence. This study assesses whether an Ethnic Influence has an effect on the frequency of any of the four fusion genes: BCR-ABL1, ETV6-RUNX1, TCF3-PBX1, and MLL-AFF1 found in ALL. To study this Ethnic Influence, mononuclear cells were obtained from bone marrow samples from 143 patients with ALL. We performed RNA extraction and reverse transcription, then assessed the quality of the cDNA by amplifying the ABL1 control gene, and finally evaluated the presence of the four transcripts by multiplex polymerase chain reaction. We found 10 patients who had the BCR-ABL1 fusion gene (7%); 3 patients (2%) were TCF3-PBX1 positive; and 6 patients (4.5%) were ETV6-RUNX1 positive. The incidence of this last fusion gene is quite low when compared to the values reported in most countries. The low incidence of the ETV6-RUNX1 fusion gene found in Guatemala matches the incidence rates that have been reported in Spain and Indian Romani. Since it is known that an Ethnic resemblance exists among these three populations, as shown by ancestral marker studies, the ALL data suggests an Ethnic Influence on the occurrence and frequency of this particular fusion gene.
Claudia Lorena Carranza Meléndez - One of the best experts on this subject based on the ideXlab platform.
-
Frequency of the ETV6-RUNX1, BCR-ABL1, TCF3-PBX1 and MLL-AFF1 fusion genes in Guatemalan Pediatric Acute Lymphoblastic Leukemia Patients and Its Ethnic Associations
Clinical Lymphoma Myeloma and Leukemia, 2015Co-Authors: Claudia Lorena Carranza Meléndez, Luisa Rosales, Mariana Herrera, Lilian Granados, Damaris Tinti, Swuanny Villagran, Mauricio Villegas, Federico Antillon, Silvana TorselliAbstract:Fusion genes involved in acute lymphoblastic leukemia (ALL) occur mostly due to genetic and environmental factors, and only a limited number of studies have reported any Ethnic Influence. This study assesses whether an Ethnic Influence has an effect on the frequency of any of the four fusion genes: BCR-ABL1, ETV6-RUNX1, TCF3-PBX1, and MLL-AFF1 found in ALL. To study this Ethnic Influence, mononuclear cells were obtained from bone marrow samples from 143 patients with ALL. We performed RNA extraction and reverse transcription, then assessed the quality of the cDNA by amplifying the ABL1 control gene, and finally evaluated the presence of the four transcripts by multiplex polymerase chain reaction. We found 10 patients who had the BCR-ABL1 fusion gene (7%); 3 patients (2%) were TCF3-PBX1 positive; and 6 patients (4.5%) were ETV6-RUNX1 positive. The incidence of this last fusion gene is quite low when compared to the values reported in most countries. The low incidence of the ETV6-RUNX1 fusion gene found in Guatemala matches the incidence rates that have been reported in Spain and Indian Romani. Since it is known that an Ethnic resemblance exists among these three populations, as shown by ancestral marker studies, the ALL data suggests an Ethnic Influence on the occurrence and frequency of this particular fusion gene.
Luisa Rosales - One of the best experts on this subject based on the ideXlab platform.
-
Frequency of the ETV6-RUNX1, BCR-ABL1, TCF3-PBX1 and MLL-AFF1 fusion genes in Guatemalan Pediatric Acute Lymphoblastic Leukemia Patients and Its Ethnic Associations
Clinical Lymphoma Myeloma and Leukemia, 2015Co-Authors: Claudia Lorena Carranza Meléndez, Luisa Rosales, Mariana Herrera, Lilian Granados, Damaris Tinti, Swuanny Villagran, Mauricio Villegas, Federico Antillon, Silvana TorselliAbstract:Fusion genes involved in acute lymphoblastic leukemia (ALL) occur mostly due to genetic and environmental factors, and only a limited number of studies have reported any Ethnic Influence. This study assesses whether an Ethnic Influence has an effect on the frequency of any of the four fusion genes: BCR-ABL1, ETV6-RUNX1, TCF3-PBX1, and MLL-AFF1 found in ALL. To study this Ethnic Influence, mononuclear cells were obtained from bone marrow samples from 143 patients with ALL. We performed RNA extraction and reverse transcription, then assessed the quality of the cDNA by amplifying the ABL1 control gene, and finally evaluated the presence of the four transcripts by multiplex polymerase chain reaction. We found 10 patients who had the BCR-ABL1 fusion gene (7%); 3 patients (2%) were TCF3-PBX1 positive; and 6 patients (4.5%) were ETV6-RUNX1 positive. The incidence of this last fusion gene is quite low when compared to the values reported in most countries. The low incidence of the ETV6-RUNX1 fusion gene found in Guatemala matches the incidence rates that have been reported in Spain and Indian Romani. Since it is known that an Ethnic resemblance exists among these three populations, as shown by ancestral marker studies, the ALL data suggests an Ethnic Influence on the occurrence and frequency of this particular fusion gene.
Federico Antillon - One of the best experts on this subject based on the ideXlab platform.
-
Frequency of the ETV6-RUNX1, BCR-ABL1, TCF3-PBX1 and MLL-AFF1 fusion genes in Guatemalan Pediatric Acute Lymphoblastic Leukemia Patients and Its Ethnic Associations
Clinical Lymphoma Myeloma and Leukemia, 2015Co-Authors: Claudia Lorena Carranza Meléndez, Luisa Rosales, Mariana Herrera, Lilian Granados, Damaris Tinti, Swuanny Villagran, Mauricio Villegas, Federico Antillon, Silvana TorselliAbstract:Fusion genes involved in acute lymphoblastic leukemia (ALL) occur mostly due to genetic and environmental factors, and only a limited number of studies have reported any Ethnic Influence. This study assesses whether an Ethnic Influence has an effect on the frequency of any of the four fusion genes: BCR-ABL1, ETV6-RUNX1, TCF3-PBX1, and MLL-AFF1 found in ALL. To study this Ethnic Influence, mononuclear cells were obtained from bone marrow samples from 143 patients with ALL. We performed RNA extraction and reverse transcription, then assessed the quality of the cDNA by amplifying the ABL1 control gene, and finally evaluated the presence of the four transcripts by multiplex polymerase chain reaction. We found 10 patients who had the BCR-ABL1 fusion gene (7%); 3 patients (2%) were TCF3-PBX1 positive; and 6 patients (4.5%) were ETV6-RUNX1 positive. The incidence of this last fusion gene is quite low when compared to the values reported in most countries. The low incidence of the ETV6-RUNX1 fusion gene found in Guatemala matches the incidence rates that have been reported in Spain and Indian Romani. Since it is known that an Ethnic resemblance exists among these three populations, as shown by ancestral marker studies, the ALL data suggests an Ethnic Influence on the occurrence and frequency of this particular fusion gene.
Mariana Herrera - One of the best experts on this subject based on the ideXlab platform.
-
Frequency of the ETV6-RUNX1, BCR-ABL1, TCF3-PBX1 and MLL-AFF1 fusion genes in Guatemalan Pediatric Acute Lymphoblastic Leukemia Patients and Its Ethnic Associations
Clinical Lymphoma Myeloma and Leukemia, 2015Co-Authors: Claudia Lorena Carranza Meléndez, Luisa Rosales, Mariana Herrera, Lilian Granados, Damaris Tinti, Swuanny Villagran, Mauricio Villegas, Federico Antillon, Silvana TorselliAbstract:Fusion genes involved in acute lymphoblastic leukemia (ALL) occur mostly due to genetic and environmental factors, and only a limited number of studies have reported any Ethnic Influence. This study assesses whether an Ethnic Influence has an effect on the frequency of any of the four fusion genes: BCR-ABL1, ETV6-RUNX1, TCF3-PBX1, and MLL-AFF1 found in ALL. To study this Ethnic Influence, mononuclear cells were obtained from bone marrow samples from 143 patients with ALL. We performed RNA extraction and reverse transcription, then assessed the quality of the cDNA by amplifying the ABL1 control gene, and finally evaluated the presence of the four transcripts by multiplex polymerase chain reaction. We found 10 patients who had the BCR-ABL1 fusion gene (7%); 3 patients (2%) were TCF3-PBX1 positive; and 6 patients (4.5%) were ETV6-RUNX1 positive. The incidence of this last fusion gene is quite low when compared to the values reported in most countries. The low incidence of the ETV6-RUNX1 fusion gene found in Guatemala matches the incidence rates that have been reported in Spain and Indian Romani. Since it is known that an Ethnic resemblance exists among these three populations, as shown by ancestral marker studies, the ALL data suggests an Ethnic Influence on the occurrence and frequency of this particular fusion gene.