The Experts below are selected from a list of 93 Experts worldwide ranked by ideXlab platform
Qilong Shen - One of the best experts on this subject based on the ideXlab platform.
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Ethoxycarbonyl difluoromethyl thio phthalimide a shelf stable electrophilic reagent with a convertible Group for the synthesis of diversified fluoroalkylthiolated compounds
Organic Letters, 2017Co-Authors: Feng Shen, Panpan Zhang, Qilong ShenAbstract:A shelf-stable and easily convertible reagent for the preparation of diversified fluoroalkylthiolated compounds, [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide, was developed. [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide is an efficient electrophilic fluoroallylthiolating reagent that reacted with electron-rich heteroarenes/arenes, β-ketoesters, oxindoles, benzofuranones, and thiols. More importantly, the Ethoxycarbonyl Group of the resulting fluoroalkylthiolated compounds could be easily converted into various other functional Groups such as chloride, alkynyl, hydrocarbonyl, carbomoyl, hydromethyl, or heteroaryl Groups.
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[[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide: A Shelf-Stable, Electrophilic Reagent with a Convertible Group for the Synthesis of Diversified Fluoroalkylthiolated Compounds
2017Co-Authors: Feng Shen, Panpan Zhang, Qilong ShenAbstract:A shelf-stable and easily convertible reagent for the preparation of diversified fluoroalkylthiolated compounds, [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide, was developed. [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide is an efficient electrophilic fluoroallylthiolating reagent that reacted with electron-rich heteroarenes/arenes, β-ketoesters, oxindoles, benzofuranones, and thiols. More importantly, the Ethoxycarbonyl Group of the resulting fluoroalkylthiolated compounds could be easily converted into various other functional Groups such as chloride, alkynyl, hydrocarbonyl, carbomoyl, hydromethyl, or heteroaryl Groups
Feng Shen - One of the best experts on this subject based on the ideXlab platform.
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Ethoxycarbonyl difluoromethyl thio phthalimide a shelf stable electrophilic reagent with a convertible Group for the synthesis of diversified fluoroalkylthiolated compounds
Organic Letters, 2017Co-Authors: Feng Shen, Panpan Zhang, Qilong ShenAbstract:A shelf-stable and easily convertible reagent for the preparation of diversified fluoroalkylthiolated compounds, [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide, was developed. [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide is an efficient electrophilic fluoroallylthiolating reagent that reacted with electron-rich heteroarenes/arenes, β-ketoesters, oxindoles, benzofuranones, and thiols. More importantly, the Ethoxycarbonyl Group of the resulting fluoroalkylthiolated compounds could be easily converted into various other functional Groups such as chloride, alkynyl, hydrocarbonyl, carbomoyl, hydromethyl, or heteroaryl Groups.
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[[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide: A Shelf-Stable, Electrophilic Reagent with a Convertible Group for the Synthesis of Diversified Fluoroalkylthiolated Compounds
2017Co-Authors: Feng Shen, Panpan Zhang, Qilong ShenAbstract:A shelf-stable and easily convertible reagent for the preparation of diversified fluoroalkylthiolated compounds, [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide, was developed. [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide is an efficient electrophilic fluoroallylthiolating reagent that reacted with electron-rich heteroarenes/arenes, β-ketoesters, oxindoles, benzofuranones, and thiols. More importantly, the Ethoxycarbonyl Group of the resulting fluoroalkylthiolated compounds could be easily converted into various other functional Groups such as chloride, alkynyl, hydrocarbonyl, carbomoyl, hydromethyl, or heteroaryl Groups
Panpan Zhang - One of the best experts on this subject based on the ideXlab platform.
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Ethoxycarbonyl difluoromethyl thio phthalimide a shelf stable electrophilic reagent with a convertible Group for the synthesis of diversified fluoroalkylthiolated compounds
Organic Letters, 2017Co-Authors: Feng Shen, Panpan Zhang, Qilong ShenAbstract:A shelf-stable and easily convertible reagent for the preparation of diversified fluoroalkylthiolated compounds, [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide, was developed. [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide is an efficient electrophilic fluoroallylthiolating reagent that reacted with electron-rich heteroarenes/arenes, β-ketoesters, oxindoles, benzofuranones, and thiols. More importantly, the Ethoxycarbonyl Group of the resulting fluoroalkylthiolated compounds could be easily converted into various other functional Groups such as chloride, alkynyl, hydrocarbonyl, carbomoyl, hydromethyl, or heteroaryl Groups.
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[[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide: A Shelf-Stable, Electrophilic Reagent with a Convertible Group for the Synthesis of Diversified Fluoroalkylthiolated Compounds
2017Co-Authors: Feng Shen, Panpan Zhang, Qilong ShenAbstract:A shelf-stable and easily convertible reagent for the preparation of diversified fluoroalkylthiolated compounds, [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide, was developed. [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide is an efficient electrophilic fluoroallylthiolating reagent that reacted with electron-rich heteroarenes/arenes, β-ketoesters, oxindoles, benzofuranones, and thiols. More importantly, the Ethoxycarbonyl Group of the resulting fluoroalkylthiolated compounds could be easily converted into various other functional Groups such as chloride, alkynyl, hydrocarbonyl, carbomoyl, hydromethyl, or heteroaryl Groups
Nagatoshi Nishiwaki - One of the best experts on this subject based on the ideXlab platform.
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alkynylation and cyanation of alkenes using diverse properties of a nitro Group
Journal of Organic Chemistry, 2018Co-Authors: Haruyasu Asahara, Ayano Sofue, Yasuyuki Kuroda, Nagatoshi NishiwakiAbstract:In the work being reported here, β-nitrostyrenes bearing an Ethoxycarbonyl Group at the β-position serve as scaffolds for the synthesis of α,β-difunctionalized alkenes. Nitrocinnamates undergo Michael addition reactions with versatile sp3- and sp2-nucleophiles such as alcohols, Grignard reagents, alkylcopper, and dialkylzinc to afford β-substituted nitroethane derivatives. However, various attempts to obtain a double bond via nitrous acid elimination failed because steric repulsion between the newly introduced sp3/sp2 substituent and the nitro Group hampered the required anti-coplanar conformation. This problem was successfully overcome using a smaller sp-nucleophile such as lithium acetylide, potassium cyanide, or trimethylsilyl cyanide. While treatment of the adduct with a strong base did not lead to the elimination of nitrous acid, the weaker triethylamine efficiently afforded functionalized enynes and acrylonitriles in high yields.
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Alkynylation and Cyanation of Alkenes Using Diverse Properties of a Nitro Group
2018Co-Authors: Haruyasu Asahara, Ayano Sofue, Yasuyuki Kuroda, Nagatoshi NishiwakiAbstract:In the work being reported here, β-nitrostyrenes bearing an Ethoxycarbonyl Group at the β-position serve as scaffolds for the synthesis of α,β-difunctionalized alkenes. Nitrocinnamates undergo Michael addition reactions with versatile sp3- and sp2-nucleophiles such as alcohols, Grignard reagents, alkylcopper, and dialkylzinc to afford β-substituted nitroethane derivatives. However, various attempts to obtain a double bond via nitrous acid elimination failed because steric repulsion between the newly introduced sp3/sp2 substituent and the nitro Group hampered the required anti-coplanar conformation. This problem was successfully overcome using a smaller sp-nucleophile such as lithium acetylide, potassium cyanide, or trimethylsilyl cyanide. While treatment of the adduct with a strong base did not lead to the elimination of nitrous acid, the weaker triethylamine efficiently afforded functionalized enynes and acrylonitriles in high yields
Susung Oh - One of the best experts on this subject based on the ideXlab platform.
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synthesis of naphthalenes via platinum catalyzed hydroarylation of aryl enynes
Organic Letters, 2012Co-Authors: Dongjin Kang, Susung OhAbstract:An efficient synthetic method of functionalized naphthalenes having hydrogen, alkyl, alkenyl, aryl, or heteroaryl Groups on the 4-position and Ethoxycarbonyl Group on the 2-position was developed through selective Pt-catalyzed 6-endo intramolecular hydroarylation of ethyl (E)-2-ethynyl/alkynyl cinnamates.